Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template

Pathway network for the Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template SuperPath

Sources:

Reactome

Pathways in the Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template SuperPath

#	Name	Source	Genes
1	Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	Reactome	ISG15 MAD2L2 NPLOC4 PCLAF PCNA POLD1 POLD2 POLD3 POLD4 POLE POLE2 POLE3 POLE4 POLH POLI POLK RCHY1 REV1 REV3L RFC1 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 RPS27A SPRTN TRIM25 UBA52 UBA7 UBB UBC UBE2L6 UFD1 USP10 USP43 VCP (see all 39) (see less)
2	DNA Damage Bypass	Reactome	CUL4A CUL4B DDB1 DTL ISG15 MAD2L2 NPLOC4 PCLAF PCNA POLD1 POLD2 POLD3 POLD4 POLE POLE2 POLE3 POLE4 POLH POLI POLK RAD18 RBX1 RCHY1 REV1 REV3L RFC1 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 RPS27A SPRTN TRIM25 UBA52 UBA7 UBB UBC UBE2B UBE2L6 UFD1 USP1 USP10 USP43 VCP WDR48 (see all 48) (see less)
3	Termination of translesion DNA synthesis	Reactome	ISG15 PCLAF PCNA POLD1 POLD2 POLD3 POLD4 POLE POLE2 POLE3 POLE4 POLH POLI POLK REV1 RFC1 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 RPS27A TRIM25 UBA52 UBA7 UBB UBC UBE2L6 USP10 USP43 (see all 32) (see less)
4	Recognition of DNA damage by PCNA-containing replication complex	Reactome	CUL4A CUL4B DDB1 DTL PCNA POLD1 POLD2 POLD3 POLD4 POLE POLE2 POLE3 POLE4 RAD18 RBX1 RFC1 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 RPS27A UBA52 UBB UBC UBE2B USP1 WDR48 (see all 30) (see less)
5	Translesion Synthesis by POLH	Reactome	NPLOC4 PCNA POLH RCHY1 RFC1 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 RPS27A SPRTN UBA52 UBB UBC UFD1 VCP (see all 19) (see less)
6	Translesion synthesis by POLK	Reactome	MAD2L2 PCNA POLK REV1 REV3L RFC1 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 RPS27A UBA52 UBB UBC (see all 17) (see less)
7	Translesion synthesis by POLI	Reactome	MAD2L2 PCNA POLI REV1 REV3L RFC1 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 RPS27A UBA52 UBB UBC (see all 17) (see less)
8	Translesion synthesis by REV1	Reactome	MAD2L2 PCNA REV1 REV3L RFC1 RFC2 RFC3 RFC4 RFC5 RPA1 RPA2 RPA3 RPS27A UBA52 UBB UBC (see all 16) (see less)

