Tyrosine Kinases / Adaptors

No Pathway Network information available for Tyrosine Kinases / Adaptors

Pathways in the Tyrosine Kinases / Adaptors SuperPath

#	Name	Source	Genes
1	Tyrosine Kinases / Adaptors	Cell Signaling Technology	ABI1 ABL1 AGR2 ALK ANGPT2 ANXA2 APBB1 ARRB1 ARRB2 AXL BCAR1 BCAR3 BCR BLK BMX BTK CBL CBLB CCDC88A CRK CRKL CSF1R CSK DAB1 DDR1 DDR2 DOCK1 DOK1 DOK2 EFNB1 EFNB2 EFNB3 EGF EGFR EPHA1 EPHA2 EPHA3 EPHA4 EPHA5 EPHA7 EPHB1 EPHB2 EPHB4 EPHB6 EPS15 EPS8 ERBB2 ERBB3 ERBB4 EREG ERRFI1 FER FES FGF1 FGF2 FGFR1 FGFR2 FGFR3 FGFR4 FGR FLT1 FLT3 FLT4 FRS2 FYN GAB1 GAB2 GAS6 GRB10 GRB2 HCK HGS IGF1R IGF2R IL2RB INSR IRS1 ITK JAK2 KDR KIT KITLG LCK LCP2 LIMD1 LRIG1 LYN MACC1 MATK MERTK MET MPZL1 MST1R NCK1 NHERF1 NPM1 NRG1 NTRK1 NTRK2 PDAP1 PDGFRA PDGFRB PEAK1 PTK2 PTK2B PTK6 PTK7 RET ROR1 ROR2 ROS1 SFN SH2B2 SH2D1A SH3KBP1 SHC1 SIRPA SOCS3 SPRED1 SPRY1 SPRY2 SRC STAM STAM2 STAP2 SYK TEC TEK TGFA TIE1 TNK1 TNK2 TYK2 TYRO3 USP8 VEGFB VEGFC WBP2 WWTR1 YAP1 YES1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZAP70 (see all 148) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	YWHAB	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta	Protein Coding	1
2	YWHAE	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Epsilon	Protein Coding	1
3	YWHAH	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Eta	Protein Coding	1
4	YWHAG	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Gamma	Protein Coding	1
5	SFN	Stratifin	Protein Coding	1
6	YWHAQ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Theta	Protein Coding	1
7	YWHAZ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta	Protein Coding	1
8	ABI1	Abl Interactor 1	Protein Coding	1
9	ABL1	ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase	Protein Coding	1
10	TNK2	Tyrosine Kinase Non Receptor 2	Protein Coding	1
11	AGR2	Anterior Gradient 2, Protein Disulphide Isomerase Family Member	Protein Coding	1
12	ALK	ALK Receptor Tyrosine Kinase	Protein Coding	1
13	ANGPT2	Angiopoietin 2	Protein Coding	1
14	ANXA2	Annexin A2	Protein Coding	1
15	SH2B2	SH2B Adaptor Protein 2	Protein Coding	1
16	ARRB1	Arrestin Beta 1	Protein Coding	1
17	ARRB2	Arrestin Beta 2	Protein Coding	1
18	AXL	AXL Receptor Tyrosine Kinase	Protein Coding	1
19	BCAR3	BCAR3 Adaptor Protein, NSP Family Member	Protein Coding	1
20	BCR	BCR Activator Of RhoGEF And GTPase	Protein Coding	1
21	BLK	BLK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
22	PTK6	Protein Tyrosine Kinase 6	Protein Coding	1
23	BTK	Bruton Tyrosine Kinase	Protein Coding	1
24	CBL	Cbl Proto-Oncogene	Protein Coding	1
25	CBLB	Cbl Proto-Oncogene B	Protein Coding	1
26	PTK7	Protein Tyrosine Kinase 7 (Inactive)	Protein Coding	1
27	CRK	CRK Proto-Oncogene, Adaptor Protein	Protein Coding	1
28	CRKL	CRK Like Proto-Oncogene, Adaptor Protein	Protein Coding	1
29	CSF1R	Colony Stimulating Factor 1 Receptor	Protein Coding	1
30	CSK	C-Terminal Src Kinase	Protein Coding	1
31	MATK	Megakaryocyte-Associated Tyrosine Kinase	Protein Coding	1
32	DAB1	DAB Adaptor Protein 1	Protein Coding	1
33	DDR1	Discoidin Domain Receptor Tyrosine Kinase 1	Protein Coding	1
34	DDR2	Discoidin Domain Receptor Tyrosine Kinase 2	Protein Coding	1
35	DOCK1	Dedicator Of Cytokinesis 1	Protein Coding	1
36	DOK1	Docking Protein 1	Protein Coding	1
37	DOK2	Docking Protein 2	Protein Coding	1
38	EFNB1	Ephrin B1	Protein Coding	1
39	EFNB2	Ephrin B2	Protein Coding	1
40	EFNB3	Ephrin B3	Protein Coding	1
41	EGF	Epidermal Growth Factor	Protein Coding	1
42	EGFR	Epidermal Growth Factor Receptor	Protein Coding	1
43	EPHA1	EPH Receptor A1	Protein Coding	1
44	EPHA2	EPH Receptor A2	Protein Coding	1
45	EPHA3	EPH Receptor A3	Protein Coding	1
46	EPHA4	EPH Receptor A4	Protein Coding	1
47	EPHA5	EPH Receptor A5	Protein Coding	1
48	EPHA7	EPH Receptor A7	Protein Coding	1
49	EPHB1	EPH Receptor B1	Protein Coding	1
50	EPHB2	EPH Receptor B2	Protein Coding	1
51	EPHB4	EPH Receptor B4	Protein Coding	1
52	EPHB6	EPH Receptor B6	Protein Coding	1
53	EREG	Epiregulin	Protein Coding	1
54	EPS15	Epidermal Growth Factor Receptor Pathway Substrate 15	Protein Coding	1
55	EPS8	EGFR Pathway Substrate 8, Signaling Adaptor	Protein Coding	1
56	BMX	BMX Non-Receptor Tyrosine Kinase	Protein Coding	1
57	PTK2	Protein Tyrosine Kinase 2	Protein Coding	1
58	APBB1	Amyloid Beta Precursor Protein Binding Family B Member 1	Protein Coding	1
