Trk receptor signaling mediated by the MAPK pathway

No Pathway Network information available for Trk receptor signaling mediated by the MAPK pathway

Pathways in the Trk receptor signaling mediated by the MAPK pathway SuperPath

#	Name	Source	Genes
1	Trk receptor signaling mediated by the MAPK pathway	PubChem	BRAF CDK5 CDK5R1 CREB1 EGR1 EHD4 ELK1 FOS MAP2K1 MAP2K3 MAP2K5 MAP3K2 MAPK14 MAPK3 MAPK7 MAPKAPK2 MEF2C NTF3 PRKCD RAF1 RIT1 RIT2 RPS6KA1 RPS6KA5 RUSC1 SRF TRPV1 (see all 27) (see less)
2	Signalling to ERK5	Reactome	MAP2K5 MAPK7

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	MAPK7	Mitogen-Activated Protein Kinase 7	Protein Coding	2
2	MAP2K5	Mitogen-Activated Protein Kinase Kinase 5	Protein Coding	2
3	RUSC1	RUN And SH3 Domain Containing 1	Protein Coding	1
4	RIT1	Ras Like Without CAAX 1	Protein Coding	1
5	RIT2	Ras Like Without CAAX 2	Protein Coding	1
6	EHD4	EH Domain Containing 4	Protein Coding	1
7	MAP3K2	Mitogen-Activated Protein Kinase Kinase Kinase 2	Protein Coding	1
8	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	1
9	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
10	RPS6KA1	Ribosomal Protein S6 Kinase A1	Protein Coding	1
11	MEF2C	Myocyte Enhancer Factor 2C	Protein Coding	1
12	EGR1	Early Growth Response 1	Protein Coding	1
13	SRF	Serum Response Factor	Protein Coding	1
14	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
15	NTF3	Neurotrophin 3	Protein Coding	1
16	ELK1	ETS Transcription Factor ELK1	Protein Coding	1
17	PRKCD	Protein Kinase C Delta	Protein Coding	1
18	MAPKAPK2	MAPK Activated Protein Kinase 2	Protein Coding	1
19	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
20	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
21	RPS6KA5	Ribosomal Protein S6 Kinase A5	Protein Coding	1
22	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
23	CDK5R1	Cyclin Dependent Kinase 5 Regulatory Subunit 1	Protein Coding	1
24	CDK5	Cyclin Dependent Kinase 5	Protein Coding	1
25	TRPV1	Transient Receptor Potential Cation Channel Subfamily V Member 1	Protein Coding	1
26	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
27	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1

