Type II interferon signaling

No Pathway Network information available for Type II interferon signaling

Pathways in the Type II interferon signaling SuperPath

#	Name	Source	Genes
1	Type II interferon signaling	WikiPathways	CIITA CXCL10 CXCL9 CYBB EIF2AK2 GBP1 H4C14 HLA-B ICAM1 IFI6 IFIT2 IFNA2 IFNB1 IFNG IFNGR1 IFNGR2 IL1B IRF1 IRF2 IRF4 IRF8 IRF9 ISG15 JAK1 JAK2 NOS2 OAS1 PRKCD PSMB9 PTPN11 REG1A SOCS1 SOCS3 SPI1 STAT1 STAT2 TAP1 (see all 37) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ISG15	ISG15 Ubiquitin Like Modifier	Protein Coding	1
2	SOCS3	Suppressor Of Cytokine Signaling 3	Protein Coding	1
3	SOCS1	Suppressor Of Cytokine Signaling 1	Protein Coding	1
4	TAP1	Transporter 1, ATP Binding Cassette Subfamily B Member	Protein Coding	1
5	STAT2	Signal Transducer And Activator Of Transcription 2	Protein Coding	1
6	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	1
7	SPI1	Spi-1 Proto-Oncogene	Protein Coding	1
8	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	1
9	PSMB9	Proteasome 20S Subunit Beta 9	Protein Coding	1
10	EIF2AK2	Eukaryotic Translation Initiation Factor 2 Alpha Kinase 2	Protein Coding	1
11	PRKCD	Protein Kinase C Delta	Protein Coding	1
12	OAS1	2''-5''-Oligoadenylate Synthetase 1	Protein Coding	1
13	NOS2	Nitric Oxide Synthase 2	Protein Coding	1
14	CXCL9	C-X-C Motif Chemokine Ligand 9	Protein Coding	1
15	CIITA	Class II Major Histocompatibility Complex Transactivator	Protein Coding	1
16	JAK2	Janus Kinase 2	Protein Coding	1
17	JAK1	Janus Kinase 1	Protein Coding	1
18	IRF4	Interferon Regulatory Factor 4	Protein Coding	1
19	IRF2	Interferon Regulatory Factor 2	Protein Coding	1
20	IRF1	Interferon Regulatory Factor 1	Protein Coding	1
21	CXCL10	C-X-C Motif Chemokine Ligand 10	Protein Coding	1
22	IL1B	Interleukin 1 Beta	Protein Coding	1
23	IFNGR2	Interferon Gamma Receptor 2	Protein Coding	1
24	IFNGR1	Interferon Gamma Receptor 1	Protein Coding	1
25	IFNG	Interferon Gamma	Protein Coding	1
26	IFNB1	Interferon Beta 1	Protein Coding	1
27	IFNA2	Interferon Alpha 2	Protein Coding	1
28	IFIT2	Interferon Induced Protein With Tetratricopeptide Repeats 2	Protein Coding	1
29	IRF8	Interferon Regulatory Factor 8	Protein Coding	1
30	ICAM1	Intercellular Adhesion Molecule 1	Protein Coding	1
31	HLA-B	Major Histocompatibility Complex, Class I, B	Protein Coding	1
32	GBP1	Guanylate Binding Protein 1	Protein Coding	1
33	IFI6	Interferon Alpha Inducible Protein 6	Protein Coding	1
34	CYBB	Cytochrome B-245 Beta Chain	Protein Coding	1
35	IRF9	Interferon Regulatory Factor 9	Protein Coding	1
36	H4C14	H4 Clustered Histone 14	Protein Coding	1
37	REG1A	Regenerating Family Member 1 Alpha	Protein Coding	1