59	FER	FER Tyrosine Kinase	Protein Coding	1
60	FES	FES Proto-Oncogene, Tyrosine Kinase	Protein Coding	1
61	FGF1	Fibroblast Growth Factor 1	Protein Coding	1
62	FGF2	Fibroblast Growth Factor 2	Protein Coding	1
63	FGFR1	Fibroblast Growth Factor Receptor 1	Protein Coding	1
64	FGFR2	Fibroblast Growth Factor Receptor 2	Protein Coding	1
65	FGFR3	Fibroblast Growth Factor Receptor 3	Protein Coding	1
66	FGFR4	Fibroblast Growth Factor Receptor 4	Protein Coding	1
67	FGR	FGR Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
68	FLT3	Fms Related Receptor Tyrosine Kinase 3	Protein Coding	1
69	FRS2	Fibroblast Growth Factor Receptor Substrate 2	Protein Coding	1
70	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
71	GAB1	GRB2 Associated Binding Protein 1	Protein Coding	1
72	GAB2	GRB2 Associated Binding Protein 2	Protein Coding	1
73	GAS6	Growth Arrest Specific 6	Protein Coding	1
74	CCDC88A	Coiled-Coil And HOOK Domain Protein 88A	Protein Coding	1
75	GRB10	Growth Factor Receptor Bound Protein 10	Protein Coding	1
76	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1
77	HCK	HCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
78	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	1
79	ERBB3	Erb-B2 Receptor Tyrosine Kinase 3	Protein Coding	1
80	ERBB4	Erb-B2 Receptor Tyrosine Kinase 4	Protein Coding	1
81	HGS	Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate	Protein Coding	1
82	IGF1R	Insulin Like Growth Factor 1 Receptor	Protein Coding	1
83	IGF2R	Insulin Like Growth Factor 2 Receptor	Protein Coding	1
84	IL2RB	Interleukin 2 Receptor Subunit Beta	Protein Coding	1
85	INSR	Insulin Receptor	Protein Coding	1
86	IRS1	Insulin Receptor Substrate 1	Protein Coding	1
87	ITK	IL2 Inducible T Cell Kinase	Protein Coding	1
88	JAK2	Janus Kinase 2	Protein Coding	1
89	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	1
90	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
91	LIMD1	LIM Domain Containing 1	Protein Coding	1
92	LRIG1	Leucine Rich Repeats And Immunoglobulin Like Domains 1	Protein Coding	1
93	LYN	LYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
94	MACC1	MET Transcriptional Regulator MACC1	Protein Coding	1
95	MERTK	MER Proto-Oncogene, Tyrosine Kinase	Protein Coding	1
96	MET	MET Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	1
97	ERRFI1	ERBB Receptor Feedback Inhibitor 1	Protein Coding	1
98	NCK1	NCK Adaptor Protein 1	Protein Coding	1
99	NHERF1	NHERF Family PDZ Scaffold Protein 1	Protein Coding	1
100	NPM1	Nucleophosmin 1	Protein Coding	1
101	NRG1	Neuregulin 1	Protein Coding	1
102	BCAR1	BCAR1 Scaffold Protein, Cas Family Member	Protein Coding	1
103	PDAP1	PDGFA Associated Protein 1	Protein Coding	1
104	PDGFRA	Platelet Derived Growth Factor Receptor Alpha	Protein Coding	1
105	PDGFRB	Platelet Derived Growth Factor Receptor Beta	Protein Coding	1
106	PEAK1	Pseudopodium Enriched Atypical Kinase 1	Protein Coding	1
107	PTK2B	Protein Tyrosine Kinase 2 Beta	Protein Coding	1
108	MPZL1	Myelin Protein Zero Like 1	Protein Coding	1
109	RET	Ret Proto-Oncogene	Protein Coding	1
110	MST1R	Macrophage Stimulating 1 Receptor	Protein Coding	1
111	ROR1	Receptor Tyrosine Kinase Like Orphan Receptor 1	Protein Coding	1
112	ROR2	Receptor Tyrosine Kinase Like Orphan Receptor 2	Protein Coding	1
113	ROS1	ROS Proto-Oncogene 1, Receptor Tyrosine Kinase	Protein Coding	1
114	KITLG	KIT Ligand	Protein Coding	1
115	SH2D1A	SH2 Domain Containing 1A	Protein Coding	1
116	SH3KBP1	SH3 Domain Containing Kinase Binding Protein 1	Protein Coding	1
117	SHC1	SHC Adaptor Protein 1	Protein Coding	1
118	SIRPA	Signal Regulatory Protein Alpha	Protein Coding	1
119	LCP2	Lymphocyte Cytosolic Protein 2	Protein Coding	1
120	SOCS3	Suppressor Of Cytokine Signaling 3	Protein Coding	1
121	SPRED1	Sprouty Related EVH1 Domain Containing 1	Protein Coding	1
122	SPRY1	Sprouty RTK Signaling Antagonist 1	Protein Coding	1
123	SPRY2	Sprouty RTK Signaling Antagonist 2	Protein Coding	1
124	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
125	STAM	Signal Transducing Adaptor Molecule	Protein Coding	1
126	STAM2	Signal Transducing Adaptor Molecule 2	Protein Coding	1
127	STAP2	Signal Transducing Adaptor Family Member 2	Protein Coding	1
128	SYK	Spleen Associated Tyrosine Kinase	Protein Coding	1
129	WWTR1	WW Domain Containing Transcription Regulator 1	Protein Coding	1
