Translation Insulin regulation of translation

Pathway network for the Translation Insulin regulation of translation SuperPath

Sources:

GeneGo (Thomson Reuters)
WikiPathways

Pathways in the Translation Insulin regulation of translation SuperPath

#	Name	Source	Genes
1	Translation Insulin regulation of translation	GeneGo (Thomson Reuters)	AKT1 AKT2 AKT3 EEF2 EEF2K EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2B5 EIF2S1 EIF2S2 EIF2S3 EIF4A1 EIF4A2 EIF4B EIF4E EIF4EBP1 EIF4G1 EIF4G3 EIF4H GRB2 GSK3B HRAS INS INSR IRS1 IRS2 MAP2K1 MAP2K2 MAPK1 MAPK3 MTOR PDPK1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PPP1CA PPP1CB PPP1CC PRKCZ RAF1 RHEB RPS6 RPS6KA1 RPS6KB1 RPS6KB2 SHC1 SOS1 SOS2 TSC1 TSC2 (see all 55) (see less)
2	Translation Regulation of EIF4F activity	GeneGo (Thomson Reuters)	AKT1 AKT2 AKT3 CDC42 EGF EGFR EIF4A1 EIF4A2 EIF4B EIF4E EIF4EBP1 EIF4G1 EIF4G2 EIF4G3 EIF4H GRB2 HRAS IGBP1 IRS1 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP3K1 MAP3K11 MAP3K7 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MKNK1 MTOR PAK1 PDPK1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PPP2CA PPP2CB PRKCZ RAC1 RAF1 RHEB RPS6KA5 RPS6KB1 RPS6KB2 SHC1 SOS1 SOS2 TAB1 TGFB1 TGFBR1 TGFBR2 TIAM1 TSC1 TSC2 (see all 62) (see less)
3	Translation Regulation of EIF2 activity	GeneGo (Thomson Reuters)	AKT1 AKT2 AKT3 CBL CSNK1A1 CSNK1A1L CSNK1D CSNK1E CSNK1G1 CSNK1G2 CSNK1G3 CSNK2A1 CSNK2A2 CSNK2B DYRK1A DYRK2 EGF EGFR EIF2AK1 EIF2AK2 EIF2AK3 EIF2AK4 EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2B5 EIF2S1 EIF2S2 EIF2S3 GAB1 GRB2 GSK3A GSK3B HRAS INS INSR IRS1 IRS2 MAP2K1 MAP2K2 MAPK1 MAPK3 PDPK1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PPP1CA PPP1CB PPP1CC RAF1 SHC1 SOS1 SOS2 (see all 57) (see less)
4	Regulation of lipid metabolism Insulin signaling-generic cascades	GeneGo (Thomson Reuters)	ACLY AKT1 AKT2 AKT3 EEF2 EEF2K EIF2B5 EIF4B EIF4EBP1 GRB2 GSK3B HRAS INS INSR IRS1 IRS2 LIPE MAP2K1 MAP2K2 MAPK1 MAPK3 MTOR PDE3B PDHA1 PDPK1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PPP1CA PPP1CB PPP1CC PPP1R1A PPP1R3A PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCZ RAF1 RHEB RPS6 RPS6KA1 RPS6KB1 RPS6KB2 SHC1 SLC2A4 SOS1 SOS2 TSC2 (see all 55) (see less)
5	Cell adhesion PLAU signaling	GeneGo (Thomson Reuters)	AKT1 AKT2 AKT3 BCAR1 CSNK2A1 CSNK2A2 CSNK2B EGF EGFR ELK1 GAB1 GRB2 HGF HRAS IL6ST ILK ITGA8 ITGB1 JAK1 MAP2K1 MAP2K2 MAPK1 MAPK3 MET NCL PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PLAT PLAU PLAUR PLG PTK2 RAF1 SERPINA5 SERPINB2 SERPINE1 SERPINE2 SHC1 SOS1 SOS2 SRC STAT1 VTN (see all 47) (see less)
6	Translation inhibitors in chronically activated PDGFRA cells	WikiPathways	AKT1 AKT2 AKT3 CSNK2A1 EIF4A1 EIF4A2 EIF4B EIF4E EIF4EBP1 EIF4G1 EIF4G3 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7 MAPK1 MAPK10 MAPK14 MAPK3 MAPK8 MAPK9 MTOR PDCD4 PDK1 PIK3CA PIK3CB PIK3CG PIK3R1 PIK3R2 PIK3R3 PIM1 PIM2 PRKACA PRKCA PRKCD RPS6 RPS6KA1 RPS6KA2 RPS6KA4 RPS6KA5 RPS6KB1 RPS6KB2 RPTOR (see all 46) (see less)
7	Transcription Receptor-mediated HIF regulation	GeneGo (Thomson Reuters)	AKT1 AKT2 AKT3 ARNT EIF4E EIF4EBP1 GRB2 HIF1A HRAS IGF1 IGF1R IGFBP3 INS INSR IRS1 IRS2 IRS4 MAP2K1 MAP2K2 MAPK1 MAPK3 MKNK1 MKNK2 MTOR PDPK1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PRKCZ PTEN RAF1 RHEB RPS6 RPS6KB1 RPS6KB2 SHC1 SOS1 SOS2 TSC2 VEGFA (see all 43) (see less)
8	Development Growth hormone signaling via PI3K/AKT and MAPK cascades	GeneGo (Thomson Reuters)	ADAM17 AKT1 AKT2 AKT3 ATF2 CEBPB DDIT3 EGR1 EIF4EBP1 ELK1 ELK4 FOS GH1 GHR GRB2 GSK3B HRAS IRS1 IRS2 JAK2 JUN JUNB MAP2K1 MAP2K3 MAP3K4 MAPK1 MAPK14 MTOR PIK3CA PIK3R1 PTK2 PTK2B PTPN11 PTPN6 RAF1 RHEB RPS6KB1 SHC1 SOS1 SOS2 SRC TSC2 (see all 42) (see less)
9	Development CNTF receptor signaling	GeneGo (Thomson Reuters)	AKT1 AKT2 AKT3 CLCF1 CNTF CNTFR CRLF1 FOS GRB2 HRAS IL6ST JAK1 JAK2 LIFR MAP2K1 MAP2K2 MAPK1 MAPK3 MTOR PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PTPN11 RAF1 RHEB RPS6KB1 RPS6KB2 SHC1 SOCS3 SOS1 SOS2 STAT1 STAT3 TSC2 (see all 37) (see less)
10	Butyrate-induced histone acetylation	WikiPathways	ACLY AKT1

