TYROBP causal network in microglia

No Pathway Network information available for TYROBP causal network in microglia

Pathways in the TYROBP causal network in microglia SuperPath

#	Name	Source	Genes
1	TYROBP causal network in microglia	WikiPathways	ABCC4 ADAP2 APBB1IP BIN2 C1QC C3 CAPG CD37 CD4 CD84 CREB3L2 CXCL16 CYTL1 DPYD ELF4 FKBP15 GAL3ST4 GAPT GIMAP2 GPX1 HCLS1 HLX IGSF6 IL10RA IL13RA1 IL18 ITGAM ITGAX ITGB2 KCNE3 LGALS9C LHFPL2 LOXL3 LYL1 MAF NCF2 NCKAP1L NPC2 NRROS PLEK PPP1R18 PYCARD RBM47 RGS1 RNASE6 RPS6KA1 RUNX3 SAMSN1 SFT2D2 SH2B3 SLC1A5 SLC7A7 SPP1 STAT5A TCIRG1 TGFBR1 TMEM106A TNFRSF1B TYROBP ZFP36L2 (see all 60) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	GAL3ST4	Galactose-3-O-Sulfotransferase 4	Protein Coding	1
2	LGALS9C	Galectin 9C	Protein Coding	1
3	CD4	CD4 Molecule	Protein Coding	1
4	SLC7A7	Solute Carrier Family 7 Member 7	Protein Coding	1
5	CD84	CD84 Molecule	Protein Coding	1
6	RUNX3	RUNX Family Transcription Factor 3	Protein Coding	1
7	LOXL3	Lysyl Oxidase Like 3	Protein Coding	1
8	CAPG	Capping Actin Protein, Gelsolin Like	Protein Coding	1
9	TYROBP	Transmembrane Immune Signaling Adaptor TYROBP	Protein Coding	1
10	C3	Complement C3	Protein Coding	1
11	C1QC	Complement C1q C Chain	Protein Coding	1
12	TNFRSF1B	TNF Receptor Superfamily Member 1B	Protein Coding	1
13	TGFBR1	Transforming Growth Factor Beta Receptor 1	Protein Coding	1
14	ZFP36L2	ZFP36 Ring Finger Protein Like 2	Protein Coding	1
15	STAT5A	Signal Transducer And Activator Of Transcription 5A	Protein Coding	1
16	SPP1	Secreted Phosphoprotein 1	Protein Coding	1
17	SLC1A5	Solute Carrier Family 1 Member 5	Protein Coding	1
18	RPS6KA1	Ribosomal Protein S6 Kinase A1	Protein Coding	1
19	RNASE6	Ribonuclease A Family Member 6	Protein Coding	1
20	RGS1	Regulator Of G Protein Signaling 1	Protein Coding	1
21	CXCL16	C-X-C Motif Chemokine Ligand 16	Protein Coding	1
22	APBB1IP	Amyloid Beta Precursor Protein Binding Family B Member 1 Interacting Protein	Protein Coding	1
23	RBM47	RNA Binding Motif Protein 47	Protein Coding	1
24	PLEK	Pleckstrin	Protein Coding	1
25	NCF2	Neutrophil Cytosolic Factor 2	Protein Coding	1
26	MAF	MAF BZIP Transcription Factor	Protein Coding	1
27	LYL1	LYL1 Basic Helix-Loop-Helix Family Member	Protein Coding	1
28	NRROS	Negative Regulator Of Reactive Oxygen Species	Protein Coding	1
29	ITGB2	Integrin Subunit Beta 2	Protein Coding	1
30	ITGAX	Integrin Subunit Alpha X	Protein Coding	1
31	ITGAM	Integrin Subunit Alpha M	Protein Coding	1
32	IL18	Interleukin 18	Protein Coding	1
33	IL13RA1	Interleukin 13 Receptor Subunit Alpha 1	Protein Coding	1
34	IL10RA	Interleukin 10 Receptor Subunit Alpha	Protein Coding	1
35	NCKAP1L	NCK Associated Protein 1 Like	Protein Coding	1
36	HCLS1	Hematopoietic Cell-Specific Lyn Substrate 1	Protein Coding	1
37	PYCARD	PYD And CARD Domain Containing	Protein Coding	1
38	GPX1	Glutathione Peroxidase 1	Protein Coding	1
39	FKBP15	FKBP Prolyl Isomerase Family Member 15	Protein Coding	1
40	DPYD	Dihydropyrimidine Dehydrogenase	Protein Coding	1
41	PPP1R18	Protein Phosphatase 1 Regulatory Subunit 18	Protein Coding	1
42	TMEM106A	Transmembrane Protein 106A	Protein Coding	1
43	NPC2	NPC Intracellular Cholesterol Transporter 2	Protein Coding	1
44	TCIRG1	T Cell Immune Regulator 1, ATPase H+ Transporting V0 Subunit A3	Protein Coding	1
45	IGSF6	Immunoglobulin Superfamily Member 6	Protein Coding	1
46	ABCC4	ATP Binding Cassette Subfamily C Member 4 (PEL Blood Group)	Protein Coding	1
47	LHFPL2	LHFPL Tetraspan Subfamily Member 2	Protein Coding	1
48	SH2B3	SH2B Adaptor Protein 3	Protein Coding	1
49	KCNE3	Potassium Voltage-Gated Channel Subfamily E Regulatory Subunit 3	Protein Coding	1
50	CD37	CD37 Molecule	Protein Coding	1
51	CREB3L2	CAMP Responsive Element Binding Protein 3 Like 2	Protein Coding	1
52	SAMSN1	SAM Domain, SH3 Domain And Nuclear Localization Signals 1	Protein Coding	1
53	ADAP2	ArfGAP With Dual PH Domains 2	Protein Coding	1
54	CYTL1	Cytokine Like 1	Protein Coding	1
55	BIN2	Bridging Integrator 2	Protein Coding	1
56	SFT2D2	SFT2 Domain Containing 2	Protein Coding	1
57	HLX	H2.0 Like Homeobox	Protein Coding	1
58	GIMAP2	GTPase, IMAP Family Member 2	Protein Coding	1
59	GAPT	GRB2 Binding Adaptor Protein, Transmembrane	Protein Coding	1
60	ELF4	E74 Like ETS Transcription Factor 4	Protein Coding	1

