Translation factors

Pathway network for the Translation factors SuperPath

Sources:

WikiPathways
Reactome

Pathways in the Translation factors SuperPath

#	Name	Source	Genes
1	Translation factors	WikiPathways	CLUH EEF1A1 EEF1A2 EEF1B2 EEF1D EEF1G EEF2 EEF2K EIF1 EIF1AX EIF1AY EIF2AK1 EIF2AK2 EIF2AK3 EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2B5 EIF2S1 EIF2S2 EIF2S3 EIF3A EIF3B EIF3C EIF3D EIF3E EIF3F EIF3G EIF3H EIF3I EIF3J EIF4A1 EIF4A2 EIF4B EIF4E EIF4EBP1 EIF4EBP2 EIF4EBP3 EIF4G1 EIF4G3 EIF4H EIF5 EIF5A EIF5B EIF6 ETF1 GSPT2 PABPC1 PAIP1 (see all 50) (see less)
2	nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell	WikiPathways	EIF1 EIF1AX EIF2S1 EIF2S2 EIF2S3 EIF3A EIF3B EIF3C EIF3D EIF3E EIF3F EIF3G EIF3H EIF3I EIF3J EIF5 (see all 16) (see less)
3	Recycling of eIF2:GDP	Reactome	EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2B5 EIF2S1 EIF2S2 EIF2S3 (see all 8) (see less)

Gene overlap in member pathways for Translation factors SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	EIF2S2	Eukaryotic Translation Initiation Factor 2 Subunit Beta	Protein Coding	3
2	EIF2S3	Eukaryotic Translation Initiation Factor 2 Subunit Gamma	Protein Coding	3
3	EIF2S1	Eukaryotic Translation Initiation Factor 2 Subunit Alpha	Protein Coding	3
4	EIF2B3	Eukaryotic Translation Initiation Factor 2B Subunit Gamma	Protein Coding	2
5	EIF2B5	Eukaryotic Translation Initiation Factor 2B Subunit Epsilon	Protein Coding	2
6	EIF2B2	Eukaryotic Translation Initiation Factor 2B Subunit Beta	Protein Coding	2
7	EIF2B4	Eukaryotic Translation Initiation Factor 2B Subunit Delta	Protein Coding	2
8	EIF3I	Eukaryotic Translation Initiation Factor 3 Subunit I	Protein Coding	2
9	EIF3H	Eukaryotic Translation Initiation Factor 3 Subunit H	Protein Coding	2
10	EIF3D	Eukaryotic Translation Initiation Factor 3 Subunit D	Protein Coding	2
11	EIF3B	Eukaryotic Translation Initiation Factor 3 Subunit B	Protein Coding	2
12	EIF3A	Eukaryotic Translation Initiation Factor 3 Subunit A	Protein Coding	2
13	EIF3E	Eukaryotic Translation Initiation Factor 3 Subunit E	Protein Coding	2
14	EIF5	Eukaryotic Translation Initiation Factor 5	Protein Coding	2
15	EIF2B1	Eukaryotic Translation Initiation Factor 2B Subunit Alpha	Protein Coding	2
16	EIF1AX	Eukaryotic Translation Initiation Factor 1A X-Linked	Protein Coding	2
17	EIF3J	Eukaryotic Translation Initiation Factor 3 Subunit J	Protein Coding	2
18	EIF3G	Eukaryotic Translation Initiation Factor 3 Subunit G	Protein Coding	2
19	EIF3F	Eukaryotic Translation Initiation Factor 3 Subunit F	Protein Coding	2
20	EIF3C	Eukaryotic Translation Initiation Factor 3 Subunit C	Protein Coding	2
21	EIF1	Eukaryotic Translation Initiation Factor 1	Protein Coding	2
22	EIF5B	Eukaryotic Translation Initiation Factor 5B	Protein Coding	1
23	GSPT2	G1 To S Phase Transition 2	Protein Coding	1
24	EIF2AK3	Eukaryotic Translation Initiation Factor 2 Alpha Kinase 3	Protein Coding	1
25	EIF2AK2	Eukaryotic Translation Initiation Factor 2 Alpha Kinase 2	Protein Coding	1
26	EIF6	Eukaryotic Translation Initiation Factor 6	Protein Coding	1
27	EIF2AK1	Eukaryotic Translation Initiation Factor 2 Alpha Kinase 1	Protein Coding	1
28	PABPC1	Poly(A) Binding Protein Cytoplasmic 1	Protein Coding	1
29	EIF5A	Eukaryotic Translation Initiation Factor 5A	Protein Coding	1
30	EIF4G1	Eukaryotic Translation Initiation Factor 4 Gamma 1	Protein Coding	1
31	EIF4EBP2	Eukaryotic Translation Initiation Factor 4E Binding Protein 2	Protein Coding	1
32	EIF4EBP1	Eukaryotic Translation Initiation Factor 4E Binding Protein 1	Protein Coding	1
33	EIF4E	Eukaryotic Translation Initiation Factor 4E	Protein Coding	1
34	EIF4A2	Eukaryotic Translation Initiation Factor 4A2	Protein Coding	1
35	EIF4A1	Eukaryotic Translation Initiation Factor 4A1	Protein Coding	1
36	EEF2	Eukaryotic Translation Elongation Factor 2	Protein Coding	1
37	EEF1B2	Eukaryotic Translation Elongation Factor 1 Beta 2	Protein Coding	1
38	EEF1A2	Eukaryotic Translation Elongation Factor 1 Alpha 2	Protein Coding	1
39	EEF1A1	Eukaryotic Translation Elongation Factor 1 Alpha 1	Protein Coding	1
40	EIF4B	Eukaryotic Translation Initiation Factor 4B	Protein Coding	1
41	EEF1G	Eukaryotic Translation Elongation Factor 1 Gamma	Protein Coding	1
42	EEF1D	Eukaryotic Translation Elongation Factor 1 Delta	Protein Coding	1
43	EIF1AY	Eukaryotic Translation Initiation Factor 1A Y-Linked	Protein Coding	1
44	EIF4G3	Eukaryotic Translation Initiation Factor 4 Gamma 3	Protein Coding	1
45	EIF4EBP3	Eukaryotic Translation Initiation Factor 4E Binding Protein 3	Protein Coding	1
46	PAIP1	Poly(A) Binding Protein Interacting Protein 1	Protein Coding	1
47	EIF4H	Eukaryotic Translation Initiation Factor 4H	Protein Coding	1
48	EEF2K	Eukaryotic Elongation Factor 2 Kinase	Protein Coding	1
49	CLUH	CLUH Binding Protein Of NUMT MRNA	Protein Coding	1
50	ETF1	Eukaryotic Translation Termination Factor 1	Protein Coding	1

