Unfolded protein response

No Pathway Network information available for Unfolded protein response

Pathways in the Unfolded protein response SuperPath

#	Name	Source	Genes
1	Unfolded protein response	WikiPathways	ATF4 ATF6 BBC3 BCL2 BCL2L11 BID DDIT3 EIF2AK3 EIF2S1 ERN1 HSPA5 IL1B MBTPS1 MBTPS2 NFE2L2 PMAIP1 PPP1R15A RTCB TNFRSF10B TP53 TXNIP XBP1 (see all 22) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	EIF2AK3	Eukaryotic Translation Initiation Factor 2 Alpha Kinase 3	Protein Coding	1
2	TNFRSF10B	TNF Receptor Superfamily Member 10b	Protein Coding	1
3	MBTPS1	Membrane Bound Transcription Factor Peptidase, Site 1	Protein Coding	1
4	XBP1	X-Box Binding Protein 1	Protein Coding	1
5	TP53	Tumor Protein P53	Protein Coding	1
6	BID	BH3 Interacting Domain Death Agonist	Protein Coding	1
7	BCL2	BCL2 Apoptosis Regulator	Protein Coding	1
8	PMAIP1	Phorbol-12-Myristate-13-Acetate-Induced Protein 1	Protein Coding	1
9	MBTPS2	Membrane Bound Transcription Factor Peptidase, Site 2	Protein Coding	1
10	NFE2L2	NFE2 Like BZIP Transcription Factor 2	Protein Coding	1
11	ATF4	Activating Transcription Factor 4	Protein Coding	1
12	IL1B	Interleukin 1 Beta	Protein Coding	1
13	HSPA5	Heat Shock Protein Family A (Hsp70) Member 5	Protein Coding	1
14	BBC3	BCL2 Binding Component 3	Protein Coding	1
15	PPP1R15A	Protein Phosphatase 1 Regulatory Subunit 15A	Protein Coding	1
16	ATF6	Activating Transcription Factor 6	Protein Coding	1
17	ERN1	Endoplasmic Reticulum To Nucleus Signaling 1	Protein Coding	1
18	EIF2S1	Eukaryotic Translation Initiation Factor 2 Subunit Alpha	Protein Coding	1
19	DDIT3	DNA Damage Inducible Transcript 3	Protein Coding	1
20	TXNIP	Thioredoxin Interacting Protein	Protein Coding	1
21	BCL2L11	BCL2 Like 11	Protein Coding	1
22	RTCB	RNA 2'',3''-Cyclic Phosphate And 5''-OH Ligase	Protein Coding	1

