Unfolded Protein Response (UPR)

Pathway network for the Unfolded Protein Response (UPR) SuperPath

Sources:

Reactome

Pathways in the Unfolded Protein Response (UPR) SuperPath

#	Name	Source	Genes
1	Unfolded Protein Response (UPR)	Reactome	ACADVL ARFGAP1 ASNS ATF3 ATF4 ATF6 ATF6B ATP6V0D1 CALR CCL2 CEBPB CEBPG CREB3 CREB3L1 CREB3L2 CREB3L3 CREB3L4 CREBRF CTDSP2 CUL7 CXCL8 CXXC1 DCP2 DCSTAMP DCTN1 DDIT3 DDX11 DIS3 DNAJB11 DNAJB9 DNAJC3 EDEM1 EIF2AK3 EIF2S1 EIF2S2 EIF2S3 ERN1 EXOSC1 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 EXTL1 EXTL2 EXTL3 FKBP14 GFPT1 GOSR2 GSK3A HDGF HERPUD1 HSP90B1 HSPA5 HYOU1 IGFBP1 KDELR3 KHSRP KLHDC3 LMNA MBTPS1 MBTPS2 MYDGF NFYA NFYB NFYC PARN PDIA5 PDIA6 PLA2G4B PPP2R5B PREB SEC31A SERP1 SHC1 SRPRA SRPRB SSR1 SULT1A3 SULT1A4 SYVN1 TATDN2 TLN1 TPP1 TSPYL2 WFS1 WIPI1 XBP1 YIF1A ZBTB17 (see all 93) (see less)
2	IRE1alpha activates chaperones	Reactome	ACADVL ARFGAP1 ATP6V0D1 CTDSP2 CUL7 CXXC1 DCTN1 DDX11 DNAJB11 DNAJB9 DNAJC3 EDEM1 ERN1 EXTL1 EXTL2 EXTL3 FKBP14 GFPT1 GOSR2 GSK3A HDGF HSPA5 HYOU1 KDELR3 KLHDC3 LMNA MYDGF PDIA5 PDIA6 PLA2G4B PPP2R5B PREB SEC31A SERP1 SHC1 SRPRA SRPRB SSR1 SULT1A3 SULT1A4 SYVN1 TATDN2 TLN1 TPP1 TSPYL2 WFS1 WIPI1 XBP1 YIF1A ZBTB17 (see all 50) (see less)
3	XBP1(S) activates chaperone genes	Reactome	ACADVL ARFGAP1 ATP6V0D1 CTDSP2 CUL7 CXXC1 DCTN1 DDX11 DNAJB11 DNAJB9 DNAJC3 EDEM1 EXTL1 EXTL2 EXTL3 FKBP14 GFPT1 GOSR2 GSK3A HDGF HYOU1 KDELR3 KLHDC3 LMNA MYDGF PDIA5 PDIA6 PLA2G4B PPP2R5B PREB SEC31A SERP1 SHC1 SRPRA SRPRB SSR1 SULT1A3 SULT1A4 SYVN1 TATDN2 TLN1 TPP1 TSPYL2 WFS1 WIPI1 XBP1 YIF1A ZBTB17 (see all 48) (see less)
4	ATF6 (ATF6-alpha) activates chaperones	Reactome	ATF4 ATF6 CALR DDIT3 HSP90B1 HSPA5 MBTPS1 MBTPS2 NFYA NFYB NFYC XBP1 (see all 12) (see less)
5	ATF6 (ATF6-alpha) activates chaperone genes	Reactome	ATF4 ATF6 CALR DDIT3 HSP90B1 HSPA5 NFYA NFYB NFYC XBP1 (see all 10) (see less)
6	CREB3 factors activate genes	Reactome	CREB3 CREB3L1 CREB3L2 CREB3L3 CREB3L4 CREBRF DCSTAMP MBTPS1 MBTPS2 (see all 9) (see less)
7	ATF6B (ATF6-beta) activates chaperones	Reactome	ATF6B HSPA5 MBTPS1 MBTPS2

