Urotensin-II-mediated signaling pathway

No Pathway Network information available for Urotensin-II-mediated signaling pathway

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

Disorders associated with Urotensin-II-mediated signaling pathway SuperPath

according to GeneCards Suite gene sharing
#DisorderTypeGenesScore
1Diffuse large b-cell lymphomaEnrichmentCREBBP, PTEN, STAT34.50
2Ehlers-danlos syndromeEnrichmentCOL1A1, COL3A1, SMAD34.50
3Breast implant-associated anaplastic large cell lymphomaEnrichmentJAK2, STAT34.49
4Granulomatous disease, chronic, x-linkedEnrichmentCYBB, NCF14.19
5Bladder cancerEnrichmentCTNNB1, EGFR, PTEN3.93
6Cowden syndrome 1EnrichmentEGFR, PTEN3.80
7Rubinstein-taybi syndrome 1EnrichmentCREBBP, EP3003.80
8Chromosome 16p13.3 deletion syndrome, proximalEnrichmentCREBBP, EP3003.80
9Squamous cell carcinoma, head and neckEnrichmentEGFR, PTEN3.65
10Ovarian cancerEnrichmentAKT1, CTNNB1, EGFR, PTEN3.47
11Chronic granulomatous diseaseEnrichmentCYBB, NCF13.42
12Cowden syndromeEnrichmentAKT1, PTEN3.42
13Familial thoracic aortic aneurysm and dissectionEnrichmentCOL3A1, SMAD33.42
14Familial thoracic aortic aneurysm and aortic dissectionEnrichmentCOL1A1, COL3A1, SMAD33.39
15Specific learning disabilityEnrichmentMAPK1, PTPN113.24
16MeningiomaEnrichmentAKT1, PTEN3.16
17MicrocephalyEnrichmentCTNNB1, EP300, MAPK1, PTPN113.14
18Aortic aneurysm, familial thoracic 1EnrichmentCOL3A1, SMAD33.02
19Rare genetic intellectual disabilityEnrichmentCREBBP, EP3002.96
20Arteriovenous malformations of the brainEnrichmentEGFR, IL62.75
21Breast cancerEnrichmentABCA1, AKT1, PTEN2.71
22ScoliosisEnrichmentCREBBP, PTPN112.55
23Colorectal cancerEnrichmentAKT1, CTNNB1, EP3002.53
24Proteus syndromeEnrichmentAKT12.48
25MetachondromatosisEnrichmentPTPN112.48
26Vacterl association with hydrocephalusEnrichmentPTEN2.48
27Immunodeficiency 34EnrichmentCYBB2.48
28Leopard syndrome 1EnrichmentPTPN112.48
29Fetal encasement syndromeEnrichmentCHUK2.48
30Encephalopathy, acute, infection-induced 7EnrichmentIRF32.48
31Acrogeria, gottron typeEnrichmentCOL3A12.48
32Immunodeficiency 15bEnrichmentIKBKB2.48
33Noonan syndrome 13EnrichmentMAPK12.48
34Immunodeficiency 15aEnrichmentIKBKB2.48
35T-cell large granular lymphocyte leukemiaEnrichmentSTAT32.48
36Papillary tumor of the pineal regionEnrichmentPTEN2.48
37Cowden syndrome 6EnrichmentAKT12.48
38Pigmented nodular adrenocortical disease, primary, 4EnrichmentPRKACA2.48
39Ataxia-telangiectasia-like disorder 2EnrichmentPCNA2.48
40Glioma susceptibility 2EnrichmentPTEN2.48
41Autoimmune disease, multisystem, infantile-onset, 1EnrichmentSTAT32.48
42Cardioacrofacial dysplasia 1EnrichmentPRKACA2.48
43Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomaliesEnrichmentRHOA2.48
44Bartsocas-papas syndrome 2EnrichmentCHUK2.48
45Menke-hennekam syndrome 1EnrichmentCREBBP2.48
46Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomaliesEnrichmentRHOA2.48
47Asphyxia neonatorumEnrichmentCOL1A12.48
48Adenoid ameloblastomaEnrichmentCTNNB12.48
49Rubinstein-taybi syndrome due to 16p13.3 microdeletionEnrichmentCREBBP2.48
50Stat3-related early-onset multisystem autoimmune diseaseEnrichmentSTAT32.48
51AtherosclerosisEnrichmentALOX52.48
52Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiencyEnrichmentCHUK2.48
53Menke-hennekam syndromeEnrichmentCREBBP2.48
54Abdominal aortic aneurysmEnrichmentCOL3A12.48
55Segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndromeEnrichmentPTEN2.48
56Chronic lymphoproliferative disorder of natural killer cellsEnrichmentSTAT32.48
