urate biosynthesis/inosine 5'-phosphate degradation

Sources:

#	Name	Source	Genes
1	urate biosynthesis/inosine 5'-phosphate degradation	PubChem	IMPDH1 IMPDH2 NT5C2 NT5E PNP XDH (see all 6) (see less)
2	inosine 5'-phosphate degradation	PubChem	IMPDH1 IMPDH2 NT5C2 NT5E PNP XDH (see all 6) (see less)
3	guanosine nucleotides degradation III	PubChem	GDA NT5C2 PNP XDH
4	guanosine nucleotides degradation	PubChem	GDA NT5C2 PNP XDH

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	NT5C2	5''-Nucleotidase, Cytosolic II	Protein Coding	4
2	PNP	Purine Nucleoside Phosphorylase	Protein Coding	4
3	XDH	Xanthine Dehydrogenase	Protein Coding	4
4	NT5E	5''-Nucleotidase Ecto	Protein Coding	2
5	IMPDH1	Inosine Monophosphate Dehydrogenase 1	Protein Coding	2
6	IMPDH2	Inosine Monophosphate Dehydrogenase 2	Protein Coding	2
7	GDA	Guanine Deaminase	Protein Coding	2

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Purine nucleoside phosphorylase deficiency	Enrichment	PNP	3.53
2	Calcification of joints and arteries	Enrichment	NT5E	3.35
3	Retinitis pigmentosa 10	Enrichment	IMPDH1	3.35
4	Impdh2 enzyme activity, variation in	Enrichment	IMPDH2	3.35
5	Leber congenital amaurosis 11	Enrichment	IMPDH1	3.35
6	Xanthinuria, type i	Enrichment	XDH	3.23
7	Spastic paraplegia 45, autosomal recessive	Enrichment	NT5C2	3.23
8	Xanthinuria, type ii	Enrichment	XDH	3.05
9	Gtp cyclohydrolase 1-deficient dopa-responsive dystonia	Enrichment	IMPDH2	2.88
10	Severe combined immunodeficiency	Enrichment	PNP	2.01
11	Dystonia	Enrichment	IMPDH2	1.81
12	Leber plus disease	Enrichment	IMPDH1	1.38
13	Retinitis pigmentosa	Enrichment	IMPDH1	1.04
14	Hereditary retinal dystrophy	Enrichment	IMPDH1	0.91
15	Fundus dystrophy	Enrichment	IMPDH1	0.91

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for urate biosynthesis/inosine 5'-phosphate degradation