Uptake and actions of bacterial toxins

Pathway network for the Uptake and actions of bacterial toxins SuperPath

Sources:

Reactome

Pathways in the Uptake and actions of bacterial toxins SuperPath

#	Name	Source	Genes
1	Uptake and actions of bacterial toxins	Reactome	ANTXR1 ANTXR2 CALM1 CALM2 CALM3 CD9 EEF2 FURIN GUCY2C HBEGF HSP90AA1 HSP90AB1 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 NHERF4 SNAP25 STX1A STX1B SV2A SV2B SV2C SYT1 SYT2 TXNRD1 VAMP1 VAMP2 (see all 30) (see less)
2	Bacterial Infection Pathways	Reactome	ANTXR1 ANTXR2 ATP6V1H B2M CALM1 CALM2 CALM3 CBL CBLL1 CD9 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 COL5A1 COL5A2 COL5A3 CORO1A CTNNB1 CTNND1 CTSG DUSP16 EEF2 ENO1 EPCAM EPS15 FN1 FURIN GRB2 GSK3A GUCY2C HBA1 HBA2 HBB HBEGF HGS HSP90AA1 HSP90AB1 KPNA1 KPNB1 LAMA1 LAMA2 LAMA3 LAMA4 LAMA5 LAMB1 LAMB2 LAMB3 LAMC1 LAMC2 LAMC3 LTF MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAPK1 MAPK3 MET MRC1 NHERF4 NOS2 PGK1 RAB5A RAB7A RNF213 RPS27A SFPQ SH3GL1 SH3GL2 SH3GL3 SH3KBP1 SNAP25 SRC STAM STAM2 STX1A STX1B SV2A SV2B SV2C SYT1 SYT2 TLR2 TRIM27 TXNRD1 UBA52 UBB UBC UPK1A VAMP1 VAMP2 VPS33B (see all 97) (see less)
3	Listeria monocytogenes entry into host cells	Reactome	CBL CBLL1 CTNNB1 CTNND1 EPS15 GRB2 HGS MET RPS27A SH3GL1 SH3GL2 SH3GL3 SH3KBP1 SRC STAM STAM2 UBA52 UBB UBC (see all 19) (see less)
4	InlB-mediated entry of Listeria monocytogenes into host cell	Reactome	CBL EPS15 GRB2 HGS MET RPS27A SH3GL1 SH3GL2 SH3GL3 SH3KBP1 STAM STAM2 UBA52 UBB UBC (see all 15) (see less)
5	Uptake and function of anthrax toxins	Reactome	ANTXR1 ANTXR2 CALM1 CALM2 CALM3 FURIN MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 (see all 12) (see less)
6	Neurotoxicity of clostridium toxins	Reactome	SNAP25 STX1A STX1B SV2A SV2B SV2C SYT1 SYT2 VAMP1 VAMP2 (see all 10) (see less)
7	InlA-mediated entry of Listeria monocytogenes into host cells	Reactome	CBLL1 CTNNB1 CTNND1 RPS27A SRC UBA52 UBB UBC (see all 8) (see less)
8	Uptake and function of diphtheria toxin	Reactome	CD9 EEF2 HBEGF HSP90AA1 HSP90AB1 TXNRD1 (see all 6) (see less)
9	Toxicity of botulinum toxin type A (botA)	Reactome	SNAP25 SV2A SV2B SV2C
10	Toxicity of botulinum toxin type G (botG)	Reactome	SYT1 VAMP1 VAMP2
11	Toxicity of botulinum toxin type B (botB)	Reactome	SYT1 SYT2 VAMP2
12	Toxicity of botulinum toxin type E (botE)	Reactome	SNAP25 SV2A SV2B
13	Toxicity of botulinum toxin type C (botC)	Reactome	SNAP25 STX1A STX1B
14	Intestinal infectious diseases	Reactome	GUCY2C NHERF4
15	Toxicity of tetanus toxin (tetX)	Reactome	VAMP2