Gene overlap in member pathways for Translation Insulin regulation of translation SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	10
2	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	9
3	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	9
4	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	9
5	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	9
6	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	9
7	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	9
8	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	8
9	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	8
10	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	8
11	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	8
12	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	8
13	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	8
14	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	8
15	SHC1	SHC Adaptor Protein 1	Protein Coding	8
16	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	8
17	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	8
18	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	8
19	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	7
20	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	7
21	RPS6KB1	Ribosomal Protein S6 Kinase B1	Protein Coding	7
22	EIF4EBP1	Eukaryotic Translation Initiation Factor 4E Binding Protein 1	Protein Coding	6
23	IRS1	Insulin Receptor Substrate 1	Protein Coding	6
24	RHEB	Ras Homolog, MTORC1 Binding	Protein Coding	6
25	RPS6KB2	Ribosomal Protein S6 Kinase B2	Protein Coding	6
26	TSC2	TSC Complex Subunit 2	Protein Coding	6
27	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	5
28	IRS2	Insulin Receptor Substrate 2	Protein Coding	5
29	EIF4B	Eukaryotic Translation Initiation Factor 4B	Protein Coding	4
30	EIF4E	Eukaryotic Translation Initiation Factor 4E	Protein Coding	4
31	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	4
32	INS	Insulin	Protein Coding	4
33	INSR	Insulin Receptor	Protein Coding	4
34	PRKCZ	Protein Kinase C Zeta	Protein Coding	4
35	RPS6	Ribosomal Protein S6	Protein Coding	4
36	EIF4A1	Eukaryotic Translation Initiation Factor 4A1	Protein Coding	3
37	EIF4A2	Eukaryotic Translation Initiation Factor 4A2	Protein Coding	3
38	EIF4G1	Eukaryotic Translation Initiation Factor 4 Gamma 1	Protein Coding	3
39	PPP1CA	Protein Phosphatase 1 Catalytic Subunit Alpha	Protein Coding	3
40	PPP1CB	Protein Phosphatase 1 Catalytic Subunit Beta	Protein Coding	3
41	PPP1CC	Protein Phosphatase 1 Catalytic Subunit Gamma	Protein Coding	3
42	RPS6KA1	Ribosomal Protein S6 Kinase A1	Protein Coding	3
43	EIF4G3	Eukaryotic Translation Initiation Factor 4 Gamma 3	Protein Coding	3
44	EIF2B5	Eukaryotic Translation Initiation Factor 2B Subunit Epsilon	Protein Coding	3
45	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	3
46	EGF	Epidermal Growth Factor	Protein Coding	3
47	EGFR	Epidermal Growth Factor Receptor	Protein Coding	3
48	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	3
49	CSNK2A1	Casein Kinase 2 Alpha 1	Protein Coding	3
50	EEF2	Eukaryotic Translation Elongation Factor 2	Protein Coding	2
51	EIF2S1	Eukaryotic Translation Initiation Factor 2 Subunit Alpha	Protein Coding	2
52	EIF2B1	Eukaryotic Translation Initiation Factor 2B Subunit Alpha	Protein Coding	2
53	EIF2S3	Eukaryotic Translation Initiation Factor 2 Subunit Gamma	Protein Coding	2
54	TSC1	TSC Complex Subunit 1	Protein Coding	2
55	EIF4H	Eukaryotic Translation Initiation Factor 4H	Protein Coding	2
56	EIF2B4	Eukaryotic Translation Initiation Factor 2B Subunit Delta	Protein Coding	2
57	EIF2B3	Eukaryotic Translation Initiation Factor 2B Subunit Gamma	Protein Coding	2
58	EIF2B2	Eukaryotic Translation Initiation Factor 2B Subunit Beta	Protein Coding	2
59	EIF2S2	Eukaryotic Translation Initiation Factor 2 Subunit Beta	Protein Coding	2
60	EEF2K	Eukaryotic Elongation Factor 2 Kinase	Protein Coding	2
61	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	2
62	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	2
63	MKNK1	MAPK Interacting Serine/Threonine Kinase 1	Protein Coding	2
64	RPS6KA5	Ribosomal Protein S6 Kinase A5	Protein Coding	2
65	CSNK2A2	Casein Kinase 2 Alpha 2	Protein Coding	2
66	CSNK2B	Casein Kinase 2 Beta	Protein Coding	2
67	GAB1	GRB2 Associated Binding Protein 1	Protein Coding	2
68	ACLY	ATP Citrate Lyase	Protein Coding	2
69	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	2
70	ELK1	ETS Transcription Factor ELK1	Protein Coding	2
71	IL6ST	Interleukin 6 Cytokine Family Signal Transducer	Protein Coding	2
72	JAK1	Janus Kinase 1	Protein Coding	2
73	PTK2	Protein Tyrosine Kinase 2	Protein Coding	2
74	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	2
75	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	2
76	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	2
77	JAK2	Janus Kinase 2	Protein Coding	2
78	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	2
79	CDC42	Cell Division Cycle 42	Protein Coding	1
80	EIF4G2	Eukaryotic Translation Initiation Factor 4 Gamma 2	Protein Coding	1
81	IGBP1	Immunoglobulin Binding Protein 1	Protein Coding	1
82	MAP3K1	Mitogen-Activated Protein Kinase Kinase Kinase 1	Protein Coding	1
83	MAP3K11	Mitogen-Activated Protein Kinase Kinase Kinase 11	Protein Coding	1
84	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	1
85	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	1
86	PPP2CB	Protein Phosphatase 2 Catalytic Subunit Beta	Protein Coding	1
87	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	1
88	MAPK13	Mitogen-Activated Protein Kinase 13	Protein Coding	1
89	RAC1	Rac Family Small GTPase 1	Protein Coding	1
90	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	1
91	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	1
92	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	1