Gene overlap in member pathways for Unfolded Protein Response (UPR) SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	HSPA5	Heat Shock Protein Family A (Hsp70) Member 5	Protein Coding	5
2	XBP1	X-Box Binding Protein 1	Protein Coding	5
3	MBTPS2	Membrane Bound Transcription Factor Peptidase, Site 2	Protein Coding	4
4	MBTPS1	Membrane Bound Transcription Factor Peptidase, Site 1	Protein Coding	4
5	PLA2G4B	Phospholipase A2 Group IVB	Protein Coding	3
6	CTDSP2	CTD Small Phosphatase 2	Protein Coding	3
7	PREB	Prolactin Regulatory Element Binding	Protein Coding	3
8	PDIA6	Protein Disulfide Isomerase Family A Member 6	Protein Coding	3
9	HYOU1	Hypoxia Up-Regulated 1	Protein Coding	3
10	YIF1A	Yip1 Interacting Factor Homolog A, Membrane Trafficking Protein	Protein Coding	3
11	PDIA5	Protein Disulfide Isomerase Family A Member 5	Protein Coding	3
12	KDELR3	KDEL Endoplasmic Reticulum Protein Retention Receptor 3	Protein Coding	3
13	KLHDC3	Kelch Domain Containing 3	Protein Coding	3
14	TPP1	Tripeptidyl Peptidase 1	Protein Coding	3
15	DCTN1	Dynactin Subunit 1	Protein Coding	3
16	DDIT3	DNA Damage Inducible Transcript 3	Protein Coding	3
17	DDX11	DEAD/H-Box Helicase 11	Protein Coding	3
18	EXTL1	Exostosin Like Glycosyltransferase 1	Protein Coding	3
19	EXTL2	Exostosin Like Glycosyltransferase 2	Protein Coding	3
20	EXTL3	Exostosin Like Glycosyltransferase 3	Protein Coding	3
21	SEC31A	SEC31 Homolog A, COPII Component	Protein Coding	3
22	ATF6	Activating Transcription Factor 6	Protein Coding	3
23	GFPT1	Glutamine--Fructose-6-Phosphate Transaminase 1	Protein Coding	3
24	SERP1	Stress Associated Endoplasmic Reticulum Protein 1	Protein Coding	3
25	GSK3A	Glycogen Synthase Kinase 3 Alpha	Protein Coding	3
26	HDGF	Heparin Binding Growth Factor	Protein Coding	3
27	CXXC1	CXXC Finger Protein 1	Protein Coding	3
28	ACADVL	Acyl-CoA Dehydrogenase Very Long Chain	Protein Coding	3
29	LMNA	Lamin A/C	Protein Coding	3
30	DNAJB9	DnaJ Heat Shock Protein Family (Hsp40) Member B9	Protein Coding	3
31	SULT1A4	Sulfotransferase Family 1A Member 4	Protein Coding	3
32	ATF4	Activating Transcription Factor 4	Protein Coding	3
33	NFYA	Nuclear Transcription Factor Y Subunit Alpha	Protein Coding	3
34	NFYB	Nuclear Transcription Factor Y Subunit Beta	Protein Coding	3
35	NFYC	Nuclear Transcription Factor Y Subunit Gamma	Protein Coding	3
36	DNAJB11	DnaJ Heat Shock Protein Family (Hsp40) Member B11	Protein Coding	3
37	FKBP14	FKBP Prolyl Isomerase 14	Protein Coding	3
38	WIPI1	WD Repeat Domain, Phosphoinositide Interacting 1	Protein Coding	3
39	PPP2R5B	Protein Phosphatase 2 Regulatory Subunit B''Beta	Protein Coding	3
40	ARFGAP1	ARF GTPase Activating Protein 1	Protein Coding	3
41	MYDGF	Myeloid Derived Growth Factor	Protein Coding	3
42	DNAJC3	DnaJ Heat Shock Protein Family (Hsp40) Member C3	Protein Coding	3
43	SRPRB	SRP Receptor Subunit Beta	Protein Coding	3
44	TSPYL2	TSPY Like 2	Protein Coding	3
45	SHC1	SHC Adaptor Protein 1	Protein Coding	3
