Transcriptional regulation of pluripotent stem cells

No Pathway Network information available for Transcriptional regulation of pluripotent stem cells

Pathways in the Transcriptional regulation of pluripotent stem cells SuperPath

#	Name	Source	Genes
1	Transcriptional regulation of pluripotent stem cells	Reactome	CRIPTO DPPA4 EPAS1 EPHA1 FGF2 FOXD3 FOXP1 HIF3A KLF4 LIN28A NANOG NR5A1 NR6A1 PBX1 POU5F1 PRDM14 SALL1 SALL4 SMAD2 SMAD4 SOX2 STAT3 ZIC3 ZSCAN10 (see all 24) (see less)
2	POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	Reactome	CRIPTO DPPA4 EPHA1 FGF2 FOXD3 NANOG NR6A1 POU5F1 SALL1 SALL4 SOX2 STAT3 ZIC3 (see all 13) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	EPHA1	EPH Receptor A1	Protein Coding	2
2	FGF2	Fibroblast Growth Factor 2	Protein Coding	2
3	NR6A1	Nuclear Receptor Subfamily 6 Group A Member 1	Protein Coding	2
4	FOXD3	Forkhead Box D3	Protein Coding	2
5	POU5F1	POU Class 5 Homeobox 1	Protein Coding	2
6	DPPA4	Developmental Pluripotency Associated 4	Protein Coding	2
7	SALL4	Spalt Like Transcription Factor 4	Protein Coding	2
8	SALL1	Spalt Like Transcription Factor 1	Protein Coding	2
9	SOX2	SRY-Box Transcription Factor 2	Protein Coding	2
10	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	2
11	CRIPTO	Cripto, EGF-CFC Family Member	Protein Coding	2
12	ZIC3	Zic Family Zinc Finger 3	Protein Coding	2
13	NANOG	Nanog Homeobox	Protein Coding	2
14	EPAS1	Endothelial PAS Domain Protein 1	Protein Coding	1
15	NR5A1	Nuclear Receptor Subfamily 5 Group A Member 1	Protein Coding	1
16	FOXP1	Forkhead Box P1	Protein Coding	1
17	SMAD2	SMAD Family Member 2	Protein Coding	1
18	SMAD4	SMAD Family Member 4	Protein Coding	1
19	PBX1	PBX Homeobox 1	Protein Coding	1
20	PRDM14	PR/SET Domain 14	Protein Coding	1
21	HIF3A	Hypoxia Inducible Factor 3 Subunit Alpha	Protein Coding	1
22	LIN28A	Lin-28 RNA Binding Posttranscriptional Regulator A	Protein Coding	1
23	ZSCAN10	Zinc Finger And SCAN Domain Containing 10	Protein Coding	1
24	KLF4	KLF Transcription Factor 4	Protein Coding	1