93	TGFBR1	Transforming Growth Factor Beta Receptor 1	Protein Coding	1
94	TGFBR2	Transforming Growth Factor Beta Receptor 2	Protein Coding	1
95	TIAM1	TIAM Rac1 Associated GEF 1	Protein Coding	1
96	TAB1	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 1	Protein Coding	1
97	CBL	Cbl Proto-Oncogene	Protein Coding	1
98	CSNK1A1	Casein Kinase 1 Alpha 1	Protein Coding	1
99	CSNK1D	Casein Kinase 1 Delta	Protein Coding	1
100	CSNK1E	Casein Kinase 1 Epsilon	Protein Coding	1
101	CSNK1G2	Casein Kinase 1 Gamma 2	Protein Coding	1
102	CSNK1G3	Casein Kinase 1 Gamma 3	Protein Coding	1
103	DYRK1A	Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A	Protein Coding	1
104	GSK3A	Glycogen Synthase Kinase 3 Alpha	Protein Coding	1
105	EIF2AK2	Eukaryotic Translation Initiation Factor 2 Alpha Kinase 2	Protein Coding	1
106	DYRK2	Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2	Protein Coding	1
107	EIF2AK3	Eukaryotic Translation Initiation Factor 2 Alpha Kinase 3	Protein Coding	1
108	EIF2AK1	Eukaryotic Translation Initiation Factor 2 Alpha Kinase 1	Protein Coding	1
109	CSNK1G1	Casein Kinase 1 Gamma 1	Protein Coding	1
110	CSNK1A1L	Casein Kinase 1 Alpha 1 Like	Protein Coding	1
111	EIF2AK4	Eukaryotic Translation Initiation Factor 2 Alpha Kinase 4	Protein Coding	1
112	LIPE	Lipase E, Hormone Sensitive Type	Protein Coding	1
113	PDE3B	Phosphodiesterase 3B	Protein Coding	1
114	PDHA1	Pyruvate Dehydrogenase E1 Subunit Alpha 1	Protein Coding	1
115	PPP1R1A	Protein Phosphatase 1 Regulatory Inhibitor Subunit 1A	Protein Coding	1
116	PPP1R3A	Protein Phosphatase 1 Regulatory Subunit 3A	Protein Coding	1
117	PRKACB	Protein Kinase CAMP-Activated Catalytic Subunit Beta	Protein Coding	1
118	PRKACG	Protein Kinase CAMP-Activated Catalytic Subunit Gamma	Protein Coding	1
119	PRKAR1A	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Alpha	Protein Coding	1
120	PRKAR1B	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Beta	Protein Coding	1
121	PRKAR2A	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Alpha	Protein Coding	1
122	PRKAR2B	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Beta	Protein Coding	1
123	SLC2A4	Solute Carrier Family 2 Member 4	Protein Coding	1
124	HGF	Hepatocyte Growth Factor	Protein Coding	1
125	ILK	Integrin Linked Kinase	Protein Coding	1
126	ITGB1	Integrin Subunit Beta 1	Protein Coding	1
127	MET	MET Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	1
128	NCL	Nucleolin	Protein Coding	1
129	SERPINE1	Serpin Family E Member 1	Protein Coding	1
130	SERPINB2	Serpin Family B Member 2	Protein Coding	1
131	SERPINA5	Serpin Family A Member 5	Protein Coding	1
132	SERPINE2	Serpin Family E Member 2	Protein Coding	1
133	PLAT	Plasminogen Activator, Tissue Type	Protein Coding	1
134	PLAU	Plasminogen Activator, Urokinase	Protein Coding	1
135	PLAUR	Plasminogen Activator, Urokinase Receptor	Protein Coding	1
136	PLG	Plasminogen	Protein Coding	1
137	VTN	Vitronectin	Protein Coding	1
138	ITGA8	Integrin Subunit Alpha 8	Protein Coding	1
139	BCAR1	BCAR1 Scaffold Protein, Cas Family Member	Protein Coding	1
140	RPS6KA2	Ribosomal Protein S6 Kinase A2	Protein Coding	1
141	RPTOR	Regulatory Associated Protein Of MTOR Complex 1	Protein Coding	1
142	MAP2K7	Mitogen-Activated Protein Kinase Kinase 7	Protein Coding	1
143	MAP2K5	Mitogen-Activated Protein Kinase Kinase 5	Protein Coding	1
144	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	1
145	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	1
146	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
147	PRKCD	Protein Kinase C Delta	Protein Coding	1
148	PRKCA	Protein Kinase C Alpha	Protein Coding	1
149	PIK3CG	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma	Protein Coding	1
150	PIM1	Pim-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
151	PDCD4	Programmed Cell Death 4	Protein Coding	1
152	PIM2	Pim-2 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
153	RPS6KA4	Ribosomal Protein S6 Kinase A4	Protein Coding	1
154	PDK1	Pyruvate Dehydrogenase Kinase 1	Protein Coding	1
155	ARNT	Aryl Hydrocarbon Receptor Nuclear Translocator	Protein Coding	1
156	MKNK2	MAPK Interacting Serine/Threonine Kinase 2	Protein Coding	1
157	HIF1A	Hypoxia Inducible Factor 1 Subunit Alpha	Protein Coding	1
158	IGF1	Insulin Like Growth Factor 1	Protein Coding	1
159	IGF1R	Insulin Like Growth Factor 1 Receptor	Protein Coding	1
160	IGFBP3	Insulin Like Growth Factor Binding Protein 3	Protein Coding	1
161	PTEN	Phosphatase And Tensin Homolog	Protein Coding	1
162	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	1
163	IRS4	Insulin Receptor Substrate 4	Protein Coding	1
164	CEBPB	CCAAT Enhancer Binding Protein Beta	Protein Coding	1
165	ATF2	Activating Transcription Factor 2	Protein Coding	1
166	DDIT3	DNA Damage Inducible Transcript 3	Protein Coding	1
167	EGR1	Early Growth Response 1	Protein Coding	1
168	ELK4	ETS Transcription Factor ELK4	Protein Coding	1
169	PTK2B	Protein Tyrosine Kinase 2 Beta	Protein Coding	1
170	GH1	Growth Hormone 1	Protein Coding	1
171	GHR	Growth Hormone Receptor	Protein Coding	1
172	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
173	JUNB	JunB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
174	MAP3K4	Mitogen-Activated Protein Kinase Kinase Kinase 4	Protein Coding	1
175	PTPN6	Protein Tyrosine Phosphatase Non-Receptor Type 6	Protein Coding	1
176	ADAM17	ADAM Metallopeptidase Domain 17	Protein Coding	1
177	CNTF	Ciliary Neurotrophic Factor	Protein Coding	1
178	CNTFR	Ciliary Neurotrophic Factor Receptor	Protein Coding	1
179	LIFR	LIF Receptor Subunit Alpha	Protein Coding	1
180	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
181	SOCS3	Suppressor Of Cytokine Signaling 3	Protein Coding	1
182	CRLF1	Cytokine Receptor Like Factor 1	Protein Coding	1
183	CLCF1	Cardiotrophin Like Cytokine Factor 1	Protein Coding	1

