tRNA Aminoacylation

Pathway network for the tRNA Aminoacylation SuperPath

Sources:

Reactome

Pathways in the tRNA Aminoacylation SuperPath

#	Name	Source	Genes
1	tRNA Aminoacylation	Reactome	AARS1 AARS2 AIMP1 AIMP2 CARS1 CARS2 DARS1 DARS2 EARS2 EEF1E1 EPRS1 FARS2 FARSA FARSB GARS1 HARS1 HARS2 IARS1 IARS2 KARS1 LARS1 LARS2 MARS1 MARS2 NARS1 NARS2 PARS2 PPA1 PPA2 QARS1 RARS1 RARS2 SARS1 SARS2 TARS1 TARS2 VARS1 VARS2 WARS1 WARS2 YARS1 YARS2 (see all 42) (see less)
2	Cytosolic tRNA aminoacylation	Reactome	AARS1 AIMP1 AIMP2 CARS1 DARS1 EEF1E1 EPRS1 FARSA FARSB GARS1 HARS1 IARS1 KARS1 LARS1 MARS1 NARS1 PPA1 QARS1 RARS1 SARS1 TARS1 VARS1 WARS1 YARS1 (see all 24) (see less)
3	Mitochondrial tRNA aminoacylation	Reactome	AARS2 CARS2 DARS2 EARS2 FARS2 GARS1 HARS2 IARS2 KARS1 LARS2 MARS2 NARS2 PARS2 PPA2 QARS1 RARS2 SARS2 TARS2 VARS2 WARS2 YARS2 (see all 21) (see less)

Gene overlap in member pathways for tRNA Aminoacylation SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	GARS1	Glycyl-TRNA Synthetase 1	Protein Coding	3
2	KARS1	Lysyl-TRNA Synthetase 1	Protein Coding	3
3	QARS1	Glutaminyl-TRNA Synthetase 1	Protein Coding	3
4	FARSB	Phenylalanyl-TRNA Synthetase Subunit Beta	Protein Coding	2
5	WARS2	Tryptophanyl TRNA Synthetase 2, Mitochondrial	Protein Coding	2
6	FARS2	Phenylalanyl-TRNA Synthetase 2, Mitochondrial	Protein Coding	2
7	EARS2	Glutamyl-TRNA Synthetase 2, Mitochondrial	Protein Coding	2
8	AARS1	Alanyl-TRNA Synthetase 1	Protein Coding	2
9	DARS1	Aspartyl-TRNA Synthetase 1	Protein Coding	2
10	EPRS1	Glutamyl-Prolyl-TRNA Synthetase 1	Protein Coding	2
11	FARSA	Phenylalanyl-TRNA Synthetase Subunit Alpha	Protein Coding	2
12	LARS2	Leucyl-TRNA Synthetase 2, Mitochondrial	Protein Coding	2
13	HARS2	Histidyl-TRNA Synthetase 2, Mitochondrial	Protein Coding	2
14	PARS2	Prolyl-TRNA Synthetase 2, Mitochondrial	Protein Coding	2
15	PPA2	Inorganic Pyrophosphatase 2	Protein Coding	2
16	HARS1	Histidyl-TRNA Synthetase 1	Protein Coding	2
17	IARS1	Isoleucyl-TRNA Synthetase 1	Protein Coding	2
18	MARS1	Methionyl-TRNA Synthetase 1	Protein Coding	2
19	NARS1	Asparaginyl-TRNA Synthetase 1	Protein Coding	2
20	YARS2	Tyrosyl-TRNA Synthetase 2	Protein Coding	2
21	LARS1	Leucyl-TRNA Synthetase 1	Protein Coding	2
22	PPA1	Inorganic Pyrophosphatase 1	Protein Coding	2
23	SARS2	Seryl-TRNA Synthetase 2, Mitochondrial	Protein Coding	2
24	DARS2	Aspartyl-TRNA Synthetase 2, Mitochondrial	Protein Coding	2
25	IARS2	Isoleucyl-TRNA Synthetase 2, Mitochondrial	Protein Coding	2
26	RARS2	Arginyl-TRNA Synthetase 2, Mitochondrial	Protein Coding	2
27	VARS2	Valyl-TRNA Synthetase 2, Mitochondrial	Protein Coding	2
28	AARS2	Alanyl-TRNA Synthetase 2, Mitochondrial	Protein Coding	2
29	RARS1	Arginyl-TRNA Synthetase 1	Protein Coding	2
30	SARS1	Seryl-TRNA Synthetase 1	Protein Coding	2
31	TARS1	Threonyl-TRNA Synthetase 1	Protein Coding	2
32	VARS1	Valyl-TRNA Synthetase 1	Protein Coding	2
33	WARS1	Tryptophanyl-TRNA Synthetase 1	Protein Coding	2
34	CARS2	Cysteinyl-TRNA Synthetase 2, Mitochondrial	Protein Coding	2
35	AIMP2	Aminoacyl TRNA Synthetase Complex Interacting Multifunctional Protein 2	Protein Coding	2
36	NARS2	Asparaginyl-TRNA Synthetase 2, Mitochondrial	Protein Coding	2
37	TARS2	Threonyl-TRNA Synthetase 2, Mitochondrial	Protein Coding	2
38	CARS1	Cysteinyl-TRNA Synthetase 1	Protein Coding	2
39	YARS1	Tyrosyl-TRNA Synthetase 1	Protein Coding	2
40	AIMP1	Aminoacyl TRNA Synthetase Complex Interacting Multifunctional Protein 1	Protein Coding	2
41	MARS2	Methionyl-TRNA Synthetase 2, Mitochondrial	Protein Coding	2
42	EEF1E1	Eukaryotic Translation Elongation Factor 1 Epsilon 1	Protein Coding	2