Gene overlap in member pathways for Uptake and actions of bacterial toxins SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SNAP25	Synaptosome Associated Protein 25	Protein Coding	6
2	VAMP2	Vesicle Associated Membrane Protein 2	Protein Coding	6
3	SYT1	Synaptotagmin 1	Protein Coding	5
4	SV2B	Synaptic Vesicle Glycoprotein 2B	Protein Coding	5
5	SV2A	Synaptic Vesicle Glycoprotein 2A	Protein Coding	5
6	STX1B	Syntaxin 1B	Protein Coding	4
7	SYT2	Synaptotagmin 2	Protein Coding	4
8	SV2C	Synaptic Vesicle Glycoprotein 2C	Protein Coding	4
9	STX1A	Syntaxin 1A	Protein Coding	4
10	VAMP1	Vesicle Associated Membrane Protein 1	Protein Coding	4
11	RPS27A	Ribosomal Protein S27a	Protein Coding	4
12	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	4
13	UBB	Ubiquitin B	Protein Coding	4
14	UBC	Ubiquitin C	Protein Coding	4
15	ANTXR2	ANTXR Cell Adhesion Molecule 2	Protein Coding	3
16	HBEGF	Heparin Binding EGF Like Growth Factor	Protein Coding	3
17	EEF2	Eukaryotic Translation Elongation Factor 2	Protein Coding	3
18	GUCY2C	Guanylate Cyclase 2C	Protein Coding	3
19	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	3
20	HSP90AB1	Heat Shock Protein 90 Alpha Family Class B Member 1	Protein Coding	3
21	FURIN	Furin, Paired Basic Amino Acid Cleaving Enzyme	Protein Coding	3
22	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	3
23	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	3
24	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	3
25	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	3
26	MAP2K7	Mitogen-Activated Protein Kinase Kinase 7	Protein Coding	3
27	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	3
28	TXNRD1	Thioredoxin Reductase 1	Protein Coding	3
29	NHERF4	NHERF Family PDZ Scaffold Protein 4	Protein Coding	3
30	CALM1	Calmodulin 1	Protein Coding	3
31	CALM2	Calmodulin 2	Protein Coding	3
32	CALM3	Calmodulin 3	Protein Coding	3
33	ANTXR1	ANTXR Cell Adhesion Molecule 1	Protein Coding	3
34	CD9	CD9 Molecule	Protein Coding	3
35	STAM2	Signal Transducing Adaptor Molecule 2	Protein Coding	3
36	CTNNB1	Catenin Beta 1	Protein Coding	3
37	CTNND1	Catenin Delta 1	Protein Coding	3
38	EPS15	Epidermal Growth Factor Receptor Pathway Substrate 15	Protein Coding	3
39	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	3
40	SH3KBP1	SH3 Domain Containing Kinase Binding Protein 1	Protein Coding	3
41	MET	MET Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	3
42	SH3GL1	SH3 Domain Containing GRB2 Like 1, Endophilin A2	Protein Coding	3
43	SH3GL2	SH3 Domain Containing GRB2 Like 2, Endophilin A1	Protein Coding	3
44	SH3GL3	SH3 Domain Containing GRB2 Like 3, Endophilin A3	Protein Coding	3
45	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	3
46	CBLL1	Cbl Proto-Oncogene Like 1	Protein Coding	3
47	STAM	Signal Transducing Adaptor Molecule	Protein Coding	3
48	CBL	Cbl Proto-Oncogene	Protein Coding	3
49	HGS	Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate	Protein Coding	3
50	LAMC3	Laminin Subunit Gamma 3	Protein Coding	1
51	UPK1A	Uroplakin 1A	Protein Coding	1
52	CORO1A	Coronin 1A	Protein Coding	1
53	COL4A1	Collagen Type IV Alpha 1 Chain	Protein Coding	1
54	COL4A2	Collagen Type IV Alpha 2 Chain	Protein Coding	1
55	COL4A3	Collagen Type IV Alpha 3 Chain	Protein Coding	1
56	COL4A4	Collagen Type IV Alpha 4 Chain	Protein Coding	1
57	COL4A5	Collagen Type IV Alpha 5 Chain	Protein Coding	1
58	COL4A6	Collagen Type IV Alpha 6 Chain	Protein Coding	1
59	COL5A1	Collagen Type V Alpha 1 Chain	Protein Coding	1
60	COL5A2	Collagen Type V Alpha 2 Chain	Protein Coding	1
61	CTSG	Cathepsin G	Protein Coding	1
62	ENO1	Enolase 1	Protein Coding	1
63	FN1	Fibronectin 1	Protein Coding	1
64	VPS33B	VPS33B Late Endosome And Lysosome Associated	Protein Coding	1
65	LAMA1	Laminin Subunit Alpha 1	Protein Coding	1
66	GSK3A	Glycogen Synthase Kinase 3 Alpha	Protein Coding	1
67	HBA1	Hemoglobin Subunit Alpha 1	Protein Coding	1
68	HBA2	Hemoglobin Subunit Alpha 2	Protein Coding	1
69	HBB	Hemoglobin Subunit Beta	Protein Coding	1
70	KPNA1	Karyopherin Subunit Alpha 1	Protein Coding	1
71	KPNB1	Karyopherin Subunit Beta 1	Protein Coding	1
72	LAMA2	Laminin Subunit Alpha 2	Protein Coding	1
73	LAMA3	Laminin Subunit Alpha 3	Protein Coding	1
74	LAMA4	Laminin Subunit Alpha 4	Protein Coding	1
75	LAMA5	Laminin Subunit Alpha 5	Protein Coding	1
76	LAMB1	Laminin Subunit Beta 1	Protein Coding	1
77	LAMB2	Laminin Subunit Beta 2	Protein Coding	1
78	LAMB3	Laminin Subunit Beta 3	Protein Coding	1
79	LAMC1	Laminin Subunit Gamma 1	Protein Coding	1
80	LAMC2	Laminin Subunit Gamma 2	Protein Coding	1
81	LTF	Lactotransferrin	Protein Coding	1
82	EPCAM	Epithelial Cell Adhesion Molecule	Protein Coding	1
83	MRC1	Mannose Receptor C-Type 1	Protein Coding	1
84	NOS2	Nitric Oxide Synthase 2	Protein Coding	1
85	COL5A3	Collagen Type V Alpha 3 Chain	Protein Coding	1
86	ATP6V1H	ATPase H+ Transporting V1 Subunit H	Protein Coding	1
87	PGK1	Phosphoglycerate Kinase 1	Protein Coding	1
88	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
89	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
90	B2M	Beta-2-Microglobulin	Protein Coding	1
91	RNF213	Ring Finger Protein 213	Protein Coding	1
92	RAB5A	RAB5A, Member RAS Oncogene Family	Protein Coding	1
93	TRIM27	Tripartite Motif Containing 27	Protein Coding	1
94	SFPQ	Splicing Factor Proline And Glutamine Rich	Protein Coding	1
95	TLR2	Toll Like Receptor 2	Protein Coding	1
96	RAB7A	RAB7A, Member RAS Oncogene Family	Protein Coding	1
97	DUSP16	Dual Specificity Phosphatase 16	Protein Coding	1