Disorders associated with Translation Insulin regulation of translation SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Rasopathy	Enrichment	HRAS, MAP2K1, MAP2K2, PPP1CB, RAF1, SOS1, SOS2	16.00
2	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, MAP2K1, MAP2K2, PTPN11, RAF1, SOS1	11.65
3	Noonan syndrome 1	Enrichment	CBL, HRAS, MAP2K1, MAP2K2, PPP1CB, RAF1, SOS1, SOS2	10.93
4	Hemimegalencephaly	Enrichment	AKT3, MTOR, PIK3CA, PTEN, RHEB	10.59
5	Leukoencephalopathy with vanishing white matter 1	Enrichment	EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5	10.53
6	Leukoencephalopathy with vanishing white matter 5	Enrichment	EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5	10.14
7	Leukoencephalopathy with vanishing white matter	Enrichment	EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5	9.91
8	Focal cortical dysplasia, type ii	Enrichment	MTOR, RHEB, TSC1, TSC2	9.59
9	Isolated focal cortical dysplasia type ii	Enrichment	MTOR, RHEB, TSC1, TSC2	9.59
10	Noonan syndrome 3	Enrichment	HRAS, PTPN11, RAF1, SOS1	8.78
11	Type 2 diabetes mellitus	Enrichment	AKT2, INSR, IRS1, IRS2, PPP1R3A, SLC2A4	7.80
12	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK1, JAK2, STAT3	7.73
13	Lung non-small cell carcinoma	Enrichment	EGFR, HRAS, MAP2K1, PIK3CA	7.39
14	Adult hepatocellular carcinoma	Enrichment	EGF, PIK3CA, TSC1, TSC2	7.31
15	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3CA, PIK3R2	7.13
16	Arteriovenous malformation	Enrichment	HRAS, MAP2K1, PIK3CA	5.81
17	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1, PIK3CA	5.66
18	Cowden syndrome	Enrichment	AKT1, PIK3CA, PTEN	5.61
19	Specific learning disability	Enrichment	GHR, MAPK1, PTPN11	5.35
20	Meningioma	Enrichment	AKT1, PIK3CA, PTEN	5.19
21	Lip and oral cavity carcinoma	Enrichment	EGFR, HRAS, PIK3CA	5.08
22	Bladder cancer	Enrichment	EGFR, HRAS, PIK3CA, TSC1	5.06
23	Colorectal cancer	Enrichment	AKT1, MET, PIK3CA, PIK3R1, SRC	4.92
24	Lymphangioleiomyomatosis	Enrichment	TSC1, TSC2	4.79
25	Loeys-dietz syndrome 2	Enrichment	TGFBR1, TGFBR2	4.69
26	Immune system disease	Enrichment	CDC42, PIK3CD	4.69
27	Stuve-wiedemann syndrome 1	Enrichment	IL6ST, LIFR	4.66
28	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.66
29	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD, PIK3R1	4.66
30	Cold-induced sweating syndrome	Enrichment	CLCF1, CRLF1	4.66
31	Immunodeficiency 14	Enrichment	PIK3CD, PIK3R1	4.66
32	Stüve-wiedemann syndrome	Enrichment	IL6ST, LIFR	4.66
33	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K1, MAP2K2	4.36
34	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3, PIK3R2	4.36
35	Cardiofaciocutaneous syndrome	Enrichment	MAP2K1, MAP2K2	4.36
36	Noonan syndrome with multiple lentigines	Enrichment	PTPN11, RAF1	4.36
37	Tuberous sclerosis 1	Enrichment	TSC1, TSC2	4.32
38	Hamartoma	Enrichment	TSC1, TSC2	4.32
39	Loeys-dietz syndrome 1	Enrichment	TGFBR1, TGFBR2	4.21
40	Crisponi/cold-induced sweating syndrome 1	Enrichment	CLCF1, CRLF1	4.14
41	Breast cancer	Enrichment	AKT1, JUN, PIK3CA, SHC1	4.08
42	Ovarian cancer	Enrichment	AKT1, EGFR, MAP3K1, PIK3CA, TSC2	4.02
43	Tuberous sclerosis	Enrichment	TSC1, TSC2	4.02
44	Insulin-like growth factor i	Enrichment	IGF1, IGF1R	4.01
45	Enophthalmos	Enrichment	CSNK2B, DYRK1A	3.98
46	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA	3.97
47	Cowden syndrome 1	Enrichment	PIK3CA, PTEN	3.84
48	Proteus syndrome	Enrichment	AKT1	3.83
49	Cowden syndrome 6	Enrichment	AKT1	3.83
50	Nevus, epidermal	Enrichment	HRAS, PIK3CA	3.82
51	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1, PIK3CA	3.82
52	Overgrowth syndrome	Enrichment	MTOR, PIK3R1	3.82
53	Lung squamous cell carcinoma	Enrichment	EGFR, PIK3CA	3.76
54	Lung cancer	Enrichment	EGFR, MET, PIK3CA	3.74
55	Myelofibrosis	Enrichment	JAK2, SRC	3.71
56	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, RAF1	3.70
57	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, PTEN	3.69
58	Follicular thyroid carcinoma	Enrichment	HRAS, PTEN	3.69
59	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3CD, PIK3R1	3.49
60	Hereditary breast carcinoma	Enrichment	AKT1, PIK3CA, PTEN	3.45
61	Ellis-van creveld syndrome	Enrichment	PRKACA, PRKACB	3.24
62	Loeys-dietz syndrome	Enrichment	TGFBR1, TGFBR2	3.14
63	Nk-cell enteropathy	Enrichment	IGF1R, PIK3CB	3.13
64	Marfan syndrome	Enrichment	TGFBR1, TGFBR2	3.04
65	Autism spectrum disorder	Enrichment	CSNK2A1, CSNK2B, DYRK1A, MAP2K1	2.95
66	Rhabdomyosarcoma	Enrichment	HRAS, PTEN	2.94
67	46,xy partial gonadal dysgenesis	Enrichment	MAP3K1, SOS1	2.74
68	Endometrial cancer	Enrichment	PIK3CA, PTEN	2.70
69	Lynch syndrome	Enrichment	PIK3CA, TGFBR2	2.68
70	Hydrops fetalis, nonimmune	Enrichment	HRAS, PTPN11	2.65
71	Hepatocellular carcinoma	Enrichment	MET, PIK3CA	2.59
72	Macrodactyly	Enrichment	PIK3CA	2.56
73	Metachondromatosis	Enrichment	PTPN11	2.56
74	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.56
75	Noonan syndrome 5	Enrichment	RAF1	2.56
76	Noonan syndrome 4	Enrichment	SOS1	2.56
77	Melorheostosis, isolated	Enrichment	MAP2K1	2.56
78	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.56
79	Dermatitis, atopic, 4	Enrichment	SOCS3	2.56
80	Leopard syndrome 1	Enrichment	PTPN11	2.56
81	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.56
82	Cowden syndrome 5	Enrichment	PIK3CA	2.56
