Transcriptional Regulatory Network in Embryonic Stem Cell

No Pathway Network information available for Transcriptional Regulatory Network in Embryonic Stem Cell

Pathways in the Transcriptional Regulatory Network in Embryonic Stem Cell SuperPath

#	Name	Source	Genes
1	Transcriptional Regulatory Network in Embryonic Stem Cell	QIAGEN	CDX2 CDYL EOMES ESX1 FOXC1 FOXD3 GATA4 GATA6 GBX2 GJD2 GRIN1 HAND1 HESX1 HNF4A HOXB1 ISL1 JARID2 KAT6A L1CAM LHX5 MEIS1 MYF5 NANOG NEUROD1 NEUROG1 ONECUT1 OTX1 PAX6 POU5F1 REST RFX4 RIF1 SALL1 SET SIX3 SKIL SMARCAD1 SOX2 STAT3 TRIM24 ZFHX3 ZIC3 (see all 42) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ZFHX3	Zinc Finger Homeobox 3	Protein Coding	1
2	CDX2	Caudal Type Homeobox 2	Protein Coding	1
3	CDYL	Chromodomain Y Like	Protein Coding	1
4	EOMES	Eomesodermin	Protein Coding	1
5	ESX1	ESX Homeobox 1	Protein Coding	1
6	FOXC1	Forkhead Box C1	Protein Coding	1
7	FOXD3	Forkhead Box D3	Protein Coding	1
8	GATA4	GATA Binding Protein 4	Protein Coding	1
9	GATA6	GATA Binding Protein 6	Protein Coding	1
10	GBX2	Gastrulation Brain Homeobox 2	Protein Coding	1
11	GJD2	Gap Junction Protein Delta 2	Protein Coding	1
12	GRIN1	Glutamate Ionotropic Receptor NMDA Type Subunit 1	Protein Coding	1
13	HAND1	Heart And Neural Crest Derivatives Expressed 1	Protein Coding	1
14	HESX1	HESX Homeobox 1	Protein Coding	1
15	HNF4A	Hepatocyte Nuclear Factor 4 Alpha	Protein Coding	1
16	HOXB1	Homeobox B1	Protein Coding	1
17	ISL1	ISL LIM Homeobox 1	Protein Coding	1
18	JARID2	Jumonji And AT-Rich Interaction Domain Containing 2	Protein Coding	1
19	L1CAM	L1 Cell Adhesion Molecule	Protein Coding	1
20	LHX5	LIM Homeobox 5	Protein Coding	1
21	MEIS1	Meis Homeobox 1	Protein Coding	1
22	MYF5	Myogenic Factor 5	Protein Coding	1
23	KAT6A	Lysine Acetyltransferase 6A	Protein Coding	1
24	NANOG	Nanog Homeobox	Protein Coding	1
25	NEUROD1	Neuronal Differentiation 1	Protein Coding	1
26	NEUROG1	Neurogenin 1	Protein Coding	1
27	ONECUT1	One Cut Homeobox 1	Protein Coding	1
28	OTX1	Orthodenticle Homeobox 1	Protein Coding	1
29	PAX6	Paired Box 6	Protein Coding	1
30	POU5F1	POU Class 5 Homeobox 1	Protein Coding	1
31	REST	RE1 Silencing Transcription Factor	Protein Coding	1
32	RFX4	Regulatory Factor X4	Protein Coding	1
33	RIF1	Replication Timing Regulatory Factor 1	Protein Coding	1
34	SALL1	Spalt Like Transcription Factor 1	Protein Coding	1
35	SET	SET Nuclear Proto-Oncogene	Protein Coding	1
36	SIX3	SIX Homeobox 3	Protein Coding	1
37	SKIL	SKI Like Proto-Oncogene	Protein Coding	1
38	SMARCAD1	SNF2 Related Chromatin Remodeling ATPase With DExD Box 1	Protein Coding	1
39	SOX2	SRY-Box Transcription Factor 2	Protein Coding	1
40	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
41	TRIM24	Tripartite Motif Containing 24	Protein Coding	1
42	ZIC3	Zic Family Zinc Finger 3	Protein Coding	1