Disorders associated with tRNA Aminoacylation SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Mitochondrial disease	Enrichment	AARS2, NARS2, RARS2, VARS2, YARS2	6.74
2	Trichothiodystrophy	Enrichment	AARS1, CARS1, TARS1	6.39
3	Interstitial lung and liver disease	Enrichment	FARSB, MARS1	5.52
4	Leukoencephalopathy, hereditary diffuse, with spheroids 1	Enrichment	AARS1, AARS2	4.55
5	Neurodevelopmental disorder with microcephaly, seizures, and cortical atrophy	Enrichment	VARS1, VARS2	4.55
6	Sensorineural hearing loss	Enrichment	HARS2, KARS1, NARS2	4.28
7	Microcephaly	Enrichment	HARS1, IARS1, KARS1, QARS1	4.23
8	Perrault syndrome	Enrichment	HARS2, LARS2	4.20
9	Perrault syndrome 2	Enrichment	HARS2, LARS2	4.09
10	Peripheral nervous system disease	Enrichment	AARS1, HARS1, IARS2	3.89
11	Neuropathy	Enrichment	AARS1, HARS1, IARS2	3.89
12	Perrault syndrome 1	Enrichment	HARS2, LARS2	3.57
13	Neuropathy, hereditary motor and sensory, okinawa type	Enrichment	AARS1, GARS1	3.30
14	Leukodystrophy	Enrichment	KARS1, RARS1	3.25
15	Non-syndromic genetic deafness	Enrichment	KARS1, LARS2	2.86
16	Primary autosomal recessive microcephaly	Enrichment	SARS1, WARS1	2.84
17	Pontocerebellar hypoplasia, type 6	Enrichment	RARS2	2.81
18	Combined oxidative phosphorylation deficiency 21	Enrichment	TARS2	2.81
19	Developmental and epileptic encephalopathy 75	Enrichment	PARS2	2.81
20	Parkinsonism-dystonia 3, childhood-onset	Enrichment	WARS2	2.81
21	Charcot-marie-tooth disease, axonal, type 2d	Enrichment	GARS1	2.81
22	Combined oxidative phosphorylation deficiency 12	Enrichment	EARS2	2.81
23	Charcot-marie-tooth disease, recessive intermediate b	Enrichment	KARS1	2.81
24	Sudden cardiac failure, infantile	Enrichment	PPA2	2.81
25	Leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation	Enrichment	DARS2	2.81
26	Combined oxidative phosphorylation deficiency 27	Enrichment	CARS2	2.81
27	Cataracts, growth hormone deficiency, sensory neuropathy, sensorineural hearing loss, and skeletal dysplasia	Enrichment	IARS2	2.81
28	Combined oxidative phosphorylation deficiency 25	Enrichment	MARS2	2.81
29	Combined oxidative phosphorylation deficiency 8	Enrichment	AARS2	2.81
30	Myopathy, lactic acidosis, and sideroblastic anemia 2	Enrichment	YARS2	2.81
31	Hyperuricemia, pulmonary hypertension, renal failure, and alkalosis syndrome	Enrichment	SARS2	2.81
32	Spinal muscular atrophy, infantile, james type	Enrichment	GARS1	2.81
33	Sudden cardiac failure, alcohol-induced	Enrichment	PPA2	2.81
34	Deafness, autosomal recessive 94	Enrichment	NARS2	2.81
35	Leukoencephalopathy, progressive, infantile-onset, with or without deafness	Enrichment	KARS1	2.81
36	Aars2-related disorder	Enrichment	AARS2	2.81
37	Charcot-marie-tooth disease type 2d	Enrichment	GARS1	2.81
38	Gout	Enrichment	DARS2	2.81
39	Leukoencephalopathy with brain stem and spinal cord involvement-high lactate syndrome	Enrichment	DARS2	2.81
40	Microcephaly-short stature-intellectual disability-facial dysmorphism syndrome	Enrichment	QARS1	2.81
41	Leukodystrophy, hypomyelinating, 3	Enrichment	AIMP1	2.75
42	Rajab interstitial lung disease with brain calcifications 1	Enrichment	FARSB	2.75