83	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.56
84	Noonan syndrome 9	Enrichment	SOS2	2.56
85	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.56
86	Stuve-wiedemann syndrome 2	Enrichment	IL6ST	2.56
87	Noonan syndrome 13	Enrichment	MAPK1	2.56
88	Hyper-ige syndrome 4a, autosomal dominant, with recurrent infections	Enrichment	IL6ST	2.56
89	Short syndrome	Enrichment	PIK3R1	2.56
90	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.56
91	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.56
92	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.56
93	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.56
94	Melorheostosis	Enrichment	MAP2K1	2.56
95	Leopard syndrome 2	Enrichment	RAF1	2.56
96	Immunodeficiency 31a	Enrichment	STAT1	2.56
97	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.56
98	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.56
99	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	2.56
100	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.56
101	Immunodeficiency 31b	Enrichment	STAT1	2.56
102	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.56
103	Hyper-ige syndrome 4b, autosomal recessive, with recurrent infections	Enrichment	IL6ST	2.56
104	Immunodeficiency 94 with autoinflammation and dysmorphic facies	Enrichment	IL6ST	2.56
105	Trigonitis	Enrichment	RAF1	2.56
106	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.56
107	Hypospadias	Enrichment	PIK3CA	2.56
108	Capillary hemangioma	Enrichment	AKT3	2.56
109	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.56
110	Rare venous malformation	Enrichment	PIK3CA	2.56
111	Diaphragmatic eventration	Enrichment	PIK3CA	2.56
112	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.56
113	Rare combined vascular malformation	Enrichment	PIK3CA	2.56
114	Cavernous lymphangioma	Enrichment	PIK3CA	2.56
115	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.56
116	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.56
117	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.56
118	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.56
119	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	2.56
120	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.56
121	Macrodactyly of toe	Enrichment	PIK3CA	2.56
122	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.56
123	Malignant astrocytoma	Enrichment	PTPN11	2.56
124	Laron syndrome	Enrichment	GHR	2.51
125	Growth hormone insensitivity, partial	Enrichment	GHR	2.51
126	Thrombocytopenia 6	Enrichment	SRC	2.51
127	Vegetative pyoderma gangrenosum	Enrichment	PTPN6	2.51
128	Bullous pyoderma gangrenosum	Enrichment	PTPN6	2.51
129	Pustular pyoderma gangrenosum	Enrichment	PTPN6	2.51
130	Classic pyoderma gangrenosum	Enrichment	PTPN6	2.51
131	Donohue syndrome	Enrichment	INSR	2.50
132	Hypothyroidism, congenital, nongoitrous, 9	Enrichment	IRS4	2.50
133	Vacterl association with hydrocephalus	Enrichment	PTEN	2.50
134	Hyperinsulinemic hypoglycemia, familial, 5	Enrichment	INSR	2.50
135	Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities	Enrichment	INSR	2.50
136	Diabetes mellitus, insulin-resistant, with acanthosis nigricans	Enrichment	INSR	2.50
137	Autism 19	Enrichment	EIF4E	2.50
138	Papillary tumor of the pineal region	Enrichment	PTEN	2.50
139	Microvascular complications of diabetes 1	Enrichment	VEGFA	2.50
140	Glioma susceptibility 2	Enrichment	PTEN	2.50
141	Segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome	Enrichment	PTEN	2.50
142	Non-immune hydrops fetalis	Enrichment	HRAS, PTPN11	2.49
143	Parkinson disease 18, autosomal dominant	Enrichment	EIF4G1	2.47
144	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.47
145	Neurodevelopmental disorder with hypotonia and speech delay, with or without seizures	Enrichment	EIF4A2	2.47
146	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.47
147	Immunodeficiency 97 with autoinflammation	Enrichment	PIK3CG	2.47
148	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.47
149	Okur-chung neurodevelopmental syndrome	Enrichment	CSNK2A1	2.47
150	Deafness, autosomal recessive 26	Enrichment	GAB1	2.46
151	Hypomagnesemia 4, renal	Enrichment	EGF	2.46
152	Deafness, autosomal recessive 39	Enrichment	HGF	2.46
153	Angioedema, hereditary, 4	Enrichment	PLG	2.46
154	Osteofibrous dysplasia	Enrichment	MET	2.46
155	Plasminogen activator inhibitor-1 deficiency	Enrichment	SERPINE1	2.46
156	Deafness, autosomal recessive 97	Enrichment	MET	2.46
157	Autism 9	Enrichment	MET	2.46
158	Arthrogryposis, distal, type 11	Enrichment	MET	2.46
159	Craniodigital syndrome and intellectual disability syndrome	Enrichment	CSNK2B	2.46
160	Congenital plasminogen activator inhibitor type 1 deficiency	Enrichment	SERPINE1	2.46
161	Lethal hydranencephaly-diaphragmatic hernia syndrome	Enrichment	PLAT	2.46
162	Egf-related primary hypomagnesemia with intellectual disability	Enrichment	EGF	2.46
163	Prostate cancer	Enrichment	PIK3CA, PTEN	2.42
164	Mehmo syndrome	Enrichment	EIF2S3	2.39
165	Leukoencephalopathy with vanishing white matter 3	Enrichment	EIF2B3	2.39
166	Spinocerebellar ataxia 26	Enrichment	EEF2	2.39
167	Noonan syndrome-like disorder with loose anagen hair 2	Enrichment	PPP1CB	2.39
168	Leukoencephalopathy with vanishing white matter 2	Enrichment	EIF2B2	2.39
