Translational Control

No Pathway Network information available for Translational Control

Pathways in the Translational Control SuperPath

#	Name	Source	Genes
1	Translational Control	Cell Signaling Technology	ADAR AGO1 AGO2 AGO3 AGO4 AKT1S1 ALYREF ARNT ATP2A1 ATP2A2 BRF2 CA12 CA9 CANX CDC73 CIRBP CLK3 CNOT1 CNOT2 CNOT3 CNOT6 CNOT7 COIL CPEB1 DAZ1 DAZL DCP1A DCP1B DDIT3 DDX3X DDX4 DDX5 DDX6 DGCR8 DHX29 DICER1 DNAJC2 DNAJC3 DROSHA EBAG9 EDC3 EDC4 EEF1A1 EEF2 EEF2K EGLN1 EIF1 EIF2AK2 EIF2AK3 EIF2AK4 EIF2B5 EIF2S1 EIF3A EIF3C EIF3H EIF3J EIF4A1 EIF4A2 EIF4A3 EIF4B EIF4E EIF4E2 EIF4EBP1 EIF4EBP2 EIF4EBP3 EIF4ENIF1 EIF4G1 EIF4G2 EIF4H EIF5 EIF5A EIF6 ELAVL1 EPAS1 ERI1 ERN1 ERO1A ERP44 ETF1 EWSR1 FLCN FMR1 FUS FXR1 FXR2 GSPT1 GTF2I HIF1A HIF1AN HIPK2 HNRNPA0 HNRNPA1 HNRNPC HNRNPD HNRNPK HNRNPLL HNRNPR HSP90B1 HSPA5 HSPA9 IGF2BP1 IGF2BP2 INTS9 IWS1 KARS1 KEAP1 KHDRBS1 KHSRP LAMTOR1 LARP1 LIN28A LIN28B LPIN1 LSM2 MBTPS2 METAP2 MKNK1 MLST8 MRPL11 MTOR NCBP1 NCL NME1 NOP53 NXF1 OS9 P4HB PABPC1 PABPN1 PAIP2 PARN PATL1 PCBP1 PCBP2 PDCD4 PDIA3 PDIA4 PIWIL1 POLDIP3 PPIG PRKRA PRP4K PTBP1 PUM1 PUM2 RACK1 RBMX RICTOR RPL11 RPL13A RPL26 RPL5 RPL7A RPS3 RPS6 RPS6KB1 RPS6KB2 RPTOR RRAGA RRAGB RRAGC RRAGD SEC61B SF3B1 SMARCA4 SMN1 SQSTM1 SRSF1 SSB SYMPK SYNCRIP TARBP2 TDRD3 TFEB TIA1 TIAL1 TSC1 TSC2 U2AF1 UPF1 UPF2 URI1 XBP1 XPO5 XRN2 YBX1 YY1 ZFP36 ZFP36L1 ZPR1 (see all 190) (see less)
2	exRNA mechanism of action and biogenesis	WikiPathways	AGO2 DGCR8 DICER1 DROSHA ERI1 XPO5 (see all 6) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	AGO2	Argonaute RISC Catalytic Component 2	Protein Coding	2
2	DGCR8	DGCR8 Microprocessor Complex Subunit	Protein Coding	2
3	DICER1	Dicer 1, Ribonuclease III	Protein Coding	2
4	DROSHA	Drosha Ribonuclease III	Protein Coding	2
5	XPO5	Exportin 5	Protein Coding	2
6	ERI1	Exoribonuclease 1	Protein Coding	2
7	EIF4EBP1	Eukaryotic Translation Initiation Factor 4E Binding Protein 1	Protein Coding	1
8	EIF4EBP2	Eukaryotic Translation Initiation Factor 4E Binding Protein 2	Protein Coding	1
9	EIF4EBP3	Eukaryotic Translation Initiation Factor 4E Binding Protein 3	Protein Coding	1
10	EIF4ENIF1	Eukaryotic Translation Initiation Factor 4E Nuclear Import Factor 1	Protein Coding	1
11	ADAR	Adenosine Deaminase RNA Specific	Protein Coding	1
12	AGO1	Argonaute RISC Component 1	Protein Coding	1
13	AGO3	Argonaute RISC Catalytic Component 3	Protein Coding	1
14	AGO4	Argonaute RISC Component 4	Protein Coding	1
15	ARNT	Aryl Hydrocarbon Receptor Nuclear Translocator	Protein Coding	1
16	ATP2A1	ATPase Sarcoplasmic/Endoplasmic Reticulum Ca2+ Transporting 1	Protein Coding	1
17	ZFP36L1	ZFP36 Ring Finger Protein Like 1	Protein Coding	1
18	CA12	Carbonic Anhydrase 12	Protein Coding	1
19	CA9	Carbonic Anhydrase 9	Protein Coding	1
20	CANX	Calnexin	Protein Coding	1
21	CDC73	Cell Division Cycle 73	Protein Coding	1
22	CIRBP	Cold Inducible RNA Binding Protein	Protein Coding	1
23	CLK3	CDC Like Kinase 3	Protein Coding	1
24	CNOT6	CCR4-NOT Transcription Complex Subunit 6	Protein Coding	1
25	CNOT7	CCR4-NOT Transcription Complex Subunit 7	Protein Coding	1
26	COIL	Coilin	Protein Coding	1
27	CPEB1	Cytoplasmic Polyadenylation Element Binding Protein 1	Protein Coding	1
28	DAZ1	Deleted In Azoospermia 1	Protein Coding	1
29	DAZL	Deleted In Azoospermia Like	Protein Coding	1
30	DCP1A	Decapping MRNA 1A	Protein Coding	1
31	DCP1B	Decapping MRNA 1B	Protein Coding	1
32	DDIT3	DNA Damage Inducible Transcript 3	Protein Coding	1
33	DHX29	DExH-Box Helicase 29	Protein Coding	1
34	DDX3X	DEAD-Box Helicase 3 X-Linked	Protein Coding	1
35	DDX4	DEAD-Box Helicase 4	Protein Coding	1
36	EIF4A3	Eukaryotic Translation Initiation Factor 4A3	Protein Coding	1
37	DDX5	DEAD-Box Helicase 5	Protein Coding	1
38	DDX6	DEAD-Box Helicase 6	Protein Coding	1
39	DNAJC2	DnaJ Heat Shock Protein Family (Hsp40) Member C2	Protein Coding	1
40	DNAJC3	DnaJ Heat Shock Protein Family (Hsp40) Member C3	Protein Coding	1
