Translation Translation regulation by Alpha-1 adrenergic receptors

No Pathway Network information available for Translation Translation regulation by Alpha-1 adrenergic receptors

Pathways in the Translation Translation regulation by Alpha-1 adrenergic receptors SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

Disorders associated with Translation Translation regulation by Alpha-1 adrenergic receptors SuperPath

according to GeneCards Suite gene sharing
#DisorderTypeGenesScore
1Noonan syndrome and noonan-related syndromeEnrichmentHRAS, MAP2K1, MAP2K2, RAF1, SOS18.53
2Noonan syndrome 1EnrichmentHRAS, MAP2K1, MAP2K2, RAF1, SOS17.50
3RasopathyEnrichmentHRAS, MAP2K1, MAP2K2, RAF1, SOS17.21
4Anastomosing haemangiomaEnrichmentGNA11, GNA14, GNAQ7.18
5Long qt syndrome 1EnrichmentCACNA1C, CALM1, CALM2, CALM3, ITPR36.88
6Focal cortical dysplasia, type iiEnrichmentMTOR, RHEB, TSC26.38
7Isolated focal cortical dysplasia type iiEnrichmentMTOR, RHEB, TSC26.38
8Noonan syndrome 3EnrichmentHRAS, RAF1, SOS15.64
9Catecholaminergic polymorphic ventricular tachycardiaEnrichmentCALM1, CALM2, CALM35.43
10Phakomatosis cesioflammeaEnrichmentGNA11, GNAQ4.78
11Congenital lipomatous overgrowth, vascular malformations, and epidermal neviEnrichmentGNA11, PIK3R14.30
12Cardiofaciocutaneous syndrome 1EnrichmentMAP2K1, MAP2K24.00
13Cardiofaciocutaneous syndromeEnrichmentMAP2K1, MAP2K24.00
14Capillary malformations, congenitalEnrichmentGNA11, GNAQ3.78
15HemimegalencephalyEnrichmentMTOR, RHEB3.65
16Melanoma, uvealEnrichmentGNA11, GNAQ3.60
17Long qt syndromeEnrichmentCACNA1C, CALM1, CALM23.56
18Melanocytic nevus syndrome, congenitalEnrichmentHRAS, RAF13.34
19Overgrowth syndromeEnrichmentMTOR, PIK3R13.33
20Arteriovenous malformationEnrichmentHRAS, MAP2K13.23
21Myopathy, x-linked, with excessive autophagyEnrichmentHRAS, MAP2K13.13
22Lung non-small cell carcinomaEnrichmentHRAS, MAP2K13.05
23Autosomal dominant non-syndromic intellectual disabilityEnrichmentCAMK2A, CAMK2B, GNB12.94
24West syndromeEnrichmentGNAO1, PLCB1, TSC22.92
25MicrocephalyEnrichmentCAMK2B, GNAO1, GNB1, MAPK12.78
26Congenital nervous system abnormalityEnrichmentCAMK2B, GNAO1, GNB5, TSC22.78
27Nervous system diseaseEnrichmentCAMK2B, GNAO1, GNB5, TSC22.78
28Rare genetic intellectual disabilityEnrichmentGNAO1, MTOR2.64
29Breast cancerEnrichmentGNG3, JUN, SHC12.44
30Anhidrosis, isolated, with normal sweat glandsEnrichmentITPR22.38
31Hypocalciuric hypercalcemia, familial, type iiEnrichmentGNA112.38
32Noonan syndrome 5EnrichmentRAF12.38
33Noonan syndrome 4EnrichmentSOS12.38
34Melorheostosis, isolatedEnrichmentMAP2K12.38
35Nail disorder, nonsyndromic congenital, 3EnrichmentPLCD12.38
36Cardiomyopathy, dilated, 1nnEnrichmentRAF12.38
37Cardiofaciocutaneous syndrome 3EnrichmentMAP2K12.38
38Neurodevelopmental disorder with involuntary movementsEnrichmentGNAO12.38
39Autoimmune lymphoproliferative syndrome, type iiiEnrichmentPRKCD2.38