169	Acrodysostosis 1 with or without hormone resistance	Enrichment	PRKAR1A	2.39
170	Carney complex, type 1	Enrichment	PRKAR1A	2.39
171	Cardioacrofacial dysplasia 2	Enrichment	PRKACB	2.39
172	Myxoma, intracardiac	Enrichment	PRKAR1A	2.39
173	Prkar1b-related neurodegenerative dementia with intermediate filaments	Enrichment	PRKAR1B	2.39
174	Advanced sleep phase syndrome, familial, 2	Enrichment	CSNK1D	2.38
175	Intellectual developmental disorder, autosomal dominant 7	Enrichment	DYRK1A	2.38
176	Leukoencephalopathy, developmental delay, and episodic neurologic regression syndrome	Enrichment	EIF2AK2	2.38
177	Leukoencephalopathy, motor delay, spasticity, and dysarthria syndrome	Enrichment	EIF2AK1	2.38
178	Dystonia 33	Enrichment	EIF2AK2	2.38
179	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	2.34
180	Multiple self-healing squamous epithelioma	Enrichment	TGFBR1	2.34
181	46,xy sex reversal 6	Enrichment	MAP3K1	2.34
182	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	2.34
183	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.34
184	Colorectal cancer, hereditary nonpolyposis, type 6	Enrichment	TGFBR2	2.34
185	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.34
186	Neurodevelopmental disorder with language delay and seizures	Enrichment	TIAM1	2.34
187	Nocarh syndrome	Enrichment	CDC42	2.34
188	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.34
189	Fibromatosis, gingival, 1	Enrichment	SOS1	2.26
190	Costello syndrome	Enrichment	HRAS	2.26
191	Pulmonic stenosis	Enrichment	SOS1	2.26
192	Crisponi/cold-induced sweating syndrome 2	Enrichment	CLCF1	2.26
193	Keratosis, seborrheic	Enrichment	PIK3CA	2.26
194	Roifman-chitayat syndrome	Enrichment	PIK3CD	2.26
195	Noonan syndrome 8	Enrichment	PIK3CA	2.26
196	Thrombocythemia 3	Enrichment	JAK2	2.26
197	Immunodeficiency 31c	Enrichment	STAT1	2.26
198	Werner syndrome	Enrichment	PTPN11	2.26
199	Cebalid syndrome	Enrichment	MTOR	2.26
200	Senior-loken syndrome 7	Enrichment	AKT3	2.26
201	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.26
202	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	2.26
203	Bardet-biedl syndrome 16	Enrichment	AKT3	2.26
204	Cold-induced sweating syndrome 2	Enrichment	CLCF1	2.26
205	Cold-induced sweating syndrome including crisponi syndrome	Enrichment	CRLF1	2.26
206	Smith-kingsmore syndrome	Enrichment	MTOR	2.26
207	Polycythemia	Enrichment	JAK2	2.26
208	Hypereosinophilic syndrome	Enrichment	JAK2	2.26
209	Tafro syndrome	Enrichment	MAP2K2	2.26
210	Wooly hair nevus	Enrichment	HRAS	2.26
211	Growth hormone deficiency, isolated partial	Enrichment	GHR	2.21
212	Kowarski syndrome	Enrichment	GH1	2.21
213	Inflammatory skin and bowel disease, neonatal, 1	Enrichment	ADAM17	2.21
214	Short stature due to growth hormone qualitative anomaly	Enrichment	GH1	2.21
215	Hyperinsulinemic hypoglycemia, familial, 4	Enrichment	INSR	2.20
216	Maturity-onset diabetes of the young, type 10	Enrichment	INS	2.20
217	Hyperproinsulinemia	Enrichment	INS	2.20
218	Diabetes mellitus, permanent neonatal, 4	Enrichment	INS	2.20
219	Vacterl with hydrocephalus	Enrichment	PTEN	2.20
220	Growth delay due to insulin-like growth factor type 1 deficiency	Enrichment	IGF1	2.20
221	Juvenile polyposis of infancy	Enrichment	PTEN	2.20
222	Fibrolamellar carcinoma	Enrichment	PRKACA	2.17
223	Plasminogen deficiency, type i	Enrichment	PLG	2.16
224	Quebec platelet disorder	Enrichment	PLAU	2.16
225	Poirier-bienvenu neurodevelopmental syndrome	Enrichment	CSNK2B	2.16
226	Childhood hepatocellular carcinoma	Enrichment	MET	2.16
227	Papillary renal cell carcinoma	Enrichment	MET	2.16
228	Hereditary angioedema	Enrichment	PLG	2.16
229	Leukoencephalopathy with vanishing white matter 4	Enrichment	EIF2B4	2.09
230	Noonan syndrome-like disorder with loose anagen hair	Enrichment	PPP1CB	2.09
231	Amelogenesis imperfecta, type ig	Enrichment	PRKAR1A	2.09
232	Vitamin d hydroxylation-deficient rickets, type 1b	Enrichment	PDE3B	2.09
233	Pigmented nodular adrenocortical disease, primary, 1	Enrichment	PRKAR1A	2.09
234	Bleeding disorder, platelet-type, 19	Enrichment	PRKACG	2.09
235	Marbach-schaaf neurodevelopmental syndrome	Enrichment	PRKAR1B	2.09
236	Usher syndrome, type iv	Enrichment	PRKAR1A	2.09
237	Acrodysostosis	Enrichment	PRKAR1A	2.09
238	Ciliary dyskinesia, primary, 18	Enrichment	PRKAR1B	2.09
239	Isolated primary pigmented nodular adrenocortical disease	Enrichment	PRKAR1A	2.09
240	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.09
241	Polycythemia vera	Enrichment	JAK2	2.09
242	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.09
243	Polycystic kidney disease, infantile severe, with tuberous sclerosis	Enrichment	TSC2	2.09
244	Nuchal bleb, familial	Enrichment	SOS1	2.09
245	Langerhans cell histiocytosis	Enrichment	MAP2K1	2.09
246	Cone-rod dystrophy 12	Enrichment	CRLF1	2.09
247	Tuberous sclerosis 2	Enrichment	TSC2	2.09
248	Large congenital melanocytic nevus	Enrichment	HRAS	2.09
249	Hyper ige syndrome	Enrichment	STAT3	2.09
250	Xanthinuria, type ii	Enrichment	TSC2	2.09
251	Spermatocytoma	Enrichment	HRAS	2.09
252	Tricuspid valve insufficiency	Enrichment	PTPN11	2.09
253	Keratoacanthoma	Enrichment	PIK3CA	2.09
254	Gastric cancer	Enrichment	PIK3CA, PTEN	2.09
255	Epiphyseal dysplasia, multiple, with early-onset diabetes mellitus	Enrichment	EIF2AK3	2.08
256	Pulmonary venoocclusive disease 1, autosomal dominant	Enrichment	EIF2AK4	2.08