Disorders associated with Transcriptional Regulatory Network in Embryonic Stem Cell SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Congenital heart defects, multiple types, 4	Enrichment	GATA4, GATA6	4.03
2	Aniridia	Enrichment	FOXC1, PAX6	4.03
3	Peters-plus syndrome	Enrichment	FOXC1, PAX6	3.38
4	Autosomal dominant non-syndromic intellectual disability	Enrichment	GRIN1, JARID2, SET	3.31
5	Septooptic dysplasia	Enrichment	HESX1, SOX2	3.22
6	Anterior segment dysgenesis	Enrichment	FOXC1, PAX6	3.02
7	Patent foramen ovale	Enrichment	GATA4, GATA6	2.86
8	Macs syndrome	Enrichment	PAX6, SOX2	2.77
9	Maturity-onset diabetes of the young	Enrichment	HNF4A, NEUROD1	2.77
10	Microphthalmia	Enrichment	PAX6, SOX2	2.68
11	Familial atrial fibrillation	Enrichment	GATA4, GATA6	2.61
12	Tetralogy of fallot	Enrichment	GATA4, GATA6	2.54
13	Basan syndrome	Enrichment	SMARCAD1	2.51
14	Adermatoglyphia	Enrichment	SMARCAD1	2.51
15	Huriez syndrome	Enrichment	SMARCAD1	2.51
16	Hydrocephalus due to congenital stenosis of aqueduct of sylvius	Enrichment	L1CAM	2.51
17	Hypertelorism and tetralogy of fallot	Enrichment	FOXC1	2.51
18	Heterotaxy, visceral, 1, x-linked	Enrichment	ZIC3	2.51
19	Maturity-onset diabetes of the young, type 6	Enrichment	NEUROD1	2.51
20	Townes-brocks syndrome 1	Enrichment	SALL1	2.51
21	Fanconi renotubular syndrome 4 with maturity-onset diabetes of the young	Enrichment	HNF4A	2.51
22	Facial paresis, hereditary congenital, 3	Enrichment	HOXB1	2.51
23	Atrioventricular septal defect 4	Enrichment	GATA4	2.51
24	Atrioventricular septal defect 5	Enrichment	GATA6	2.51
25	Wilms tumor 6	Enrichment	REST	2.51
26	Corpus callosum, partial agenesis of, x-linked	Enrichment	L1CAM	2.51
27	Hydrocephalus, congenital, x-linked	Enrichment	L1CAM	2.51
28	Masa syndrome	Enrichment	L1CAM	2.51
29	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.51
30	Developmental delay with variable intellectual disability and dysmorphic facies	Enrichment	JARID2	2.51
31	Atrial fibrillation, familial, 8	Enrichment	ZFHX3	2.51
32	Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal recessive	Enrichment	GRIN1	2.51
33	Ophthalmoplegia, external, with rib and vertebral anomalies	Enrichment	MYF5	2.51
34	Atrial septal defect 2	Enrichment	GATA4	2.51
35	Deafness, autosomal dominant 27	Enrichment	REST	2.51
36	Testicular anomalies with or without congenital heart disease	Enrichment	GATA4	2.51
37	Arboleda-tham syndrome	Enrichment	KAT6A	2.51
38	Developmental and epileptic encephalopathy 101	Enrichment	GRIN1	2.51
39	Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominant	Enrichment	GRIN1	2.51
40	Atrial septal defect 9	Enrichment	GATA6	2.51
41	Fibromatosis, gingival, 5	Enrichment	REST	2.51
42	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.51
43	8p23.1 microdeletion syndrome	Enrichment	GATA4	2.51
44	Cranial dysinnervation disorder, congenital, with absent corneal reflex and developmental delay	Enrichment	NEUROG1	2.51
45	Congenital hereditary facial paralysis-variable hearing loss syndrome	Enrichment	HOXB1	2.51
46	Keratoderma with scleroatrophy of the extremities	Enrichment	SMARCAD1	2.51
47	Sirenomelia	Enrichment	CDX2	2.51
48	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.51
49	Hyperinsulinism due to hnf4a deficiency	Enrichment	HNF4A	2.51
50	Partial atrioventricular septal defect with ventricular hypoplasia	Enrichment	GATA4	2.51
51	X-linked complicated spastic paraplegia type 1	Enrichment	L1CAM	2.51
52	Intellectual disability, autosomal dominant 8	Enrichment	GRIN1	2.51