41	EDC3	Enhancer Of MRNA Decapping 3	Protein Coding	1
42	EDC4	Enhancer Of MRNA Decapping 4	Protein Coding	1
43	EEF1A1	Eukaryotic Translation Elongation Factor 1 Alpha 1	Protein Coding	1
44	EEF2	Eukaryotic Translation Elongation Factor 2	Protein Coding	1
45	EEF2K	Eukaryotic Elongation Factor 2 Kinase	Protein Coding	1
46	EGLN1	Egl-9 Family Hypoxia Inducible Factor 1	Protein Coding	1
47	EIF1	Eukaryotic Translation Initiation Factor 1	Protein Coding	1
48	EIF2S1	Eukaryotic Translation Initiation Factor 2 Subunit Alpha	Protein Coding	1
49	EIF2B5	Eukaryotic Translation Initiation Factor 2B Subunit Epsilon	Protein Coding	1
50	EIF3J	Eukaryotic Translation Initiation Factor 3 Subunit J	Protein Coding	1
51	EIF3A	Eukaryotic Translation Initiation Factor 3 Subunit A	Protein Coding	1
52	EIF3C	Eukaryotic Translation Initiation Factor 3 Subunit C	Protein Coding	1
53	EIF3H	Eukaryotic Translation Initiation Factor 3 Subunit H	Protein Coding	1
54	EIF4A1	Eukaryotic Translation Initiation Factor 4A1	Protein Coding	1
55	EIF4A2	Eukaryotic Translation Initiation Factor 4A2	Protein Coding	1
56	EIF4B	Eukaryotic Translation Initiation Factor 4B	Protein Coding	1
57	EIF4E	Eukaryotic Translation Initiation Factor 4E	Protein Coding	1
58	EIF4E2	Eukaryotic Translation Initiation Factor 4E Family Member 2	Protein Coding	1
59	EIF4G1	Eukaryotic Translation Initiation Factor 4 Gamma 1	Protein Coding	1
60	EIF4G2	Eukaryotic Translation Initiation Factor 4 Gamma 2	Protein Coding	1
61	EIF4H	Eukaryotic Translation Initiation Factor 4H	Protein Coding	1
62	EIF5	Eukaryotic Translation Initiation Factor 5	Protein Coding	1
63	EIF5A	Eukaryotic Translation Initiation Factor 5A	Protein Coding	1
64	EIF6	Eukaryotic Translation Initiation Factor 6	Protein Coding	1
65	ERO1A	Endoplasmic Reticulum Oxidoreductase 1 Alpha	Protein Coding	1
66	ERP44	Endoplasmic Reticulum Protein 44	Protein Coding	1
67	ETF1	Eukaryotic Translation Termination Factor 1	Protein Coding	1
68	EWSR1	EWS RNA Binding Protein 1	Protein Coding	1
69	FLCN	Folliculin	Protein Coding	1
70	FMR1	Fragile X Messenger Ribonucleoprotein 1	Protein Coding	1
71	FXR1	FMR1 Autosomal Homolog 1	Protein Coding	1
72	FXR2	FMR1 Autosomal Homolog 2	Protein Coding	1
73	EIF2AK4	Eukaryotic Translation Initiation Factor 2 Alpha Kinase 4	Protein Coding	1
74	NOP53	NOP53 Ribosome Biogenesis Factor	Protein Coding	1
75	PDIA3	Protein Disulfide Isomerase Family A Member 3	Protein Coding	1
76	HSPA5	Heat Shock Protein Family A (Hsp70) Member 5	Protein Coding	1
77	HSP90B1	Heat Shock Protein 90 Beta Family Member 1	Protein Coding	1
78	GSPT1	G1 To S Phase Transition 1	Protein Coding	1
79	GTF2I	General Transcription Factor IIi	Protein Coding	1
80	HIF1A	Hypoxia Inducible Factor 1 Subunit Alpha	Protein Coding	1
81	HIF1AN	Hypoxia Inducible Factor 1 Subunit Alpha Inhibitor	Protein Coding	1
82	EPAS1	Endothelial PAS Domain Protein 1	Protein Coding	1
83	HIPK2	Homeodomain Interacting Protein Kinase 2	Protein Coding	1
84	HNRNPA0	Heterogeneous Nuclear Ribonucleoprotein A0	Protein Coding	1
85	HNRNPA1	Heterogeneous Nuclear Ribonucleoprotein A1	Protein Coding	1
86	HNRNPC	Heterogeneous Nuclear Ribonucleoprotein C	Protein Coding	1
87	HNRNPD	Heterogeneous Nuclear Ribonucleoprotein D	Protein Coding	1
88	PCBP1	Poly(RC) Binding Protein 1	Protein Coding	1
89	PCBP2	Poly(RC) Binding Protein 2	Protein Coding	1
90	PTBP1	Polypyrimidine Tract Binding Protein 1	Protein Coding	1
91	HNRNPK	Heterogeneous Nuclear Ribonucleoprotein K	Protein Coding	1
92	FUS	FUS RNA Binding Protein	Protein Coding	1
93	HNRNPR	Heterogeneous Nuclear Ribonucleoprotein R	Protein Coding	1
94	HNRNPLL	Heterogeneous Nuclear Ribonucleoprotein L Like	Protein Coding	1
95	HSPA9	Heat Shock Protein Family A (Hsp70) Member 9	Protein Coding	1
96	ELAVL1	ELAV Like RNA Binding Protein 1	Protein Coding	1
97	IGF2BP1	Insulin Like Growth Factor 2 MRNA Binding Protein 1	Protein Coding	1
98	IGF2BP2	Insulin Like Growth Factor 2 MRNA Binding Protein 2	Protein Coding	1
