tRNA-uridine 2-thiolation (cytoplasmic)
Pathways in the tRNA-uridine 2-thiolation (cytoplasmic) SuperPath
| # | Name | Source | Genes |
|---|---|---|---|
| 1 | tRNA-uridine 2-thiolation (cytoplasmic) | PubChem |
Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways
| # | Symbol | Description | Category | # Related Pathways |
|---|---|---|---|---|
| 1 | NFS1 | NFS1 Cysteine Desulfurase | Protein Coding | 1 |
| 2 | CTU1 | Cytosolic Thiouridylase Subunit 1 | Protein Coding | 1 |
| 3 | ALKBH8 | AlkB Homolog 8, TRNA Methyltransferase | Protein Coding | 1 |
| 4 | CTU2 | Cytosolic Thiouridylase Subunit 2 | Protein Coding | 1 |
| 5 | TRMT112 | TRNA Methyltransferase Activator Subunit 11-2 | Protein Coding | 1 |
| 6 | MPST | Mercaptopyruvate Sulfurtransferase | Protein Coding | 1 |
| 7 | MOCS3 | Molybdenum Cofactor Synthesis 3 | Protein Coding | 1 |
Disorders associated with tRNA-uridine 2-thiolation (cytoplasmic) SuperPath
according to GeneCards Suite gene sharing
| # | Disorder | Type | Genes | Score |
|---|---|---|---|---|
| 1 | Intellectual developmental disorder, autosomal recessive 71 | Enrichment | ALKBH8 | 3.29 |
| 2 | Combined oxidative phosphorylation deficiency 52 | Enrichment | NFS1 | 3.29 |
| 3 | Microcephaly, facial dysmorphism, renal agenesis, and ambiguous genitalia syndrome | Enrichment | CTU2 | 3.29 |
| 4 | Molybdenum cofactor deficiency, type b2 | Enrichment | MOCS3 | 3.29 |
| 5 | Combined oxidative phosphorylation deficiency 19 | Enrichment | NFS1 | 2.81 |
| 6 | Cakut | Enrichment | CTU2 | 1.76 |
| 7 | Autosomal recessive non-syndromic intellectual disability | Enrichment | ALKBH8 | 1.53 |
| 8 | Microcephaly | Enrichment | CTU2 | 1.21 |