Disorders associated with Type II interferon signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK1, JAK2	4.66
2	Behcet syndrome	Enrichment	HLA-B, IFNGR1	2.92
3	Malaria	Enrichment	ICAM1, NOS2	2.75
4	Spondyloarthropathy 1	Enrichment	HLA-B	2.56
5	Metachondromatosis	Enrichment	PTPN11	2.56
6	Helicobacter pylori infection	Enrichment	IFNGR1	2.56
7	Immunodeficiency 34	Enrichment	CYBB	2.56
8	Skin/hair/eye pigmentation, variation in, 8	Enrichment	IRF4	2.56
9	Dermatitis, atopic, 4	Enrichment	SOCS3	2.56
10	Leopard syndrome 1	Enrichment	PTPN11	2.56
11	Immunodeficiency 38 with basal ganglia calcification	Enrichment	ISG15	2.56
12	Immunodeficiency 32a	Enrichment	IRF8	2.56
13	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.56
14	Immunodeficiency 27a	Enrichment	IFNGR1	2.56
15	Immunodeficiency 69	Enrichment	IFNG	2.56
16	Agammaglobulinemia 10, autosomal dominant	Enrichment	SPI1	2.56
17	Pseudo-torch syndrome 3	Enrichment	STAT2	2.56
18	Immunodeficiency 131	Enrichment	IRF4	2.56
19	Leukoencephalopathy, developmental delay, and episodic neurologic regression syndrome	Enrichment	EIF2AK2	2.56
20	Ankylosing spondylitis 1	Enrichment	HLA-B	2.56
21	Immunodeficiency 27b	Enrichment	IFNGR1	2.56
22	Immunodeficiency 31a	Enrichment	STAT1	2.56
23	Proteasome-associated autoinflammatory syndrome 6	Enrichment	PSMB9	2.56
24	Immunodeficiency 31b	Enrichment	STAT1	2.56
25	Immunodeficiency 100 with pulmonary alveolar proteinosis and hypogammaglobulinemia	Enrichment	OAS1	2.56
26	Reactive arthritis	Enrichment	HLA-B	2.56
27	Dystonia 33	Enrichment	EIF2AK2	2.56
28	Immunodeficiency 65 viral infections	Enrichment	IRF9	2.56
29	Agammaglobulinemia	Enrichment	SPI1	2.56
30	Pulmonary arterial hypertension associated with connective tissue disease	Enrichment	HLA-B	2.56
31	Whipple disease	Enrichment	IRF4	2.56
32	Infantile-onset pulmonary alveolar proteinosis-hypogammaglobulinemia	Enrichment	OAS1	2.56
33	Autosomal dominant mendelian susceptibility to mycobacterial diseases due to partial ifngammar2 deficiency	Enrichment	IFNGR2	2.56
34	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	2.56
35	Malignant astrocytoma	Enrichment	PTPN11	2.56
36	Immunodeficiency 32b	Enrichment	IRF8	2.26
37	Severe cutaneous adverse reaction	Enrichment	HLA-B	2.26
38	Thrombocythemia 3	Enrichment	JAK2	2.26
39	Immunodeficiency 31c	Enrichment	STAT1	2.26
40	Werner syndrome	Enrichment	PTPN11	2.26
41	Proteasome-associated autoinflammatory syndrome 3	Enrichment	PSMB9	2.26
42	Stevens-johnson syndrome	Enrichment	HLA-B	2.26
43	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	2.26
44	Polycythemia	Enrichment	JAK2	2.26
45	Hypereosinophilic syndrome	Enrichment	JAK2	2.26
46	Immunodeficiency 117	Enrichment	IRF1	2.26
47	Gastric cancer	Enrichment	IL1B, IRF1	2.22
48	Immune thrombocytopenia	Enrichment	SOCS1	2.09
49	Takayasu arteritis	Enrichment	HLA-B	2.09
50	Polycythemia vera	Enrichment	JAK2	2.09
51	Tuberous sclerosis 1	Enrichment	IFNG	2.09
52	Hepatitis c virus	Enrichment	IFNG	2.09
53	Tuberous sclerosis 2	Enrichment	IFNG	2.09
54	Immunodeficiency 28	Enrichment	IFNGR2	2.09
55	Autoinflammatory syndrome, familial, with or without immunodeficiency	Enrichment	SOCS1	2.09
56	Torsion dystonia 1	Enrichment	EIF2AK2	2.09
57	Immunodeficiency 44	Enrichment	STAT2	2.09
58	Tricuspid valve insufficiency	Enrichment	PTPN11	2.09
59	Erythrocytosis, familial, 1	Enrichment	JAK2	1.96