Disorders associated with Transcriptional regulation of pluripotent stem cells SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Heterotaxy, visceral, 1, x-linked	Enrichment	ZIC3	3.02
2	Townes-brocks syndrome 1	Enrichment	SALL1	3.02
3	Ivic syndrome	Enrichment	SALL4	3.02
4	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	3.02
5	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	3.02
6	Oculovertebral syndrome	Enrichment	NR6A1	3.02
7	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	3.02
8	Sall4-related disorders	Enrichment	SALL4	3.02
9	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	3.02
10	Earlobe crease	Enrichment	FOXP1	2.75
11	46,xx sex reversal 4	Enrichment	NR5A1	2.75
12	Spermatogenic failure 8	Enrichment	NR5A1	2.75
13	Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay	Enrichment	PBX1	2.75
14	Erythrocytosis, familial, 4	Enrichment	EPAS1	2.75
15	Otofacial neurodevelopmental syndrome	Enrichment	ZSCAN10	2.75
16	Premature ovarian failure 7	Enrichment	NR5A1	2.75
17	Loeys-dietz syndrome 6	Enrichment	SMAD2	2.75
18	Congenital heart defects, multiple types, 8, with or without heterotaxy	Enrichment	SMAD2	2.75
19	Heritable thoracic aortic disease	Enrichment	SMAD4	2.75
20	Multiple paragangliomas associated with polycythemia	Enrichment	EPAS1	2.75
21	Vacterl association, x-linked, with or without hydrocephalus	Enrichment	ZIC3	2.72
22	Duane-radial ray syndrome	Enrichment	SALL4	2.72
23	Townes-brocks syndrome	Enrichment	SALL1	2.72
24	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	SMAD2, SMAD4	2.57
25	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.54
26	Autoimmune disease 1	Enrichment	FOXD3	2.54
27	Breast implant-associated anaplastic large cell lymphoma	Enrichment	STAT3	2.54
28	Hyper ige syndrome	Enrichment	STAT3	2.54
29	Duane retraction syndrome	Enrichment	SALL4	2.54
30	Myhre syndrome	Enrichment	SMAD4	2.45
31	Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome	Enrichment	SMAD4	2.45
32	Intellectual developmental disorder with language impairment and with or without autistic features	Enrichment	FOXP1	2.45
33	Erythrocytosis, familial, 3	Enrichment	EPAS1	2.45
34	46,xy sex reversal 3	Enrichment	NR5A1	2.45
35	B-lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3)	Enrichment	PBX1	2.45
36	B-lymphoblastic leukemia/lymphoma with recurrent genetic abnormality	Enrichment	FOXP1	2.45
37	Renal hypoplasia, bilateral	Enrichment	PBX1	2.45
38	Microphthalmia, syndromic 3	Enrichment	SOX2	2.42
39	Isolated congenitally uncorrected transposition of the great arteries	Enrichment	ZIC3	2.42
40	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative	Enrichment	SALL4	2.32
41	Juvenile polyposis syndrome	Enrichment	SMAD4	2.28
42	46,xx sex reversal 1	Enrichment	NR5A1	2.28
43	Loeys-dietz syndrome 1	Enrichment	SMAD2	2.28
44	Spermatogenic failure 1	Enrichment	NR5A1	2.15
45	Permanent neonatal diabetes mellitus	Enrichment	STAT3	2.12
46	Lymphoma, mucosa-associated lymphoid type	Enrichment	FOXP1	2.05
47	Nonsyndromic 46,xx testicular disorders/differences of sex development	Enrichment	NR5A1	2.05
48	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	SMAD4	2.05
49	Nanophthalmos	Enrichment	SOX2	1.98
50	Atrial septal defect 1	Enrichment	FOXP1	1.98
51	46,xy disorder of sex development	Enrichment	NR5A1	1.98
52	Autosomal dominant secondary polycythemia	Enrichment	EPAS1	1.98
53	Sporadic pheochromocytoma/secreting paraganglioma	Enrichment	EPAS1	1.98
54	Septooptic dysplasia	Enrichment	SOX2	1.94
55	Gallbladder cancer	Enrichment	SMAD4	1.91
56	Hereditary hemorrhagic telangiectasia	Enrichment	SMAD4	1.91
57	Acute promyelocytic leukemia	Enrichment	STAT3	1.91
58	Difference of sex development	Enrichment	NR5A1	1.85
59	Septopreoptic holoprosencephaly	Enrichment	CRIPTO	1.85
60	Midline interhemispheric variant of holoprosencephaly	Enrichment	CRIPTO	1.85
61	Microform holoprosencephaly	Enrichment	CRIPTO	1.82
62	Lobar holoprosencephaly	Enrichment	CRIPTO	1.82
63	Loeys-dietz syndrome	Enrichment	SMAD2	1.80
64	Alobar holoprosencephaly	Enrichment	CRIPTO	1.79
65	Semilobar holoprosencephaly	Enrichment	CRIPTO	1.77
66	Diffuse large b-cell lymphoma	Enrichment	STAT3	1.74
67	Macs syndrome	Enrichment	SOX2	1.72
68	46,xy complete gonadal dysgenesis	Enrichment	NR5A1	1.71
69	Visceral heterotaxy	Enrichment	ZIC3	1.68
70	Microphthalmia	Enrichment	SOX2	1.68
71	46 xx gonadal dysgenesis	Enrichment	NR5A1	1.68
72	46,xy partial gonadal dysgenesis	Enrichment	NR5A1	1.61
73	Rare genetic intellectual disability	Enrichment	FOXP1	1.58
74	Cakut	Enrichment	SALL1	1.49
75	Pancreatic cancer	Enrichment	SMAD4	1.36
76	Strabismus	Enrichment	FOXP1	1.33
77	Male infertility	Enrichment	NR5A1	1.23
78	Gastric cancer	Enrichment	SMAD4	1.13
79	Sensorineural hearing loss	Enrichment	ZSCAN10	1.09
80	Thrombocytopenia	Enrichment	SMAD4	1.09
81	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	NR5A1	1.02
82	Autism	Enrichment	FOXP1	0.92
83	Colorectal cancer	Enrichment	SMAD4	0.84
84	Autism spectrum disorder	Enrichment	PBX1	0.75
85	Inherited cancer-predisposing syndrome	Enrichment	SMAD4	0.68

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Transcriptional regulation of pluripotent stem cells

Pathway Network for Transcriptional regulation of pluripotent stem cells

Member Pathways for Transcriptional regulation of pluripotent stem cells

Pathways in the Transcriptional regulation of pluripotent stem cells SuperPath

Associated Genes for Transcriptional regulation of pluripotent stem cells

Associated Disorders for Transcriptional regulation of pluripotent stem cells

Disorders associated with Transcriptional regulation of pluripotent stem cells SuperPath

STRING Interaction Network for Transcriptional regulation of pluripotent stem cells

Sources for Transcriptional regulation of pluripotent stem cells