Ubiquitination Cascade

No Pathway Network information available for Ubiquitination Cascade

Pathways in the Ubiquitination Cascade SuperPath

#	Name	Source	Genes
1	Ubiquitination Cascade	R&D Systems	BIRC2 CDC34 CYLD ITCH MDM2 OTUB1 OTUB2 OTUD3 OTUD7B OTULIN RNF31 RNF4 STAMBP STUB1 TRIM63 UBA1 UBB UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2F UBE2G1 UBE2G2 UBE2H UBE2J1 UBE2J2 UBE2K UBE2L3 UBE2L6 UBE2M UBE2N UBE2Q1 UBE2Q2 UBE2R2 UBE2S UBE2T UBE2V1 UBE2W UBE2Z UBE3A XIAP YOD1 ZRANB1 (see all 49) (see less)
2	Synthesis of active ubiquitin: roles of E1 and E2 enzymes	Reactome	CDC34 OTULIN RPS27A UBA1 UBA52 UBA6 UBB UBC UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2E1 UBE2E3 UBE2G1 UBE2G2 UBE2H UBE2K UBE2L3 UBE2Q2 UBE2R2 UBE2S UBE2T UBE2W UBE2Z UCHL3 USP5 USP7 USP9X (see all 30) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	UBB	Ubiquitin B	Protein Coding	2
2	UBA1	Ubiquitin Like Modifier Activating Enzyme 1	Protein Coding	2
3	UBE2A	Ubiquitin Conjugating Enzyme E2 A	Protein Coding	2
4	UBE2B	Ubiquitin Conjugating Enzyme E2 B	Protein Coding	2
5	UBE2K	Ubiquitin Conjugating Enzyme E2 K	Protein Coding	2
6	UBE2H	Ubiquitin Conjugating Enzyme E2 H	Protein Coding	2
7	CDC34	Cell Division Cycle 34, Ubiquitin Conjugating Enzyme	Protein Coding	2
8	UBE2D1	Ubiquitin Conjugating Enzyme E2 D1	Protein Coding	2
9	UBE2D2	Ubiquitin Conjugating Enzyme E2 D2	Protein Coding	2
10	UBE2E1	Ubiquitin Conjugating Enzyme E2 E1	Protein Coding	2
11	UBE2L3	Ubiquitin Conjugating Enzyme E2 L3	Protein Coding	2
12	UBE2C	Ubiquitin Conjugating Enzyme E2 C	Protein Coding	2
13	UBE2E3	Ubiquitin Conjugating Enzyme E2 E3	Protein Coding	2
14	UBE2G1	Ubiquitin Conjugating Enzyme E2 G1	Protein Coding	2
15	UBE2G2	Ubiquitin Conjugating Enzyme E2 G2	Protein Coding	2
16	UBE2Q2	Ubiquitin Conjugating Enzyme E2 Q2	Protein Coding	2
17	UBE2R2	Ubiquitin Conjugating Enzyme E2 R2	Protein Coding	2
18	UBE2S	Ubiquitin Conjugating Enzyme E2 S	Protein Coding	2
19	UBE2T	Ubiquitin Conjugating Enzyme E2 T	Protein Coding	2
20	UBE2W	Ubiquitin Conjugating Enzyme E2 W	Protein Coding	2
21	UBE2Z	Ubiquitin Conjugating Enzyme E2 Z	Protein Coding	2
22	OTULIN	OTU Deubiquitinase With Linear Linkage Specificity	Protein Coding	2
23	UBE2D3	Ubiquitin Conjugating Enzyme E2 D3	Protein Coding	1
24	UBE2D4	Ubiquitin Conjugating Enzyme E2 D4	Protein Coding	1
25	UBE2L6	Ubiquitin Conjugating Enzyme E2 L6	Protein Coding	1
26	UBE2N	Ubiquitin Conjugating Enzyme E2 N	Protein Coding	1
27	UBE2V1	Ubiquitin Conjugating Enzyme E2 V1	Protein Coding	1
28	UBE2F	Ubiquitin Conjugating Enzyme E2 F (Putative)	Protein Coding	1
29	UBE2J1	Ubiquitin Conjugating Enzyme E2 J1	Protein Coding	1
30	UBE2J2	Ubiquitin Conjugating Enzyme E2 J2	Protein Coding	1
31	UBE2M	Ubiquitin Conjugating Enzyme E2 M	Protein Coding	1
32	UBE2Q1	Ubiquitin Conjugating Enzyme E2 Q1	Protein Coding	1
33	STUB1	STIP1 Homology And U-Box Containing Protein 1	Protein Coding	1
34	BIRC2	Baculoviral IAP Repeat Containing 2	Protein Coding	1
35	UBE3A	Ubiquitin Protein Ligase E3A	Protein Coding	1
36	ITCH	Itchy E3 Ubiquitin Protein Ligase	Protein Coding	1
37	RNF31	Ring Finger Protein 31	Protein Coding	1
38	MDM2	MDM2 Proto-Oncogene	Protein Coding	1
39	TRIM63	Tripartite Motif Containing 63	Protein Coding	1
40	RNF4	Ring Finger Protein 4	Protein Coding	1
41	XIAP	X-Linked Inhibitor Of Apoptosis	Protein Coding	1
42	OTUD3	OTU Deubiquitinase 3	Protein Coding	1
43	YOD1	YOD1 Deubiquitinase	Protein Coding	1
44	OTUD7B	OTU Deubiquitinase 7B	Protein Coding	1
45	ZRANB1	Zinc Finger RANBP2-Type Containing 1	Protein Coding	1
46	OTUB1	OTU Deubiquitinase, Ubiquitin Aldehyde Binding 1	Protein Coding	1
47	OTUB2	OTU Deubiquitinase, Ubiquitin Aldehyde Binding 2	Protein Coding	1
48	STAMBP	STAM Binding Protein	Protein Coding	1
49	CYLD	CYLD Lysine 63 Deubiquitinase	Protein Coding	1
50	UBA6	Ubiquitin Like Modifier Activating Enzyme 6	Protein Coding	1
51	RPS27A	Ribosomal Protein S27a	Protein Coding	1
52	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	1
53	UBC	Ubiquitin C	Protein Coding	1
54	UCHL3	Ubiquitin C-Terminal Hydrolase L3	Protein Coding	1
55	USP7	Ubiquitin Specific Peptidase 7	Protein Coding	1
56	USP5	Ubiquitin Specific Peptidase 5	Protein Coding	1
57	USP9X	Ubiquitin Specific Peptidase 9 X-Linked	Protein Coding	1

