TRP channels

No Pathway Network information available for TRP channels

Pathways in the TRP channels SuperPath

#	Name	Source	Genes
1	TRP channels	Reactome	MCOLN1 MCOLN2 MCOLN3 RIPK1 RIPK3 TRPA1 TRPC1 TRPC3 TRPC4 TRPC4AP TRPC5 TRPC6 TRPC7 TRPM1 TRPM2 TRPM3 TRPM4 TRPM5 TRPM6 TRPM7 TRPM8 TRPV1 TRPV2 TRPV3 TRPV4 TRPV5 TRPV6 (see all 27) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	RIPK3	Receptor Interacting Serine/Threonine Kinase 3	Protein Coding	1
2	TRPM6	Transient Receptor Potential Cation Channel Subfamily M Member 6	Protein Coding	1
3	TRPV3	Transient Receptor Potential Cation Channel Subfamily V Member 3	Protein Coding	1
4	MCOLN2	Mucolipin TRP Cation Channel 2	Protein Coding	1
5	TRPC4AP	Transient Receptor Potential Cation Channel Subfamily C Member 4 Associated Protein	Protein Coding	1
6	TRPM5	Transient Receptor Potential Cation Channel Subfamily M Member 5	Protein Coding	1
7	TRPM1	Transient Receptor Potential Cation Channel Subfamily M Member 1	Protein Coding	1
8	TRPV2	Transient Receptor Potential Cation Channel Subfamily V Member 2	Protein Coding	1
9	TRPM4	Transient Receptor Potential Cation Channel Subfamily M Member 4	Protein Coding	1
10	TRPM7	Transient Receptor Potential Cation Channel Subfamily M Member 7	Protein Coding	1
11	MCOLN3	Mucolipin TRP Cation Channel 3	Protein Coding	1
12	TRPV6	Transient Receptor Potential Cation Channel Subfamily V Member 6	Protein Coding	1
13	TRPV5	Transient Receptor Potential Cation Channel Subfamily V Member 5	Protein Coding	1
14	TRPC7	Transient Receptor Potential Cation Channel Subfamily C Member 7	Protein Coding	1
15	MCOLN1	Mucolipin TRP Cation Channel 1	Protein Coding	1
16	TRPV4	Transient Receptor Potential Cation Channel Subfamily V Member 4	Protein Coding	1
17	TRPC1	Transient Receptor Potential Cation Channel Subfamily C Member 1	Protein Coding	1
18	TRPC3	Transient Receptor Potential Cation Channel Subfamily C Member 3	Protein Coding	1
19	TRPC4	Transient Receptor Potential Cation Channel Subfamily C Member 4	Protein Coding	1
20	TRPC5	Transient Receptor Potential Cation Channel Subfamily C Member 5	Protein Coding	1
21	TRPC6	Transient Receptor Potential Cation Channel Subfamily C Member 6	Protein Coding	1
22	TRPM2	Transient Receptor Potential Cation Channel Subfamily M Member 2	Protein Coding	1
23	TRPV1	Transient Receptor Potential Cation Channel Subfamily V Member 1	Protein Coding	1
24	TRPM8	Transient Receptor Potential Cation Channel Subfamily M Member 8	Protein Coding	1
25	TRPM3	Transient Receptor Potential Cation Channel Subfamily M Member 3	Protein Coding	1
26	RIPK1	Receptor Interacting Serine/Threonine Kinase 1	Protein Coding	1
27	TRPA1	Transient Receptor Potential Cation Channel Subfamily A Member 1	Protein Coding	1