130	TEC	Tec Protein Tyrosine Kinase	Protein Coding	1
131	TGFA	Transforming Growth Factor Alpha	Protein Coding	1
132	TIE1	Tyrosine Kinase With Immunoglobulin Like And EGF Like Domains 1	Protein Coding	1
133	TEK	TEK Receptor Tyrosine Kinase	Protein Coding	1
134	TNK1	Tyrosine Kinase Non Receptor 1	Protein Coding	1
135	NTRK1	Neurotrophic Receptor Tyrosine Kinase 1	Protein Coding	1
136	NTRK2	Neurotrophic Receptor Tyrosine Kinase 2	Protein Coding	1
137	TYK2	Tyrosine Kinase 2	Protein Coding	1
138	TYRO3	TYRO3 Protein Tyrosine Kinase	Protein Coding	1
139	USP8	Ubiquitin Specific Peptidase 8	Protein Coding	1
140	VEGFB	Vascular Endothelial Growth Factor B	Protein Coding	1
141	VEGFC	Vascular Endothelial Growth Factor C	Protein Coding	1
142	FLT1	Fms Related Receptor Tyrosine Kinase 1	Protein Coding	1
143	KDR	Kinase Insert Domain Receptor	Protein Coding	1
144	FLT4	Fms Related Receptor Tyrosine Kinase 4	Protein Coding	1
145	WBP2	WW Domain Binding Protein 2	Protein Coding	1
146	YAP1	Yes1 Associated Transcriptional Regulator	Protein Coding	1
147	YES1	YES Proto-Oncogene 1, Src Family Tyrosine Kinase	Protein Coding	1
148	ZAP70	Zeta Chain Of T Cell Receptor Associated Protein Kinase 70	Protein Coding	1

Disorders associated with Tyrosine Kinases / Adaptors SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Hemifacial hyperplasia	Enrichment	EFNB1, FGFR2, FGFR3	4.90
2	Acute myeloid leukemia with maturation	Enrichment	FLT3, KIT, NPM1	4.90
3	Primary hypereosinophilic syndrome	Enrichment	FGFR1, PDGFRA, PDGFRB	4.90
4	Ovarian cancer	Enrichment	ALK, EGFR, ERBB2, KIT, MET, NTRK1, PDGFRA, RET	4.85
5	Testicular germ cell tumor	Enrichment	FGFR3, KIT, KITLG	4.60
6	Lung squamous cell carcinoma	Enrichment	ALK, EGFR, FGFR3	4.60
7	Giant cell glioblastoma	Enrichment	EGFR, FGFR1, FGFR3, ROS1	4.54
8	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	ABL1, BCR, FLT3	4.37
9	Lymphatic malformation 1	Enrichment	EPHB4, FLT4	3.93
10	Intracranial hypertension, idiopathic	Enrichment	EPHB4, FLT4	3.93
11	Pfeiffer syndrome	Enrichment	FGFR1, FGFR2	3.93
12	Jackson-weiss syndrome	Enrichment	FGFR1, FGFR2	3.93
13	Lymphoproliferative syndrome	Enrichment	ITK, SH2D1A	3.93
14	Hereditary lymphedema i	Enrichment	EPHB4, FLT4	3.93
15	Acute myeloid leukemia without maturation	Enrichment	FLT3, NPM1	3.93
16	Lymphomatoid papulosis	Enrichment	NPM1, TYK2	3.93
17	Primary cutaneous anaplastic large cell lymphoma	Enrichment	NPM1, TYK2	3.93
18	Tetralogy of fallot	Enrichment	EPHB4, FLT4, KDR, RET	3.77
19	Lip and oral cavity carcinoma	Enrichment	ABL1, EGFR, KIT	3.58
20	Bladder cancer	Enrichment	EGFR, ERBB2, ERBB3, FGFR3	3.58
21	Nk-cell enteropathy	Enrichment	AXL, ERBB4, IGF1R	3.47
22	Crouzon syndrome	Enrichment	FGFR2, FGFR3	3.45
23	Lacrimoauriculodentodigital syndrome 1	Enrichment	FGFR2, FGFR3	3.45
24	Thyroid carcinoma, familial medullary	Enrichment	NTRK1, RET	3.45
25	Chromosome 8p11 myeloproliferative syndrome	Enrichment	BCR, FGFR1	3.45
26	Testicular germ cell cancer	Enrichment	FGFR3, KIT	3.45
27	Colorectal cancer	Enrichment	ERBB2, FGFR2, FGFR3, MET, RET, SRC	3.43
28	Lung cancer	Enrichment	ALK, EGFR, ERBB2, MET	3.41
29	Lung cancer susceptibility 3	Enrichment	EGFR, ERBB2, ROS1	3.37
30	Gliosarcoma	Enrichment	EGFR, FGFR1, FGFR3	3.19
31	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	BCR, CRKL	3.16
32	Saethre-chotzen syndrome	Enrichment	FGFR2, FGFR3	3.16
33	Malignant epithelioid hemangioendothelioma	Enrichment	WWTR1, YAP1	3.16
34	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CBL, YWHAZ	3.16
35	Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)	Enrichment	FLT3, KIT	3.16
36	Leukemia, acute myeloid	Enrichment	FLT3, JAK2, KIT, NPM1	3.04
37	Myeloproliferative neoplasm	Enrichment	CBL, JAK2	2.94
38	Acute myeloid leukemia with t(8;21)(q22;q22) translocation	Enrichment	FLT3, KIT	2.94
39	Hepatocellular carcinoma	Enrichment	IGF2R, MET, RET	2.77
40	Hemangioma, capillary infantile	Enrichment	FLT4, KDR	2.76
41	46,xy disorder of sex development	Enrichment	FGFR3, INSR	2.76
42	Precursor t-cell acute lymphoblastic leukemia	Enrichment	ABL1, BCR, FLT3	2.72
43	Myelofibrosis	Enrichment	JAK2, SRC	2.62
44	Gastrointestinal stromal tumor	Enrichment	KIT, PDGFRA	2.62
45	Leukemia, chronic myeloid	Enrichment	ABL1, BCR	2.62
46	Pilomyxoid astrocytoma	Enrichment	FGFR1, NTRK2	2.62