Disorders associated with Ubiquitination Cascade SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Intellectual developmental disorder, x-linked 99	Enrichment	USP9X	2.66
2	Fanconi anemia, complementation group t	Enrichment	UBE2T	2.66
3	Immunodeficiency 107 invasive staphylococcus aureus infection	Enrichment	OTULIN	2.66
4	Intellectual developmental disorder, x-linked, syndromic, nascimento type	Enrichment	UBE2A	2.66
5	Intellectual developmental disorder, x-linked 99, syndromic, female-restricted	Enrichment	USP9X	2.66
6	Syndromic x-linked intellectual disability nascimento type	Enrichment	UBE2A	2.66
7	Autoinflammation, panniculitis, and dermatosis syndrome, autosomal recessive	Enrichment	OTULIN	2.66
8	Female-restricted syndromic x-linked intellectual disability 99	Enrichment	USP9X	2.66
9	Autoinflammation, panniculitis, and dermatosis syndrome, autosomal dominant	Enrichment	OTULIN	2.66
10	Lymphoproliferative syndrome, x-linked, 2	Enrichment	XIAP	2.44
11	Accelerated tumor formation	Enrichment	MDM2	2.44
12	Lessel-kubisch syndrome	Enrichment	MDM2	2.44
13	Cardiomyopathy, familial hypertrophic, 31	Enrichment	TRIM63	2.44
14	Autoimmune disease, multisystem, with facial dysmorphism	Enrichment	ITCH	2.44
15	Immunodeficiency 115 with autoinflammation	Enrichment	RNF31	2.44
16	Syndromic multisystem autoimmune disease due to itch deficiency	Enrichment	ITCH	2.44
17	15q11q13 microduplication syndrome	Enrichment	UBE3A	2.44
18	Vexas syndrome	Enrichment	UBA1	2.35
19	Spinal muscular atrophy, x-linked 2	Enrichment	UBA1	2.35
20	Hao-fountain syndrome	Enrichment	USP7	2.35
21	Submucosal cleft palate	Enrichment	UBB	2.35
22	Cleft hard palate	Enrichment	UBB	2.35
23	Craniometaphyseal dysplasia, autosomal dominant	Enrichment	OTULIN	2.18
24	Uvula, bifid	Enrichment	UBB	2.18
25	Cleft soft palate	Enrichment	UBB	2.18
26	Hyperpigmentation of the skin	Enrichment	USP9X	2.18
27	Cylindromatosis, familial	Enrichment	CYLD	2.14
28	Trichoepithelioma, multiple familial, 1	Enrichment	CYLD	2.14
29	Spinocerebellar ataxia 48	Enrichment	STUB1	2.14
30	Frontotemporal dementia and/or amyotrophic lateral sclerosis 8	Enrichment	CYLD	2.14
31	Brooke-spiegler syndrome	Enrichment	CYLD	2.14
32	Microcephaly-capillary malformation syndrome	Enrichment	STAMBP	2.14
33	Angelman syndrome due to maternal 15q11q13 deletion	Enrichment	UBE3A	2.14
34	Autoinflammatory syndrome with pyogenic bacterial infection and amylopectinosis	Enrichment	RNF31	2.14
35	Chondrocalcinosis 2	Enrichment	OTULIN	2.05
36	Dedifferentiated liposarcoma	Enrichment	MDM2	1.97
37	Well-differentiated liposarcoma	Enrichment	MDM2	1.97
38	Angelman syndrome due to imprinting defect in 15q11-q13	Enrichment	UBE3A	1.97
39	Lymphoproliferative syndrome 2	Enrichment	XIAP	1.84
40	Angelman syndrome	Enrichment	UBE3A	1.67
41	Li-fraumeni syndrome	Enrichment	MDM2	1.67
42	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	STUB1	1.67
43	Fanconi anemia, complementation group a	Enrichment	UBE2T	1.13
44	Non-syndromic x-linked intellectual disability	Enrichment	USP9X	1.12
45	Systemic lupus erythematosus	Enrichment	UBE2L3	1.08
46	Autoinflammatory disease	Enrichment	XIAP	1.08
47	Hypertrophic cardiomyopathy	Enrichment	TRIM63	0.84
48	Myeloma, multiple	Enrichment	CYLD	0.74
49	Inherited cancer-predisposing syndrome	Enrichment	CYLD	0.42

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Ubiquitination Cascade

Pathway Network for Ubiquitination Cascade

Member Pathways for Ubiquitination Cascade

Pathways in the Ubiquitination Cascade SuperPath

Associated Genes for Ubiquitination Cascade

Associated Disorders for Ubiquitination Cascade

Disorders associated with Ubiquitination Cascade SuperPath

STRING Interaction Network for Ubiquitination Cascade

Sources for Ubiquitination Cascade