Disorders associated with Translation factors SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Leukoencephalopathy with vanishing white matter 1	Enrichment	EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5	10.55
2	Leukoencephalopathy with vanishing white matter 5	Enrichment	EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5	10.37
3	Leukoencephalopathy with vanishing white matter	Enrichment	EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5	10.26
4	Mehmo syndrome	Enrichment	EIF2S3	3.23
5	Leukoencephalopathy with vanishing white matter 3	Enrichment	EIF2B3	3.23
6	Leukoencephalopathy with vanishing white matter 2	Enrichment	EIF2B2	3.23
7	Leukoencephalopathy with vanishing white matter 4	Enrichment	EIF2B4	2.93
8	Intellectual developmental disorder, autosomal recessive 67	Enrichment	EIF3F	2.63
9	Parkinson disease 18, autosomal dominant	Enrichment	EIF4G1	2.43
10	Neurodevelopmental disorder with thin corpus callosum, hypotonia, and absent language	Enrichment	EEF1D	2.43
11	Leukoencephalopathy, developmental delay, and episodic neurologic regression syndrome	Enrichment	EIF2AK2	2.43
12	Autism 19	Enrichment	EIF4E	2.43
13	Leukoencephalopathy, motor delay, spasticity, and dysarthria syndrome	Enrichment	EIF2AK1	2.43
14	Spinocerebellar ataxia 26	Enrichment	EEF2	2.43
15	Neurodevelopmental disorder with hypotonia and speech delay, with or without seizures	Enrichment	EIF4A2	2.43
16	Intellectual developmental disorder, autosomal dominant 38	Enrichment	EEF1A2	2.43
17	Faundes-banka syndrome	Enrichment	EIF5A	2.43
18	Dystonia 33	Enrichment	EIF2AK2	2.43
19	Chromosome 5q deletion syndrome	Enrichment	EEF1D	2.13
20	Epiphyseal dysplasia, multiple, with early-onset diabetes mellitus	Enrichment	EIF2AK3	2.13
21	Developmental and epileptic encephalopathy 33	Enrichment	EEF1A2	2.13
22	Leukodystrophy, hypomyelinating, 17	Enrichment	EIF2AK1	2.13
23	Spastic paraplegia 46, autosomal recessive	Enrichment	EEF1A2	2.13
24	Premature menopause	Enrichment	EIF2B2	2.12
25	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	EIF3F	1.98
26	Menkes disease	Enrichment	EIF2AK3	1.96
27	Heparin cofactor ii deficiency	Enrichment	EIF4G3	1.96
28	Torsion dystonia 1	Enrichment	EIF2AK2	1.96
29	Brittle bone disorder	Enrichment	EIF2B2	1.87
30	Autosomal recessive non-syndromic intellectual disability	Enrichment	EEF1B2, EEF1D	1.71
31	Autosomal recessive intellectual developmental disorder	Enrichment	EEF1D	1.66
32	Hereditary breast ovarian cancer syndrome	Enrichment	EIF2B5	1.50
33	Differentiated thyroid carcinoma	Enrichment	EIF1AX	1.47
34	Primary ovarian insufficiency	Enrichment	EIF2B2	1.46
35	Congenital nervous system abnormality	Enrichment	EIF2B2	1.22
36	Nervous system disease	Enrichment	EIF2B2	1.22
37	Myeloma, multiple	Enrichment	EIF1AX	1.19
38	Williams-beuren syndrome	Enrichment	EIF4H	1.15
39	Complex neurodevelopmental disorder	Enrichment	EIF4A2, EIF5A	1.12
40	Parkinson disease, late-onset	Enrichment	EIF4G1	1.07
41	Autosomal dominant non-syndromic intellectual disability	Enrichment	EEF1A2	0.77
42	Undetermined early-onset epileptic encephalopathy	Enrichment	EEF1A2	0.73
43	Autism	Enrichment	GSPT2	0.63

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Translation factors

Pathway Network for Translation factors

Pathway network for the Translation factors SuperPath

Member Pathways for Translation factors

Pathways in the Translation factors SuperPath

Gene overlap in member pathways for Translation factors SuperPath

Associated Genes for Translation factors

Associated Disorders for Translation factors

Disorders associated with Translation factors SuperPath

STRING Interaction Network for Translation factors

Sources for Translation factors