46	SRPRA	SRP Receptor Subunit Alpha	Protein Coding	3
47	SSR1	Signal Sequence Receptor Subunit 1	Protein Coding	3
48	SULT1A3	Sulfotransferase Family 1A Member 3	Protein Coding	3
49	TLN1	Talin 1	Protein Coding	3
50	HSP90B1	Heat Shock Protein 90 Beta Family Member 1	Protein Coding	3
51	WFS1	Wolframin ER Transmembrane Glycoprotein	Protein Coding	3
52	ZBTB17	Zinc Finger And BTB Domain Containing 17	Protein Coding	3
53	CALR	Calreticulin	Protein Coding	3
54	SYVN1	Synoviolin 1	Protein Coding	3
55	ATP6V0D1	ATPase H+ Transporting V0 Subunit D1	Protein Coding	3
56	GOSR2	Golgi SNAP Receptor Complex Member 2	Protein Coding	3
57	EDEM1	ER Degradation Enhancing Alpha-Mannosidase Like Protein 1	Protein Coding	3
58	TATDN2	TatD DNase Domain Containing 2	Protein Coding	3
59	CUL7	Cullin 7	Protein Coding	3
60	CREB3	CAMP Responsive Element Binding Protein 3	Protein Coding	2
61	ATF6B	Activating Transcription Factor 6 Beta	Protein Coding	2
62	CREB3L4	CAMP Responsive Element Binding Protein 3 Like 4	Protein Coding	2
63	CREBRF	CREB3 Regulatory Factor	Protein Coding	2
64	ERN1	Endoplasmic Reticulum To Nucleus Signaling 1	Protein Coding	2
65	CREB3L2	CAMP Responsive Element Binding Protein 3 Like 2	Protein Coding	2
66	DCSTAMP	Dendrocyte Expressed Seven Transmembrane Protein	Protein Coding	2
67	CREB3L3	CAMP Responsive Element Binding Protein 3 Like 3	Protein Coding	2
68	CREB3L1	CAMP Responsive Element Binding Protein 3 Like 1	Protein Coding	2
69	CEBPB	CCAAT Enhancer Binding Protein Beta	Protein Coding	1
70	CEBPG	CCAAT Enhancer Binding Protein Gamma	Protein Coding	1
71	EXOSC8	Exosome Component 8	Protein Coding	1
72	EXOSC6	Exosome Component 6	Protein Coding	1
73	DCP2	Decapping MRNA 2	Protein Coding	1
74	EIF2S1	Eukaryotic Translation Initiation Factor 2 Subunit Alpha	Protein Coding	1
75	EIF2S3	Eukaryotic Translation Initiation Factor 2 Subunit Gamma	Protein Coding	1
76	DIS3	DIS3 Exosome Endoribonuclease And 3''''-5'''' Exoribonuclease	Protein Coding	1
77	EXOSC7	Exosome Component 7	Protein Coding	1
78	EXOSC2	Exosome Component 2	Protein Coding	1
79	IGFBP1	Insulin Like Growth Factor Binding Protein 1	Protein Coding	1
80	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	1
81	ASNS	Asparagine Synthetase (Glutamine-Hydrolyzing)	Protein Coding	1
82	ATF3	Activating Transcription Factor 3	Protein Coding	1
83	PARN	Poly(A)-Specific Ribonuclease	Protein Coding	1
84	EXOSC3	Exosome Component 3	Protein Coding	1
85	EXOSC1	Exosome Component 1	Protein Coding	1
86	EXOSC9	Exosome Component 9	Protein Coding	1
87	EXOSC4	Exosome Component 4	Protein Coding	1
88	EXOSC5	Exosome Component 5	Protein Coding	1
89	CCL2	C-C Motif Chemokine Ligand 2	Protein Coding	1
90	KHSRP	KH-Type Splicing Regulatory Protein	Protein Coding	1
91	EIF2S2	Eukaryotic Translation Initiation Factor 2 Subunit Beta	Protein Coding	1
92	EIF2AK3	Eukaryotic Translation Initiation Factor 2 Alpha Kinase 3	Protein Coding	1
93	HERPUD1	Homocysteine Inducible ER Protein With Ubiquitin Like Domain 1	Protein Coding	1

