Type II diabetes mellitus

No Pathway Network information available for Type II diabetes mellitus

Pathways in the Type II diabetes mellitus SuperPath

#	Name	Source	Genes
1	Type II diabetes mellitus	WikiPathways	ADIPOQ CACNA1A GK IKBKB INS-IGF2 INSR IRS1 KCNJ11 MAFA MAPK1 MAPK8 MTOR PDX1 PHKA2 PIK3R5 PRKCD PRKCZ SLC2A2 SLC2A4 SOCS4 SURF1 TNF (see all 22) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ADIPOQ	Adiponectin, C1Q And Collagen Domain Containing	Protein Coding	1
2	CACNA1A	Calcium Voltage-Gated Channel Subunit Alpha1 A	Protein Coding	1
3	INS-IGF2	INS-IGF2 Readthrough	Protein Coding	1
4	TNF	Tumor Necrosis Factor	Protein Coding	1
5	SURF1	SURF1 Cytochrome C Oxidase Assembly Factor	Protein Coding	1
6	SLC2A4	Solute Carrier Family 2 Member 4	Protein Coding	1
7	SLC2A2	Solute Carrier Family 2 Member 2	Protein Coding	1
8	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
9	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
10	PRKCZ	Protein Kinase C Zeta	Protein Coding	1
11	PRKCD	Protein Kinase C Delta	Protein Coding	1
12	PHKA2	Phosphorylase Kinase Regulatory Subunit Alpha 2	Protein Coding	1
13	KCNJ11	Potassium Inwardly Rectifying Channel Subfamily J Member 11	Protein Coding	1
14	IRS1	Insulin Receptor Substrate 1	Protein Coding	1
15	PDX1	Pancreatic And Duodenal Homeobox 1	Protein Coding	1
16	INSR	Insulin Receptor	Protein Coding	1
17	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	1
18	GK	Glycerol Kinase	Protein Coding	1
19	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	1
20	PIK3R5	Phosphoinositide-3-Kinase Regulatory Subunit 5	Protein Coding	1
21	SOCS4	Suppressor Of Cytokine Signaling 4	Protein Coding	1
22	MAFA	MAF BZIP Transcription Factor A	Protein Coding	1