Disorders associated with TYROBP causal network in microglia SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Autoinflammatory syndrome, familial, x-linked, behcet-like 2	Enrichment	ELF4	2.35
2	Systemic lupus erythematosus 6	Enrichment	ITGAM	2.35
3	Cataract 21, multiple types	Enrichment	MAF	2.35
4	Hemolytic uremic syndrome, atypical 5	Enrichment	C3	2.35
5	Multiple self-healing squamous epithelioma	Enrichment	TGFBR1	2.35
6	Oocyte/zygote/embryo maturation arrest 13	Enrichment	ZFP36L2	2.35
7	C1q deficiency 3	Enrichment	C1QC	2.35
8	Okt4 epitope deficiency	Enrichment	CD4	2.35
9	Seizures, early-onset, with neurodegeneration and brain calcifications	Enrichment	NRROS	2.35
10	Ayme-gripp syndrome	Enrichment	MAF	2.35
11	Brugada syndrome 6	Enrichment	KCNE3	2.35
12	Glutathione peroxidase deficiency	Enrichment	GPX1	2.35
13	Macular degeneration, age-related, 9	Enrichment	C3	2.35
14	Complement component 3 deficiency, autosomal recessive	Enrichment	C3	2.35
15	Immunodeficiency 79	Enrichment	CD4	2.35
16	Complement component 3 deficiency	Enrichment	C3	2.35
17	Membranoproliferative glomerulonephritis	Enrichment	C3	2.35
18	Primary membranoproliferative glomerulonephritis	Enrichment	C3	2.35
19	Female infertility due to an implantation defect of genetic origin	Enrichment	ZFP36L2	2.35
20	Diaphragmatic hernia-short bowel-asplenia syndrome	Enrichment	HLX	2.35
21	Growth retardation-mild developmental delay-chronic hepatitis syndrome	Enrichment	SH2B3	2.35
22	1p21.3 microdeletion syndrome	Enrichment	DPYD	2.35
23	Leukocyte adhesion deficiency, type i	Enrichment	ITGB2	2.05
24	Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1	Enrichment	TYROBP	2.05
25	Niemann-pick disease, type c2	Enrichment	NPC2	2.05
26	Isolated growth hormone deficiency, type iii, with agammaglobulinemia	Enrichment	ELF4	2.05
27	Loeys-dietz syndrome 2	Enrichment	TGFBR1	2.05
28	Inflammatory bowel disease 28, autosomal recessive	Enrichment	IL10RA	2.05
29	Leukocyte adhesion deficiency, type iii	Enrichment	ITGB2	2.05
30	Developmental and epileptic encephalopathy 28	Enrichment	MAF	2.05
31	Spinocerebellar ataxia, autosomal recessive 12	Enrichment	MAF	2.05
32	Immunodeficiency 72 with autoinflammation and lymphoproliferation	Enrichment	NCKAP1L	2.05
33	Myopia 28, autosomal recessive	Enrichment	LOXL3	2.05
34	Osteopetrosis, autosomal recessive 1	Enrichment	TCIRG1	2.05
35	Inflammatory bowel disease 28	Enrichment	IL10RA	2.05
36	Niemann-pick disease type c, severe perinatal form	Enrichment	NPC2	2.05
37	Niemann-pick disease type c, severe early infantile neurologic onset	Enrichment	NPC2	2.05
38	Niemann-pick disease type c, juvenile neurologic onset	Enrichment	NPC2	2.05
39	Niemann-pick disease type c, adult neurologic onset	Enrichment	NPC2	2.05
40	Immunodeficiency 72	Enrichment	NCKAP1L	2.05
41	Niemann-pick disease type c, late infantile neurologic onset	Enrichment	NPC2	2.05
42	Systemic lupus erythematosus	Enrichment	ITGAM, SPP1	1.89
43	Choreoacanthocytosis	Enrichment	TCIRG1	1.88
44	Thrombocythemia 1	Enrichment	SH2B3	1.88
45	Neutropenia, severe congenital, 1, autosomal dominant	Enrichment	TCIRG1	1.88
46	Lysinuric protein intolerance	Enrichment	SLC7A7	1.88
47	Dysosteosclerosis	Enrichment	TCIRG1	1.88
48	Mycosis fungoides	Enrichment	TNFRSF1B	1.88