40Sturge-weber syndromeEnrichmentGNAQ2.38
41Neurodevelopmental disorder with hypotonia and dysmorphic faciesEnrichmentGNB22.38
42Noonan syndrome 13EnrichmentMAPK12.38
43Charcot-marie-tooth disease, demyelinating, type 1jEnrichmentITPR32.38
44Intellectual developmental disorder, autosomal recessive 63EnrichmentCAMK2A2.38
45Intellectual developmental disorder, autosomal dominant 54EnrichmentCAMK2B2.38
46Short syndromeEnrichmentPIK3R12.38
47Developmental and epileptic encephalopathy 17EnrichmentGNAO12.38
48Lodder-merla syndrome, type 2, with developmental delay and with or without cardiac arrhythmiaEnrichmentGNB52.38
49Brugada syndrome 3EnrichmentCACNA1C2.38
50MelorheostosisEnrichmentMAP2K12.38
51Leopard syndrome 2EnrichmentRAF12.38
52Immunodeficiency 36 with lymphoproliferationEnrichmentPIK3R12.38
53Cardiofaciocutaneous syndrome 4EnrichmentMAP2K22.38
54Long qt syndrome 16EnrichmentCALM32.38
55Hypocalcemia, autosomal dominant 2EnrichmentGNA112.38
56Charcot-marie-tooth disease, dominant intermediate fEnrichmentGNB42.38
57Agammaglobulinemia 7, autosomal recessiveEnrichmentPIK3R12.38
58Thrombocytopenia 6EnrichmentSRC2.38
59Intellectual developmental disorder, autosomal dominant 42EnrichmentGNB12.38
60Sick sinus syndrome 4EnrichmentGNB22.38
61Intellectual developmental disorder, autosomal dominant 53EnrichmentCAMK2A2.38
62TrigonitisEnrichmentRAF12.38
63Intellectual developmental disorder, autosomal dominant 59EnrichmentCAMK2G2.38
64Long qt syndrome 15EnrichmentCALM22.38
65Immunodeficiency 133 with ectodermal dysplasia with or without peripheral neuropathyEnrichmentITPR32.38
66Atypical timothy syndromeEnrichmentCACNA1C2.38
67Timothy syndrome type 2EnrichmentCACNA1C2.38
68Gnao1-related disorderEnrichmentGNAO12.38
69Phakomatosis pigmentokeratoticaEnrichmentHRAS2.38
70Phakomatosis cesiomarmorataEnrichmentGNA112.38
71Kaposiform hemangioendotheliomaEnrichmentGNA142.38
72Timothy syndrome type 1EnrichmentCACNA1C2.38
73Cacna1c-related disordersEnrichmentCACNA1C2.38
74Cardiomyopathy, familial hypertrophic, 1EnrichmentCACNA1C, RAF12.36
75Cardiac valvular dysplasia 1EnrichmentPLD12.32
76Parkinson disease 18, autosomal dominantEnrichmentEIF4G12.32
77Autism 19EnrichmentEIF4E2.32
78Spinocerebellar ataxia 26EnrichmentEEF22.32
79Neurodevelopmental disorder with hypotonia and speech delay, with or without seizuresEnrichmentEIF4A22.32
80Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomaliesEnrichmentRHOA2.32
81Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomaliesEnrichmentRHOA2.32
82Spinocerebellar ataxia 29EnrichmentITPR12.08
83Fibromatosis, gingival, 1EnrichmentSOS12.08
84Costello syndromeEnrichmentHRAS2.08
85Cutis marmorata telangiectatica congenitaEnrichmentGNA112.08
86Timothy syndromeEnrichmentCACNA1C2.08
87Pulmonic stenosisEnrichmentSOS12.08
88Ventricular tachycardia, catecholaminergic polymorphic, 4EnrichmentCALM12.08
89Angioma, tuftedEnrichmentGNA142.08