99	INTS9	Integrator Complex Subunit 9	Protein Coding	1
100	ERN1	Endoplasmic Reticulum To Nucleus Signaling 1	Protein Coding	1
101	IWS1	Interacts With SUPT6H, CTD Assembly Factor 1	Protein Coding	1
102	KARS1	Lysyl-TRNA Synthetase 1	Protein Coding	1
103	KEAP1	Kelch Like ECH Associated Protein 1	Protein Coding	1
104	KHDRBS1	KH RNA Binding Domain Containing, Signal Transduction Associated 1	Protein Coding	1
105	KHSRP	KH-Type Splicing Regulatory Protein	Protein Coding	1
106	LAMTOR1	Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 1	Protein Coding	1
107	LARP1	La Ribonucleoprotein 1, Translational Regulator	Protein Coding	1
108	LIN28A	Lin-28 RNA Binding Posttranscriptional Regulator A	Protein Coding	1
109	LIN28B	Lin-28 RNA Binding Posttranscriptional Regulator B	Protein Coding	1
110	LPIN1	Lipin 1	Protein Coding	1
111	LSM2	LSM2 Homolog, U6 Small Nuclear RNA And MRNA Degradation Associated	Protein Coding	1
112	MLST8	MTOR Associated Protein MLST8	Protein Coding	1
113	MBTPS2	Membrane Bound Transcription Factor Peptidase, Site 2	Protein Coding	1
114	METAP2	Methionyl Aminopeptidase 2	Protein Coding	1
115	MKNK1	MAPK Interacting Serine/Threonine Kinase 1	Protein Coding	1
116	MRPL11	Mitochondrial Ribosomal Protein L11	Protein Coding	1
117	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	1
118	NCBP1	Nuclear Cap Binding Protein Subunit 1	Protein Coding	1
119	NCL	Nucleolin	Protein Coding	1
120	NME1	NME/NM23 Nucleoside Diphosphate Kinase 1	Protein Coding	1
121	CNOT1	CCR4-NOT Transcription Complex Subunit 1	Protein Coding	1
122	CNOT2	CCR4-NOT Transcription Complex Subunit 2	Protein Coding	1
123	CNOT3	CCR4-NOT Transcription Complex Subunit 3	Protein Coding	1
124	SYNCRIP	Synaptotagmin Binding Cytoplasmic RNA Interacting Protein	Protein Coding	1
125	NXF1	Nuclear RNA Export Factor 1	Protein Coding	1
126	OS9	OS9 Endoplasmic Reticulum Lectin	Protein Coding	1
127	RPS6KB1	Ribosomal Protein S6 Kinase B1	Protein Coding	1
128	RPS6KB2	Ribosomal Protein S6 Kinase B2	Protein Coding	1
129	PABPC1	Poly(A) Binding Protein Cytoplasmic 1	Protein Coding	1
130	PABPN1	Poly(A) Binding Protein Nuclear 1	Protein Coding	1
131	PRKRA	Protein Activator Of Interferon Induced Protein Kinase EIF2AK2	Protein Coding	1
132	PAIP2	Poly(A) Binding Protein Interacting Protein 2	Protein Coding	1
133	PARN	Poly(A)-Specific Ribonuclease	Protein Coding	1
134	PATL1	PAT1 Homolog 1, Processing Body MRNA Decay Factor	Protein Coding	1
135	PDCD4	Programmed Cell Death 4	Protein Coding	1
136	P4HB	Prolyl 4-Hydroxylase Subunit Beta	Protein Coding	1
137	PDIA4	Protein Disulfide Isomerase Family A Member 4	Protein Coding	1
138	EIF2AK3	Eukaryotic Translation Initiation Factor 2 Alpha Kinase 3	Protein Coding	1
139	PIWIL1	Piwi Like RNA-Mediated Gene Silencing 1	Protein Coding	1
140	EIF2AK2	Eukaryotic Translation Initiation Factor 2 Alpha Kinase 2	Protein Coding	1
141	PPIG	Peptidylprolyl Isomerase G	Protein Coding	1
142	AKT1S1	AKT1 Substrate 1	Protein Coding	1
143	PRP4K	Pre-MRNA Processing Factor Kinase PRP4K	Protein Coding	1
144	PUM1	Pumilio RNA Binding Family Member 1	Protein Coding	1
145	PUM2	Pumilio RNA Binding Family Member 2	Protein Coding	1
146	RACK1	Receptor For Activated C Kinase 1	Protein Coding	1
147	RPTOR	Regulatory Associated Protein Of MTOR Complex 1	Protein Coding	1
148	RBMX	RNA Binding Motif Protein X-Linked	Protein Coding	1
149	EBAG9	Estrogen Receptor Binding Site Associated Antigen 9	Protein Coding	1
150	UPF1	UPF1 RNA Helicase And ATPase	Protein Coding	1
151	RICTOR	RPTOR Independent Companion Of MTOR Complex 2	Protein Coding	1
152	URI1	URI1 Prefoldin Like Chaperone	Protein Coding	1
153	RPL11	Ribosomal Protein L11	Protein Coding	1
154	RPL13A	Ribosomal Protein L13a	Protein Coding	1
155	RPL26	Ribosomal Protein L26	Protein Coding	1
156	RPL5	Ribosomal Protein L5	Protein Coding	1
157	RPL7A	Ribosomal Protein L7a	Protein Coding	1
158	RPS3	Ribosomal Protein S3	Protein Coding	1