47	Myeloma, multiple	Enrichment	FGFR3, FLT3, MST1R, YAP1	2.49
48	Inherited cancer-predisposing syndrome	Enrichment	ALK, EGFR, KIT, MET, PDGFRA, RET	2.49
49	Hirschsprung disease 1	Enrichment	ERBB2, ERBB3, RET	2.42
50	Differentiated thyroid carcinoma	Enrichment	ALK, NTRK1, RET	2.42
51	Primary ovarian insufficiency	Enrichment	IGF2R, JAK2, KDR, NTRK1	2.41
52	Arteriovenous malformation	Enrichment	EPHB4, TEK	2.39
53	Non-immune hydrops fetalis	Enrichment	ANGPT2, EPHB4, FLT4	2.34
54	Myopathy, x-linked, with excessive autophagy	Enrichment	EPHB4, TEK	2.30
55	Lung non-small cell carcinoma	Enrichment	EGFR, ERBB2	2.21
56	Renal hypodysplasia/aplasia 3	Enrichment	FGFR3, RET	2.14
57	Lymphatic malformation 5	Enrichment	EPHB4	1.96
58	Multiple endocrine neoplasia, type iib	Enrichment	RET	1.96
59	Brachydactyly, type b1	Enrichment	ROR2	1.96
60	Erythroleukemia, familial	Enrichment	ERBB3	1.96
61	Hypochondroplasia	Enrichment	FGFR3	1.96
62	Beare-stevenson cutis gyrata syndrome	Enrichment	FGFR2	1.96
63	Paget disease, extramammary	Enrichment	ERBB2	1.96
64	Osteoglophonic dysplasia	Enrichment	FGFR1	1.96
65	Thanatophoric dysplasia, type i	Enrichment	FGFR3	1.96
66	Trigonocephaly 1	Enrichment	FGFR1	1.96
67	Donohue syndrome	Enrichment	INSR	1.96
68	Muenke syndrome	Enrichment	FGFR3	1.96
69	Premature aging syndrome, penttinen type	Enrichment	PDGFRB	1.96
70	Hyperinsulinemic hypoglycemia, familial, 5	Enrichment	INSR	1.96
71	Deafness, autosomal recessive 26	Enrichment	GAB1	1.96
72	Legius syndrome	Enrichment	SPRED1	1.96
73	Immunodeficiency 35	Enrichment	TYK2	1.96
74	Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities	Enrichment	INSR	1.96
75	Immunodeficiency 61	Enrichment	SH3KBP1	1.96
76	Hypomagnesemia 4, renal	Enrichment	EGF	1.96
77	Nephrolithiasis/osteoporosis, hypophosphatemic, 2	Enrichment	NHERF1	1.96
78	Diabetes mellitus, insulin-resistant, with acanthosis nigricans	Enrichment	INSR	1.96
79	Hypereosinophilic syndrome, idiopathic	Enrichment	PDGFRA	1.96
80	Mastocytosis, cutaneous	Enrichment	KIT	1.96
81	Scaphocephaly, maxillary retrusion, and impaired intellectual development	Enrichment	FGFR2	1.96
82	Apert syndrome	Enrichment	FGFR2	1.96
83	Neuroblastoma 3	Enrichment	ALK	1.96
84	Dermatitis, atopic, 4	Enrichment	SOCS3	1.96
85	Coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or impaired intellectual development	Enrichment	YAP1	1.96
86	Hyperpigmentation with or without hypopigmentation, familial progressive	Enrichment	KITLG	1.96
87	Myofibromatosis, infantile, 1	Enrichment	PDGFRB	1.96
88	Thanatophoric dysplasia, type ii	Enrichment	FGFR3	1.96
89	Iga nephropathy 3	Enrichment	SPRY2	1.96
90	Lethal congenital contracture syndrome 2	Enrichment	ERBB3	1.96
91	Gist-plus syndrome	Enrichment	PDGFRA	1.96
92	Camptodactyly, tall stature, and hearing loss syndrome	Enrichment	FGFR3	1.96
93	Transient erythroblastopenia of childhood	Enrichment	TEC	1.96
94	Bent bone dysplasia syndrome 1	Enrichment	FGFR2	1.96
95	Visceral neuropathy, familial, 2, autosomal recessive	Enrichment	ERBB2	1.96
96	Deafness, autosomal recessive 108	Enrichment	ROR1	1.96
97	Immunodeficiency 81	Enrichment	LCP2	1.96
98	Immunodeficiency 82 with systemic inflammation	Enrichment	SYK	1.96
99	Developmental and epileptic encephalopathy 58	Enrichment	NTRK2	1.96
100	Respiratory infections, recurrent, and failure to thrive with or without diarrhea	Enrichment	AGR2	1.96
101	Lymphoproliferative syndrome, x-linked, 1	Enrichment	SH2D1A	1.96
102	Venous malformations, multiple cutaneous and mucosal	Enrichment	TEK	1.96
103	Immunodeficiency 63 with lymphoproliferation and autoimmunity	Enrichment	IL2RB	1.96
104	Immunodeficiency 48	Enrichment	ZAP70	1.96
105	Craniofrontonasal syndrome	Enrichment	EFNB1	1.96
106	Hereditary lymphedema id	Enrichment	VEGFC	1.96
107	Osteofibrous dysplasia	Enrichment	MET	1.96
108	Spondylometaepiphyseal dysplasia, short limb-hand type	Enrichment	DDR2	1.96
109	Isolated growth hormone deficiency type iii	Enrichment	BTK	1.96
110	Myeloid and lymphoid neoplasms associated with pdgfra rearrangement	Enrichment	PDGFRA	1.96
111	Lymphatic malformation 4	Enrichment	VEGFC	1.96
112	Uveal coloboma-cleft lip and palate-intellectual disability	Enrichment	YAP1	1.96
113	Deafness, autosomal recessive 97	Enrichment	MET	1.96
114	Prostate cancer/brain cancer susceptibility	Enrichment	EPHB2	1.96