57Microcystic stromal tumorEnrichmentCTNNB12.48
58HypoalphalipoproteinemiaEnrichmentABCA12.48
59Malignant astrocytomaEnrichmentPTPN112.48
60Congenital nervous system abnormalityEnrichmentCREBBP, CTNNB1, PTEN2.29
61Nervous system diseaseEnrichmentCREBBP, CTNNB1, PTEN2.29
62Ehlers-danlos syndrome, vascular typeEnrichmentCOL3A12.18
63Epiphyseal dysplasia, multiple, 1EnrichmentCOL1A12.18
64Ehlers-danlos syndrome, hypermobility typeEnrichmentCOL3A12.18
65Camurati-engelmann disease 1EnrichmentTGFB12.18
66Spondyloepimetaphyseal dysplasia, strudwick typeEnrichmentFN12.18
67Granulomatous disease, chronic, autosomal recessive, 1EnrichmentNCF12.18
68Spondylometaphyseal dysplasia, corner fracture typeEnrichmentFN12.18
69Tangier diseaseEnrichmentABCA12.18
70Thumb deformityEnrichmentCREBBP2.18
71Osteopathia striata with cranial sclerosisEnrichmentCTNNB12.18
72Dermatofibrosarcoma protuberansEnrichmentCOL1A12.18
73Cardiomyopathy, dilated, 1pEnrichmentPLN2.18
74Atrial fibrillation, familial, 6EnrichmentNPPA2.18
75Immunodeficiency, common variable, 12, with autoimmunityEnrichmentNFKB12.18
76Thrombocythemia 3EnrichmentJAK22.18
77Cardiomyopathy, familial hypertrophic, 18EnrichmentPLN2.18
78Loeys-dietz syndrome 3EnrichmentSMAD32.18
79Combined osteogenesis imperfecta and ehlers-danlos syndrome 1EnrichmentCOL1A12.18
80Werner syndromeEnrichmentPTPN112.18
81Ehlers-danlos syndrome, arthrochalasia type, 2EnrichmentCOL1A12.18
82Autoinflammatory disease, familial, behcet-like 3EnrichmentRELA2.18
83Menke-hennekam syndrome 2EnrichmentEP3002.18
84Polymicrogyria with or without vascular-type ehlers-danlos syndromeEnrichmentCOL3A12.18
85Inflammatory bowel disease, immunodeficiency, and encephalopathyEnrichmentTGFB12.18
86Childhood hepatocellular carcinomaEnrichmentCTNNB12.18
87Rela fusion-positive ependymomaEnrichmentRELA2.18
88Aortic dissectionEnrichmentCOL3A12.18
89Acute myeloid leukemia with kat6a-crebbp fusionEnrichmentCREBBP2.18
90Camurati-engelmann diseaseEnrichmentTGFB12.18
91Stickler syndrome, type iiEnrichmentCOL1A12.18
92Fibrolamellar carcinomaEnrichmentPRKACA2.18
93PolycythemiaEnrichmentJAK22.18
94Juvenile nasopharyngeal angiofibromaEnrichmentCTNNB12.18
95Ehlers-danlos/osteogenesis imperfecta syndromeEnrichmentCOL1A12.18
96Vacterl with hydrocephalusEnrichmentPTEN2.18
97Hypereosinophilic syndromeEnrichmentJAK22.18
98Isolated atrial standstillEnrichmentNPPA2.18
99TeratomaEnrichmentCTNNB12.18
100Common variable immunodeficiency 12EnrichmentNFKB12.18
101Juvenile polyposis of infancyEnrichmentPTEN2.18
102Gastric cancerEnrichmentIL1B, PTEN2.05
103Hypertrophic cardiomyopathyEnrichmentPLN, PTPN112.05
104Hereditary breast carcinomaEnrichmentAKT1, PTEN2.03
105Inherited cancer-predisposing syndromeEnrichmentEGFR, PTEN, PTPN112.02
106Desmoid disease, hereditaryEnrichmentCTNNB12.00
107Hyper-ige syndrome 1, autosomal dominant, with recurrent infectionsEnrichmentSTAT32.00
108Polycythemia veraEnrichmentJAK22.00
109Granulomatous disease, chronic, autosomal recessive, 2EnrichmentNCF12.00
110Glomerulopathy with fibronectin deposits 2EnrichmentFN12.00
111Neurodevelopmental disorder with spastic diplegia and visual defectsEnrichmentCTNNB12.00
112Caffey diseaseEnrichmentCOL1A12.00
113Atrial standstill 2EnrichmentNPPA2.00
114Neonatal nephrocutaneous inflammatory syndromeEnrichmentEGFR2.00
115Anus, imperforateEnrichmentCTNNB12.00
116Exudative vitreoretinopathy 7EnrichmentCTNNB12.00
117Hypoalphalipoproteinemia, primary, 2EnrichmentABCA12.00
