Ubiquitin-Proteasome Dependent Proteolysis

No Pathway Network information available for Ubiquitin-Proteasome Dependent Proteolysis

Pathways in the Ubiquitin-Proteasome Dependent Proteolysis SuperPath

#	Name	Source	Genes
1	Ubiquitin-Proteasome Dependent Proteolysis	QIAGEN	HACE1 HECW1 HECW2 ITCH PAN2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 RNF8 SMURF1 SMURF2 STUB1 TRAF7 UBA1 UBA3 UBA5 UBB UBC UBD UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E3 UBE2F UBE2G1 UBE2H UBE2I UBE2J1 UBE2J2 UBE2L3 UBE2L6 UBE2M UBE2N UBE2Q1 UBE2R2 UBE2S UBE2T UBE2U UBE2V1 UBE2V2 UBE3A UBE3B UBE3C UBR1 UBR2 UBR5 USP1 USP10 USP11 USP12 USP13 USP14 USP15 USP16 USP17L9P USP18 USP19 USP2 USP20 USP21 USP25 USP26 USP28 USP29 USP3 USP30 USP31 USP32 USP33 USP34 USP35 USP36 USP37 USP38 USP39 USP4 USP40 USP41P USP42 USP43 USP44 USP46 USP47 USP48 USP49 USP5 USP51 USP53 USP54 USP6 USP7 USP8 USP9X USP9Y WWP1 WWP2 (see all 124) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	UBR2	Ubiquitin Protein Ligase E3 Component N-Recognin 2	Protein Coding	1
2	UBE2S	Ubiquitin Conjugating Enzyme E2 S	Protein Coding	1
3	UBR5	Ubiquitin Protein Ligase E3 Component N-Recognin 5	Protein Coding	1
4	HACE1	HECT Domain And Ankyrin Repeat Containing E3 Ubiquitin Protein Ligase 1	Protein Coding	1
5	HECW2	HECT, C2 And WW Domain Containing E3 Ubiquitin Protein Ligase 2	Protein Coding	1
6	UBE2T	Ubiquitin Conjugating Enzyme E2 T	Protein Coding	1
7	ITCH	Itchy E3 Ubiquitin Protein Ligase	Protein Coding	1
8	USP49	Ubiquitin Specific Peptidase 49	Protein Coding	1
9	UBE2U	Ubiquitin Conjugating Enzyme E2 U	Protein Coding	1
10	UBE2F	Ubiquitin Conjugating Enzyme E2 F (Putative)	Protein Coding	1
11	HECW1	HECT, C2 And WW Domain Containing E3 Ubiquitin Protein Ligase 1	Protein Coding	1
12	PSMD6	Proteasome 26S Subunit, Non-ATPase 6	Protein Coding	1
13	PSMA1	Proteasome 20S Subunit Alpha 1	Protein Coding	1
14	PSMA2	Proteasome 20S Subunit Alpha 2	Protein Coding	1
15	PSMA3	Proteasome 20S Subunit Alpha 3	Protein Coding	1
16	PSMA4	Proteasome 20S Subunit Alpha 4	Protein Coding	1
17	PSMA5	Proteasome 20S Subunit Alpha 5	Protein Coding	1
18	PSMA6	Proteasome 20S Subunit Alpha 6	Protein Coding	1
19	PSMA7	Proteasome 20S Subunit Alpha 7	Protein Coding	1
20	PSMB1	Proteasome 20S Subunit Beta 1	Protein Coding	1
21	PSMB2	Proteasome 20S Subunit Beta 2	Protein Coding	1
22	PSMB3	Proteasome 20S Subunit Beta 3	Protein Coding	1
23	PSMB4	Proteasome 20S Subunit Beta 4	Protein Coding	1
24	PSMB5	Proteasome 20S Subunit Beta 5	Protein Coding	1
25	PSMB6	Proteasome 20S Subunit Beta 6	Protein Coding	1
26	PSMB7	Proteasome 20S Subunit Beta 7	Protein Coding	1
27	PSMC1	Proteasome 26S Subunit, ATPase 1	Protein Coding	1
28	PSMC2	Proteasome 26S Subunit, ATPase 2	Protein Coding	1
29	PSMC3	Proteasome 26S Subunit, ATPase 3	Protein Coding	1
30	PSMC4	Proteasome 26S Subunit, ATPase 4	Protein Coding	1