Gene overlap in member pathways for Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PCNA	Proliferating Cell Nuclear Antigen	Protein Coding	8
2	RFC1	Replication Factor C Subunit 1	Protein Coding	8
3	RFC2	Replication Factor C Subunit 2	Protein Coding	8
4	RFC3	Replication Factor C Subunit 3	Protein Coding	8
5	RFC4	Replication Factor C Subunit 4	Protein Coding	8
6	RFC5	Replication Factor C Subunit 5	Protein Coding	8
7	RPA1	Replication Protein A1	Protein Coding	8
8	RPA2	Replication Protein A2	Protein Coding	8
9	RPA3	Replication Protein A3	Protein Coding	8
10	RPS27A	Ribosomal Protein S27a	Protein Coding	8
11	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	8
12	UBB	Ubiquitin B	Protein Coding	8
13	UBC	Ubiquitin C	Protein Coding	8
14	REV1	REV1 DNA Directed Polymerase	Protein Coding	6
15	MAD2L2	Mitotic Arrest Deficient 2 Like 2	Protein Coding	5
16	REV3L	REV3 Like, DNA Directed Polymerase Zeta Catalytic Subunit	Protein Coding	5
17	POLD3	DNA Polymerase Delta 3, Accessory Subunit	Protein Coding	4
18	POLI	DNA Polymerase Iota	Protein Coding	4
19	POLK	DNA Polymerase Kappa	Protein Coding	4
20	POLE3	DNA Polymerase Epsilon 3, Accessory Subunit	Protein Coding	4
21	POLD1	DNA Polymerase Delta 1, Catalytic Subunit	Protein Coding	4
22	POLD2	DNA Polymerase Delta 2, Accessory Subunit	Protein Coding	4
23	POLE	DNA Polymerase Epsilon, Catalytic Subunit	Protein Coding	4
24	POLE2	DNA Polymerase Epsilon 2, Accessory Subunit	Protein Coding	4
25	POLH	DNA Polymerase Eta	Protein Coding	4
26	POLE4	DNA Polymerase Epsilon 4, Accessory Subunit	Protein Coding	4
27	POLD4	DNA Polymerase Delta 4, Accessory Subunit	Protein Coding	4
28	USP43	Ubiquitin Specific Peptidase 43	Protein Coding	3
29	RCHY1	Ring Finger And CHY Zinc Finger Domain Containing 1	Protein Coding	3
30	NPLOC4	NPL4 Homolog, Ubiquitin Recognition Factor	Protein Coding	3
31	UBA7	Ubiquitin Like Modifier Activating Enzyme 7	Protein Coding	3
32	UFD1	Ubiquitin Recognition Factor In ER Associated Degradation 1	Protein Coding	3
33	VCP	Valosin Containing Protein	Protein Coding	3
34	TRIM25	Tripartite Motif Containing 25	Protein Coding	3
35	SPRTN	SprT-Like N-Terminal Domain	Protein Coding	3
36	USP10	Ubiquitin Specific Peptidase 10	Protein Coding	3
37	UBE2L6	Ubiquitin Conjugating Enzyme E2 L6	Protein Coding	3
38	ISG15	ISG15 Ubiquitin Like Modifier	Protein Coding	3
39	PCLAF	PCNA Clamp Associated Factor	Protein Coding	3
40	DDB1	Damage Specific DNA Binding Protein 1	Protein Coding	2
41	DTL	Denticleless E3 Ubiquitin Protein Ligase Adapter	Protein Coding	2
42	RAD18	RAD18 E3 Ubiquitin Protein Ligase	Protein Coding	2
43	WDR48	WD Repeat Domain 48	Protein Coding	2
44	UBE2B	Ubiquitin Conjugating Enzyme E2 B	Protein Coding	2
45	USP1	Ubiquitin Specific Peptidase 1	Protein Coding	2
46	CUL4B	Cullin 4B	Protein Coding	2
47	CUL4A	Cullin 4A	Protein Coding	2
48	RBX1	Ring-Box 1	Protein Coding	2