159	RRAGA	Ras Related GTP Binding A	Protein Coding	1
160	RRAGB	Ras Related GTP Binding B	Protein Coding	1
161	RRAGC	Ras Related GTP Binding C	Protein Coding	1
162	RRAGD	Ras Related GTP Binding D	Protein Coding	1
163	RPS6	Ribosomal Protein S6	Protein Coding	1
164	SEC61B	SEC61 Translocon Subunit Beta	Protein Coding	1
165	ATP2A2	ATPase Sarcoplasmic/Endoplasmic Reticulum Ca2+ Transporting 2	Protein Coding	1
166	SRSF1	Serine And Arginine Rich Splicing Factor 1	Protein Coding	1
167	SF3B1	Splicing Factor 3b Subunit 1	Protein Coding	1
168	POLDIP3	DNA Polymerase Delta Interacting Protein 3	Protein Coding	1
169	SMARCA4	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit ATPase 4	Protein Coding	1
170	SMN1	Survival Of Motor Neuron 1, Telomeric	Protein Coding	1
171	SQSTM1	Sequestosome 1	Protein Coding	1
172	SSB	Small RNA Binding Exonuclease Protection Factor La	Protein Coding	1
173	SYMPK	Symplekin Scaffold Protein	Protein Coding	1
174	TDRD3	Tudor Domain Containing 3	Protein Coding	1
175	TFEB	Transcription Factor EB	Protein Coding	1
176	BRF2	BRF2 General Transcription Factor IIIB Subunit	Protein Coding	1
177	ALYREF	Aly/REF Export Factor	Protein Coding	1
178	TIA1	TIA1 Cytotoxic Granule Associated RNA Binding Protein	Protein Coding	1
179	TIAL1	TIA1 Cytotoxic Granule Associated RNA Binding Protein Like 1	Protein Coding	1
180	TARBP2	TARBP2 Subunit Of RISC Loading Complex	Protein Coding	1
181	TSC1	TSC Complex Subunit 1	Protein Coding	1
182	TSC2	TSC Complex Subunit 2	Protein Coding	1
183	ZFP36	ZFP36 Ring Finger Protein	Protein Coding	1
184	U2AF1	U2 Small Nuclear RNA Auxiliary Factor 1	Protein Coding	1
185	UPF2	UPF2 Regulator Of Nonsense Mediated MRNA Decay	Protein Coding	1
186	XBP1	X-Box Binding Protein 1	Protein Coding	1
187	XRN2	5''-3'' Exoribonuclease 2	Protein Coding	1
188	YBX1	Y-Box Binding Protein 1	Protein Coding	1
189	YY1	YY1 Transcription Factor	Protein Coding	1
190	ZPR1	ZPR1 Zinc Finger	Protein Coding	1

Disorders associated with Translational Control SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Pineoblastoma	Enrichment	DICER1, DROSHA	6.79
2	Complex neurodevelopmental disorder	Enrichment	AGO1, AGO2, CNOT1, CNOT3, DDX6, EIF4A2, EIF5A, HNRNPC, SYNCRIP, UPF1	5.03
3	Focal cortical dysplasia, type ii	Enrichment	MTOR, TSC1, TSC2	4.97
4	Isolated focal cortical dysplasia type ii	Enrichment	MTOR, TSC1, TSC2	4.97
5	Welander distal myopathy	Enrichment	SQSTM1, TIA1	3.71
6	Lymphangioleiomyomatosis	Enrichment	TSC1, TSC2	3.71
7	Goiter, multinodular 1, with or without sertoli-leydig cell tumors	Enrichment	DICER1, KEAP1	3.71
8	Erythrocytosis, familial, 3	Enrichment	EGLN1, EPAS1	3.71
9	Rhabdomyosarcoma, embryonal, 2	Enrichment	DICER1	3.35
10	Hoxha-aliu syndrome	Enrichment	ERI1	3.35
11	Dicer1 syndrome	Enrichment	DICER1	3.35
12	Pleuropulmonary blastoma	Enrichment	DICER1	3.35
13	Global developmental delay, lung cysts, overgrowth, and wilms tumor	Enrichment	DICER1	3.35
14	Malignant sertoli-leydig cell tumor of ovary	Enrichment	DICER1	3.35
15	Spondyloepimetaphyseal dysplasia, guo-campeau type	Enrichment	ERI1	3.35
16	Supratentorial primitive neuroectodermal tumor	Enrichment	DICER1	3.35
17	Gynandroblastoma	Enrichment	DICER1	3.35
18	Dicer1 tumor predisposition	Enrichment	DICER1	3.35
19	Tuberous sclerosis 1	Enrichment	TSC1, TSC2	3.24
20	Hamartoma	Enrichment	TSC1, TSC2	3.24
21	Myxoid liposarcoma	Enrichment	DDIT3, FUS	3.24
22	Premature ovarian failure 3	Enrichment	AGO2	3.05
23	Vertebral anomalies and variable endocrine and t-cell dysfunction	Enrichment	DICER1	3.05
24	Malignant granulosa cell tumor of the ovary	Enrichment	DICER1	3.05
25	Tuberous sclerosis	Enrichment	TSC1, TSC2	2.94
26	Lessel-kreienkamp syndrome	Enrichment	AGO2	2.88
27	Embryonal rhabdomyosarcoma	Enrichment	DICER1	2.75
28	Osteogenesis imperfecta, type i	Enrichment	MBTPS2, P4HB	2.55
29	Autosomal dominant secondary polycythemia	Enrichment	EGLN1, EPAS1	2.55
30	Neuroblastoma	Enrichment	LIN28B, SMARCA4	2.29