31	PSMC5	Proteasome 26S Subunit, ATPase 5	Protein Coding	1
32	PSMC6	Proteasome 26S Subunit, ATPase 6	Protein Coding	1
33	PSMD1	Proteasome 26S Subunit, Non-ATPase 1	Protein Coding	1
34	PSMD2	Proteasome 26S Subunit Ubiquitin Receptor, Non-ATPase 2	Protein Coding	1
35	PSMD3	Proteasome 26S Subunit, Non-ATPase 3	Protein Coding	1
36	PSMD4	Proteasome 26S Subunit Ubiquitin Receptor, Non-ATPase 4	Protein Coding	1
37	PSMD5	Proteasome 26S Subunit, Non-ATPase 5	Protein Coding	1
38	PSMD7	Proteasome 26S Subunit, Non-ATPase 7	Protein Coding	1
39	TRAF7	TNF Receptor Associated Factor 7	Protein Coding	1
40	RNF8	Ring Finger Protein 8	Protein Coding	1
41	SMURF1	SMAD Specific E3 Ubiquitin Protein Ligase 1	Protein Coding	1
42	SMURF2	SMAD Specific E3 Ubiquitin Protein Ligase 2	Protein Coding	1
43	STUB1	STIP1 Homology And U-Box Containing Protein 1	Protein Coding	1
44	UBB	Ubiquitin B	Protein Coding	1
45	UBC	Ubiquitin C	Protein Coding	1
46	UBD	Ubiquitin Like Modifier D	Protein Coding	1
47	UBA1	Ubiquitin Like Modifier Activating Enzyme 1	Protein Coding	1
48	UBA3	Ubiquitin Like Modifier Activating Enzyme 3	Protein Coding	1
49	UBA5	Ubiquitin Like Modifier Activating Enzyme 5	Protein Coding	1
50	UBE2A	Ubiquitin Conjugating Enzyme E2 A	Protein Coding	1
51	UBE2B	Ubiquitin Conjugating Enzyme E2 B	Protein Coding	1
52	UBE2C	Ubiquitin Conjugating Enzyme E2 C	Protein Coding	1
53	UBE2D1	Ubiquitin Conjugating Enzyme E2 D1	Protein Coding	1
54	UBE2D2	Ubiquitin Conjugating Enzyme E2 D2	Protein Coding	1
55	UBE2D3	Ubiquitin Conjugating Enzyme E2 D3	Protein Coding	1
56	UBE2E1	Ubiquitin Conjugating Enzyme E2 E1	Protein Coding	1
57	UBE2E3	Ubiquitin Conjugating Enzyme E2 E3	Protein Coding	1
58	UBE2G1	Ubiquitin Conjugating Enzyme E2 G1	Protein Coding	1
59	UBE2H	Ubiquitin Conjugating Enzyme E2 H	Protein Coding	1
60	UBE2I	Ubiquitin Conjugating Enzyme E2 I	Protein Coding	1
61	UBE2J1	Ubiquitin Conjugating Enzyme E2 J1	Protein Coding	1
62	UBE2J2	Ubiquitin Conjugating Enzyme E2 J2	Protein Coding	1
63	UBE2L3	Ubiquitin Conjugating Enzyme E2 L3	Protein Coding	1
64	UBE2L6	Ubiquitin Conjugating Enzyme E2 L6	Protein Coding	1
65	UBE2M	Ubiquitin Conjugating Enzyme E2 M	Protein Coding	1
66	UBE2N	Ubiquitin Conjugating Enzyme E2 N	Protein Coding	1
67	UBE2Q1	Ubiquitin Conjugating Enzyme E2 Q1	Protein Coding	1
68	UBE2R2	Ubiquitin Conjugating Enzyme E2 R2	Protein Coding	1
69	UBE2V1	Ubiquitin Conjugating Enzyme E2 V1	Protein Coding	1
70	UBE2V2	Ubiquitin Conjugating Enzyme E2 V2	Protein Coding	1
71	UBE3A	Ubiquitin Protein Ligase E3A	Protein Coding	1
72	UBE3B	Ubiquitin Protein Ligase E3B	Protein Coding	1
73	UBE3C	Ubiquitin Protein Ligase E3C	Protein Coding	1
74	UBR1	Ubiquitin Protein Ligase E3 Component N-Recognin 1	Protein Coding	1
75	USP1	Ubiquitin Specific Peptidase 1	Protein Coding	1
76	USP10	Ubiquitin Specific Peptidase 10	Protein Coding	1
77	USP11	Ubiquitin Specific Peptidase 11	Protein Coding	1