53	Anorectal malformation	Enrichment	CDX2	2.51
54	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.51
55	Microcephaly-polymicrogyria-corpus callosum agenesis syndrome	Enrichment	EOMES	2.51
56	Cakut	Enrichment	FOXC1, SALL1	2.31
57	Keratitis, hereditary	Enrichment	PAX6	2.21
58	Foveal hypoplasia 1	Enrichment	PAX6	2.21
59	Holoprosencephaly 2	Enrichment	SIX3	2.21
60	Maturity-onset diabetes of the young, type 1	Enrichment	HNF4A	2.21
61	Fibromatosis, gingival, 1	Enrichment	REST	2.21
62	Axenfeld-rieger syndrome, type 3	Enrichment	FOXC1	2.21
63	Vacterl association, x-linked, with or without hydrocephalus	Enrichment	ZIC3	2.21
64	Axenfeld-rieger anomaly with partially absent eye muscles, distinctive face, hydrocephaly, and skeletal abnormalities	Enrichment	FOXC1	2.21
65	Pituitary hormone deficiency, combined or isolated, 1	Enrichment	HESX1	2.21
66	Solitary median maxillary central incisor	Enrichment	SIX3	2.21
67	Optic nerve hypoplasia, bilateral	Enrichment	PAX6	2.21
68	Neutropenia, severe congenital, 8, autosomal dominant	Enrichment	GATA6	2.21
69	Anterior segment dysgenesis 3	Enrichment	FOXC1	2.21
70	Bladder exstrophy	Enrichment	ISL1	2.21
71	Bilateral generalized polymicrogyria	Enrichment	GRIN1	2.21
72	Townes-brocks syndrome	Enrichment	SALL1	2.21
73	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	KAT6A	2.21
74	46,xy sex reversal 3	Enrichment	GATA4	2.21
75	Intellectual developmental disorder, autosomal dominant 58	Enrichment	SET	2.21
76	Axenfeld-rieger syndrome	Enrichment	FOXC1	2.21
77	Hyperinsulinism	Enrichment	HNF4A	2.21
78	Hyperinsulinism due to hnf1a deficiency	Enrichment	HNF4A	2.21
79	Type 2 diabetes mellitus	Enrichment	HNF4A, NEUROD1	2.13
80	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.03
81	Gillespie syndrome	Enrichment	PAX6	2.03
82	Heart defects, congenital, and other congenital anomalies	Enrichment	GATA6	2.03
83	Spinocerebellar ataxia 4	Enrichment	ZFHX3	2.03
84	Autoimmune disease 1	Enrichment	FOXD3	2.03
85	Arthrogryposis multiplex congenita 6	Enrichment	RIF1	2.03
86	Breast implant-associated anaplastic large cell lymphoma	Enrichment	STAT3	2.03
87	Hyper ige syndrome	Enrichment	STAT3	2.03
88	Aniridia 1	Enrichment	PAX6	1.91
89	Nemaline myopathy 2	Enrichment	RIF1	1.91
90	Microphthalmia, syndromic 3	Enrichment	SOX2	1.91
91	Schizencephaly	Enrichment	SIX3	1.91
92	Maturity-onset diabetes of the young, type 3	Enrichment	HNF4A	1.91
93	Eyelid coloboma	Enrichment	PAX6	1.91
94	Transposition of the great arteries	Enrichment	GATA4	1.91
95	Middle aortic syndrome	Enrichment	GATA6	1.91
96	Gingival fibromatosis	Enrichment	REST	1.91
97	Isolated congenitally uncorrected transposition of the great arteries	Enrichment	ZIC3	1.91
98	Lens coloboma	Enrichment	PAX6	1.91
99	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	ESX1, GATA4	1.89
100	Ventricular septal defect 1	Enrichment	GATA4	1.81
101	Muscular dystrophy, limb-girdle, autosomal recessive 23	Enrichment	L1CAM	1.81
102	Juvenile glaucoma	Enrichment	FOXC1	1.81
103	Coloboma of choroid and retina	Enrichment	PAX6	1.81
104	Persistent truncus arteriosus	Enrichment	GATA6	1.81
105	Hypothyroidism due to deficient transcription factors involved in pituitary development or function	Enrichment	HESX1	1.81
106	Coloboma of optic nerve	Enrichment	PAX6	1.73
107	Conotruncal heart malformations	Enrichment	GATA6	1.73
108	Wilms tumor, aniridia, genitourinary anomalies, and impaired intellectual development syndrome	Enrichment	PAX6	1.73
109	Anterior segment dysgenesis 5	Enrichment	PAX6	1.73