43	Infantile liver failure syndrome 1	Enrichment	LARS1	2.75
44	Charcot-marie-tooth disease, dominant intermediate c	Enrichment	YARS1	2.75
45	Developmental and epileptic encephalopathy 29	Enrichment	AARS1	2.75
46	Neurodevelopmental disorder with microcephaly, ataxia, and seizures	Enrichment	SARS1	2.75
47	Neurodevelopmental disorder with microcephaly, impaired language, and gait abnormalities	Enrichment	NARS1	2.75
48	Growth retardation, impaired intellectual development, hypotonia, and hepatopathy	Enrichment	IARS1	2.75
49	Leukodystrophy, hypomyelinating, 9	Enrichment	RARS1	2.75
50	Charcot-marie-tooth disease, axonal, type 2n	Enrichment	AARS1	2.75
51	Trichothiodystrophy 8, nonphotosensitive	Enrichment	AARS1	2.75
52	Hypomyelination with brainstem and spinal cord involvement and leg spasticity	Enrichment	DARS1	2.75
53	Neurodevelopmental disorder with microcephaly, impaired language, epilepsy, and gait abnormalities	Enrichment	NARS1	2.75
54	Charcot-marie-tooth disease, axonal, type 2u	Enrichment	MARS1	2.75
55	Neuronopathy, distal hereditary motor, autosomal dominant 9	Enrichment	WARS1	2.75
56	Neurodevelopmental disorder with microcephaly and speech delay, with or without brain abnormalities	Enrichment	WARS1	2.75
57	Leukodystrophy, hypomyelinating, 15	Enrichment	EPRS1	2.75
58	Leukoencephalopathy, hereditary diffuse, with spheroids 2	Enrichment	AARS1	2.75
59	Trichothiodystrophy 9, nonphotosensitive	Enrichment	MARS1	2.75
60	Trichothiodystrophy 7, nonphotosensitive	Enrichment	TARS1	2.75
61	Rajab interstitial lung disease with brain calcifications 2	Enrichment	FARSA	2.75
62	Brain calcification, rajab type	Enrichment	FARSB	2.75
63	Pulmonary alveolar proteinosis	Enrichment	MARS1	2.75
64	Liver cirrhosis	Enrichment	FARSB	2.75
65	Nonsyndromic hearing loss	Enrichment	KARS1, LARS2	2.72
66	Charcot-marie-tooth disease	Enrichment	AARS1, GARS1	2.63
67	Spastic ataxia 3, autosomal recessive	Enrichment	MARS2	2.51
68	Combined oxidative phosphorylation deficiency 14	Enrichment	FARS2	2.51
69	Hydrops, lactic acidosis, and sideroblastic anemia	Enrichment	LARS2	2.51
70	Intellectual developmental disorder, autosomal dominant 43	Enrichment	QARS1	2.51
71	Leukoencephalopathy, progressive, with ovarian failure	Enrichment	AARS2	2.51
72	Spastic paraplegia 77, autosomal recessive	Enrichment	FARS2	2.51
73	Combined oxidative phosphorylation deficiency 20	Enrichment	VARS2	2.51
74	Deafness, congenital, and adult-onset progressive leukoencephalopathy	Enrichment	KARS1	2.51
75	Deafness, autosomal recessive 89	Enrichment	KARS1	2.51
76	Spastic ataxia 3	Enrichment	MARS2	2.51
77	Perrault syndrome 4	Enrichment	LARS2	2.51
78	Usher syndrome, type iiib	Enrichment	HARS1	2.45
79	Charcot-marie-tooth disease, axonal, type 2w	Enrichment	HARS1	2.45
80	Spastic paraplegia 70, autosomal recessive	Enrichment	MARS1	2.45
81	Leukodystrophy, hypomyelinating, 17	Enrichment	AIMP2	2.45
82	Autosomal dominant charcot-marie-tooth disease type 2w	Enrichment	HARS1	2.45
83	Combined oxidative phosphorylation deficiency 1	Enrichment	NARS2	2.33