78	USP12	Ubiquitin Specific Peptidase 12	Protein Coding	1
79	USP13	Ubiquitin Specific Peptidase 13	Protein Coding	1
80	USP14	Ubiquitin Specific Peptidase 14	Protein Coding	1
81	USP15	Ubiquitin Specific Peptidase 15	Protein Coding	1
82	USP16	Ubiquitin Specific Peptidase 16	Protein Coding	1
83	USP17L9P	Ubiquitin Specific Peptidase 17 Like Family Member 9, Pseudogene	Pseudogene	1
84	USP18	Ubiquitin Specific Peptidase 18	Protein Coding	1
85	USP19	Ubiquitin Specific Peptidase 19	Protein Coding	1
86	USP2	Ubiquitin Specific Peptidase 2	Protein Coding	1
87	USP20	Ubiquitin Specific Peptidase 20	Protein Coding	1
88	USP21	Ubiquitin Specific Peptidase 21	Protein Coding	1
89	USP25	Ubiquitin Specific Peptidase 25	Protein Coding	1
90	USP26	Ubiquitin Specific Peptidase 26	Protein Coding	1
91	USP28	Ubiquitin Specific Peptidase 28	Protein Coding	1
92	USP29	Ubiquitin Specific Peptidase 29	Protein Coding	1
93	USP3	Ubiquitin Specific Peptidase 3	Protein Coding	1
94	USP30	Ubiquitin Specific Peptidase 30	Protein Coding	1
95	USP31	Ubiquitin Specific Peptidase 31	Protein Coding	1
96	USP32	Ubiquitin Specific Peptidase 32	Protein Coding	1
97	USP33	Ubiquitin Specific Peptidase 33	Protein Coding	1
98	USP34	Ubiquitin Specific Peptidase 34	Protein Coding	1
99	USP35	Ubiquitin Specific Peptidase 35	Protein Coding	1
100	USP36	Ubiquitin Specific Peptidase 36	Protein Coding	1
101	USP37	Ubiquitin Specific Peptidase 37	Protein Coding	1
102	USP38	Ubiquitin Specific Peptidase 38	Protein Coding	1
103	USP39	Ubiquitin Specific Peptidase 39	Protein Coding	1
104	USP4	Ubiquitin Specific Peptidase 4	Protein Coding	1
105	USP40	Ubiquitin Specific Peptidase 40	Protein Coding	1
106	USP41P	Ubiquitin Specific Peptidase 41, Pseudogene	Pseudogene	1
107	USP42	Ubiquitin Specific Peptidase 42	Protein Coding	1
108	USP43	Ubiquitin Specific Peptidase 43	Protein Coding	1
109	USP44	Ubiquitin Specific Peptidase 44	Protein Coding	1
110	USP46	Ubiquitin Specific Peptidase 46	Protein Coding	1
111	USP47	Ubiquitin Specific Peptidase 47	Protein Coding	1
112	USP48	Ubiquitin Specific Peptidase 48	Protein Coding	1
113	USP5	Ubiquitin Specific Peptidase 5	Protein Coding	1
114	USP51	Ubiquitin Specific Peptidase 51	Protein Coding	1
115	PAN2	Poly(A) Specific Ribonuclease Subunit PAN2	Protein Coding	1
116	USP53	Ubiquitin Specific Peptidase 53	Protein Coding	1
117	USP54	Ubiquitin Specific Peptidase 54	Protein Coding	1
118	USP6	Ubiquitin Specific Peptidase 6	Protein Coding	1
119	USP7	Ubiquitin Specific Peptidase 7	Protein Coding	1
120	USP8	Ubiquitin Specific Peptidase 8	Protein Coding	1
121	USP9X	Ubiquitin Specific Peptidase 9 X-Linked	Protein Coding	1
122	USP9Y	Ubiquitin Specific Peptidase 9 Y-Linked	Protein Coding	1
123	WWP1	WW Domain Containing E3 Ubiquitin Protein Ligase 1	Protein Coding	1
124	WWP2	WW Domain Containing E3 Ubiquitin Protein Ligase 2	Protein Coding	1