Disorders associated with Type II diabetes mellitus SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Type 2 diabetes mellitus	Enrichment	INSR, IRS1, KCNJ11, PDX1, SLC2A2, SLC2A4	10.21
2	Permanent neonatal diabetes mellitus	Enrichment	INS-IGF2, KCNJ11, PDX1	6.69
3	Neonatal diabetes mellitus	Enrichment	INS-IGF2, KCNJ11	4.82
4	Diabetes mellitus	Enrichment	INS-IGF2, KCNJ11	3.86
5	Maturity-onset diabetes of the young	Enrichment	KCNJ11, PDX1	3.33
6	Insulinomatosis and diabetes mellitus	Enrichment	MAFA	2.79
7	Pancreatic agenesis 1	Enrichment	PDX1	2.79
8	Donohue syndrome	Enrichment	INSR	2.79
9	Hyperinsulinemic hypoglycemia, familial, 2	Enrichment	KCNJ11	2.79
10	Hyperinsulinemic hypoglycemia, familial, 5	Enrichment	INSR	2.79
11	Maturity-onset diabetes of the young, type 4	Enrichment	PDX1	2.79
12	Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities	Enrichment	INSR	2.79
13	Diabetes mellitus, insulin-resistant, with acanthosis nigricans	Enrichment	INSR	2.79
14	Ataxia-oculomotor apraxia 3	Enrichment	PIK3R5	2.79
15	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.79
16	Immunodeficiency 15b	Enrichment	IKBKB	2.79
17	Noonan syndrome 13	Enrichment	MAPK1	2.79
18	Immunodeficiency 15a	Enrichment	IKBKB	2.79
19	Diabetes mellitus, transient neonatal, 3	Enrichment	KCNJ11	2.79
20	Diabetes mellitus, permanent neonatal, 2	Enrichment	KCNJ11	2.79
21	Maturity-onset diabetes of the young, type 13	Enrichment	KCNJ11	2.79
22	Sporadic hemiplegic migraine	Enrichment	CACNA1A	2.79
23	Intermediate dend syndrome	Enrichment	KCNJ11	2.79
24	Diazoxide-resistant focal hyperinsulinism due to kir6.2 deficiency	Enrichment	KCNJ11	2.79
25	Benign paroxysmal torticollis of infancy	Enrichment	CACNA1A	2.79
26	Autosomal dominant hyperinsulinism due to kir6.2 deficiency	Enrichment	KCNJ11	2.79
27	Autosomal recessive hyperinsulinism due to kir6.2 deficiency	Enrichment	KCNJ11	2.79
28	Pancreas, dorsal, agenesis of	Enrichment	PDX1	2.49
29	Fanconi-bickel syndrome	Enrichment	SLC2A2	2.49
30	Glycogen storage disease ixa1	Enrichment	PHKA2	2.49
31	Glycerol kinase deficiency	Enrichment	GK	2.49
32	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2	Enrichment	PIK3R5	2.49
33	Alternating hemiplegia of childhood 1	Enrichment	CACNA1A	2.49
34	Hyperinsulinemic hypoglycemia, familial, 4	Enrichment	INSR	2.49
35	Diabetes mellitus, permanent neonatal, 1	Enrichment	KCNJ11	2.49
36	Silver-russell syndrome 3	Enrichment	INS-IGF2	2.49
37	Mitochondrial complex iv deficiency, nuclear type 6	Enrichment	SURF1	2.49
38	Maturity-onset diabetes of the young, type 10	Enrichment	INS-IGF2	2.49
39	Hyperproinsulinemia	Enrichment	INS-IGF2	2.49
40	Cebalid syndrome	Enrichment	MTOR	2.49
41	Immunodeficiency 127	Enrichment	TNF	2.49
42	Charcot-marie-tooth disease type 4k	Enrichment	SURF1	2.49
43	Diabetes mellitus, permanent neonatal, 4	Enrichment	INS-IGF2	2.49
44	Smith-kingsmore syndrome	Enrichment	MTOR	2.49
45	Charcot-marie-tooth disease, demyelinating, type 4k	Enrichment	SURF1	2.49
46	Glycogen storage disease due to liver phosphorylase kinase deficiency	Enrichment	PHKA2	2.49
47	Hyperinsulinism	Enrichment	KCNJ11	2.49
48	Glycogen storage disease viii	Enrichment	PHKA2	2.49
49	Progressive bulbar palsy	Enrichment	CACNA1A	2.49
50	Type 1 diabetes mellitus 2	Enrichment	INS-IGF2	2.31
51	Psoriatic arthritis	Enrichment	TNF	2.31
52	Adiponectin deficiency	Enrichment	ADIPOQ	2.31
53	Neurodevelopmental disorder with hypotonia, language delay, and skeletal defects with or without seizures	Enrichment	CACNA1A	2.31
54	Migraine without aura	Enrichment	TNF	2.31