115	Skin/hair/eye pigmentation, variation in, 7	Enrichment	KITLG	1.96
116	Crouzon syndrome with acanthosis nigricans	Enrichment	FGFR3	1.96
117	Lymphoproliferative syndrome 1	Enrichment	ITK	1.96
118	Autism 9	Enrichment	MET	1.96
119	Basal ganglia calcification, idiopathic, 4	Enrichment	PDGFRB	1.96
120	Amyotrophic lateral sclerosis 19	Enrichment	ERBB4	1.96
121	Nasopharyngeal carcinoma 3	Enrichment	MST1R	1.96
122	Spinocerebellar ataxia 37	Enrichment	DAB1	1.96
123	Deafness, autosomal recessive 102	Enrichment	EPS8	1.96
124	Myeloid and lymphoid neoplasms associated with pdgfrb rearrangement	Enrichment	PDGFRB	1.96
125	Acute myeloid leukemia with minimal differentiation	Enrichment	FLT3	1.96
126	Obesity, hyperphagia, and developmental delay	Enrichment	NTRK2	1.96
127	Achondroplasia, severe, with developmental delay and acanthosis nigricans	Enrichment	FGFR3	1.96
128	Kosaki overgrowth syndrome	Enrichment	PDGFRB	1.96
129	Developmental and epileptic encephalopathy 56	Enrichment	YWHAG	1.96
130	Autoimmune disease, multisystem, infantile-onset, 2	Enrichment	ZAP70	1.96
131	Hartsfield syndrome	Enrichment	FGFR1	1.96
132	Congenital heart defects, multiple types, 7	Enrichment	FLT4	1.96
133	Immunodeficiency 22	Enrichment	LCK	1.96
134	Bleeding disorder, platelet-type, 22	Enrichment	EPHB2	1.96
135	Thrombocytopenia 6	Enrichment	SRC	1.96
136	Glaucoma 3, primary congenital, e	Enrichment	TEK	1.96
137	Deafness, autosomal recessive 107	Enrichment	WBP2	1.96
138	Autoinflammatory disease, systemic, with vasculitis	Enrichment	LYN	1.96
139	Brain abnormalities, neurodegeneration, and dysosteosclerosis	Enrichment	CSF1R	1.96
140	Infantile-onset mesial temporal lobe epilepsy with severe cognitive regression	Enrichment	TNK2	1.96
141	Ocular pterygium-digital keloid dysplasia syndrome	Enrichment	PDGFRB	1.96
142	Peho-like syndrome	Enrichment	CCDC88A	1.96
143	Chronic mast cell leukemia	Enrichment	KIT	1.96
144	Warburg-cinotti syndrome	Enrichment	DDR2	1.96
145	Tufted angioma of skin	Enrichment	KDR	1.96
146	Deafness, autosomal dominant 69	Enrichment	KITLG	1.96
147	Arthrogryposis, distal, type 11	Enrichment	MET	1.96
148	Lacrimoauriculodentodigital syndrome 2	Enrichment	FGFR3	1.96
149	Autoinflammation with pulmonary and cutaneous vasculitis	Enrichment	HCK	1.96
150	Csf1r-related disorder	Enrichment	CSF1R	1.96
151	Autosomal recessive spastic paraplegia type 59	Enrichment	USP8	1.96
152	Bockenheimer syndrome	Enrichment	TEK	1.96
153	Colitis	Enrichment	SYK	1.96
154	Acute myeloid leukemia with multilineage dysplasia	Enrichment	NPM1	1.96
155	Isolated bone marrow mastocytosis	Enrichment	KIT	1.96
156	Thyroid cancer	Enrichment	RET	1.96
157	Smoldering systemic mastocytosis	Enrichment	KIT	1.96
158	Acute myeloid leukemia with npm1 somatic mutations	Enrichment	NPM1	1.96
159	Alk-positive anaplastic large cell lymphoma	Enrichment	ALK	1.96
160	Fgfr3-related chondrodysplasia	Enrichment	FGFR3	1.96
161	Mastocytosis	Enrichment	KIT	1.96
162	Congenital primary lymphedema of gordon	Enrichment	VEGFC	1.96
163	Camptodactyly-tall stature-scoliosis-hearing loss syndrome	Enrichment	FGFR3	1.96
164	Familial progressive hyperpigmentation	Enrichment	KITLG	1.96
165	Early-onset calcifying leukoencephalopathy-skeletal dysplasia	Enrichment	CSF1R	1.96
166	Cutaneous mastocytoma	Enrichment	KIT	1.96
167	Typical urticaria pigmentosa	Enrichment	KIT	1.96
168	Nodular urticaria pigmentosa	Enrichment	KIT	1.96
169	Silver-russell syndrome due to maternal uniparental disomy of chromosome 7	Enrichment	GRB10	1.96
170	Hartsfield-bixler-demyer syndrome	Enrichment	FGFR1	1.96
171	Alk-positive large b-cell lymphoma	Enrichment	ALK	1.96
172	Pseudoxanthomatous diffuse cutaneous mastocytosis	Enrichment	KIT	1.96
173	Telangiectasia macularis eruptiva perstans	Enrichment	KIT	1.96
174	Acute mast cell leukemia	Enrichment	KIT	1.96
175	Egf-related primary hypomagnesemia with intellectual disability	Enrichment	EGF	1.96
176	Distal 17p13.3 microdeletion syndrome	Enrichment	YWHAE	1.96
177	Non-syndromic unicoronal craniosynostosis	Enrichment	FGFR2	1.96
178	Familial progressive hyper- and hypopigmentation	Enrichment	KITLG	1.96
179	Plaque-form urticaria pigmentosa	Enrichment	KIT	1.96
180	Serous carcinoma of the corpus uteri	Enrichment	ERBB2	1.96
181	Ephb4-related lymphatic-related hydrops fetalis	Enrichment	EPHB4	1.96
