Unblocking of NMDA receptors, glutamate binding and activation

Pathway network for the Unblocking of NMDA receptors, glutamate binding and activation SuperPath

Sources:

Reactome

Pathways in the Unblocking of NMDA receptors, glutamate binding and activation SuperPath

#	Name	Source	Genes
1	Unblocking of NMDA receptors, glutamate binding and activation	Reactome	ACTN2 CALM1 CALM2 CALM3 CAMK2A CAMK2B CAMK2D CAMK2G DLG1 DLG2 DLG3 DLG4 GRIA1 GRIA2 GRIA3 GRIA4 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D NEFL (see all 22) (see less)
2	Long-term potentiation	Reactome	ACTN2 CALM1 CALM2 CALM3 CAMK2A CAMK2B CAMK2D CAMK2G DLG1 DLG2 DLG3 DLG4 ERBB4 GRIA1 GRIA2 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D NEFL NRG1 NRGN SRC (see all 24) (see less)
3	Negative regulation of NMDA receptor-mediated neuronal transmission	Reactome	ACTN2 CALM1 CALM2 CALM3 CAMK1 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 DLG1 DLG2 DLG3 DLG4 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D NEFL PPM1E PPM1F (see all 22) (see less)

Gene overlap in member pathways for Unblocking of NMDA receptors, glutamate binding and activation SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	DLG1	Discs Large MAGUK Scaffold Protein 1	Protein Coding	3
2	DLG2	Discs Large MAGUK Scaffold Protein 2	Protein Coding	3
3	DLG3	Discs Large MAGUK Scaffold Protein 3	Protein Coding	3
4	DLG4	Discs Large MAGUK Scaffold Protein 4	Protein Coding	3
5	GRIN1	Glutamate Ionotropic Receptor NMDA Type Subunit 1	Protein Coding	3
6	GRIN2A	Glutamate Ionotropic Receptor NMDA Type Subunit 2A	Protein Coding	3
7	GRIN2B	Glutamate Ionotropic Receptor NMDA Type Subunit 2B	Protein Coding	3
8	GRIN2C	Glutamate Ionotropic Receptor NMDA Type Subunit 2C	Protein Coding	3
9	GRIN2D	Glutamate Ionotropic Receptor NMDA Type Subunit 2D	Protein Coding	3
10	NEFL	Neurofilament Light Chain	Protein Coding	3
11	CALM1	Calmodulin 1	Protein Coding	3
12	CALM2	Calmodulin 2	Protein Coding	3
13	CALM3	Calmodulin 3	Protein Coding	3
14	CAMK2A	Calcium/Calmodulin Dependent Protein Kinase II Alpha	Protein Coding	3
15	CAMK2B	Calcium/Calmodulin Dependent Protein Kinase II Beta	Protein Coding	3
16	CAMK2D	Calcium/Calmodulin Dependent Protein Kinase II Delta	Protein Coding	3
17	CAMK2G	Calcium/Calmodulin Dependent Protein Kinase II Gamma	Protein Coding	3
18	ACTN2	Actinin Alpha 2	Protein Coding	3
19	GRIA1	Glutamate Ionotropic Receptor AMPA Type Subunit 1	Protein Coding	2
20	GRIA2	Glutamate Ionotropic Receptor AMPA Type Subunit 2	Protein Coding	2
21	GRIA3	Glutamate Ionotropic Receptor AMPA Type Subunit 3	Protein Coding	1
22	GRIA4	Glutamate Ionotropic Receptor AMPA Type Subunit 4	Protein Coding	1
23	ERBB4	Erb-B2 Receptor Tyrosine Kinase 4	Protein Coding	1
24	NRG1	Neuregulin 1	Protein Coding	1
25	NRGN	Neurogranin	Protein Coding	1
26	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
27	PPM1E	Protein Phosphatase, Mg2+/Mn2+ Dependent 1E	Protein Coding	1
28	CAMK4	Calcium/Calmodulin Dependent Protein Kinase IV	Protein Coding	1
29	CAMK1	Calcium/Calmodulin Dependent Protein Kinase I	Protein Coding	1
30	PPM1F	Protein Phosphatase, Mg2+/Mn2+ Dependent 1F	Protein Coding	1