90Night blindness, congenital stationary, type 1hEnrichmentGNB32.08
91Long qt syndrome 14EnrichmentCALM12.08
92Long qt syndrome 8EnrichmentCACNA1C2.08
93Autosomal dominant hypocalcemiaEnrichmentGNA112.08
94Lodder-merla syndrome, type 1, with impaired intellectual development and cardiac arrhythmiaEnrichmentGNB52.08
95Tafro syndromeEnrichmentMAP2K22.08
96Cerebral visual impairmentEnrichmentGNB12.08
97Wooly hair nevusEnrichmentHRAS2.08
98DystoniaEnrichmentCAMK2B, GNB12.04
99LymphangioleiomyomatosisEnrichmentTSC22.02
100Cebalid syndromeEnrichmentMTOR2.02
101Smith-kingsmore syndromeEnrichmentMTOR2.02
102Cerebral palsyEnrichmentCACNA1C, GNB11.95
103Gillespie syndromeEnrichmentITPR11.91
104Nuchal bleb, familialEnrichmentSOS11.91
105Langerhans cell histiocytosisEnrichmentMAP2K11.91
106Immunodeficiency 14a with lymphoproliferation, autosomal dominantEnrichmentPIK3R11.91
107Neurodevelopmental disorder with hypotonia, language delay, and skeletal defects with or without seizuresEnrichmentCACNA1C1.91
108Large congenital melanocytic nevusEnrichmentHRAS1.91
109Immunodeficiency 14EnrichmentPIK3R11.91
110SpermatocytomaEnrichmentHRAS1.91
111Tuberous sclerosis 1EnrichmentTSC21.84
112Polycystic kidney disease, infantile severe, with tuberous sclerosisEnrichmentTSC21.84
113Heparin cofactor ii deficiencyEnrichmentEIF4G31.84
114Tuberous sclerosis 2EnrichmentTSC21.84
115HamartomaEnrichmentTSC21.84
116Xanthinuria, type iiEnrichmentTSC21.84
117Autism spectrum disorderEnrichmentGNB1, MAP2K1, TSC21.81
118Schimmelpenning-feuerstein-mims syndromeEnrichmentHRAS1.78
119Spastic paraplegia 17, autosomal dominantEnrichmentGNG31.78
120Neurofibromatosis-noonan syndromeEnrichmentMAP2K21.78
121Lipodystrophy, congenital generalized, type 2EnrichmentGNG31.78
122Ventricular fibrillation, paroxysmal familial, 1EnrichmentCACNA1C1.78
123Chromosome 22q11.2 deletion syndrome, distalEnrichmentMAPK11.78
124Spinocerebellar ataxia 15EnrichmentITPR11.78
125Developmental and epileptic encephalopathy 12EnrichmentPLCB11.78
126Congenital generalized lipodystrophyEnrichmentFOS1.78
127Noonan syndrome with multiple lentiginesEnrichmentRAF11.78
128Epidermolytic nevusEnrichmentHRAS1.78
129Gingival fibromatosisEnrichmentSOS11.78
130Familial sick sinus syndromeEnrichmentGNB21.78
131Tuberous sclerosisEnrichmentTSC21.72
132Heart conduction diseaseEnrichmentCACNA1C1.69
133Histiocytoid hemangiomaEnrichmentFOS1.69
134Klippel-trenaunay-weber syndromeEnrichmentGNAQ1.61
135Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathyEnrichmentCALM11.61
136Spinocerebellar ataxia, autosomal recessive 16EnrichmentITPR11.61
137Hemihyperplasia, isolatedEnrichmentRHOA1.55
138Nevus, epidermalEnrichmentHRAS1.54
139Thyroid cancer, nonmedullary, 2EnrichmentHRAS1.54
140MyelofibrosisEnrichmentSRC1.54
141Capillary malformation-arteriovenous malformation 1EnrichmentMAP2K11.54
142Pilomyxoid astrocytomaEnrichmentRAF11.54
143Follicular thyroid carcinomaEnrichmentHRAS1.54