Disorders associated with Unfolded Protein Response (UPR) SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Myxofibrosarcoma	Enrichment	CREB3L1, CREB3L2	5.93
2	Pontocerebellar hypoplasia, type 1e	Enrichment	EXOSC3, EXOSC8, EXOSC9	5.21
3	Osteogenesis imperfecta, type iii	Enrichment	CREB3L1, MBTPS2	4.39
4	Olmsted syndrome, x-linked	Enrichment	MBTPS2	3.53
5	Osteogenesis imperfecta, type xix	Enrichment	MBTPS2	3.53
6	Keratosis follicularis spinulosa decalvans, x-linked	Enrichment	MBTPS2	3.53
7	Cataract, alopecia, oral mucosal disorder, and psoriasis-like syndrome	Enrichment	MBTPS1	3.53
8	Ifap syndrome	Enrichment	MBTPS2	3.53
9	Bresek syndrome	Enrichment	MBTPS2	3.53
10	Congenital muscular dystrophy	Enrichment	FKBP14, LMNA	3.47
11	Spondyloepiphyseal dysplasia, kondo-fu type	Enrichment	MBTPS1	3.23
12	Osteogenesis imperfecta, type xvi	Enrichment	CREB3L1	3.18
13	Hypertriglyceridemia 2	Enrichment	CREB3L3	3.18
14	Major affective disorder 7	Enrichment	XBP1	3.13
15	Achromatopsia 7	Enrichment	ATF6	3.13
16	Ifap syndrome 1, with or without bresheck syndrome	Enrichment	MBTPS2	3.05
17	Keratosis follicularis spinulosa decalvans	Enrichment	MBTPS2	3.05
18	Mutilating palmoplantar keratoderma with periorificial keratotic plaques	Enrichment	MBTPS2	3.05
19	Transient infantile hypertriglyceridemia and hepatosteatosis	Enrichment	CREB3L3	2.88
20	Osteogenesis imperfecta, type i	Enrichment	MBTPS2	2.75
21	Thrombocythemia 1	Enrichment	CALR	2.66
22	Myxoid liposarcoma	Enrichment	DDIT3	2.66
23	Hypertriglyceridemia 1	Enrichment	CREB3L3	2.58
24	Budd-chiari syndrome	Enrichment	CALR	2.53
25	Cataract 41	Enrichment	WFS1	2.45
26	Perry syndrome	Enrichment	DCTN1	2.45
27	Wolfram syndrome 1	Enrichment	WFS1	2.45
28	Deafness, autosomal dominant 6	Enrichment	WFS1	2.45
29	Spinocerebellar ataxia, autosomal recessive 7	Enrichment	TPP1	2.45
30	Wolfram-like syndrome, autosomal dominant	Enrichment	WFS1	2.45
31	Halperin-birk syndrome	Enrichment	SEC31A	2.45
32	Immunoskeletal dysplasia with neurodevelopmental abnormalities	Enrichment	EXTL3	2.45
33	Neuronopathy, distal hereditary motor, autosomal dominant 14	Enrichment	DCTN1	2.45
34	Warsaw breakage syndrome	Enrichment	DDX11	2.45
35	Atypical werner syndrome	Enrichment	LMNA	2.45
36	Polycystic kidney disease 6 with or without polycystic liver disease	Enrichment	DNAJB11	2.45
37	Mandibuloacral dysplasia	Enrichment	LMNA	2.45
38	Atrioventricular block	Enrichment	LMNA	2.45
39	Wolfram-like syndrome	Enrichment	WFS1	2.45
40	Capillary leak syndrome	Enrichment	TLN1	2.45
41	Lmna-related cardiocutaneous progeria syndrome	Enrichment	LMNA	2.45
42	Skeletal dysplasia-t-cell immunodeficiency-developmental delay syndrome	Enrichment	EXTL3	2.45
43	Autosomal semi-dominant severe lipodystrophic laminopathy	Enrichment	LMNA	2.45
44	Wfs1 spectrum disorder	Enrichment	WFS1	2.45
45	Autosomal recessive axonal hereditary motor and sensory neuropathy	Enrichment	LMNA	2.45