Disorders associated with Unblocking of NMDA receptors, glutamate binding and activation SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Autosomal dominant non-syndromic intellectual disability	Enrichment	CAMK2A, CAMK2B, ERBB4, GRIA1, GRIN1, GRIN2B	9.59
2	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1, CALM2, CALM3	6.69
3	Long qt syndrome 1	Enrichment	CALM1, CALM2, CALM3	4.84
4	West syndrome	Enrichment	GRIA3, GRIN1, GRIN2B	4.33
5	Complex neurodevelopmental disorder	Enrichment	DLG4, GRIA4, GRIN2B	3.00
6	Long qt syndrome	Enrichment	CALM1, CALM2	2.95
7	Dystonia	Enrichment	CAMK2B, GRIA3	2.84
8	Epilepsy, focal, with speech disorder and with or without impaired intellectual development	Enrichment	GRIN2A	2.79
9	Cardiomyopathy, dilated, 1aa, with or without left ventricular noncompaction	Enrichment	ACTN2	2.79
10	Charcot-marie-tooth disease, demyelinating, type 1f	Enrichment	NEFL	2.79
11	Developmental and epileptic encephalopathy 27	Enrichment	GRIN2B	2.79
12	Intellectual developmental disorder, autosomal recessive 63	Enrichment	CAMK2A	2.79
13	Intellectual developmental disorder, autosomal dominant 54	Enrichment	CAMK2B	2.79
14	Congenital myopathy 8	Enrichment	ACTN2	2.79
15	Charcot-marie-tooth disease, dominant intermediate g	Enrichment	NEFL	2.79
16	Intellectual developmental disorder, x-linked, syndromic, wu type	Enrichment	GRIA3	2.79
17	Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal recessive	Enrichment	GRIN1	2.79
18	Intellectual developmental disorder, autosomal dominant 6, with or without seizures	Enrichment	GRIN2B	2.79
19	Charcot-marie-tooth disease type 1f	Enrichment	NEFL	2.79
20	Long qt syndrome 16	Enrichment	CALM3	2.79
21	Neurodevelopmental disorder with language impairment and behavioral abnormalities	Enrichment	GRIA2	2.79
22	Developmental and epileptic encephalopathy 101	Enrichment	GRIN1	2.79
23	Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominant	Enrichment	GRIN1	2.79
24	Neurodevelopmental disorder with or without seizures and gait abnormalities	Enrichment	GRIA4	2.79
25	Intellectual developmental disorder, autosomal dominant 67	Enrichment	GRIA1	2.79
26	Myopathy, distal, 6, adult-onset, autosomal dominant	Enrichment	ACTN2	2.79
27	Intellectual developmental disorder, autosomal dominant 53	Enrichment	CAMK2A	2.79
28	Intellectual developmental disorder, autosomal recessive 76	Enrichment	GRIA1	2.79
29	Intellectual developmental disorder, autosomal dominant 59	Enrichment	CAMK2G	2.79
30	Long qt syndrome 15	Enrichment	CALM2	2.79
31	Syndromic x-linked intellectual disability 94	Enrichment	GRIA3	2.79
32	Charcot-marie-tooth disease type 2b5	Enrichment	NEFL	2.79
33	Grin2b-related neurodevelopmental disorder	Enrichment	GRIN2B	2.79
34	Landau-kleffner syndrome	Enrichment	GRIN2A	2.79
35	Intellectual disability, autosomal dominant 8	Enrichment	GRIN1	2.79
36	Gria2-related neurodevelopmental disorder	Enrichment	GRIA2	2.79
37	Early-onset epileptic encephalopathy and intellectual disability due to grin2a mutation	Enrichment	GRIN2A	2.79
38	Grin2a-related disorders	Enrichment	GRIN2A	2.79
39	Amyotrophic lateral sclerosis 19	Enrichment	ERBB4	2.75
40	Thrombocytopenia 6	Enrichment	SRC	2.75
41	Epilepsy	Enrichment	GRIN2A, GRIN2B	2.72
42	Benign epilepsy with centrotemporal spikes	Enrichment	GRIN1, GRIN2A	2.70
43	Centralopathic epilepsy	Enrichment	GRIN1, GRIN2A	2.66
44	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	2.49
45	Long qt syndrome 14	Enrichment	CALM1	2.49
46	Intellectual developmental disorder, x-linked 90	Enrichment	DLG3	2.49
47	Bilateral generalized polymicrogyria	Enrichment	GRIN1	2.49
48	Intellectual developmental disorder, autosomal dominant 21	Enrichment	GRIN2A	2.49
49	Developmental and epileptic encephalopathy 46	Enrichment	GRIN2D	2.49
50	Vulto-van silfhout-de vries syndrome	Enrichment	DLG4	2.49
51	Rolandic epilepsy-speech dyspraxia syndrome	Enrichment	GRIN2A	2.49