Disorders associated with Ubiquitin-Proteasome Dependent Proteolysis SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Primary hyperaldosteronism	Enrichment	USP48, USP8	2.54
2	Spermatogenic failure, x-linked, 6	Enrichment	USP26	2.04
3	Intellectual developmental disorder, x-linked 99	Enrichment	USP9X	2.04
4	Johanson-blizzard syndrome	Enrichment	UBR1	2.04
5	Spastic paraplegia and psychomotor retardation with or without seizures	Enrichment	HACE1	2.04
6	Fanconi anemia, complementation group t	Enrichment	UBE2T	2.04
7	Kaufman oculocerebrofacial syndrome	Enrichment	UBE3B	2.04
8	Neurodevelopmental disorder with microcephaly, hypotonia, and absent language	Enrichment	PSMB1	2.04
9	Intellectual developmental disorder, x-linked, syndromic, nascimento type	Enrichment	UBE2A	2.04
10	Intellectual developmental disorder, x-linked 99, syndromic, female-restricted	Enrichment	USP9X	2.04
11	Syndromic x-linked intellectual disability nascimento type	Enrichment	UBE2A	2.04
12	Deafness, cataract, impaired intellectual development, and polyneuropathy	Enrichment	PSMC3	2.04
13	Autoimmune disease, multisystem, with facial dysmorphism	Enrichment	ITCH	2.04
14	Deafness, autosomal dominant 85	Enrichment	USP48	2.04
15	Cardiac, facial, and digital anomalies with developmental delay	Enrichment	TRAF7	2.04
16	Cholestasis, progressive familial intrahepatic, 7, with or without hearing loss	Enrichment	USP53	2.04
17	Neurodevelopmental disorder with absent speech and movement and behavioral abnormalities	Enrichment	UBE3C	2.04
18	Pseudo-torch syndrome 2	Enrichment	USP18	2.04
19	Spastic paraplegia-severe developmental delay-epilepsy syndrome	Enrichment	HACE1	2.04
20	Female-restricted syndromic x-linked intellectual disability 99	Enrichment	USP9X	2.04
21	Autosomal recessive spastic paraplegia type 59	Enrichment	USP8	2.04
22	Syndromic multisystem autoimmune disease due to itch deficiency	Enrichment	ITCH	2.04
23	Epilepsy, idiopathic generalized 19	Enrichment	USP25	2.04
24	Neurodevelopmental disorder with speech delay and behavioral abnormalities	Enrichment	UBR5	2.04
25	Traf7-associated heart defect-digital anomalies-facial dysmorphism-motor and speech delay syndrome	Enrichment	TRAF7	2.04
26	15q11q13 microduplication syndrome	Enrichment	UBE3A	2.04
27	Pituitary adenoma 4, acth-secreting	Enrichment	USP8	1.74
28	Spermatogenic failure, y-linked, 2	Enrichment	USP9Y	1.74
29	Vexas syndrome	Enrichment	UBA1	1.74
30	Spinocerebellar ataxia, autosomal recessive 24	Enrichment	UBA5	1.74
31	Neurodevelopmental disorder with hypotonia, seizures, and absent language	Enrichment	HECW2	1.74
32	Birk-aharoni syndrome	Enrichment	PSMC1	1.74
33	Spondyloepiphyseal dysplasia, nishimura type	Enrichment	WWP2	1.74
34	Spinocerebellar ataxia 48	Enrichment	STUB1	1.74
35	Spinal muscular atrophy, x-linked 2	Enrichment	UBA1	1.74
36	Proteasome-associated autoinflammatory syndrome 3	Enrichment	PSMB4	1.74
37	Pseudosarcomatous fibromatosis	Enrichment	USP6	1.74
38	Hao-fountain syndrome	Enrichment	USP7	1.74