31	Renal hypodysplasia/aplasia 3	Enrichment	ERI1	2.28
32	Adult hepatocellular carcinoma	Enrichment	TSC1, TSC2	2.18
33	Rhabdomyosarcoma	Enrichment	DICER1	2.15
34	Frontotemporal dementia and/or amyotrophic lateral sclerosis 1	Enrichment	FUS, SQSTM1	2.09
35	Myelodysplastic syndrome	Enrichment	SF3B1, U2AF1	2.01
36	Atrial heart septal defect	Enrichment	RPL5, SMARCA4	2.01
37	Interatrial communication	Enrichment	RPL5, SMARCA4	2.01
38	Inherited cancer-predisposing syndrome	Enrichment	CDC73, DICER1, FLCN, SMARCA4, TSC1, TSC2	1.97
39	Pulmonary hypertension, primary, 1	Enrichment	EIF2AK4, RPL5	1.86
40	Diamond-blackfan anemia	Enrichment	RPL11, RPL26, RPL5	1.86
41	Cole-carpenter syndrome 1	Enrichment	P4HB	1.85
42	Paget disease of bone 3	Enrichment	SQSTM1	1.85
43	Pneumothorax, primary spontaneous	Enrichment	FLCN	1.85
44	Hyperchlorhidrosis, isolated	Enrichment	CA12	1.85
45	Intellectual developmental disorder, x-linked, syndromic, gustavson type	Enrichment	RBMX	1.85
46	Olmsted syndrome, x-linked	Enrichment	MBTPS2	1.85
47	Robin sequence with cleft mandible and limb anomalies	Enrichment	EIF4A3	1.85
48	Osteogenesis imperfecta, type xix	Enrichment	MBTPS2	1.85
49	Keratosis follicularis spinulosa decalvans, x-linked	Enrichment	MBTPS2	1.85
50	Parathyroid carcinoma	Enrichment	CDC73	1.85
51	Hyperparathyroidism 2 with jaw tumors	Enrichment	CDC73	1.85
52	Parkinson disease 18, autosomal dominant	Enrichment	EIF4G1	1.85
53	Dyskeratosis congenita, autosomal recessive 6	Enrichment	PARN	1.85
54	Even-plus syndrome	Enrichment	HSPA9	1.85
55	Anemia, sideroblastic, 4	Enrichment	HSPA9	1.85
56	Tremor, hereditary essential, 4	Enrichment	FUS	1.85
57	Diamond-blackfan anemia 7	Enrichment	RPL11	1.85
58	Corpus callosum, agenesis of, with facial anomalies and robin sequence	Enrichment	DDX3X	1.85
59	Holoprosencephaly 12 with or without pancreatic agenesis	Enrichment	CNOT1	1.85
60	Inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 3	Enrichment	HNRNPA1	1.85
61	Myopathy, distal, with rimmed vacuoles	Enrichment	SQSTM1	1.85
62	Growth restriction, hypoplastic kidneys, alopecia, and distinctive facies	Enrichment	ZPR1	1.85
63	Frontotemporal dementia and/or amyotrophic lateral sclerosis 3	Enrichment	SQSTM1	1.85
64	Intellectual developmental disorder with impaired language and dysmorphic facies	Enrichment	DDX6	1.85
65	Neurodevelopmental disorder with motor abnormalities, seizures, and facial dysmorphism	Enrichment	PUM1	1.85
66	Leukoencephalopathy, developmental delay, and episodic neurologic regression syndrome	Enrichment	EIF2AK2	1.85
67	Birt-hogg-dube syndrome	Enrichment	FLCN	1.85
68	Intellectual developmental disorder, x-linked, syndromic, snijders blok type	Enrichment	DDX3X	1.85
69	Hemoglobin, high altitude adaptation	Enrichment	EGLN1	1.85
70	Autism 19	Enrichment	EIF4E	1.85
71	Charcot-marie-tooth disease, recessive intermediate b	Enrichment	KARS1	1.85
72	Spinocerebellar ataxia 26	Enrichment	EEF2	1.85
73	Major affective disorder 7	Enrichment	XBP1	1.85
74	Myopathy, distal, 3	Enrichment	HNRNPA1	1.85
75	Erythrocytosis, familial, 4	Enrichment	EPAS1	1.85
76	Diamond-blackfan anemia 11	Enrichment	RPL26	1.85
77	Neurodevelopmental disorder with hypotonia and speech delay, with or without seizures	Enrichment	EIF4A2	1.85
78	Amyotrophic lateral sclerosis 20	Enrichment	HNRNPA1	1.85
79	Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 4	Enrichment	PARN	1.85
80	Cdc73-related disorders	Enrichment	CDC73	1.85
81	Neurodevelopmental disorder with dysmorphic facies and skeletal and brain abnormalities	Enrichment	HNRNPR	1.85
82	Smarca4-deficient sarcoma of thorax	Enrichment	SMARCA4	1.85
83	Ovarian small cell carcinoma	Enrichment	SMARCA4	1.85
84	Ddx3x-related neurodevelopmental disorder	Enrichment	DDX3X	1.85
85	Intellectual developmental disorder, autosomal recessive 50	Enrichment	EDC3	1.85
86	Vissers-bodmer syndrome	Enrichment	CNOT1	1.85
87	Faundes-banka syndrome	Enrichment	EIF5A	1.85