Disorders associated with Uptake and actions of bacterial toxins SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Primary bacterial infectious disease	Direct
2	Bacterial infectious disease	Direct
3	Listeriosis	Direct
4	Anthrax disease	Direct
5	Foodborne botulism	Direct
6	Tetanus	Direct
7	Diphtheria	Direct
8	Duodenal atresia	Enrichment	GUCY2C	3.53
9	Diarrhea 6	Enrichment	GUCY2C	3.53
10	Congenital diarrhea 6	Enrichment	GUCY2C	3.53
11	Intestinal obstruction in the newborn due to guanylate cyclase 2c deficiency	Enrichment	GUCY2C	3.53
12	Diarrhea 3, secretory sodium, congenital, with or without other congenital anomalies	Enrichment	GUCY2C	3.35
13	Meconium ileus	Enrichment	GUCY2C	3.23

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Uptake and actions of bacterial toxins

Pathway Network for Uptake and actions of bacterial toxins

Pathway network for the Uptake and actions of bacterial toxins SuperPath

Member Pathways for Uptake and actions of bacterial toxins

Pathways in the Uptake and actions of bacterial toxins SuperPath

Gene overlap in member pathways for Uptake and actions of bacterial toxins SuperPath

Associated Genes for Uptake and actions of bacterial toxins

Associated Disorders for Uptake and actions of bacterial toxins

Disorders associated with Uptake and actions of bacterial toxins SuperPath

STRING Interaction Network for Uptake and actions of bacterial toxins

Sources for Uptake and actions of bacterial toxins