60	Anemia, autoimmune hemolytic	Enrichment	SOCS1	1.96
61	Temporal arteritis	Enrichment	HLA-B	1.96
62	Granulomatous disease, chronic, x-linked	Enrichment	CYBB	1.96
63	Budd-chiari syndrome	Enrichment	JAK2	1.96
64	Mhc class i deficiency 1	Enrichment	TAP1	1.96
65	Mhc class i deficiency	Enrichment	TAP1	1.96
66	Hepatitis b	Enrichment	IFNGR1	1.96
67	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	PTPN11	1.96
68	Noonan syndrome with multiple lentigines	Enrichment	PTPN11	1.96
69	Cerebral malaria	Enrichment	ICAM1	1.96
70	Immunodeficiency by defective expression of mhc class i	Enrichment	TAP1	1.96
71	Lymphoma	Enrichment	PTPN11	1.87
72	Myeloproliferative neoplasm	Enrichment	JAK2	1.87
73	Idiopathic aplastic anemia	Enrichment	IFNG	1.87
74	Patent ductus arteriosus	Enrichment	PTPN11	1.79
75	Chronic mucocutaneous candidiasis	Enrichment	STAT1	1.79
76	Myelofibrosis	Enrichment	JAK2	1.72
77	Noonan syndrome 3	Enrichment	PTPN11	1.72
78	Essential thrombocythemia	Enrichment	JAK2	1.72
79	Rheumatoid arthritis	Enrichment	CIITA	1.61
80	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.61
81	Chronic granulomatous disease	Enrichment	CYBB	1.61
82	Mhc class ii deficiency	Enrichment	CIITA	1.61
83	Aplastic anemia	Enrichment	IFNG	1.57
84	Autosomal non-syndromic agammaglobulinemia	Enrichment	SPI1	1.57
85	Pectus excavatum	Enrichment	PTPN11	1.53
86	Mhc class ii deficiency 1	Enrichment	CIITA	1.53
87	Lung non-small cell carcinoma	Enrichment	IRF1	1.53
88	Specific learning disability	Enrichment	PTPN11	1.53
89	Epicanthus	Enrichment	PTPN11	1.49
90	Juvenile myelomonocytic leukemia	Enrichment	PTPN11	1.49
91	Congenital long qt syndrome	Enrichment	PTPN11	1.49
92	Noonan syndrome and noonan-related syndrome	Enrichment	PTPN11	1.40
93	Human immunodeficiency virus type 1	Enrichment	IFNG	1.32
94	Patent foramen ovale	Enrichment	PTPN11	1.32
95	Diffuse large b-cell lymphoma	Enrichment	SOCS1	1.30
96	Esophageal atresia/tracheoesophageal fistula	Enrichment	IRF8	1.30
97	Multisystem inflammatory syndrome in children	Enrichment	IFNB1	1.23
98	Noonan syndrome 1	Enrichment	PTPN11	1.22
99	Scoliosis	Enrichment	PTPN11	1.20
100	Hydrops fetalis, nonimmune	Enrichment	PTPN11	1.16
101	Rasopathy	Enrichment	PTPN11	1.16
102	Strabismus	Enrichment	PTPN11	1.15
103	Long qt syndrome 1	Enrichment	PTPN11	1.10
104	Non-immune hydrops fetalis	Enrichment	PTPN11	1.09
105	Lung cancer	Enrichment	IRF1	1.08
106	Systemic lupus erythematosus	Enrichment	SOCS1	0.99
107	Leukemia, acute myeloid	Enrichment	JAK2	0.98
108	Hypertrophic cardiomyopathy	Enrichment	PTPN11	0.95
109	Thrombocytopenia	Enrichment	PTPN11	0.91
110	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	0.85
111	Primary ovarian insufficiency	Enrichment	JAK2	0.83
112	Autism spectrum disorder	Enrichment	PTPN11	0.59
113	Microcephaly	Enrichment	PTPN11	0.54
114	Inherited cancer-predisposing syndrome	Enrichment	PTPN11	0.52

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Type II interferon signaling

Pathway Network for Type II interferon signaling

Member Pathways for Type II interferon signaling

Pathways in the Type II interferon signaling SuperPath

Associated Genes for Type II interferon signaling

Associated Disorders for Type II interferon signaling

Disorders associated with Type II interferon signaling SuperPath

STRING Interaction Network for Type II interferon signaling

Sources for Type II interferon signaling