uracil degradation I (reductive)
Pathway network for the uracil degradation I (reductive) SuperPath
Sources:
- PubChem
- GeneGo (Thomson Reuters)
Pathways in the uracil degradation I (reductive) SuperPath
| # | Name | Source | Genes |
|---|---|---|---|
| 1 | uracil degradation I (reductive) | PubChem | |
| 2 | Beta-alanine metabolism | GeneGo (Thomson Reuters) | |
| 3 | uracil degradation | PubChem |
Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways
| # | Symbol | Description | Category | # Related Pathways |
|---|---|---|---|---|
| 1 | UPB1 | Beta-Ureidopropionase 1 | Protein Coding | 3 |
| 2 | DPYS | Dihydropyrimidinase | Protein Coding | 3 |
| 3 | DPYD | Dihydropyrimidine Dehydrogenase | Protein Coding | 3 |
| 4 | ABAT | 4-Aminobutyrate Aminotransferase | Protein Coding | 1 |
| 5 | AOC1 | Amine Oxidase Copper Containing 1 | Protein Coding | 1 |
| 6 | ALDH9A1 | Aldehyde Dehydrogenase 9 Family Member A1 | Protein Coding | 1 |
| 7 | GAD1 | Glutamate Decarboxylase 1 | Protein Coding | 1 |
| 8 | GAD2 | Glutamate Decarboxylase 2 | Protein Coding | 1 |
| 9 | CSAD | Cysteine Sulfinic Acid Decarboxylase | Protein Coding | 1 |
| 10 | CNDP1 | Carnosine Dipeptidase 1 | Protein Coding | 1 |
Disorders associated with uracil degradation I (reductive) SuperPath
according to GeneCards Suite gene sharing
| # | Disorder | Type | Genes | Score |
|---|---|---|---|---|
| 1 | Dihydropyrimidinase deficiency | Enrichment | DPYS | 3.66 |
| 2 | Beta-ureidopropionase deficiency | Enrichment | UPB1 | 3.66 |
| 3 | 1p21.3 microdeletion syndrome | Enrichment | DPYD | 3.66 |
| 4 | Dihydropyrimidine dehydrogenase deficiency | Enrichment | DPYD | 3.18 |
| 5 | Developmental and epileptic encephalopathy 89 | Enrichment | GAD1 | 3.13 |
| 6 | Gaba aminotransferase deficiency | Enrichment | ABAT | 3.13 |
| 7 | Gaba-transaminase deficiency | Enrichment | ABAT | 3.13 |
| 8 | Neurodevelopmental disorder with progressive spasticity and brain white matter abnormalities | Enrichment | GAD1 | 2.53 |
| 9 | Spastic quadriplegic cerebral palsy | Enrichment | GAD1 | 2.53 |