Disorders associated with Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Polymerase proofreading-related polyposis	Enrichment	POLD1, POLE	4.85
2	Familial colorectal cancer type x	Enrichment	POLD1, POLE	3.59
3	Fanconi anemia, complementation group v	Enrichment	MAD2L2	2.93
4	Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 6	Enrichment	RPA1	2.93
5	Ataxia-telangiectasia-like disorder 2	Enrichment	PCNA	2.93
6	Morimoto-ryu-malicdan neuromuscular syndrome	Enrichment	RFC4	2.93
7	Inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 1	Enrichment	VCP	2.85
8	Ruijs-aalfs syndrome	Enrichment	SPRTN	2.85
9	Frontotemporal dementia and/or amyotrophic lateral sclerosis 6	Enrichment	VCP	2.85
10	Multisystem proteinopathy	Enrichment	VCP	2.85
11	Adult-onset distal myopathy due to vcp mutation	Enrichment	VCP	2.85
12	Colorectal cancer	Enrichment	POLD1, POLE, REV3L	2.71
13	Cystic fibrosis with helicobacter pylori gastritis, megaloblastic anemia, and impaired intellectual development	Enrichment	POLE	2.66
14	Colorectal cancer 10	Enrichment	POLD1	2.66
15	Colorectal cancer 12	Enrichment	POLE	2.66
16	White-kernohan syndrome	Enrichment	DDB1	2.66
17	Immunodeficiency 120	Enrichment	POLD1	2.66
18	Mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome	Enrichment	POLD1	2.66
19	Autosomal recessive spastic paraplegia type 60	Enrichment	WDR48	2.66
20	Immunodeficiency 122	Enrichment	POLD3	2.66
21	Cerebellar ataxia, neuropathy, and vestibular areflexia syndrome	Enrichment	RFC1	2.63
22	Submucosal cleft palate	Enrichment	UBB	2.63
23	Cleft hard palate	Enrichment	UBB	2.63
24	Immunodeficiency 38 with basal ganglia calcification	Enrichment	ISG15	2.63
25	Neurodevelopmental disorder with hypotonia, speech delay, and dysmorphic facies	Enrichment	POLK	2.60
26	Amyotrophic lateral sclerosis 6 with or without frontotemporal dementia	Enrichment	VCP	2.55
27	Spastic paraplegia-paget disease of bone syndrome	Enrichment	VCP	2.55
28	Uvula, bifid	Enrichment	UBB	2.45
29	Cleft soft palate	Enrichment	UBB	2.45
30	Childhood apraxia of speech	Enrichment	RFC3	2.45
31	Inclusion body myopathy with paget disease of bone and frontotemporal dementia	Enrichment	VCP	2.38
32	Intellectual developmental disorder, x-linked, syndromic, cabezas type	Enrichment	CUL4B	2.35
33	Intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies	Enrichment	POLE	2.35
34	Pettigrew syndrome	Enrichment	CUL4B	2.35
35	Intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, genital anomalies, and immunodeficiency	Enrichment	POLE	2.35
36	Facial dysmorphism, immunodeficiency, livedo, and short stature	Enrichment	POLE	2.35
37	Moebius syndrome	Enrichment	REV3L	2.23
38	Dementia, lewy body	Enrichment	VCP	2.16
39	Charcot-marie-tooth disease, axonal, type 2e	Enrichment	VCP	2.16
40	Progressive non-fluent aphasia	Enrichment	VCP	1.90
41	Behavioral variant of frontotemporal dementia	Enrichment	VCP	1.90
42	Frontotemporal dementia and/or amyotrophic lateral sclerosis 1	Enrichment	VCP	1.86
43	Xeroderma pigmentosum, variant type	Enrichment	POLH	1.82
44	Digeorge syndrome	Enrichment	UFD1	1.78
45	Alzheimer's disease	Enrichment	VCP	1.74
46	Oligospermia	Enrichment	SPRTN	1.74
47	Parkinson's disease	Enrichment	RFC1	1.65
48	Williams-beuren syndrome	Enrichment	RFC2	1.63
49	Alzheimer disease, familial, 1	Enrichment	VCP	1.63
50	Combined immunodeficiency	Enrichment	POLD1	1.62
51	Combined t cell and b cell immunodeficiency	Enrichment	POLD1	1.62
52	Combined t and b cell immunodeficiency	Enrichment	POLD1	1.62
53	Neuropathy, hereditary motor and sensory, okinawa type	Enrichment	VCP	1.58
54	Parkinson disease, late-onset	Enrichment	RFC1	1.55
55	Inherited cancer-predisposing syndrome	Enrichment	POLD1, POLE	1.47
56	Prostate cancer	Enrichment	POLK	1.45
57	Fanconi anemia, complementation group a	Enrichment	MAD2L2	1.39
58	Pancreatic cancer	Enrichment	POLD1	1.27
59	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	VCP	1.11

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template

Pathway Network for Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template

Pathway network for the Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template SuperPath

Member Pathways for Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template

Pathways in the Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template SuperPath

Gene overlap in member pathways for Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template SuperPath

Associated Genes for Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template

Associated Disorders for Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template

Disorders associated with Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template SuperPath

STRING Interaction Network for Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template

Sources for Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template