110	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.61
111	Combined pituitary hormone deficiency	Enrichment	HESX1	1.61
112	Hydrops fetalis	Enrichment	L1CAM	1.56
113	Cat eye syndrome	Enrichment	PAX6	1.52
114	Nemaline myopathy	Enrichment	RIF1	1.52
115	Nanophthalmos	Enrichment	SOX2	1.47
116	Microphthalmia/coloboma 12	Enrichment	PAX6	1.40
117	Diaphragmatic hernia, congenital	Enrichment	GATA6	1.40
118	Acute promyelocytic leukemia	Enrichment	STAT3	1.40
119	Stereotypic movement disorder	Enrichment	JARID2	1.40
120	Aortic aneurysm, familial thoracic 1	Enrichment	GATA4	1.37
121	Heart disease	Enrichment	GATA4	1.37
122	Pituitary stalk interruption syndrome	Enrichment	HESX1	1.37
123	46,xy partial gonadal dysgenesis	Enrichment	GATA4	1.37
124	Coloboma of macula	Enrichment	PAX6	1.34
125	Wilms tumor 1	Enrichment	REST	1.34
126	Septopreoptic holoprosencephaly	Enrichment	SIX3	1.34
127	Male infertility with spermatogenesis disorder	Enrichment	HESX1	1.34
128	Midline interhemispheric variant of holoprosencephaly	Enrichment	SIX3	1.34
129	Microform holoprosencephaly	Enrichment	SIX3	1.31
130	Lobar holoprosencephaly	Enrichment	SIX3	1.31
131	Polycystic liver disease	Enrichment	HNF4A	1.29
132	Syndromic intellectual disability	Enrichment	KAT6A	1.29
133	Autosomal dominant polycystic liver disease	Enrichment	HNF4A	1.29
134	Alobar holoprosencephaly	Enrichment	SIX3	1.29
135	Heart, malformation of	Enrichment	GATA4	1.27
136	Early infantile developmental and epileptic encephalopathy	Enrichment	GRIN1	1.27
137	Semilobar holoprosencephaly	Enrichment	SIX3	1.27
138	Diffuse large b-cell lymphoma	Enrichment	STAT3	1.24
139	Craniosynostosis	Enrichment	KAT6A	1.22
140	Visceral heterotaxy	Enrichment	ZIC3	1.18
141	Kallmann syndrome	Enrichment	HESX1	1.16
142	Precursor t-cell acute lymphoblastic leukemia	Enrichment	SET	1.16
143	Scoliosis	Enrichment	MYF5	1.14
144	Muscular dystrophy	Enrichment	RIF1	1.14
145	Developmental and epileptic encephalopathy 1	Enrichment	GRIN1	1.13
146	Prostate cancer	Enrichment	ZFHX3	1.07
147	Differentiated thyroid carcinoma	Enrichment	TRIM24	1.07
148	Benign epilepsy with centrotemporal spikes	Enrichment	GRIN1	0.92
149	Centralopathic epilepsy	Enrichment	GRIN1	0.90
150	West syndrome	Enrichment	GRIN1	0.89
151	Hypertelorism	Enrichment	PAX6	0.83
152	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	REST	0.83
153	Autosomal recessive non-syndromic intellectual disability	Enrichment	GRIN1	0.78
154	Autism	Enrichment	JARID2	0.70
155	Dilated cardiomyopathy	Enrichment	GATA6	0.66
156	Ovarian cancer	Enrichment	TRIM24	0.57
157	Autism spectrum disorder	Enrichment	KAT6A	0.54
158	Complex neurodevelopmental disorder	Enrichment	JARID2	0.49
159	Hereditary retinal dystrophy	Enrichment	NEUROD1	0.22
160	Fundus dystrophy	Enrichment	NEUROD1	0.22

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Transcriptional Regulatory Network in Embryonic Stem Cell

Pathway Network for Transcriptional Regulatory Network in Embryonic Stem Cell

Member Pathways for Transcriptional Regulatory Network in Embryonic Stem Cell

Pathways in the Transcriptional Regulatory Network in Embryonic Stem Cell SuperPath

Associated Genes for Transcriptional Regulatory Network in Embryonic Stem Cell

Associated Disorders for Transcriptional Regulatory Network in Embryonic Stem Cell

Disorders associated with Transcriptional Regulatory Network in Embryonic Stem Cell SuperPath

STRING Interaction Network for Transcriptional Regulatory Network in Embryonic Stem Cell

Sources for Transcriptional Regulatory Network in Embryonic Stem Cell