Disorders associated with TRP channels SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Hypomagnesemia 1, intestinal	Enrichment	TRPM6, TRPM7	4.94
2	Metatropic dysplasia	Enrichment	TRPV4	2.70
3	Parastremmatic dwarfism	Enrichment	TRPV4	2.70
4	Spondylometaphyseal dysplasia, kozlowski type	Enrichment	TRPV4	2.70
5	Neuronopathy, distal hereditary motor, autosomal dominant 8	Enrichment	TRPV4	2.70
6	Brachyolmia type 3	Enrichment	TRPV4	2.70
7	Sodium serum level quantitative trait locus 1	Enrichment	TRPV4	2.70
8	Focal segmental glomerulosclerosis 2	Enrichment	TRPC6	2.70
9	Spondyloepiphyseal dysplasia, maroteaux type	Enrichment	TRPV4	2.70
10	Scapuloperoneal spinal muscular atrophy	Enrichment	TRPV4	2.70
11	Avascular necrosis of femoral head, primary, 2	Enrichment	TRPV4	2.70
12	Spinocerebellar ataxia 41	Enrichment	TRPC3	2.70
13	Neurodevelopmental disorder with hypotonia, dysmorphic facies, and skeletal anomalies, with or without seizures	Enrichment	TRPM3	2.70
14	Progressive familial heart block, type ib	Enrichment	TRPM4	2.70
15	Erythrokeratodermia variabilis et progressiva 6	Enrichment	TRPM4	2.70
16	Skeletal dysplasia and progressive central nervous system degeneration, lethal	Enrichment	TRPV4	2.70
17	Digital arthropathy-brachydactyly, familial	Enrichment	TRPV4	2.70
18	Olmsted syndrome 1	Enrichment	TRPV3	2.70
19	Hyperparathyroidism	Enrichment	TRPV6	2.70
20	Palmoplantar keratoderma, nonepidermolytic, focal 2	Enrichment	TRPV3	2.70
21	Autoinflammation with episodic fever and lymphadenopathy	Enrichment	RIPK1	2.70
22	Hyperparathyroidism, transient neonatal	Enrichment	TRPV6	2.70
23	Cataract 50 with or without glaucoma	Enrichment	TRPM3	2.70
24	Cramp-fasciculation syndrome	Enrichment	TRPA1	2.70
25	Trpv4-related bone disorder	Enrichment	TRPV4	2.70
26	Amyotrophic lateral sclerosis-parkinsonism/dementia complex 1	Enrichment	TRPM7	2.40
27	Hyperparathyroidism, neonatal severe	Enrichment	TRPV6	2.40
28	Hereditary motor and sensory neuropathy, type iic	Enrichment	TRPV4	2.40
29	Birk-barel syndrome	Enrichment	TRPM3	2.40
30	Retinal dystrophy and iris coloboma with or without cataract	Enrichment	TRPM3	2.40
31	Mucolipidosis iv	Enrichment	MCOLN1	2.40
32	Palmoplantar keratoderma, nonepidermolytic, focal 1	Enrichment	TRPV3	2.40
33	Corneal dystrophy, lisch epithelial	Enrichment	MCOLN1	2.40
34	Familial avascular necrosis of the femoral head	Enrichment	TRPV4	2.40
35	Immunodeficiency 57 with autoinflammation	Enrichment	RIPK1	2.40
36	Episodic pain syndrome, familial, 1	Enrichment	TRPA1	2.22
37	Mucolipidosis	Enrichment	MCOLN1	2.22
38	Mutilating palmoplantar keratoderma with periorificial keratotic plaques	Enrichment	TRPV3	2.22
39	Periventricular leukomalacia	Enrichment	MCOLN1	2.22
40	Mulibrey nanism	Enrichment	TRPM3	2.10
41	Bone mineral density quantitative trait locus 15	Enrichment	TRPV6	2.10
42	Hereditary progressive cardiac conduction defect	Enrichment	TRPM4	2.10
43	Night blindness, congenital stationary, type 1c	Enrichment	TRPM1	2.00
44	Night blindness	Enrichment	TRPM1	2.00
45	Genetic motor neuron disease	Enrichment	TRPV4	2.00
46	Inflammatory bowel disease 25, autosomal recessive	Enrichment	RIPK1	1.92
47	Il10-related early-onset inflammatory bowel disease	Enrichment	RIPK1	1.92
48	Erythrokeratodermia variabilis et progressiva 1	Enrichment	TRPM4	1.80
49	Autosomal dominant macrothrombocytopenia	Enrichment	TRPM7	1.70
50	Primary bone dysplasia	Enrichment	TRPV4	1.70
51	Immune deficiency disease	Enrichment	RIPK1	1.66
52	Osteochondrodysplasia	Enrichment	TRPV4	1.66
53	Clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly	Enrichment	TRPV4	1.59
54	Clubfoot	Enrichment	TRPV4	1.59
55	Pancreatitis, hereditary	Enrichment	TRPV6	1.48
56	Beckwith-wiedemann syndrome	Enrichment	TRPV4	1.45
57	Neuromuscular disease	Enrichment	TRPV4	1.45
58	Focal segmental glomerulosclerosis	Enrichment	TRPC6	1.41
59	Congenital stationary night blindness	Enrichment	TRPM1	1.35
60	Brugada syndrome	Enrichment	TRPM4	1.30
61	Connective tissue disease	Enrichment	TRPV4	1.21
62	Genetic steroid-resistant nephrotic syndrome	Enrichment	TRPC6	1.18
63	Eye disease	Enrichment	TRPM6	1.17
64	Charcot-marie-tooth disease	Enrichment	TRPV4	1.10
65	Nephrotic syndrome	Enrichment	TRPC6	1.08
66	Autosomal dominant non-syndromic intellectual disability	Enrichment	TRPM3	1.02
67	Hereditary breast ovarian cancer syndrome	Enrichment	RIPK1	0.98
68	Congenital nervous system abnormality	Enrichment	MCOLN1	0.72
69	Nervous system disease	Enrichment	MCOLN1	0.72
70	Retinitis pigmentosa	Enrichment	TRPM6	0.46
71	Hereditary retinal dystrophy	Enrichment	TRPM1	0.35
72	Fundus dystrophy	Enrichment	TRPM1	0.35

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for TRP channels

Member Pathways for TRP channels

Pathways in the TRP channels SuperPath

Associated Genes for TRP channels

Associated Disorders for TRP channels

Disorders associated with TRP channels SuperPath

STRING Interaction Network for TRP channels

Sources for TRP channels