118Tethered spinal cord syndromeEnrichmentCREBBP2.00
119Desmoid tumorEnrichmentCTNNB12.00
120Hyper ige syndromeEnrichmentSTAT32.00
121Intrinsic cardiomyopathyEnrichmentPLN2.00
122Intraocular pressure quantitative trait locusEnrichmentCREBBP2.00
123Laryngeal squamous cell carcinomaEnrichmentPTEN2.00
124High bone mass osteogenesis imperfectaEnrichmentCOL1A12.00
125Neonatal inflammatory skin and bowel diseaseEnrichmentEGFR2.00
126Tricuspid valve insufficiencyEnrichmentPTPN112.00
127Kaposi sarcomaEnrichmentIL61.88
128Ehlers-danlos syndrome, arthrochalasia type, 1EnrichmentCOL1A11.88
129Erythrocytosis, familial, 1EnrichmentJAK21.88
130PhenylketonuriaEnrichmentCOL1A11.88
131Budd-chiari syndromeEnrichmentJAK21.88
132Hypoalphalipoproteinemia, primary, 1EnrichmentABCA11.88
133Chromosome 22q11.2 deletion syndrome, distalEnrichmentMAPK11.88
134PilomatrixomaEnrichmentCTNNB11.88
135Alazami syndromeEnrichmentCTNNB11.88
136Aortic aneurysmEnrichmentSMAD31.88
137CraniopharyngiomaEnrichmentCTNNB11.88
138Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemiaEnrichmentPTPN111.88
139Noonan syndrome with multiple lentiginesEnrichmentPTPN111.88
140Cerebral malariaEnrichmentICAM11.88
141Osteogenesis imperfecta with normal sclerae, dominant formEnrichmentCOL1A11.88
142Systemic-onset juvenile idiopathic arthritisEnrichmentIL61.88
143GliomaEnrichmentPTEN1.88
144Exudative vitreoretinopathy 1EnrichmentCTNNB11.78
145Macrocephaly/autism syndromeEnrichmentPTEN1.78
146Rheumatoid arthritis, systemic juvenileEnrichmentIL61.78
147Rubinstein-taybi syndrome 2EnrichmentEP3001.78
148LymphomaEnrichmentPTPN111.78
149Cardiac arrestEnrichmentPLN1.78
150Myeloproliferative neoplasmEnrichmentJAK21.78
151HemangiomaEnrichmentPTEN1.78
152Acute megakaryocytic leukemiaEnrichmentPTEN1.78
153HemimegalencephalyEnrichmentPTEN1.78
154Familial cerebral saccular aneurysmEnrichmentCOL3A11.78
155Ehlers-danlos syndrome, classic type, 1EnrichmentCOL1A11.70
156Osteogenesis imperfecta, type iEnrichmentCOL1A11.70
157Weyers acrofacial dysostosisEnrichmentCTNNB11.70
158Hemihyperplasia, isolatedEnrichmentRHOA1.70
159Type 1 diabetes mellitusEnrichmentIL61.70
160Renal tubular dysgenesisEnrichmentAGTR11.70
161Inflammatory bowel disease 25, autosomal recessiveEnrichmentTGFB11.70
162KeratoconusEnrichmentCOL1A11.70
163Patent ductus arteriosusEnrichmentPTPN111.70
164Adrenocortical carcinomaEnrichmentCTNNB11.70
165Il10-related early-onset inflammatory bowel diseaseEnrichmentTGFB11.70
166Breast adenocarcinomaEnrichmentAKT11.70
167Lung squamous cell carcinomaEnrichmentEGFR1.70
168HypertrichosisEnrichmentCREBBP1.70
169Classic ehlers-danlos syndromeEnrichmentCOL1A11.70
170Osteogenesis imperfecta, type iiEnrichmentCOL1A11.64
171Thyroid cancer, nonmedullary, 2EnrichmentPTEN1.64
172MyelofibrosisEnrichmentJAK21.64
173Noonan syndrome 3EnrichmentPTPN111.64
174Essential thrombocythemiaEnrichmentJAK21.64
175Gallbladder cancerEnrichmentCTNNB11.64
176Common variable immunodeficiencyEnrichmentNFKB11.64
177Follicular thyroid carcinomaEnrichmentPTEN1.64
178Spastic paraplegia 4, autosomal dominantEnrichmentCOL3A11.58
179Exudative vitreoretinopathyEnrichmentCTNNB11.58
180Permanent neonatal diabetes mellitusEnrichmentSTAT31.58
181Cardiomyopathy, familial hypertrophic, 4EnrichmentNCF11.53
182Charge syndromeEnrichmentEP3001.53
183Ellis-van creveld syndromeEnrichmentPRKACA1.53
184Inflammatory bowel disease 1EnrichmentIL61.53
185Arrhythmogenic right ventricular dysplasia, familial, 9EnrichmentPLN1.53
