Tyrosine catabolism

Sources:

#	Name	Source	Genes
1	Tyrosine catabolism	Reactome	FAH GSTZ1 HGD HPD TAT
2	Phenylalanine and tyrosine metabolism	Reactome	ASRGL1 FAH GSTZ1 HGD HPD IL4I1 KYAT1 PAH PCBD1 QDPR TAT (see all 11) (see less)
3	Phenylalanine metabolism	Reactome	ASRGL1 IL4I1 KYAT1 PAH PCBD1 QDPR (see all 6) (see less)
4	tyrosine degradation	PubChem	FAH GSTZ1 HGD HPD TAT
5	L-tyrosine degradation I	PubChem	FAH GSTZ1 HGD HPD TAT
6	Tyrosine metabolism and related disorders	WikiPathways	FAH HGD HPD TAT

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	FAH	Fumarylacetoacetate Hydrolase	Protein Coding	5
2	HGD	Homogentisate 1,2-Dioxygenase	Protein Coding	5
3	HPD	4-Hydroxyphenylpyruvate Dioxygenase	Protein Coding	5
4	TAT	Tyrosine Aminotransferase	Protein Coding	5
5	GSTZ1	Glutathione S-Transferase Zeta 1	Protein Coding	4
6	IL4I1	Interleukin 4 Induced 1	Protein Coding	2
7	PAH	Phenylalanine Hydroxylase	Protein Coding	2
8	PCBD1	Pterin-4 Alpha-Carbinolamine Dehydratase 1	Protein Coding	2
9	QDPR	Quinoid Dihydropteridine Reductase	Protein Coding	2
10	ASRGL1	Asparaginase And Isoaspartyl Peptidase 1	Protein Coding	2
11	KYAT1	Kynurenine Aminotransferase 1	Protein Coding	2

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Tyrosinemia	Enrichment	FAH, HPD	6.71
2	Tyrosinemia, type ii	Enrichment	FAH, TAT	6.41
3	Hyperphenylalaninemia, bh4-deficient, a	Enrichment	PAH, QDPR	5.61
4	T-substance anomaly	Enrichment	FAH	3.53
5	Alkaptonuria	Enrichment	HGD	3.53
6	Maleylacetoacetate isomerase deficiency	Enrichment	GSTZ1	3.43
7	Tetrahydrobiopterin-responsive hyperphenylalaninemia/phenylketonuria	Enrichment	PAH	3.35
8	Tyrosinemia, type i	Enrichment	FAH	3.23
9	Tyrosinemia, type iii	Enrichment	HPD	3.23
10	Hawkinsinuria	Enrichment	HPD	3.23
11	Mannosidosis, beta a, lysosomal	Enrichment	FAH	3.05
12	Hyperphenylalaninemia, bh4-deficient, c	Enrichment	QDPR	3.05
13	Striatonigral degeneration, infantile	Enrichment	IL4I1	3.05
14	Hyperphenylalaninemia, bh4-deficient, d	Enrichment	PCBD1	3.05
15	Neurodevelopmental disorder with spasticity, hypomyelinating leukodystrophy, and brain abnormalities	Enrichment	PAH	3.05
16	Pituitary hormone deficiency, combined, 2	Enrichment	PAH	2.88
17	Hyperphenylalaninemia due to tetrahydrobiopterin deficiency	Enrichment	QDPR	2.88
18	Phenylketonuria	Enrichment	PAH	2.75
19	Propionic acidemia	Enrichment	PAH	2.75
20	Pulmonary hypertension, primary, 1	Enrichment	PAH	2.24
21	Rasopathy	Enrichment	PAH	1.94
22	Breast cancer	Enrichment	PAH	1.49

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Tyrosine catabolism