182	Bullous diffuse cutaneous mastocytosis	Enrichment	KIT	1.96
183	Zap70-related severe combined immunodeficiency	Enrichment	ZAP70	1.96
184	Temporomandibular joint anomaly	Enrichment	DOCK1	1.96
185	Gastrointestinal system disease	Enrichment	RET	1.96
186	Vein of galen aneurysmal malformation	Enrichment	EPHB4	1.96
187	Multiple endocrine neoplasia	Enrichment	RET	1.96
188	Testis seminoma	Enrichment	KIT	1.96
189	Hydrocephalus	Enrichment	FGFR2, PDGFRB	1.95
190	Noonan syndrome and noonan-related syndrome	Enrichment	CBL, SPRED1	1.95
191	Rhabdomyosarcoma	Enrichment	ALK, CBL	1.89
192	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	EPS8, MET, ROR1, WBP2	1.79
193	Hypertelorism	Enrichment	EFNB1, FGFR2, RET	1.72
194	Craniosynostosis	Enrichment	FGFR2, FGFR3	1.70
195	Blue rubber bleb nevus	Enrichment	TEK	1.66
196	Myeloproliferative disorder, chronic, with eosinophilia	Enrichment	PDGFRB	1.66
197	Insensitivity to pain, congenital, with anhidrosis	Enrichment	NTRK1	1.66
198	Pituitary adenoma 4, acth-secreting	Enrichment	USP8	1.66
199	Visceral neuropathy, familial, 1, autosomal recessive	Enrichment	ERBB3	1.66
200	Ovarian germ cell cancer	Enrichment	CBL	1.66
201	Cervical cancer	Enrichment	FGFR3	1.66
202	Isolated growth hormone deficiency, type iii, with agammaglobulinemia	Enrichment	BTK	1.66
203	Piebald trait	Enrichment	KIT	1.66
204	Hyperinsulinemic hypoglycemia, familial, 4	Enrichment	INSR	1.66
205	Aural atresia, congenital	Enrichment	FGFR2	1.66
206	Keratosis, seborrheic	Enrichment	FGFR3	1.66
207	Encephalocraniocutaneous lipomatosis	Enrichment	FGFR1	1.66
208	Maturity-onset diabetes of the young, type 11	Enrichment	BLK	1.66
209	Angioma, tufted	Enrichment	KDR	1.66
210	Thrombocythemia 3	Enrichment	JAK2	1.66
211	Pain sensitivity quantitative trait locus 1	Enrichment	NTRK1	1.66
212	Antley-bixler syndrome without genital anomalies or disordered steroidogenesis	Enrichment	FGFR2	1.66
213	Myopia 28, autosomal recessive	Enrichment	DOK1	1.66
214	Waardenburg syndrome, type 2f	Enrichment	KITLG	1.66
215	Lymphatic malformation 11	Enrichment	TIE1	1.66
216	Agammaglobulinemia, x-linked	Enrichment	BTK	1.66
217	Congenital heart defects and skeletal malformations syndrome	Enrichment	ABL1	1.66
218	Hypophosphatemia	Enrichment	NHERF1	1.66
219	Infantile myofibromatosis	Enrichment	PDGFRB	1.66
220	Autoimmune disease, multisystem, infantile-onset, 3	Enrichment	CBLB	1.66
221	Childhood hepatocellular carcinoma	Enrichment	MET	1.66
222	Split hand-foot malformation	Enrichment	FGFR2	1.66
223	Rosette-forming glioneuronal tumor	Enrichment	FGFR1	1.66
224	Papillary renal cell carcinoma	Enrichment	MET	1.66
225	Medullary thyroid carcinoma	Enrichment	RET	1.66
226	Cervix carcinoma	Enrichment	FGFR3	1.66
227	Retinitis pigmentosa 38	Enrichment	MERTK	1.66
228	Polycythemia	Enrichment	JAK2	1.66
229	Lymphatic malformation 10	Enrichment	ANGPT2	1.66
230	Interfrontal craniofaciosynostosis	Enrichment	FGFR1	1.66
231	Autosomal dominant nonsyndromic deafness	Enrichment	FGFR2	1.66
232	Chronic eosinophilic leukemia	Enrichment	PDGFRA	1.66
233	Arthritis	Enrichment	SYK	1.66
234	Hypereosinophilic syndrome	Enrichment	JAK2	1.66
235	Malignant germ cell tumor of ovary	Enrichment	CBL	1.66
236	B-lymphoblastic leukemia/lymphoma with recurrent genetic abnormality	Enrichment	PDGFRA	1.66
237	Mixed phenotype acute leukemia with t(9;22)(q34.1;q11.2)	Enrichment	FLT3	1.66
238	Dominant hypophosphatemia with nephrolithiasis or osteoporosis	Enrichment	NHERF1	1.66
239	B-lymphoblastic leukemia/lymphoma with t	Enrichment	KIT	1.66
240	Tooth agenesis	Enrichment	FGFR1, TGFA	1.63
241	Achondroplasia	Enrichment	FGFR3	1.49
242	Hypogonadotropic hypogonadism 2 with or without anosmia	Enrichment	FGFR1	1.49
243	Larsen syndrome	Enrichment	FGFR3	1.49
244	Polycythemia vera	Enrichment	JAK2	1.49
245	Leukoencephalopathy, hereditary diffuse, with spheroids 1	Enrichment	CSF1R	1.49
246	Niemann-pick disease, type a	Enrichment	APBB1	1.49
247	Agammaglobulinemia 1, autosomal recessive	Enrichment	BTK	1.49
248	Niemann-pick disease, type b	Enrichment	APBB1	1.49
249	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	1.49
250	Miller-dieker lissencephaly syndrome	Enrichment	YWHAE	1.49
251	Chromosome 17p13.3, centromeric, duplication syndrome	Enrichment	YWHAE	1.49
252	Agammaglobulinemia 1	Enrichment	BTK	1.49
253	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK2	1.49