46	Laminopathy	Enrichment	LMNA	2.45
47	Osteogenesis imperfecta, type iv	Enrichment	MBTPS2	2.42
48	Myelofibrosis	Enrichment	CALR	2.29
49	Essential thrombocythemia	Enrichment	CALR	2.29
50	Pontocerebellar hypoplasia	Enrichment	EXOSC3, EXOSC9	2.18
51	Dyskeratosis congenita, autosomal recessive 6	Enrichment	PARN	2.16
52	Pontocerebellar hypoplasia, type 1f	Enrichment	EXOSC1	2.16
53	Mehmo syndrome	Enrichment	EIF2S3	2.16
54	Cerebellar ataxia, brain abnormalities, and cardiac conduction defects	Enrichment	EXOSC5	2.16
55	Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 4	Enrichment	PARN	2.16
56	Pontocerebellar hypoplasia, type 1c	Enrichment	EXOSC8	2.16
57	Pontocerebellar hypoplasia, type 1d	Enrichment	EXOSC9	2.16
58	Short stature, hearing loss, retinitis pigmentosa, and distinctive facies	Enrichment	EXOSC2	2.16
59	Mandibuloacral dysplasia with type a lipodystrophy	Enrichment	LMNA	2.15
60	Ceroid lipofuscinosis, neuronal, 2	Enrichment	TPP1	2.15
61	Immunodeficiency 59 and hypoglycemia	Enrichment	HYOU1	2.15
62	Heart-hand syndrome, slovenian type	Enrichment	LMNA	2.15
63	Charcot-marie-tooth disease, axonal, type 2b1	Enrichment	LMNA	2.15
64	Cardiomyopathy, dilated, with hypergonadotropic hypogonadism	Enrichment	LMNA	2.15
65	Ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus	Enrichment	DNAJC3	2.15
66	Myasthenic syndrome, congenital, 12	Enrichment	GFPT1	2.15
67	Ceroid lipofuscinosis, neuronal, 3	Enrichment	TPP1	2.15
68	Cardiomyopathy, dilated, 1d	Enrichment	LMNA	2.15
69	Restrictive dermopathy 2	Enrichment	LMNA	2.15
70	Emery-dreifuss muscular dystrophy 3, autosomal recessive	Enrichment	LMNA	2.15
71	Ehlers-danlos syndrome, kyphoscoliotic type, 2	Enrichment	FKBP14	2.15
72	Lipodystrophy, familial partial, type 1	Enrichment	LMNA	2.15
73	Wolfram syndrome	Enrichment	WFS1	2.15
74	Distal hereditary motor neuropathy type 7	Enrichment	DCTN1	2.15
75	Familial partial lipodystrophy	Enrichment	LMNA	2.15
76	Charcot-marie-tooth disease type 2b1	Enrichment	LMNA	2.15
77	Achromatopsia	Enrichment	ATF6	2.13
78	Charcot-marie-tooth disease	Enrichment	DCTN1, LMNA	2.04
79	Three m syndrome 1	Enrichment	CUL7	1.98
80	Heart defects, congenital, and other congenital anomalies	Enrichment	ACADVL	1.98
81	Restrictive dermopathy 1	Enrichment	LMNA	1.98
82	Lipodystrophy, familial partial, type 2	Enrichment	LMNA	1.98
83	Muscular dystrophy, congenital, lmna-related	Enrichment	LMNA	1.98
84	Epilepsy, progressive myoclonic, 6	Enrichment	GOSR2	1.98
85	Muscular dystrophy, congenital, with or without seizures	Enrichment	GOSR2	1.98
86	Intellectual developmental disorder, autosomal dominant 62	Enrichment	ACADVL	1.98
87	Dlg4-related synaptopathy	Enrichment	ACADVL	1.98
88	Restrictive dermopathy	Enrichment	LMNA	1.98
89	Epiphyseal dysplasia, multiple, with early-onset diabetes mellitus	Enrichment	EIF2AK3	1.86