Disorders associated with Trk receptor signaling mediated by the MAPK pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Noonan syndrome and noonan-related syndrome	Enrichment	BRAF, MAP2K1, RAF1, RIT1	7.78
2	Noonan syndrome 1	Enrichment	BRAF, MAP2K1, RAF1, RIT1	6.97
3	Rasopathy	Enrichment	BRAF, MAP2K1, RAF1, RIT1	6.74
4	Langerhans cell histiocytosis	Enrichment	BRAF, MAP2K1	4.94
5	Cardiofaciocutaneous syndrome 1	Enrichment	BRAF, MAP2K1	4.64
6	Cardiofaciocutaneous syndrome	Enrichment	BRAF, MAP2K1	4.64
7	Noonan syndrome with multiple lentigines	Enrichment	BRAF, RAF1	4.64
8	Pilomyxoid astrocytoma	Enrichment	BRAF, RAF1	4.10
9	Melanocytic nevus syndrome, congenital	Enrichment	BRAF, RAF1	3.97
10	Lung non-small cell carcinoma	Enrichment	BRAF, MAP2K1	3.68
11	Scoliosis, isolated 1	Enrichment	MAPK7	3.53
12	Noonan syndrome 5	Enrichment	RAF1	2.70
13	Melorheostosis, isolated	Enrichment	MAP2K1	2.70
14	Noonan syndrome 7	Enrichment	BRAF	2.70
15	Leopard syndrome 3	Enrichment	BRAF	2.70
16	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.70
17	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.70
18	Lissencephaly 7 with cerebellar hypoplasia	Enrichment	CDK5	2.70
19	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.70
20	Neurodevelopmental disorder with hypotonia, stereotypic hand movements, and impaired language	Enrichment	MEF2C	2.70
21	Lymphangioma	Enrichment	BRAF	2.70
22	Phace association	Enrichment	BRAF	2.70
23	Melorheostosis	Enrichment	MAP2K1	2.70
24	Leopard syndrome 2	Enrichment	RAF1	2.70
25	Trigonitis	Enrichment	RAF1	2.70
26	5q14.3 microdeletion syndrome	Enrichment	MEF2C	2.70
27	Complete atrioventricular septal defect without ventricular hypoplasia	Enrichment	MEF2C	2.70
28	Syringocystadenoma papilliferum	Enrichment	BRAF	2.70
29	Ganglioglioma	Enrichment	BRAF	2.70
30	Nongerminomatous germ cell tumor	Enrichment	BRAF	2.70
31	Phace syndrome	Enrichment	BRAF	2.70
32	Mef2c-related disorder	Enrichment	MEF2C	2.70
33	Classic hairy cell leukemia	Enrichment	BRAF	2.70
34	Pulmonic stenosis	Enrichment	BRAF	2.40
35	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.40
36	Noonan syndrome 8	Enrichment	RIT1	2.40
37	Ataxia-telangiectasia	Enrichment	BRAF	2.22
38	Tethered spinal cord syndrome	Enrichment	BRAF	2.22
39	Melanoma of soft tissue	Enrichment	CREB1	2.22
40	Thyroid cancer, nonmedullary, 1	Enrichment	BRAF	2.10
41	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	RIT1	2.10
42	Congenital generalized lipodystrophy	Enrichment	FOS	2.10
43	Craniopharyngioma	Enrichment	BRAF	2.10
44	Newborn respiratory distress syndrome	Enrichment	BRAF	2.10
45	Histiocytoid hemangioma	Enrichment	FOS	2.00
46	Dilated cardiomyopathy	Enrichment	BRAF, RAF1	1.96
47	Wilms tumor 5	Enrichment	BRAF	1.92
48	Thyroid cancer, nonmedullary, 2	Enrichment	BRAF	1.86
49	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1	1.86
50	Noonan syndrome 3	Enrichment	RAF1	1.86
51	Gallbladder cancer	Enrichment	BRAF	1.86
52	Follicular thyroid carcinoma	Enrichment	BRAF	1.86
53	Lymphoma, non-hodgkin, familial	Enrichment	BRAF	1.80
54	Cardiomyopathy, familial hypertrophic, 4	Enrichment	BRAF	1.75
55	Arteriovenous malformation	Enrichment	MAP2K1	1.75
56	Primary hyperaldosteronism	Enrichment	BRAF	1.75
57	Ventricular septal defect	Enrichment	BRAF	1.75
58	Autism spectrum disorder	Enrichment	MAP2K1, MEF2C	1.71
59	Myopathy, x-linked, with excessive autophagy	Enrichment	MAP2K1	1.70
60	Melanoma	Enrichment	BRAF	1.70
61	Lip and oral cavity carcinoma	Enrichment	BRAF	1.63
62	Lung cancer susceptibility 3	Enrichment	BRAF	1.56
63	Heart disease	Enrichment	RIT1	1.56
64	Wilms tumor 1	Enrichment	BRAF	1.53
65	Melanoma, cutaneous malignant 1	Enrichment	BRAF	1.48
66	Dandy-walker syndrome	Enrichment	BRAF	1.48
67	Arteriovenous malformations of the brain	Enrichment	BRAF	1.43
68	Diffuse large b-cell lymphoma	Enrichment	BRAF	1.43
69	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.33
70	Hydrops fetalis, nonimmune	Enrichment	RIT1	1.30
71	Differentiated thyroid carcinoma	Enrichment	BRAF	1.25
72	Non-immune hydrops fetalis	Enrichment	RIT1	1.22
73	Lung cancer	Enrichment	BRAF	1.21
74	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	1.20
75	Left ventricular noncompaction	Enrichment	RAF1	1.17
76	Hypertelorism	Enrichment	RIT1	1.01
77	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	1.00
78	Myeloma, multiple	Enrichment	BRAF	0.98
79	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	MEF2C	0.96
80	Colorectal cancer	Enrichment	BRAF	0.80

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Trk receptor signaling mediated by the MAPK pathway

Pathway Network for Trk receptor signaling mediated by the MAPK pathway

Member Pathways for Trk receptor signaling mediated by the MAPK pathway

Pathways in the Trk receptor signaling mediated by the MAPK pathway SuperPath

Associated Genes for Trk receptor signaling mediated by the MAPK pathway

Associated Disorders for Trk receptor signaling mediated by the MAPK pathway

Disorders associated with Trk receptor signaling mediated by the MAPK pathway SuperPath

STRING Interaction Network for Trk receptor signaling mediated by the MAPK pathway

Sources for Trk receptor signaling mediated by the MAPK pathway