257	Ovarian germ cell cancer	Enrichment	CBL	2.08
258	Pulmonary venoocclusive disease 2, autosomal recessive	Enrichment	EIF2AK4	2.08
259	Pulmonary venoocclusive disease 1	Enrichment	EIF2AK4	2.08
260	Pulmonary venoocclusive disease 2	Enrichment	EIF2AK4	2.08
261	Leukodystrophy, hypomyelinating, 17	Enrichment	EIF2AK1	2.08
262	Malignant germ cell tumor of ovary	Enrichment	CBL	2.08
263	Pulmonary venoocclusive disease	Enrichment	EIF2AK4	2.08
264	Camurati-engelmann disease 1	Enrichment	TGFB1	2.04
265	Corpus callosum, agenesis of, with impaired intellectual development, ocular coloboma, and micrognathia	Enrichment	IGBP1	2.04
266	Microvascular complications of diabetes 5	Enrichment	TGFBR2	2.04
267	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.04
268	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	2.04
269	Camurati-engelmann disease	Enrichment	TGFB1	2.04
270	Houge-janssens syndrome 3	Enrichment	PPP2CA	2.04
271	Corpus callosum agenesis-intellectual disability-coloboma-micrognathia syndrome	Enrichment	IGBP1	2.04
272	Neutrophilic dermatosis, acute febrile	Enrichment	PTPN6	2.03
273	Isolated growth hormone deficiency, type ib	Enrichment	GH1	2.03
274	Myxoid liposarcoma	Enrichment	DDIT3	2.03
275	Neonatal inflammatory skin and bowel disease	Enrichment	ADAM17	2.03
276	Type 1 diabetes mellitus 2	Enrichment	INS	2.02
277	Laryngeal squamous cell carcinoma	Enrichment	PTEN	2.02
278	Growth delay due to insulin-like growth factor i resistance	Enrichment	IGF1R	2.02
279	Enchondromatosis	Enrichment	HIF1A	2.02
280	Thrombocytopenia	Enrichment	PTPN11, SRC	2.02
281	Heparin cofactor ii deficiency	Enrichment	EIF4G3	1.99
282	Prognathism, mandibular	Enrichment	CSNK2B	1.98
283	Angioedema, hereditary, 1	Enrichment	PLG	1.98
284	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	1.98
285	Renal cell carcinoma	Enrichment	MET	1.98
286	Erythrocytosis, familial, 1	Enrichment	JAK2	1.96
287	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS	1.96
288	Budd-chiari syndrome	Enrichment	JAK2	1.96
289	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	1.96
290	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.96
291	Congenital generalized lipodystrophy	Enrichment	FOS	1.96
292	Cold-induced sweating syndrome 1	Enrichment	CRLF1	1.96
293	Cerebrovascular disease	Enrichment	PIK3CA	1.96
294	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	PTPN11	1.96
295	Epidermolytic nevus	Enrichment	HRAS	1.96
296	Idiopathic achalasia	Enrichment	CRLF1	1.96
297	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.96
298	Gingival fibromatosis	Enrichment	SOS1	1.96
299	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	1.96
300	Vitamin d hydroxylation-deficient rickets, type 1a	Enrichment	PDE3B	1.92
301	Lipodystrophy, familial partial, type 6	Enrichment	LIPE	1.92
302	Isolated growth hormone deficiency, type ii	Enrichment	GH1	1.91
303	Menkes disease	Enrichment	EIF2AK3	1.90
304	Torsion dystonia 1	Enrichment	EIF2AK2	1.90
305	Advanced sleep phase syndrome	Enrichment	CSNK1D	1.90
306	Neonatal diabetes mellitus	Enrichment	INS	1.90
307	Glioma	Enrichment	PTEN	1.90
308	Capillary malformations, congenital	Enrichment	PIK3CA	1.87
309	Lymphoma	Enrichment	PTPN11	1.87
310	Myeloproliferative neoplasm	Enrichment	JAK2	1.87
311	Histiocytoid hemangioma	Enrichment	FOS	1.87
312	Frontometaphyseal dysplasia	Enrichment	MAP3K7	1.86
313	Syndactyly	Enrichment	CSNK2B	1.86
314	Pseudomyogenic hemangioendothelioma	Enrichment	SERPINE1	1.86
315	Enchondromatosis, multiple, ollier type	Enrichment	HIF1A	1.80
316	Macrocephaly/autism syndrome	Enrichment	PTEN	1.80
317	Hemangioma	Enrichment	PTEN	1.80
318	Acute megakaryocytic leukemia	Enrichment	PTEN	1.80
319	Pyruvate dehydrogenase e1-alpha deficiency	Enrichment	PDHA1	1.79
320	Carney complex variant	Enrichment	PRKAR1A	1.79
321	Arrhythmogenic right ventricular dysplasia, familial, 10	Enrichment	PRKAR1A	1.79
322	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.79
323	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.79
324	Patent ductus arteriosus	Enrichment	PTPN11	1.79
325	Chronic mucocutaneous candidiasis	Enrichment	STAT1	1.79
326	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	TGFBR1, TGFBR2	1.76
327	Alzheimer disease 2	Enrichment	PLAU	1.76
328	Aortic aneurysm	Enrichment	TGFBR1	1.74
329	Type 1 diabetes mellitus	Enrichment	INS	1.72
330	46,xy disorder of sex development	Enrichment	INSR	1.72
331	Polycystic kidney disease 1 with or without polycystic liver disease	Enrichment	TSC2	1.72
332	Renal cell carcinoma, papillary, 1	Enrichment	MTOR	1.72
333	Polycystic kidney disease 1	Enrichment	TSC2	1.72
334	Essential thrombocythemia	Enrichment	JAK2	1.72
335	Gallbladder cancer	Enrichment	PIK3CA	1.72
336	Pilomyxoid astrocytoma	Enrichment	RAF1	1.72
337	Megacolon	Enrichment	AKT3	1.72
338	Complex neurodevelopmental disorder	Enrichment	EIF4A2, PPP2CA, TIAM1	1.72
339	Aggressive systemic mastocytosis	Enrichment	CBL	1.68
340	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.67
341	Squamous cell carcinoma, head and neck	Enrichment	PTEN	1.66
342	Multiple enchondromatosis, maffucci type	Enrichment	HIF1A	1.66
343	Inherited cancer-predisposing syndrome	Enrichment	EGFR, TSC1, TSC2	1.65
344	Keratoconus	Enrichment	TSC1	1.62
345	Adrenocortical carcinoma	Enrichment	PRKAR1A	1.62