Disorders associated with Unfolded protein response SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Squamous cell carcinoma, head and neck	Enrichment	TNFRSF10B, TP53	4.28
2	Olmsted syndrome, x-linked	Enrichment	MBTPS2	2.79
3	Osteogenesis imperfecta, type xix	Enrichment	MBTPS2	2.79
4	Keratosis follicularis spinulosa decalvans, x-linked	Enrichment	MBTPS2	2.79
5	Bone marrow failure syndrome 5	Enrichment	TP53	2.79
6	Immunodeficiency, developmental delay, and hypohomocysteinemia	Enrichment	NFE2L2	2.79
7	Papilloma of choroid plexus	Enrichment	TP53	2.79
8	Basal cell carcinoma 7	Enrichment	TP53	2.79
9	Anaplastic thyroid carcinoma	Enrichment	TP53	2.79
10	Major affective disorder 7	Enrichment	XBP1	2.79
11	Cataract, alopecia, oral mucosal disorder, and psoriasis-like syndrome	Enrichment	MBTPS1	2.79
12	Achromatopsia 7	Enrichment	ATF6	2.79
13	Ductal carcinoma in situ	Enrichment	TP53	2.79
14	Ifap syndrome	Enrichment	MBTPS2	2.79
15	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.79
16	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.79
17	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.79
18	Choroid plexus cancer	Enrichment	TP53	2.79
19	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.79
20	Bresek syndrome	Enrichment	MBTPS2	2.79
21	Gastric cancer	Enrichment	IL1B, TP53	2.66
22	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.49
23	Epiphyseal dysplasia, multiple, with early-onset diabetes mellitus	Enrichment	EIF2AK3	2.49
24	Cervical cancer	Enrichment	TP53	2.49
25	Lymphoma, hodgkin, classic	Enrichment	TP53	2.49
26	Intravascular large b-cell lymphoma	Enrichment	BCL2	2.49
27	Congenital fibrosarcoma	Enrichment	TP53	2.49
28	Li-fraumeni syndrome 1	Enrichment	TP53	2.49
29	Sarcoma	Enrichment	TP53	2.49
30	Cervix carcinoma	Enrichment	TP53	2.49
31	Hodgkin's lymphoma	Enrichment	TP53	2.49
32	Spondyloepiphyseal dysplasia, kondo-fu type	Enrichment	MBTPS1	2.49
33	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.49
34	Ifap syndrome 1, with or without bresheck syndrome	Enrichment	MBTPS2	2.31
35	Menkes disease	Enrichment	EIF2AK3	2.31
36	Osteogenic sarcoma	Enrichment	TP53	2.31
37	Nasopharyngeal carcinoma	Enrichment	TP53	2.31
38	Keratosis follicularis spinulosa decalvans	Enrichment	MBTPS2	2.31
39	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL2	2.31
40	Mutilating palmoplantar keratoderma with periorificial keratotic plaques	Enrichment	MBTPS2	2.31
41	Atypical teratoid rhabdoid tumor	Enrichment	TP53	2.31
42	Anaplastic astrocytoma	Enrichment	TP53	2.31
43	Myxoid liposarcoma	Enrichment	DDIT3	2.31
44	Squamous cell carcinoma	Enrichment	TP53	2.31
45	Adenocarcinoma	Enrichment	TP53	2.31
46	Laryngeal squamous cell carcinoma	Enrichment	TNFRSF10B	2.31
47	Bone osteosarcoma	Enrichment	TP53	2.31
48	Small cell cancer of the lung	Enrichment	TP53	2.19
49	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	2.19
50	Lung sarcomatoid carcinoma	Enrichment	TP53	2.19
51	Embryonal rhabdomyosarcoma	Enrichment	TP53	2.19
52	Rhabdomyosarcoma 2	Enrichment	TP53	2.09
53	Follicular lymphoma	Enrichment	BCL2	2.09
54	Lymphoma	Enrichment	TP53	2.09
55	Acute megakaryocytic leukemia	Enrichment	TP53	2.09
56	Colorectal cancer	Enrichment	NFE2L2, TP53	2.06
57	Li-fraumeni syndrome	Enrichment	TP53	2.01
58	Osteogenesis imperfecta, type i	Enrichment	MBTPS2	2.01
59	Adrenocortical carcinoma	Enrichment	TP53	2.01
60	Breast adenocarcinoma	Enrichment	TP53	2.01
61	Esophageal cancer	Enrichment	TP53	1.95
62	Essential thrombocythemia	Enrichment	TP53	1.95
63	Gallbladder cancer	Enrichment	TP53	1.95
64	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	1.95
65	Glioma susceptibility 1	Enrichment	TP53	1.89
66	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.89
67	Adult hepatocellular carcinoma	Enrichment	TP53	1.84
68	Primary hyperaldosteronism	Enrichment	TP53	1.84
69	Leukemia, chronic lymphocytic	Enrichment	TP53	1.79
70	Achromatopsia	Enrichment	ATF6	1.79
71	Familial colorectal cancer	Enrichment	TP53	1.79
72	Myelodysplastic syndrome	Enrichment	TP53	1.75
73	Lip and oral cavity carcinoma	Enrichment	TP53	1.71
74	Osteogenesis imperfecta, type iv	Enrichment	MBTPS2	1.68
75	Lung cancer susceptibility 3	Enrichment	TP53	1.65
76	Osteogenesis imperfecta, type iii	Enrichment	MBTPS2	1.62
77	Rhabdomyosarcoma	Enrichment	TP53	1.59
78	Gliosarcoma	Enrichment	TP53	1.59
79	Giant cell glioblastoma	Enrichment	TP53	1.56
80	Diffuse large b-cell lymphoma	Enrichment	TP53	1.52
81	Hepatoblastoma	Enrichment	TP53	1.47
82	Hepatocellular carcinoma	Enrichment	TP53	1.45
83	Diamond-blackfan anemia 1	Enrichment	TP53	1.44
84	Pancreatic cancer	Enrichment	TP53	1.40
85	Bladder cancer	Enrichment	TP53	1.34
86	Prostate cancer	Enrichment	TP53	1.34
87	Lung cancer	Enrichment	NFE2L2	1.30
88	Diamond-blackfan anemia	Enrichment	TP53	1.25
89	Leukemia, acute myeloid	Enrichment	TP53	1.20
90	Hereditary breast carcinoma	Enrichment	TP53	1.16
91	Hereditary breast ovarian cancer syndrome	Enrichment	TP53	1.07
92	Myeloma, multiple	Enrichment	TP53	1.06
93	Cone-rod dystrophy 2	Enrichment	ATF6	0.98
94	Breast cancer	Enrichment	TP53	0.94
95	Ovarian cancer	Enrichment	TP53	0.82
96	Inherited cancer-predisposing syndrome	Enrichment	TP53	0.71
97	Hereditary retinal dystrophy	Enrichment	ATF6	0.42
98	Fundus dystrophy	Enrichment	ATF6	0.42

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Unfolded protein response

Pathway Network for Unfolded protein response

Member Pathways for Unfolded protein response

Pathways in the Unfolded protein response SuperPath

Associated Genes for Unfolded protein response

Associated Disorders for Unfolded protein response

Disorders associated with Unfolded protein response SuperPath

STRING Interaction Network for Unfolded protein response

Sources for Unfolded protein response