90	Congenital pontocerebellar hypoplasia type 1	Enrichment	EXOSC3	1.86
91	Hutchinson-gilford progeria syndrome	Enrichment	LMNA	1.85
92	Acyl-coa dehydrogenase, very long-chain, deficiency of	Enrichment	ACADVL	1.85
93	Emery-dreifuss muscular dystrophy 1, x-linked	Enrichment	LMNA	1.85
94	Microtia-anotia	Enrichment	LMNA	1.85
95	Emery-dreifuss muscular dystrophy	Enrichment	LMNA	1.85
96	Sick sinus syndrome	Enrichment	LMNA	1.85
97	Brittle bone disorder	Enrichment	CREB3L1	1.82
98	Autosomal recessive limb-girdle muscular dystrophy type 2b	Enrichment	LMNA	1.76
99	Histiocytoid hemangioma	Enrichment	LMNA	1.76
100	Genetic motor neuron disease	Enrichment	DCTN1	1.76
101	Congenital myasthenic syndromes with glycosylation defect	Enrichment	GFPT1	1.76
102	Menkes disease	Enrichment	EIF2AK3	1.69
103	Pontocerebellar hypoplasia, type 1b	Enrichment	EXOSC3	1.69
104	Cerebellar disease	Enrichment	EXOSC3	1.69
105	Asparagine synthetase deficiency	Enrichment	ASNS	1.69
106	Congenital microcephaly - severe encephalopathy - progressive cerebral atrophy syndrome	Enrichment	ASNS	1.69
107	Spinocerebellar ataxia, autosomal recessive 29	Enrichment	ASNS	1.69
108	Angelman syndrome	Enrichment	TPP1	1.68
109	Emery-dreifuss muscular dystrophy 2, autosomal dominant	Enrichment	LMNA	1.68
110	Shwachman-diamond syndrome 1	Enrichment	SRPRA	1.68
111	Bethlem myopathy 1a	Enrichment	LMNA	1.61
112	Polymicrogyria, bilateral perisylvian, x-linked	Enrichment	WFS1	1.61
113	Severe congenital neutropenia	Enrichment	SRPRA	1.55
114	Myocarditis	Enrichment	LMNA	1.55
115	Arrhythmogenic right ventricular dysplasia, familial, 9	Enrichment	LMNA	1.50
116	Bilateral perisylvian polymicrogyria	Enrichment	WFS1	1.50
117	Cystic kidney disease	Enrichment	DNAJB11	1.50
118	Amyotrophic lateral sclerosis 1	Enrichment	DCTN1	1.46
119	Myasthenic syndrome, congenital, 4c, associated with acetylcholine receptor deficiency	Enrichment	GFPT1	1.46
120	Progressive myoclonus epilepsy	Enrichment	GOSR2	1.46
121	Frontotemporal dementia 1	Enrichment	DCTN1	1.42
122	Diabetes mellitus	Enrichment	WFS1	1.42
123	Pulmonary fibrosis	Enrichment	PARN	1.39
124	Hoyeraal-hreidarsson syndrome	Enrichment	PARN	1.39
125	Cardiac conduction defect	Enrichment	LMNA	1.38
126	Muscular dystrophy, limb-girdle, autosomal recessive 2	Enrichment	LMNA	1.38
127	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	LMNA	1.38
128	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	LMNA	1.38
129	Myoclonic epilepsy of unverricht and lundborg	Enrichment	GOSR2	1.31
130	Congenital myasthenic syndrome	Enrichment	GFPT1	1.31
131	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	LMNA	1.31
132	Cone-rod dystrophy 2	Enrichment	ATF6	1.31
133	Spastic ataxia	Enrichment	EXOSC8, WFS1	1.29
134	Neuronal ceroid lipofuscinosis	Enrichment	TPP1	1.29
135	Autosomal dominant polycystic kidney disease	Enrichment	DNAJB11	1.29
136	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	LMNA	1.26