346	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.61
347	Isolated growth hormone deficiency, type ia	Enrichment	GH1	1.61
348	Lennox-gastaut syndrome	Enrichment	MAPK10	1.57
349	Polymicrogyria	Enrichment	AKT3	1.57
350	Inflammatory bowel disease 25, autosomal recessive	Enrichment	TGFB1	1.57
351	Il10-related early-onset inflammatory bowel disease	Enrichment	TGFB1	1.57
352	Classic ehlers-danlos syndrome	Enrichment	TGFBR1	1.57
353	Arthrogryposis, distal, type 1a	Enrichment	MET	1.56
354	Renal hypodysplasia/aplasia 1	Enrichment	ITGA8	1.56
355	Pectus excavatum	Enrichment	PTPN11	1.53
356	Renal agenesis, bilateral	Enrichment	ITGA8	1.51
357	Melanoma	Enrichment	PTEN	1.50
358	Esophageal cancer	Enrichment	TGFBR2	1.50
359	Epicanthus	Enrichment	PTPN11	1.49
360	Juvenile myelomonocytic leukemia	Enrichment	PTPN11	1.49
361	Congenital long qt syndrome	Enrichment	PTPN11	1.49
362	Meningioma, familial	Enrichment	PTEN	1.46
363	Diabetes mellitus	Enrichment	INS	1.46
364	Uterine corpus cancer	Enrichment	PTEN	1.46
365	Aortic valve disease 1	Enrichment	SOS1	1.46
366	Acute promyelocytic leukemia	Enrichment	STAT3	1.46
367	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	HGF, MET	1.42
368	Hypercholesterolemia, familial, 1	Enrichment	GHR	1.40
369	Renal cell carcinoma, nonpapillary	Enrichment	MTOR	1.40
370	Autosomal dominant polycystic kidney disease	Enrichment	TSC2	1.40
371	Rare genetic intellectual disability	Enrichment	MTOR	1.40
372	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.39
373	Chromosome 1p36 deletion syndrome	Enrichment	PRKCZ	1.39
374	Osteoporosis	Enrichment	SRC	1.37
375	Neural tube defects	Enrichment	ITGB1	1.36
376	Microcephaly	Enrichment	MAPK1, PTPN11	1.35
377	Congenital nervous system abnormality	Enrichment	PTEN, TSC2	1.35
378	Nervous system disease	Enrichment	PTEN, TSC2	1.35
379	Heritable pulmonary arterial hypertension	Enrichment	EIF2AK4	1.34
380	Familial hypercholesterolemia	Enrichment	GHR	1.34
381	Lung cancer susceptibility 3	Enrichment	EGFR	1.32
382	Heart, malformation of	Enrichment	MAPK1	1.32
383	Patent foramen ovale	Enrichment	PTPN11	1.32
384	46,xy complete gonadal dysgenesis	Enrichment	MAP3K1	1.31
385	Diffuse large b-cell lymphoma	Enrichment	STAT3	1.30
386	Premature menopause	Enrichment	EIF2B2	1.29
387	Pulmonary disease, chronic obstructive	Enrichment	PDE3B	1.29
388	Pulmonary hypertension, primary, 1	Enrichment	EIF2AK4	1.27
389	Gliosarcoma	Enrichment	EGFR	1.27
390	Alzheimer disease, familial, 1	Enrichment	PLAU	1.24
391	Giant cell glioblastoma	Enrichment	EGFR	1.24
392	Kidney disease	Enrichment	TSC1	1.23
393	Male infertility with spermatogenesis disorder	Enrichment	DYRK1A	1.21
394	Maturity-onset diabetes of the young	Enrichment	INS	1.21
395	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.20
396	Scoliosis	Enrichment	PTPN11	1.20
397	Arteriovenous malformations of the brain	Enrichment	EGFR	1.19
398	Dandy-walker syndrome	Enrichment	PPP1CB	1.18
399	Sudden infant death syndrome	Enrichment	PDHA1	1.18
400	Strabismus	Enrichment	PTPN11	1.15
401	Differentiated thyroid carcinoma	Enrichment	HRAS	1.12
402	Williams-beuren syndrome	Enrichment	EIF4H	1.11
403	Parkinson disease, late-onset	Enrichment	EIF4G1	1.11
404	Long qt syndrome 1	Enrichment	PTPN11	1.10
405	Ehlers-danlos syndrome	Enrichment	TGFBR2	1.08
406	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	1.06
407	Microphthalmia	Enrichment	DYRK1A	1.05
408	Cakut	Enrichment	LIFR	1.05
409	Brittle bone disorder	Enrichment	EIF2B2	1.05
410	Left ventricular noncompaction	Enrichment	RAF1	1.04
411	Developmental and epileptic encephalopathy 1	Enrichment	CSNK1E	1.00
412	Leukemia, acute myeloid	Enrichment	JAK2	0.98
413	Cystic fibrosis	Enrichment	PLG	0.98
414	Hypertrophic cardiomyopathy	Enrichment	PTPN11	0.95
415	West syndrome	Enrichment	TSC2	0.95
416	Hypertelorism	Enrichment	PIK3CA	0.88
417	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.87
418	Connective tissue disease	Enrichment	TGFBR2	0.86
419	Myeloma, multiple	Enrichment	PIK3R2	0.85
420	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	0.85
421	Primary ovarian insufficiency	Enrichment	JAK2	0.83
422	Sensorineural hearing loss	Enrichment	HGF	0.81
423	Autosomal dominant non-syndromic intellectual disability	Enrichment	CSNK2B	0.80
424	Hereditary breast ovarian cancer syndrome	Enrichment	PTEN	0.79
425	Dilated cardiomyopathy	Enrichment	RAF1	0.71
426	Primary ciliary dyskinesia	Enrichment	PRKAR1B	0.57

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Translation Insulin regulation of translation

Pathway Network for Translation Insulin regulation of translation

Pathway network for the Translation Insulin regulation of translation SuperPath

Member Pathways for Translation Insulin regulation of translation

Pathways in the Translation Insulin regulation of translation SuperPath

Gene overlap in member pathways for Translation Insulin regulation of translation SuperPath

Associated Genes for Translation Insulin regulation of translation

Associated Disorders for Translation Insulin regulation of translation

Disorders associated with Translation Insulin regulation of translation SuperPath

STRING Interaction Network for Translation Insulin regulation of translation

Sources for Translation Insulin regulation of translation