88	Finnish upper limb-onset distal myopathy	Enrichment	HNRNPA1	1.85
89	Dystonia 33	Enrichment	EIF2AK2	1.85
90	Congenital myopathy 9b, proximal, with minicore lesions	Enrichment	FXR1	1.85
91	Ifap syndrome	Enrichment	MBTPS2	1.85
92	Intellectual developmental disorder with nasal speech, dysmorphic facies, and variable skeletal anomalies	Enrichment	CNOT2	1.85
93	Congenital myopathy 9a	Enrichment	FXR1	1.85
94	Amyotrophic lateral sclerosis 26 with or without frontotemporal dementia	Enrichment	TIA1	1.85
95	Leukoencephalopathy, progressive, infantile-onset, with or without deafness	Enrichment	KARS1	1.85
96	Cerebellar ataxia type 47	Enrichment	PUM1	1.85
97	Intellectual developmental disorder, autosomal dominant 74	Enrichment	HNRNPC	1.85
98	Multiple paragangliomas associated with polycythemia	Enrichment	EPAS1	1.85
99	Rhabdomyolysis 2	Enrichment	ATP2A2	1.85
100	Relapsing-remitting multiple sclerosis	Enrichment	HNRNPA1	1.85
101	Xq27.3q28 duplication syndrome	Enrichment	FMR1	1.85
102	Familial spontaneous pneumothorax	Enrichment	FLCN	1.85
103	Bresek syndrome	Enrichment	MBTPS2	1.85
104	Pancreatic agenesis-holoprosencephaly syndrome	Enrichment	CNOT1	1.85
105	Adar-related hereditary spastic paraplegia	Enrichment	ADAR	1.85
106	Pum1-related cerebellar ataxia	Enrichment	PUM1	1.85
107	Tubular renal disease-cardiomyopathy syndrome	Enrichment	RRAGD	1.85
108	X-linked intellectual disability-hypotonia-movement disorder syndrome	Enrichment	DDX3X	1.85
109	Renal cell carcinoma, nonpapillary	Enrichment	FLCN, MTOR	1.74
110	Rare genetic intellectual disability	Enrichment	DDX3X, MTOR	1.74
111	Hereditary breast ovarian cancer syndrome	Enrichment	DROSHA	1.62
112	Birt-hogg-dube syndrome 1	Enrichment	FLCN	1.56
113	Acrokeratosis verruciformis	Enrichment	ATP2A2	1.56
114	Epiphyseal dysplasia, multiple, with early-onset diabetes mellitus	Enrichment	EIF2AK3	1.56
115	Pulmonary venoocclusive disease 1, autosomal dominant	Enrichment	EIF2AK4	1.56
116	Brody disease	Enrichment	ATP2A1	1.56
117	Intellectual developmental disorder, x-linked, syndromic, shashi type	Enrichment	RBMX	1.56
118	Histiocytoma, angiomatoid fibrous	Enrichment	EWSR1	1.56
119	Amyotrophic lateral sclerosis 6 with or without frontotemporal dementia	Enrichment	FUS	1.56
120	Diamond-blackfan anemia 6	Enrichment	RPL5	1.56
121	Rhabdoid tumor predisposition syndrome 2	Enrichment	SMARCA4	1.56
122	Hyperparathyroidism 1	Enrichment	CDC73	1.56
123	Dyschromatosis symmetrica hereditaria	Enrichment	ADAR	1.56
124	Pulmonary venoocclusive disease 2, autosomal recessive	Enrichment	EIF2AK4	1.56
125	Ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus	Enrichment	DNAJC3	1.56
126	Aicardi-goutieres syndrome 6	Enrichment	ADAR	1.56
127	Dystonia 16	Enrichment	PRKRA	1.56
128	Neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset	Enrichment	SQSTM1	1.56
129	Gabriele-de vries syndrome	Enrichment	YY1	1.56
130	Deafness, congenital, and adult-onset progressive leukoencephalopathy	Enrichment	KARS1	1.56
131	Hypomagnesemia 7, renal, with or without dilated cardiomyopathy	Enrichment	RRAGD	1.56
132	Neurodevelopmental disorder with dysmorphic facies and behavioral abnormalities	Enrichment	SRSF1	1.56
133	Neurodevelopmental disorder with language delay and behavioral abnormalities, with or without seizures	Enrichment	AGO1	1.56
134	Cebalid syndrome	Enrichment	MTOR	1.56
135	Deafness, autosomal recessive 89	Enrichment	KARS1	1.56
136	Pulmonary venoocclusive disease 1	Enrichment	EIF2AK4	1.56
137	Pulmonary venoocclusive disease 2	Enrichment	EIF2AK4	1.56
138	Alopecia-intellectual disability syndrome 4	Enrichment	CNOT1	1.56
139	Rhabdoid tumor predisposition syndrome	Enrichment	SMARCA4	1.56
140	Syndromic x-linked intellectual disability shashi type	Enrichment	RBMX	1.56
141	Developmental and epileptic encephalopathy 78	Enrichment	YY1	1.56
142	Otosclerosis 12	Enrichment	SMARCA4	1.56
143	Coffin-siris syndrome 4	Enrichment	SMARCA4	1.56
144	Insulinoma	Enrichment	YY1	1.56