254	Hamartoma	Enrichment	FGFR3	1.49
255	Lymphatic malformation 7	Enrichment	EPHB4	1.49
256	Gingival overgrowth	Enrichment	RET	1.49
257	Capillary malformation-arteriovenous malformation 2	Enrichment	EPHB4	1.49
258	T-cell acute lymphoblastic leukemia	Enrichment	ABL1	1.49
259	Spermatocytoma	Enrichment	FGFR3	1.49
260	Growth delay due to insulin-like growth factor i resistance	Enrichment	IGF1R	1.49
261	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	1.49
262	Mixed phenotype acute leukemia with t	Enrichment	FLT3	1.49
263	Renal cell carcinoma	Enrichment	MET	1.49
264	Testicular cancer	Enrichment	FGFR3	1.49
265	Hydrops fetalis, nonimmune	Enrichment	EPHB4, FLT4	1.49
266	Erythrocytosis, familial, 1	Enrichment	JAK2	1.37
267	Budd-chiari syndrome	Enrichment	JAK2	1.37
268	Glaucoma 3, primary infantile, b	Enrichment	TEK	1.37
269	Cholangiocarcinoma	Enrichment	ROS1	1.37
270	Barrett esophagus	Enrichment	ERBB2	1.37
271	Central hypoventilation syndrome, congenital, 1	Enrichment	RET	1.37
272	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	ABL1	1.37
273	Chronic myelomonocytic leukemia	Enrichment	FLT3	1.37
274	Non-syndromic bicoronal craniosynostosis	Enrichment	FGFR3	1.37
275	Systemic mastocytosis with associated hematologic neoplasm	Enrichment	KIT	1.37
276	Glioma	Enrichment	FGFR2	1.37
277	Haddad syndrome	Enrichment	RET	1.37
278	Pseudomyogenic hemangioendothelioma	Enrichment	WWTR1	1.37
279	Severe combined immunodeficiency	Enrichment	LCK, ZAP70	1.30
280	Cataract 6, multiple types	Enrichment	EPHA2	1.27
281	Multiple endocrine neoplasia, type iia	Enrichment	RET	1.27
282	Niemann-pick disease, type c1	Enrichment	APBB1	1.27
283	Microcephaly 1, primary, autosomal recessive	Enrichment	ANGPT2	1.27
284	Robinow syndrome, autosomal recessive 1	Enrichment	ROR2	1.27
285	Insulin-like growth factor i	Enrichment	IGF1R	1.27
286	Pre-eclampsia	Enrichment	FLT1	1.27
287	Niemann-pick disease	Enrichment	APBB1	1.27
288	Holoprosencephaly	Enrichment	FGFR1	1.27
289	Aniridia	Enrichment	EPHA2	1.27
290	Aggressive systemic mastocytosis	Enrichment	CBL	1.27
291	Endometrial stromal sarcoma	Enrichment	YWHAE	1.27
292	Cowden syndrome 1	Enrichment	EGFR	1.20
293	Split-hand/foot malformation 1	Enrichment	FGFR2	1.20
294	Holoprosencephaly 1	Enrichment	FGFR1	1.20
295	Inflammatory myofibroblastic tumor	Enrichment	ALK	1.20
296	Autosomal recessive robinow syndrome	Enrichment	ROR2	1.20
297	Kidney clear cell sarcoma	Enrichment	YWHAE	1.20
298	Sporadic pheochromocytoma/secreting paraganglioma	Enrichment	RET	1.20
299	Nevus, epidermal	Enrichment	FGFR3	1.13
300	Glaucoma 3, primary congenital, a	Enrichment	TEK	1.13
301	Squamous cell carcinoma, head and neck	Enrichment	EGFR	1.13
302	Waardenburg syndrome, type 2e	Enrichment	KITLG	1.13
303	Capillary malformation-arteriovenous malformation 1	Enrichment	EPHB4	1.13
304	Renal cell carcinoma, papillary, 1	Enrichment	MET	1.13
305	Neuropathy, hereditary sensory and autonomic, type v	Enrichment	NTRK1	1.13
306	Essential thrombocythemia	Enrichment	JAK2	1.13
307	Oligoarticular juvenile idiopathic arthritis	Enrichment	IL2RB	1.13
308	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	IL2RB	1.13
309	Moyamoya angiopathy	Enrichment	ABL1	1.13
310	Type 2 diabetes mellitus	Enrichment	INSR, IRS1	1.12
311	Gastric cancer	Enrichment	ERBB2, FGFR2	1.10
312	Arthrogryposis, distal, type 1a	Enrichment	MET	1.08
313	Melanocytic nevus syndrome, congenital	Enrichment	ALK	1.08
314	Glioma susceptibility 1	Enrichment	ERBB2	1.08
315	Basal ganglia calcification, idiopathic, 1	Enrichment	PDGFRB	1.08
316	Renal hypodysplasia/aplasia 1	Enrichment	RET	1.08
317	Hypothyroidism	Enrichment	RET	1.08
318	Neuroblastoma	Enrichment	ALK	1.08
319	Early-onset posterior polar cataract	Enrichment	EPHA2	1.08
320	Neurofibromatosis, type i	Enrichment	SPRED1	1.03
321	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.03
322	Atypical chronic myeloid leukemia, bcr-abl1 negative	Enrichment	FLT3	1.03
323	Adult hepatocellular carcinoma	Enrichment	EGF	1.03
324	Hypogonadotropic hypogonadism	Enrichment	FGFR1	1.03
325	Congenital central hypoventilation syndrome	Enrichment	RET	1.03
326	Primary hyperaldosteronism	Enrichment	USP8	1.03
327	Ventricular septal defect	Enrichment	TEK	1.03
328	Renal agenesis, bilateral	Enrichment	RET	1.03