49	Granulomatous disease, chronic, autosomal recessive, 2	Enrichment	NCF2	1.88
50	Dihydropyrimidine dehydrogenase deficiency	Enrichment	DPYD	1.88
51	C1q deficiency 1	Enrichment	C1QC	1.88
52	Osteopetrosis, autosomal recessive 6	Enrichment	TCIRG1	1.88
53	Loeys-dietz syndrome 1	Enrichment	TGFBR1	1.88
54	Myxofibrosarcoma	Enrichment	CREB3L2	1.88
55	Genetic atypical hemolytic-uremic syndrome	Enrichment	C3	1.88
56	Saczary syndrome	Enrichment	TNFRSF1B	1.88
57	Erythrocytosis, familial, 1	Enrichment	SH2B3	1.76
58	Aortic aneurysm	Enrichment	TGFBR1	1.76
59	3-methylglutaconic aciduria, type viii	Enrichment	LOXL3	1.76
60	Autosomal recessive osteopetrosis	Enrichment	TCIRG1	1.76
61	Congenital blue dot cataract	Enrichment	MAF	1.76
62	Autosomal recessive stickler syndrome	Enrichment	LOXL3	1.76
63	Pediatric systemic lupus erythematosus	Enrichment	SPP1	1.76
64	Niemann-pick disease, type c1	Enrichment	NPC2	1.66
65	Osteopetrosis	Enrichment	TCIRG1	1.66
66	Niemann-pick disease	Enrichment	NPC2	1.66
67	Histiocytoid hemangioma	Enrichment	ZFP36L2	1.66
68	Autosomal dominant severe congenital neutropenia	Enrichment	TCIRG1	1.66
69	Hypokalemic periodic paralysis, type 1	Enrichment	KCNE3	1.58
70	Il10-related early-onset inflammatory bowel disease	Enrichment	IL10RA	1.58
71	Classic ehlers-danlos syndrome	Enrichment	TGFBR1	1.58
72	Atypical hemolytic uremic syndrome with complement gene abnormality	Enrichment	C3	1.58
73	Myelofibrosis	Enrichment	SH2B3	1.51
74	Essential thrombocythemia	Enrichment	SH2B3	1.51
75	Severe congenital neutropenia	Enrichment	TCIRG1	1.46
76	Cataract - microcornea syndrome	Enrichment	MAF	1.46
77	Immunodeficiency due to a classical component pathway complement deficiency	Enrichment	C1QC	1.46
78	Loeys-dietz syndrome	Enrichment	TGFBR1	1.41
79	Chronic granulomatous disease	Enrichment	NCF2	1.41
80	Cataract 30, multiple types	Enrichment	MAF	1.36
81	Marfan syndrome	Enrichment	TGFBR1	1.36
82	Stickler syndrome	Enrichment	LOXL3	1.36
83	Pectus excavatum	Enrichment	TGFBR1	1.32
84	Atypical hemolytic-uremic syndrome	Enrichment	C3	1.19
85	Multisystem inflammatory syndrome in children	Enrichment	CD84	1.03
86	Autoinflammatory disease	Enrichment	SLC7A7	1.00
87	Developmental and epileptic encephalopathy 1	Enrichment	MAF	0.98
88	Brugada syndrome	Enrichment	KCNE3	0.96
89	Benign epilepsy with centrotemporal spikes	Enrichment	MAF	0.78
90	Centralopathic epilepsy	Enrichment	MAF	0.76
91	West syndrome	Enrichment	MAF	0.75
92	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	TGFBR1	0.75
93	Myeloma, multiple	Enrichment	SH2B3	0.66
94	Microcephaly	Enrichment	NPC2	0.37
95	Inherited cancer-predisposing syndrome	Enrichment	SH2B3	0.35

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

TYROBP causal network in microglia

Pathway Network for TYROBP causal network in microglia

Member Pathways for TYROBP causal network in microglia

Pathways in the TYROBP causal network in microglia SuperPath

Associated Genes for TYROBP causal network in microglia

Associated Disorders for TYROBP causal network in microglia

Disorders associated with TYROBP causal network in microglia SuperPath

STRING Interaction Network for TYROBP causal network in microglia

Sources for TYROBP causal network in microglia