145	Paget's disease of bone	Enrichment	SQSTM1	1.56
146	Smith-kingsmore syndrome	Enrichment	MTOR	1.56
147	Autosomal recessive sideroblastic anemia	Enrichment	HSPA9	1.56
148	Long-olsen-distelmaier syndrome	Enrichment	RRAGC	1.56
149	Pulmonary venoocclusive disease	Enrichment	EIF2AK4	1.56
150	Symmetrical dyschromatosis of extremities	Enrichment	ADAR	1.56
151	Desmoplastic small round cell tumor	Enrichment	EWSR1	1.56
152	Spastic paraplegia-paget disease of bone syndrome	Enrichment	SQSTM1	1.56
153	Williams-beuren syndrome	Enrichment	EIF4H, GTF2I	1.50
154	Diamond-blackfan anemia 1	Enrichment	RPL11, RPL5	1.39
155	Precursor t-cell acute lymphoblastic leukemia	Enrichment	CNOT3, DDX3X	1.39
156	Darier-white disease	Enrichment	ATP2A2	1.38
157	Oculopharyngeal muscular dystrophy 1	Enrichment	PABPN1	1.38
158	Right atrial isomerism	Enrichment	UPF1	1.38
159	Spinal muscular atrophy, type iii	Enrichment	SMN1	1.38
160	Spinal muscular atrophy, type i	Enrichment	SMN1	1.38
161	Spinal muscular atrophy, type ii	Enrichment	SMN1	1.38
162	Ifap syndrome 1, with or without bresheck syndrome	Enrichment	MBTPS2	1.38
163	Polycystic kidney disease, infantile severe, with tuberous sclerosis	Enrichment	TSC2	1.38
164	Menkes disease	Enrichment	EIF2AK3	1.38
165	Spinal muscular atrophy, type iv	Enrichment	SMN1	1.38
166	Myoglobinuria, acute recurrent, autosomal recessive	Enrichment	LPIN1	1.38
167	Tuberous sclerosis 2	Enrichment	TSC2	1.38
168	Congenital heart defects, multiple types, 6	Enrichment	UPF1	1.38
169	Keratosis follicularis spinulosa decalvans	Enrichment	MBTPS2	1.38
170	Distal myopathy	Enrichment	HNRNPA1	1.38
171	Inclusion body myopathy with paget disease of bone and frontotemporal dementia	Enrichment	HNRNPA1	1.38
172	Torsion dystonia 1	Enrichment	EIF2AK2	1.38
173	Mutilating palmoplantar keratoderma with periorificial keratotic plaques	Enrichment	MBTPS2	1.38
174	Potocki-lupski syndrome	Enrichment	FLCN	1.38
175	Xanthinuria, type ii	Enrichment	TSC2	1.38
176	Chromophobe renal cell carcinoma	Enrichment	FLCN	1.38
177	Parathyroid adenoma	Enrichment	CDC73	1.38
178	Familial isolated hyperparathyroidism	Enrichment	CDC73	1.38
179	Cole-carpenter syndrome	Enrichment	P4HB	1.38
180	Myxofibrosarcoma	Enrichment	FUS	1.38
181	Melanoma of soft tissue	Enrichment	EWSR1	1.38
182	Myelodysplastic syndrome with ring sideroblasts	Enrichment	SF3B1	1.38
183	Enchondromatosis	Enrichment	HIF1A	1.38
184	Ovarian cancer	Enrichment	DICER1	1.36
185	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	FUS, HNRNPA1, SQSTM1	1.32
186	Hypertriglyceridemia 1	Enrichment	ZPR1	1.26
187	Paget disease of bone 2, early-onset	Enrichment	SQSTM1	1.26
188	Fragile x tremor/ataxia syndrome	Enrichment	FMR1	1.26
189	Au-kline syndrome	Enrichment	HNRNPK	1.26
190	Intellectual developmental disorder with speech delay, autism, and dysmorphic facies	Enrichment	CNOT3	1.26
191	Fragile x-associated tremor/ataxia syndrome	Enrichment	FMR1	1.26
192	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	SF3B1	1.26
193	Pilocytic astrocytoma	Enrichment	FLCN	1.26
194	Hereditary recurrent myoglobinuria	Enrichment	LPIN1	1.26
195	Paget's disease of bone 2	Enrichment	SQSTM1	1.26
196	Transposition of the great arteries	Enrichment	UPF1	1.26
197	Familial infantile bilateral striatal necrosis	Enrichment	ADAR	1.26
198	Enchondromatosis, multiple, ollier type	Enrichment	HIF1A	1.17
199	Premature ovarian failure 1	Enrichment	FMR1	1.17
200	Fragile x syndrome	Enrichment	FMR1	1.17
201	Chondrosarcoma, extraskeletal myxoid	Enrichment	EWSR1	1.17
202	Hemangioma	Enrichment	RPL5	1.17
203	Spinal muscular atrophy	Enrichment	SMN1	1.17
204	Hemimegalencephaly	Enrichment	MTOR	1.17
205	Melanoma, uveal	Enrichment	SF3B1	1.09
206	Keratoconus	Enrichment	TSC1	1.09
207	Pulmonary fibrosis	Enrichment	PARN	1.09
208	Hoyeraal-hreidarsson syndrome	Enrichment	PARN	1.09
209	Sporadic pheochromocytoma/secreting paraganglioma	Enrichment	EPAS1	1.09