329	Autosomal dominant non-syndromic intellectual disability	Enrichment	ERBB4, YWHAZ	0.99
330	Meier-gorlin syndrome 1	Enrichment	FGFR2	0.98
331	Nephrolithiasis	Enrichment	NHERF1	0.98
332	Primary bone dysplasia	Enrichment	FGFR3	0.98
333	Immune deficiency disease	Enrichment	SYK	0.94
334	Frontotemporal dementia 1	Enrichment	CSF1R	0.94
335	Leukemia, acute lymphoblastic	Enrichment	FLT3	0.94
336	Combined immunodeficiency	Enrichment	ZAP70	0.94
337	Osteochondrodysplasia	Enrichment	FGFR3	0.94
338	Ichthyosis	Enrichment	IL2RB	0.94
339	Combined t cell and b cell immunodeficiency	Enrichment	ZAP70	0.94
340	Specific learning disability	Enrichment	YWHAG	0.94
341	Combined t and b cell immunodeficiency	Enrichment	ZAP70	0.94
342	Septooptic dysplasia	Enrichment	FGFR1	0.91
343	Juvenile myelomonocytic leukemia	Enrichment	CBL	0.91
344	Undetermined early-onset epileptic encephalopathy	Enrichment	NTRK2, YWHAG	0.90
345	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	CSF1R, ERBB4	0.88
346	Microphthalmia/coloboma 12	Enrichment	YAP1	0.88
347	Acute promyelocytic leukemia	Enrichment	NPM1	0.88
348	Alzheimer's disease	Enrichment	CSF1R	0.88
349	Hypogonadotropic hypogonadism 7 with or without anosmia	Enrichment	FGFR1	0.85
350	Osteoporosis	Enrichment	SRC	0.85
351	Pheochromocytoma	Enrichment	RET	0.85
352	Heart disease	Enrichment	ABL1	0.85
353	Cataract	Enrichment	EPHA2	0.85
354	Cleft lip/palate	Enrichment	PDGFRA	0.85
355	Microcephaly	Enrichment	ABL1, IGF1R, YWHAG	0.82
356	Coloboma of macula	Enrichment	YAP1	0.82
357	Renal cell carcinoma, nonpapillary	Enrichment	MET	0.82
358	Male infertility with spermatogenesis disorder	Enrichment	SPRED1	0.82
359	Microform holoprosencephaly	Enrichment	FGFR1	0.79
360	Lobar holoprosencephaly	Enrichment	FGFR1	0.79
361	Alzheimer disease, familial, 1	Enrichment	CSF1R	0.77
362	Dandy-walker syndrome	Enrichment	PDGFRB	0.77
363	Cataract 44	Enrichment	EPHA2	0.77
364	Semilobar holoprosencephaly	Enrichment	FGFR1	0.75
365	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	FGFR1	0.75
366	Early-onset nuclear cataract	Enrichment	EPHA2	0.75
367	Arteriovenous malformations of the brain	Enrichment	EGFR	0.73
368	Diffuse large b-cell lymphoma	Enrichment	BTK	0.73
369	Parkinson's disease	Enrichment	TNK2	0.73
370	Dyskeratosis congenita	Enrichment	NPM1	0.73
371	Maturity-onset diabetes of the young	Enrichment	BLK	0.71
372	Breast cancer	Enrichment	RET, SHC1	0.71
373	Endometrial cancer	Enrichment	FGFR2	0.69
374	Hepatoblastoma	Enrichment	FGFR3	0.69
375	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	RET	0.69
376	Noonan syndrome 1	Enrichment	CBL	0.65
377	Kallmann syndrome	Enrichment	FGFR1	0.65
378	Autoinflammatory disease	Enrichment	SH2D1A	0.64
379	Rasopathy	Enrichment	CBL	0.60
380	Prostate cancer	Enrichment	EPHB2	0.56
381	Primary autosomal recessive microcephaly	Enrichment	ANGPT2	0.53
382	Connective tissue disease	Enrichment	FGFR3	0.53
383	Fetal akinesia deformation sequence 1	Enrichment	ROR2	0.48
384	Systemic lupus erythematosus	Enrichment	BLK	0.46
385	Cerebral palsy	Enrichment	PDGFRB	0.46
386	Distal arthrogryposis	Enrichment	ROR2	0.43
387	West syndrome	Enrichment	NTRK2	0.42
388	Hereditary breast carcinoma	Enrichment	RET	0.42
389	Sensorineural hearing loss	Enrichment	RET	0.39
390	Thrombocytopenia	Enrichment	SRC	0.39
391	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	KITLG	0.36
392	Spastic ataxia	Enrichment	DAB1	0.36
393	Hereditary breast ovarian cancer syndrome	Enrichment	BCAR1	0.34
394	Deafness, autosomal recessive	Enrichment	EPS8	0.30
395	Autosomal recessive nonsyndromic deafness	Enrichment	EPS8	0.30
396	Congenital nervous system abnormality	Enrichment	FGFR3	0.16
397	Nervous system disease	Enrichment	FGFR3	0.16
398	Retinitis pigmentosa	Enrichment	MERTK	0.04
399	Hereditary retinal dystrophy	Enrichment	MERTK	0.02
400	Fundus dystrophy	Enrichment	MERTK	0.02

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Tyrosine Kinases / Adaptors

Pathway Network for Tyrosine Kinases / Adaptors

Member Pathways for Tyrosine Kinases / Adaptors

Pathways in the Tyrosine Kinases / Adaptors SuperPath

Associated Genes for Tyrosine Kinases / Adaptors

Associated Disorders for Tyrosine Kinases / Adaptors

Disorders associated with Tyrosine Kinases / Adaptors SuperPath

STRING Interaction Network for Tyrosine Kinases / Adaptors

Sources for Tyrosine Kinases / Adaptors