55	Hereditary episodic ataxia	Enrichment	CACNA1A	2.31
56	Dend syndrome	Enrichment	KCNJ11	2.31
57	Migraine, familial hemiplegic, 1	Enrichment	CACNA1A	2.19
58	Spinocerebellar ataxia 6	Enrichment	CACNA1A	2.19
59	Dermatitis, atopic	Enrichment	KCNJ11	2.19
60	Aland island eye disease	Enrichment	PHKA2	2.19
61	Developmental and epileptic encephalopathy 2	Enrichment	CACNA1A	2.19
62	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.19
63	Focal cortical dysplasia, type ii	Enrichment	MTOR	2.19
64	Developmental and epileptic encephalopathy 42	Enrichment	CACNA1A	2.19
65	Developmental and epileptic encephalopathy 52	Enrichment	CACNA1A	2.19
66	Episodic ataxia	Enrichment	CACNA1A	2.19
67	Familial or sporadic hemiplegic migraine	Enrichment	CACNA1A	2.19
68	Cerebral malaria	Enrichment	TNF	2.19
69	Isolated focal cortical dysplasia type ii	Enrichment	MTOR	2.19
70	Episodic ataxia, type 2	Enrichment	CACNA1A	2.09
71	Transient neonatal diabetes mellitus	Enrichment	KCNJ11	2.09
72	Hypoglycemia	Enrichment	KCNJ11	2.09
73	Phosphorylase kinase deficiency	Enrichment	PHKA2	2.09
74	Vascular dementia	Enrichment	TNF	2.09
75	Hemimegalencephaly	Enrichment	MTOR	2.09
76	Hyperinsulinemic hypoglycemia, familial, 1	Enrichment	KCNJ11	2.01
77	Hypertrichosis	Enrichment	KCNJ11	2.01
78	46,xy disorder of sex development	Enrichment	INSR	2.01
79	Nonsyndromic genetic hyperinsulinism	Enrichment	KCNJ11	2.01
80	Silver-russell syndrome 1	Enrichment	INS-IGF2	1.95
81	Renal cell carcinoma, papillary, 1	Enrichment	MTOR	1.95
82	Overgrowth syndrome	Enrichment	MTOR	1.95
83	Lennox-gastaut syndrome	Enrichment	CACNA1A	1.89
84	Alternating hemiplegia of childhood	Enrichment	CACNA1A	1.89
85	Difference of sex development	Enrichment	CACNA1A	1.89
86	Migraine with or without aura 1	Enrichment	CACNA1A	1.75
87	Asthma	Enrichment	TNF	1.75
88	Specific learning disability	Enrichment	MAPK1	1.75
89	Congenital long qt syndrome	Enrichment	SLC2A2	1.71
90	Alzheimer's disease	Enrichment	TNF	1.68
91	Chromosome 1p36 deletion syndrome	Enrichment	PRKCZ	1.68
92	Renal cell carcinoma, nonpapillary	Enrichment	MTOR	1.62
93	Wilms tumor 1	Enrichment	INS-IGF2	1.62
94	Rare genetic intellectual disability	Enrichment	MTOR	1.62
95	Beckwith-wiedemann syndrome	Enrichment	INS-IGF2	1.54
96	Heart, malformation of	Enrichment	MAPK1	1.54
97	Mitochondrial complex iv deficiency, nuclear type 1	Enrichment	SURF1	1.45
98	Malaria	Enrichment	TNF	1.44
99	Auditory neuropathy	Enrichment	CACNA1A	1.38
100	Strabismus	Enrichment	CACNA1A	1.37
101	Long qt syndrome 1	Enrichment	SLC2A2	1.32
102	Severe combined immunodeficiency	Enrichment	IKBKB	1.28
103	Systemic lupus erythematosus	Enrichment	TNF	1.21
104	Cerebral palsy	Enrichment	CACNA1A	1.21
105	Undetermined early-onset epileptic encephalopathy	Enrichment	CACNA1A	1.06
106	Leigh syndrome, nuclear	Enrichment	SURF1	0.97
107	Leigh disease	Enrichment	SURF1	0.93
108	Colorectal cancer	Enrichment	INS-IGF2	0.88
109	Mitochondrial disease	Enrichment	SURF1	0.88
110	Congenital nervous system abnormality	Enrichment	CACNA1A	0.80
111	Nervous system disease	Enrichment	CACNA1A	0.80
112	Microcephaly	Enrichment	MAPK1	0.74

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Type II diabetes mellitus

Pathway Network for Type II diabetes mellitus

Member Pathways for Type II diabetes mellitus

Pathways in the Type II diabetes mellitus SuperPath

Associated Genes for Type II diabetes mellitus

Associated Disorders for Type II diabetes mellitus

Disorders associated with Type II diabetes mellitus SuperPath

STRING Interaction Network for Type II diabetes mellitus

Sources for Type II diabetes mellitus