39	Chromosome 2p16.1-p15 deletion syndrome	Enrichment	USP34	1.74
40	Blepharophimosis - intellectual disability syndrome	Enrichment	UBE3B	1.74
41	Bronchiectasis	Enrichment	USP11	1.74
42	Multifocal pattern dystrophy simulating fundus flavimaculatus	Enrichment	UBR2	1.74
43	Angelman syndrome due to maternal 15q11q13 deletion	Enrichment	UBE3A	1.74
44	Submucosal cleft palate	Enrichment	UBB	1.74
45	Cleft hard palate	Enrichment	UBB	1.74
46	Proteasome-associated autoinflammatory syndrome 1	Enrichment	PSMB4	1.57
47	Uvula, bifid	Enrichment	UBB	1.57
48	Cleft soft palate	Enrichment	UBB	1.57
49	Developmental and epileptic encephalopathy 44	Enrichment	UBA5	1.57
50	Proteosome-associated autoinflammatory syndrome	Enrichment	PSMB4	1.57
51	Cholestasis	Enrichment	USP53	1.57
52	Thyroid hemiagenesis	Enrichment	PSMD3	1.57
53	Angelman syndrome due to imprinting defect in 15q11-q13	Enrichment	UBE3A	1.57
54	Hyperpigmentation of the skin	Enrichment	USP9X	1.57
55	Variegate porphyria	Enrichment	USP21	1.35
56	Angelman syndrome	Enrichment	UBE3A	1.27
57	Developmental dysplasia of the hip 1	Enrichment	PSMC3	1.27
58	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	STUB1	1.27
59	Patent ductus arteriosus	Enrichment	PSMC3	1.27
60	Progressive familial intrahepatic cholestasis	Enrichment	USP53	1.21
61	Neuroblastoma	Enrichment	HACE1	1.15
62	Chromosome y microdeletion syndrome	Enrichment	USP9Y	1.15
63	Polymicrogyria	Enrichment	PSMC3	1.06
64	Meningioma	Enrichment	TRAF7	0.98
65	Patent foramen ovale	Enrichment	PSMC3	0.82
66	Myocardial infarction	Enrichment	PSMA6	0.74
67	Non-syndromic male infertility due to sperm motility disorder	Enrichment	USP26	0.72
68	Male infertility	Enrichment	USP26	0.57
69	Fanconi anemia, complementation group a	Enrichment	UBE2T	0.56
70	Non-syndromic x-linked intellectual disability	Enrichment	USP9X	0.55
71	Developmental and epileptic encephalopathy	Enrichment	UBA5	0.55
72	Systemic lupus erythematosus	Enrichment	UBE2L3	0.52
73	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	USP48	0.42
74	Undetermined early-onset epileptic encephalopathy	Enrichment	UBA5	0.40
75	Congenital nervous system abnormality	Enrichment	HECW2	0.21
76	Nervous system disease	Enrichment	HECW2	0.21
77	Microcephaly	Enrichment	PSMC3	0.17
78	Hereditary retinal dystrophy	Enrichment	UBR2	0.03
79	Fundus dystrophy	Enrichment	UBR2	0.03

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Ubiquitin-Proteasome Dependent Proteolysis

Pathway Network for Ubiquitin-Proteasome Dependent Proteolysis

Member Pathways for Ubiquitin-Proteasome Dependent Proteolysis

Pathways in the Ubiquitin-Proteasome Dependent Proteolysis SuperPath

Associated Genes for Ubiquitin-Proteasome Dependent Proteolysis

Associated Disorders for Ubiquitin-Proteasome Dependent Proteolysis

Disorders associated with Ubiquitin-Proteasome Dependent Proteolysis SuperPath

STRING Interaction Network for Ubiquitin-Proteasome Dependent Proteolysis

Sources for Ubiquitin-Proteasome Dependent Proteolysis