52	Epilepsy-aphasia spectrum	Enrichment	GRIN2A	2.49
53	Autosomal recessive non-syndromic intellectual disability	Enrichment	GRIA1, GRIN1	2.41
54	Heart defects, congenital, and other congenital anomalies	Enrichment	DLG4	2.31
55	Auditory neuropathy and optic atrophy	Enrichment	GRIN2C	2.31
56	Intellectual developmental disorder, autosomal dominant 62	Enrichment	DLG4	2.31
57	Neurodevelopmental disorder with hypotonia and impaired expressive language and with or without seizures	Enrichment	DLG4	2.31
58	Intrinsic cardiomyopathy	Enrichment	ACTN2	2.31
59	Dlg4-related synaptopathy	Enrichment	DLG4	2.31
60	Acyl-coa dehydrogenase, very long-chain, deficiency of	Enrichment	DLG4	2.19
61	Astigmatism	Enrichment	GRIN2B	2.19
62	Mulibrey nanism	Enrichment	PPM1E	2.19
63	Charcot-marie-tooth disease, axonal, type 2e	Enrichment	NEFL	2.09
64	Sleep disorder	Enrichment	GRIN2B	2.09
65	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	2.01
66	Myelofibrosis	Enrichment	SRC	1.91
67	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	1.89
68	Autism spectrum disorder	Enrichment	GRIA1, GRIN2B	1.88
69	Microcephaly	Enrichment	CAMK2B, GRIN2B	1.78
70	Cleft lip/palate	Enrichment	DLG1	1.65
71	Nk-cell enteropathy	Enrichment	ERBB4	1.64
72	Osteoporosis	Enrichment	SRC	1.61
73	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	ACTN2	1.59
74	Sudden infant death syndrome	Enrichment	CALM2	1.56
75	Early infantile developmental and epileptic encephalopathy	Enrichment	GRIN1	1.54
76	Neuropathy, hereditary motor and sensory, okinawa type	Enrichment	NEFL	1.52
77	Craniosynostosis	Enrichment	GRIN2B	1.50
78	Scoliosis	Enrichment	GRIN2B	1.42
79	Developmental and epileptic encephalopathy 1	Enrichment	GRIN1	1.40
80	Auditory neuropathy	Enrichment	NEFL	1.38
81	Peripheral nervous system disease	Enrichment	NEFL	1.30
82	Neuropathy	Enrichment	NEFL	1.30
83	Familial hypertrophic cardiomyopathy	Enrichment	ACTN2	1.28
84	Left ventricular noncompaction	Enrichment	ACTN2	1.26
85	Non-syndromic x-linked intellectual disability	Enrichment	DLG3	1.25
86	Developmental and epileptic encephalopathy	Enrichment	GRIA3	1.25
87	Cerebral palsy	Enrichment	GRIN2B	1.21
88	Charcot-marie-tooth disease	Enrichment	NEFL	1.19
89	Hypertrophic cardiomyopathy	Enrichment	ACTN2	1.17
90	Sensorineural hearing loss	Enrichment	NEFL	1.12
91	Body mass index quantitative trait locus 11	Enrichment	GRIA4	1.11
92	Thrombocytopenia	Enrichment	SRC	1.09
93	Familial isolated dilated cardiomyopathy	Enrichment	ACTN2	1.08
94	Undetermined early-onset epileptic encephalopathy	Enrichment	GRIN2D	1.06
95	Schizophrenia	Enrichment	DLG2	1.04
96	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	ERBB4	1.01
97	Autism	Enrichment	CAMK2G	0.96
98	Dilated cardiomyopathy	Enrichment	ACTN2	0.91
99	Colorectal cancer	Enrichment	SRC	0.84
100	Congenital nervous system abnormality	Enrichment	CAMK2B	0.80
101	Nervous system disease	Enrichment	CAMK2B	0.80

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Unblocking of NMDA receptors, glutamate binding and activation

Pathway Network for Unblocking of NMDA receptors, glutamate binding and activation

Pathway network for the Unblocking of NMDA receptors, glutamate binding and activation SuperPath

Member Pathways for Unblocking of NMDA receptors, glutamate binding and activation

Pathways in the Unblocking of NMDA receptors, glutamate binding and activation SuperPath

Gene overlap in member pathways for Unblocking of NMDA receptors, glutamate binding and activation SuperPath

Associated Genes for Unblocking of NMDA receptors, glutamate binding and activation

Associated Disorders for Unblocking of NMDA receptors, glutamate binding and activation

Disorders associated with Unblocking of NMDA receptors, glutamate binding and activation SuperPath

STRING Interaction Network for Unblocking of NMDA receptors, glutamate binding and activation

Sources for Unblocking of NMDA receptors, glutamate binding and activation