84	Microcephaly, progressive, with seizures and cerebral and cerebellar atrophy	Enrichment	QARS1	2.33
85	Neurodevelopmental disorder, mitochondrial, with abnormal movements and lactic acidosis, with or without seizures	Enrichment	WARS2	2.33
86	Dend syndrome	Enrichment	NARS2	2.33
87	Autosomal recessive non-syndromic intellectual disability	Enrichment	AIMP1, SARS1	2.33
88	Leigh syndrome, nuclear	Enrichment	FARS2, IARS2	2.30
89	Visceral steatosis, congenital	Enrichment	YARS1	2.28
90	Microcephaly, developmental delay, and brittle hair syndrome	Enrichment	CARS1	2.28
91	Neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset 2	Enrichment	YARS1	2.28
92	Mitochondrial complex i deficiency, nuclear type 35	Enrichment	NARS1	2.28
93	Steatotic liver disease	Enrichment	YARS1	2.28
94	Leigh disease	Enrichment	FARS2, IARS2	2.22
95	Myopathy, lactic acidosis, and sideroblastic anemia 1	Enrichment	YARS2	2.21
96	Combined oxidative phosphorylation deficiency 24	Enrichment	NARS2	2.21
97	Neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset 1	Enrichment	YARS1	2.15
98	Oculomotor apraxia	Enrichment	HARS1	2.15
99	Neuronopathy, distal hereditary motor, autosomal dominant 5	Enrichment	GARS1	2.11
100	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	KARS1, NARS2	2.08
101	Liver failure, infantile, transient	Enrichment	LARS1	2.05
102	Inflammatory myofibroblastic tumor	Enrichment	CARS1	1.98
103	Spastic ataxia	Enrichment	DARS2, HARS1	1.93
104	Usher syndrome, type iiia	Enrichment	HARS1	1.91
105	Retinal degeneration	Enrichment	YARS1	1.91
106	Undetermined early-onset epileptic encephalopathy	Enrichment	AARS1, PARS2	1.89
107	Leukoencephalopathy with vanishing white matter	Enrichment	AARS2	1.86
108	Optic nerve disease	Enrichment	KARS1	1.81
109	Mitochondrial encephalomyopathy	Enrichment	FARS2	1.81
110	Mitochondrial myopathy	Enrichment	LARS2	1.77
111	Lactic acidosis	Enrichment	KARS1	1.73
112	Clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly	Enrichment	DARS2	1.70
113	Clubfoot	Enrichment	DARS2	1.70
114	Cataract	Enrichment	IARS2	1.67
115	Hypertension	Enrichment	DARS2	1.61
116	Pontocerebellar hypoplasia	Enrichment	RARS2	1.56
117	Arteriovenous malformations of the brain	Enrichment	SARS1	1.48
118	Scoliosis	Enrichment	HARS1	1.38
119	Fetal akinesia deformation sequence 1	Enrichment	EARS2	1.25
120	Distal arthrogryposis	Enrichment	EARS2	1.20
121	Deafness, autosomal recessive	Enrichment	KARS1	1.03
122	Autosomal recessive nonsyndromic deafness	Enrichment	KARS1	1.02
123	Rare genetic deafness	Enrichment	LARS2	0.94
124	Complex neurodevelopmental disorder	Enrichment	WARS1	0.70

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

tRNA Aminoacylation

Pathway Network for tRNA Aminoacylation

Pathway network for the tRNA Aminoacylation SuperPath

Member Pathways for tRNA Aminoacylation

Pathways in the tRNA Aminoacylation SuperPath

Gene overlap in member pathways for tRNA Aminoacylation SuperPath

Associated Genes for tRNA Aminoacylation

Associated Disorders for tRNA Aminoacylation

Disorders associated with tRNA Aminoacylation SuperPath

STRING Interaction Network for tRNA Aminoacylation

Sources for tRNA Aminoacylation