144Catecholaminergic polymorphic ventricular tachycardia 1EnrichmentCALM11.49
145HypothyroidismEnrichmentGNB11.49
146Choreatic diseaseEnrichmentGNAO11.49
147Polycystic kidney disease 1 with or without polycystic liver diseaseEnrichmentTSC21.48
148Renal cell carcinoma, papillary, 1EnrichmentMTOR1.48
149Polycystic kidney disease 1EnrichmentTSC21.48
150Developmental and epileptic encephalopathy 14EnrichmentPLCB11.44
151Neurodevelopmental disorder with dysmorphic facies and distal limb anomaliesEnrichmentCACNA1C1.44
152Autosomal non-syndromic agammaglobulinemiaEnrichmentPIK3R11.39
153Adult hepatocellular carcinomaEnrichmentTSC21.37
154Leukemia, acute lymphoblasticEnrichmentGNB11.35
155Myelodysplastic syndromeEnrichmentGNB11.35
156Movement diseaseEnrichmentGNAO11.35
157Specific learning disabilityEnrichmentMAPK11.35
158Cardiac conduction defectEnrichmentCACNA1C1.31
159Lip and oral cavity carcinomaEnrichmentHRAS1.31
160Congenital long qt syndromeEnrichmentITPR31.31
161Colorectal cancerEnrichmentPIK3R1, SRC1.30
162Aortic valve disease 1EnrichmentSOS11.28
163Nk-cell enteropathyEnrichmentPIK3CB1.28
164Multiple sclerosisEnrichmentITPR11.25
165OsteoporosisEnrichmentSRC1.25
16646,xy partial gonadal dysgenesisEnrichmentSOS11.25
167Anterior segment dysgenesisEnrichmentITPR11.22
168RhabdomyosarcomaEnrichmentHRAS1.19
169Hypertension, essentialEnrichmentGNB31.17
170Cleft palate, isolatedEnrichmentGNB11.17
171Sudden infant death syndromeEnrichmentCALM21.17
172Renal cell carcinoma, nonpapillaryEnrichmentMTOR1.16
173Autosomal dominant polycystic kidney diseaseEnrichmentTSC21.16
174Heart, malformation ofEnrichmentMAPK11.14
175Early infantile developmental and epileptic encephalopathyEnrichmentGNAO11.14
176Attention deficit-hyperactivity disorderEnrichmentGNB51.06
177Congenital stationary night blindnessEnrichmentGNB31.04
178Complex neurodevelopmental disorderEnrichmentCACNA1C, GNB21.03
179Developmental and epileptic encephalopathy 1EnrichmentGNAO11.01
180Hydrops fetalis, nonimmuneEnrichmentHRAS0.99
181Brugada syndromeEnrichmentCACNA1C0.99
182StrabismusEnrichmentGNB10.98
183Parkinson disease, late-onsetEnrichmentEIF4G10.96
184Bladder cancerEnrichmentHRAS0.95
185Differentiated thyroid carcinomaEnrichmentHRAS0.95
186Non-immune hydrops fetalisEnrichmentHRAS0.92
187Familial hypertrophic cardiomyopathyEnrichmentRAF10.89
188Left ventricular noncompactionEnrichmentRAF10.87
189Developmental and epileptic encephalopathyEnrichmentGNAO10.86
190Benign epilepsy with centrotemporal spikesEnrichmentPLCB10.81
191Centralopathic epilepsyEnrichmentPLCB10.79
192ThrombocytopeniaEnrichmentSRC0.74
193Spastic ataxiaEnrichmentITPR10.71
194Familial isolated dilated cardiomyopathyEnrichmentRAF10.71
195AutismEnrichmentCAMK2G0.59
196Dilated cardiomyopathyEnrichmentRAF10.55
197Ovarian cancerEnrichmentTSC20.41
198Inherited cancer-predisposing syndromeEnrichmentTSC20.33

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