137	Cardiomyopathy, dilated, 1e	Enrichment	LMNA	1.23
138	Neuromuscular disease	Enrichment	LMNA	1.21
139	Polycystic kidney disease	Enrichment	DNAJB11	1.21
140	Early-onset nuclear cataract	Enrichment	WFS1	1.21
141	Neuropathy, hereditary motor and sensory, okinawa type	Enrichment	LMNA	1.19
142	Cardiomyopathy, dilated, 1a	Enrichment	LMNA	1.14
143	Cardiomyopathy, familial hypertrophic, 1	Enrichment	LMNA	1.09
144	Muscular dystrophy	Enrichment	LMNA	1.09
145	Brugada syndrome	Enrichment	LMNA	1.05
146	Long qt syndrome	Enrichment	LMNA	0.98
147	Peripheral nervous system disease	Enrichment	LMNA	0.97
148	Neuropathy	Enrichment	LMNA	0.97
149	Interstitial lung disease 2	Enrichment	PARN	0.96
150	Human immunodeficiency virus type 1	Enrichment	CCL2	0.93
151	Left ventricular noncompaction	Enrichment	LMNA	0.93
152	Non-syndromic genetic deafness	Enrichment	WFS1	0.92
153	Congenital myopathy	Enrichment	EXOSC3	0.91
154	Dyskeratosis congenita	Enrichment	PARN	0.91
155	Myopathy	Enrichment	ACADVL	0.88
156	Lissencephaly	Enrichment	EXOSC3	0.87
157	Type 2 diabetes mellitus	Enrichment	WFS1	0.86
158	Nonsyndromic hearing loss	Enrichment	WFS1	0.86
159	Optic atrophy plus syndrome	Enrichment	WFS1	0.84
160	Congenital nervous system abnormality	Enrichment	EXOSC3, TPP1	0.78
161	Nervous system disease	Enrichment	EXOSC3, TPP1	0.78
162	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	WFS1	0.77
163	Familial isolated dilated cardiomyopathy	Enrichment	LMNA	0.77
164	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	DCTN1	0.73
165	Hereditary retinal dystrophy	Enrichment	ATF6	0.71
166	Fundus dystrophy	Enrichment	ATF6	0.71
167	Deafness, autosomal recessive	Enrichment	GOSR2	0.70
168	Autosomal recessive nonsyndromic deafness	Enrichment	GOSR2	0.69
169	Fetal akinesia deformation sequence 1	Enrichment	EXOSC3	0.65
170	Breast cancer	Enrichment	SHC1	0.63
171	Rare genetic deafness	Enrichment	WFS1	0.61
172	Dilated cardiomyopathy	Enrichment	LMNA	0.61
173	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	GOSR2	0.57
174	Hereditary breast ovarian cancer syndrome	Enrichment	HERPUD1	0.50
175	Myeloma, multiple	Enrichment	DIS3	0.49
176	Microcephaly	Enrichment	EXOSC3	0.24

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Unfolded Protein Response (UPR)

Pathway Network for Unfolded Protein Response (UPR)

Pathway network for the Unfolded Protein Response (UPR) SuperPath

Member Pathways for Unfolded Protein Response (UPR)

Pathways in the Unfolded Protein Response (UPR) SuperPath

Gene overlap in member pathways for Unfolded Protein Response (UPR) SuperPath

Associated Genes for Unfolded Protein Response (UPR)

Associated Disorders for Unfolded Protein Response (UPR)

Disorders associated with Unfolded Protein Response (UPR) SuperPath

STRING Interaction Network for Unfolded Protein Response (UPR)

Sources for Unfolded Protein Response (UPR)