186Coronary heart disease 5EnrichmentABCA11.53
187Leukemia, acute lymphoblastic 3EnrichmentJAK21.53
188Loeys-dietz syndromeEnrichmentSMAD31.53
189Adult hepatocellular carcinomaEnrichmentCTNNB11.53
190Ciliary dyskinesia, primary, 3EnrichmentNFKB11.49
191MelanomaEnrichmentPTEN1.49
192Primary bone dysplasiaEnrichmentCOL1A11.49
193Pectus excavatumEnrichmentPTPN111.44
194AsthmaEnrichmentALOX51.44
195Meningioma, familialEnrichmentPTEN1.44
196OsteochondrodysplasiaEnrichmentCOL1A11.44
197Lung non-small cell carcinomaEnrichmentEGFR1.44
198Uterine corpus cancerEnrichmentPTEN1.44
199Cardiac conduction defectEnrichmentPLN1.41
200EpicanthusEnrichmentPTPN111.41
201Juvenile myelomonocytic leukemiaEnrichmentPTPN111.41
202Lip and oral cavity carcinomaEnrichmentEGFR1.41
203Congenital long qt syndromeEnrichmentPTPN111.41
204Osteogenesis imperfecta, type ivEnrichmentCOL1A11.37
205Acute promyelocytic leukemiaEnrichmentSTAT31.37
206OsteoporosisEnrichmentCOL1A11.34
207MedulloblastomaEnrichmentCTNNB11.34
208Lung cancer susceptibility 3EnrichmentEGFR1.34
209Heart diseaseEnrichmentCREBBP1.34
210Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variantEnrichmentPLN1.34
211Polydactyly, postaxial, type a1EnrichmentEP3001.31
212Corpus callosum, agenesis ofEnrichmentCREBBP1.31
213Osteogenesis imperfecta, type iiiEnrichmentCOL1A11.31
214Isolated corpus callosum agenesisEnrichmentCREBBP1.31
215Intellectual disability-hypoplastic corpus callosum-preauricular tag syndromeEnrichmentCREBBP1.31
216Noonan syndrome and noonan-related syndromeEnrichmentPTPN111.31
217Autism spectrum disorderEnrichmentPTEN, PTPN111.30
218RhabdomyosarcomaEnrichmentPTEN1.29
219GliosarcomaEnrichmentEGFR1.29
220Hypertension, essentialEnrichmentAGTR11.26
221Sudden infant death syndromeEnrichmentPLN1.26
222Polycystic liver diseaseEnrichmentCTNNB11.26
223Giant cell glioblastomaEnrichmentEGFR1.26
224Autosomal dominant polycystic liver diseaseEnrichmentCTNNB11.26
225Heart, malformation ofEnrichmentMAPK11.24
226Patent foramen ovaleEnrichmentPTPN111.24
227Williams-beuren syndromeEnrichmentNCF11.19
228Endometrial cancerEnrichmentPTEN1.17
229HepatoblastomaEnrichmentCTNNB11.17
230Hepatocellular carcinomaEnrichmentCTNNB11.15
231Multisystem inflammatory syndrome in childrenEnrichmentIRF31.15
232Noonan syndrome 1EnrichmentPTPN111.13
233Brittle bone disorderEnrichmentCOL1A11.13
234MalariaEnrichmentICAM11.13
235Familial atrial fibrillationEnrichmentNPPA1.12
236Hydrops fetalis, nonimmuneEnrichmentPTPN111.08
237RasopathyEnrichmentPTPN111.08
238StrabismusEnrichmentPTPN111.07
239Prostate cancerEnrichmentPTEN1.04
240Long qt syndrome 1EnrichmentPTPN111.02
241Non-immune hydrops fetalisEnrichmentPTPN111.01
242Lung cancerEnrichmentEGFR1.00
243Cystic fibrosisEnrichmentTGFB11.00
244Connective tissue diseaseEnrichmentSMAD31.00
245Severe combined immunodeficiencyEnrichmentIKBKB0.98
246Leukemia, acute myeloidEnrichmentJAK20.90
247Type 2 diabetes mellitusEnrichmentIL60.88
248Nephrotic syndromeEnrichmentFN10.88
249ThrombocytopeniaEnrichmentPTPN110.83
250HypertelorismEnrichmentCOL1A10.80
251Familial isolated dilated cardiomyopathyEnrichmentPLN0.79
252Hereditary breast ovarian cancer syndromeEnrichmentPTEN0.78
253Myeloma, multipleEnrichmentCREBBP0.77
254Male infertility with azoospermia or oligozoospermia due to single gene mutationEnrichmentPTPN110.77
255Primary ovarian insufficiencyEnrichmentJAK20.75
256AutismEnrichmentCREBBP0.67
257Dilated cardiomyopathyEnrichmentPLN0.63

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