210	Polycystic kidney disease 1 with or without polycystic liver disease	Enrichment	TSC2	1.03
211	Multiple endocrine neoplasia, type i	Enrichment	CDC73	1.03
212	Leukoencephalopathy with vanishing white matter 1	Enrichment	EIF2B5	1.03
213	Leukemia, chronic myeloid	Enrichment	SF3B1	1.03
214	Renal cell carcinoma, papillary, 1	Enrichment	MTOR	1.03
215	Multiple enchondromatosis, maffucci type	Enrichment	HIF1A	1.03
216	Polycystic kidney disease 1	Enrichment	TSC2	1.03
217	Renal cell carcinoma with mit translocations	Enrichment	TFEB	1.03
218	Overgrowth syndrome	Enrichment	MTOR	1.03
219	Hereditary clear cell renal cell carcinoma	Enrichment	FLCN	1.03
220	Ewing sarcoma	Enrichment	EWSR1	0.97
221	Leukoencephalopathy with vanishing white matter 5	Enrichment	EIF2B5	0.97
222	Chromosome y microdeletion syndrome	Enrichment	DAZ1	0.97
223	Neurofibromatosis, type i	Enrichment	EWSR1	0.92
224	Leukoencephalopathy with vanishing white matter	Enrichment	EIF2B5	0.92
225	Ventricular septal defect	Enrichment	SMARCA4	0.92
226	Behavioral variant of frontotemporal dementia	Enrichment	SQSTM1	0.92
227	Aicardi-goutiares syndrome	Enrichment	ADAR	0.92
228	Juvenile amyotrophic lateral sclerosis	Enrichment	FUS	0.92
229	Aplastic anemia	Enrichment	RPL5	0.88
230	Aicardi-goutieres syndrome	Enrichment	ADAR	0.88
231	Optic nerve disease	Enrichment	KARS1	0.88
232	Heritable pulmonary arterial hypertension	Enrichment	EIF2AK4	0.84
233	Lactic acidosis	Enrichment	KARS1	0.81
234	Hypercholesterolemia, familial, 1	Enrichment	SMARCA4	0.78
235	Osteogenesis imperfecta, type iv	Enrichment	MBTPS2	0.78
236	Protein-deficiency anemia	Enrichment	RPL11	0.78
237	Coffin-siris syndrome 1	Enrichment	SMARCA4	0.72
238	Osteogenesis imperfecta, type iii	Enrichment	MBTPS2	0.72
239	Familial hypercholesterolemia	Enrichment	SMARCA4	0.72
240	Autosomal dominant polycystic kidney disease	Enrichment	TSC2	0.72
241	Kidney disease	Enrichment	TSC1	0.72
242	Primary ovarian insufficiency	Enrichment	KHDRBS1, RICTOR	0.70
243	Cerebellar hypoplasia/atrophy, epilepsy, and global developmental delay	Enrichment	DDX3X	0.69
244	Cleft palate, isolated	Enrichment	SMARCA4	0.67
245	Interstitial lung disease 2	Enrichment	PARN	0.67
246	Dyskeratosis congenita	Enrichment	PARN	0.63
247	Leukodystrophy	Enrichment	KARS1	0.61
248	Parkinson disease, late-onset	Enrichment	EIF4G1	0.54
249	Strabismus	Enrichment	UPF1	0.50
250	Bladder cancer	Enrichment	TSC1	0.47
251	Colorectal cancer	Enrichment	ADAR, FLCN	0.46
252	Male infertility	Enrichment	PIWIL1	0.42
253	Non-syndromic genetic deafness	Enrichment	KARS1	0.40
254	Cerebral palsy	Enrichment	SMARCA4	0.37
255	Leukemia, acute myeloid	Enrichment	SF3B1	0.36
256	Type 2 diabetes mellitus	Enrichment	IGF2BP2	0.35
257	Nonsyndromic hearing loss	Enrichment	KARS1	0.35
258	West syndrome	Enrichment	TSC2	0.33
259	Hereditary breast carcinoma	Enrichment	CDC73	0.33
260	Sensorineural hearing loss	Enrichment	KARS1	0.31
261	Microcephaly	Enrichment	DDX3X, KARS1	0.29
262	Hypertelorism	Enrichment	UPF1	0.28
263	Spastic ataxia	Enrichment	PUM1	0.28
264	Autosomal recessive non-syndromic intellectual disability	Enrichment	EDC3	0.25
265	Deafness, autosomal recessive	Enrichment	KARS1	0.23
266	Autosomal recessive nonsyndromic deafness	Enrichment	KARS1	0.23
267	Breast cancer	Enrichment	CDC73	0.18
268	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	KARS1	0.14
269	Congenital nervous system abnormality	Enrichment	TSC2	0.11
270	Nervous system disease	Enrichment	TSC2	0.11
271	Autism spectrum disorder	Enrichment	TSC2	0.10

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Translational Control

Pathway Network for Translational Control

Member Pathways for Translational Control

Pathways in the Translational Control SuperPath

Associated Genes for Translational Control

Associated Disorders for Translational Control

Disorders associated with Translational Control SuperPath

STRING Interaction Network for Translational Control

Sources for Translational Control