Uricosurics Pathway, Pharmacodynamics
Pathways in the Uricosurics Pathway, Pharmacodynamics SuperPath
| # | Name | Source | Genes |
|---|---|---|---|
| 1 | Uricosurics Pathway, Pharmacodynamics | PharmGKB | |
| 2 | Defective SLC2A9 causes hypouricemia renal 2 (RHUC2) | Reactome |
Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways
| # | Symbol | Description | Category | # Related Pathways |
|---|---|---|---|---|
| 1 | SLC2A9 | Solute Carrier Family 2 Member 9 | Protein Coding | 2 |
| 2 | SLC17A1 | Solute Carrier Family 17 Member 1 | Protein Coding | 1 |
| 3 | ABCC4 | ATP Binding Cassette Subfamily C Member 4 (PEL Blood Group) | Protein Coding | 1 |
| 4 | PDZK1 | PDZ Domain Containing 1 | Protein Coding | 1 |
| 5 | LGALS9 | Galectin 9 | Protein Coding | 1 |
| 6 | SLC22A6 | Solute Carrier Family 22 Member 6 | Protein Coding | 1 |
| 7 | SLC22A8 | Solute Carrier Family 22 Member 8 | Protein Coding | 1 |
| 8 | SLC22A13 | Solute Carrier Family 22 Member 13 | Protein Coding | 1 |
| 9 | SLC17A3 | Solute Carrier Family 17 Member 3 | Protein Coding | 1 |
| 10 | SLC22A11 | Solute Carrier Family 22 Member 11 | Protein Coding | 1 |
| 11 | ABCG2 | ATP Binding Cassette Subfamily G Member 2 (JR Blood Group) | Protein Coding | 1 |
| 12 | SLC22A12 | Solute Carrier Family 22 Member 12 | Protein Coding | 1 |
Disorders associated with Uricosurics Pathway, Pharmacodynamics SuperPath
according to GeneCards Suite gene sharing
| # | Disorder | Type | Genes | Score |
|---|---|---|---|---|
| 1 | Renal tubular transport disease | Direct | ||
| 2 | Familial renal hypouricemia | Enrichment | SLC22A12, SLC2A9 | 6.14 |
| 3 | Hypouricemia, renal, 1 | Enrichment | SLC22A12 | 3.05 |
| 4 | Uric acid concentration, serum, quantitative trait locus 4 | Enrichment | SLC17A3 | 3.05 |
| 5 | Uric acid concentration, serum, quantitative trait locus 1 | Enrichment | ABCG2 | 3.05 |
| 6 | Blood group, junior system | Enrichment | ABCG2 | 3.05 |
| 7 | Hypouricemia, renal, 2 | Enrichment | SLC2A9 | 2.75 |
