UVA-Induced MAPK Signaling

No Pathway Network information available for UVA-Induced MAPK Signaling

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

Disorders associated with UVA-Induced MAPK Signaling SuperPath

according to GeneCards Suite gene sharing
#DisorderTypeGenesScore
1Noonan syndrome 1EnrichmentHRAS, KRAS, MRAS, NRAS, RRAS, RRAS28.62
2RasopathyEnrichmentHRAS, KRAS, MRAS, NRAS, RRAS26.54
3Lung non-small cell carcinomaEnrichmentEGFR, HRAS, KRAS, NRAS6.54
4Bladder cancerEnrichmentATM, EGFR, HRAS, KRAS, TP536.29
5Schimmelpenning-feuerstein-mims syndromeEnrichmentHRAS, KRAS, NRAS6.17
6Glioma susceptibility 1EnrichmentH3-3A, H3C1, TP535.53
7Nevus, epidermalEnrichmentHRAS, KRAS, NRAS5.24
8Bryant-li-bhoj neurodevelopmental syndrome 2EnrichmentH3-3A, H3-3B4.84
9Myeloma, multipleEnrichmentATM, H3C1, KRAS, PIK3R2, TP534.83
10Ras-associated autoimmune leukoproliferative disorderEnrichmentKRAS, NRAS4.51
11Juvenile myelomonocytic leukemiaEnrichmentKRAS, NRAS, RRAS4.45
12Lip and oral cavity carcinomaEnrichmentEGFR, HRAS, TP534.45
13Lung cancer susceptibility 3EnrichmentEGFR, KRAS, TP534.23
14Breast cancerEnrichmentATM, CASP8, JUN, KRAS, TP534.21
15Noonan syndrome and noonan-related syndromeEnrichmentHRAS, KRAS, NRAS4.14
16GliosarcomaEnrichmentATM, EGFR, TP534.05
17Large congenital melanocytic nevusEnrichmentHRAS, NRAS4.03
18AdenocarcinomaEnrichmentATM, TP534.03
19Giant cell glioblastomaEnrichmentATM, EGFR, TP533.96
20Lung sarcomatoid carcinomaEnrichmentKRAS, TP533.73
21Chronic myelogenous leukemia, bcr-abl1 positiveEnrichmentKRAS, NRAS3.73
22Breast adenocarcinomaEnrichmentAKT1, TP533.67
23Ovarian cancerEnrichmentATM, EGFR, KRAS, RRAS2, TP533.60
24Squamous cell carcinoma, head and neckEnrichmentEGFR, TP533.52
25Overgrowth syndromeEnrichmentMTOR, PIK3R13.52
26Pancreatic cancerEnrichmentATM, KRAS, TP533.45
27Lung squamous cell carcinomaEnrichmentEGFR, KRAS3.34
28Differentiated thyroid carcinomaEnrichmentHRAS, KRAS, NRAS3.25
29Thyroid cancer, nonmedullary, 2EnrichmentHRAS, NRAS3.19
30Leukemia, chronic myeloidEnrichmentKRAS, NRAS3.19
31Noonan syndrome 3EnrichmentHRAS, KRAS3.19
32Gallbladder cancerEnrichmentKRAS, TP533.19
33Follicular thyroid carcinomaEnrichmentHRAS, NRAS3.19
34Lung cancerEnrichmentCASP8, EGFR, KRAS3.13
35Specific learning disabilityEnrichmentMAPK1, RPS6KA33.11
36Melanocytic nevus syndrome, congenitalEnrichmentHRAS, NRAS3.07
37Adult hepatocellular carcinomaEnrichmentCASP8, TP532.96
38Leukemia, chronic lymphocyticEnrichmentATM, TP532.87
39Colorectal cancerEnrichmentATM, NRAS, PIK3R1, TP532.85
40Leukemia, acute myeloidEnrichmentKRAS, NRAS, TP532.84
41Gastric cancerEnrichmentATM, KRAS, TP532.75
42Hereditary breast carcinomaEnrichmentATM, KRAS, TP532.72
43RhabdomyosarcomaEnrichmentHRAS, TP532.45
44Hereditary breast ovarian cancer syndromeEnrichmentATM, KRAS, TP532.44
45Proteus syndromeEnrichmentAKT12.42
46Coffin-lowry syndromeEnrichmentRPS6KA32.42
47Melorheostosis, isolatedEnrichmentMAP2K12.42
48Cardiofaciocutaneous syndrome 3EnrichmentMAP2K12.42
49Ataxia-oculomotor apraxia 3EnrichmentPIK3R52.42
50Autoimmune lymphoproliferative syndrome, type iiiEnrichmentPRKCD2.42
51Noonan syndrome 13EnrichmentMAPK12.42
52Short syndromeEnrichmentPIK3R12.42
53Bone marrow failure syndrome 5EnrichmentTP532.42
54Papilloma of choroid plexusEnrichmentTP532.42
55Basal cell carcinoma 7EnrichmentTP532.42
56Autism 19EnrichmentEIF4E2.42
57Intellectual developmental disorder, x-linked 19EnrichmentRPS6KA32.42
58Anaplastic thyroid carcinomaEnrichmentTP532.42
59Spinocerebellar ataxia 14EnrichmentPRKCG2.42
60MelorheostosisEnrichmentMAP2K12.42
61Immunodeficiency 36 with lymphoproliferationEnrichmentPIK3R12.42
62Cowden syndrome 6EnrichmentAKT12.42
63Agammaglobulinemia 7, autosomal recessiveEnrichmentPIK3R12.42
64Ductal carcinoma in situEnrichmentTP532.42
65Congenital heart defects and ectodermal dysplasiaEnrichmentPRKD12.42
66Bryant-li-bhoj neurodevelopmental syndrome 1EnrichmentH3-3A2.42
67Thyroid gland undifferentiated carcinomaEnrichmentTP532.42
68Small-cell carcinoma of the ovary of hypercalcemic typeEnrichmentTP532.42
69Symptomatic form of coffin-lowry syndrome in female carriersEnrichmentRPS6KA32.42
70Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtypeEnrichmentTP532.42
71Choroid plexus cancerEnrichmentTP532.42
72Pleomorphic xanthoastrocytomaEnrichmentTP532.42
73Malignant epithelial tumor of salivary glandsEnrichmentPRKD12.42
74Arteriovenous malformations of the brainEnrichmentEGFR, KRAS2.30
75Oculoectodermal syndromeEnrichmentKRAS2.25
76Caspase 8 deficiencyEnrichmentCASP82.25
77Nail disorder, nonsyndromic congenital, 3EnrichmentPLCD12.25
78Melanosis, neurocutaneousEnrichmentNRAS2.25
79Noonan syndrome 6EnrichmentNRAS2.25
80Noonan syndrome 11EnrichmentMRAS2.25
81Spondylometaphyseal dysplasia with corneal dystrophyEnrichmentPLCB32.25
82Immune dysregulation, autoimmunity, and autoinflammationEnrichmentPLCG12.25
83Auriculocondylar syndrome 2aEnrichmentPLCB42.25
84Cardiofaciocutaneous syndrome 2EnrichmentKRAS2.25
85Thrombocytopenia 4EnrichmentCYCS2.25
86Immunodeficiency 31aEnrichmentSTAT12.25
87Autoinflammation, antibody deficiency, and immune dysregulationEnrichmentPLCG22.25
88Endometrial serous adenocarcinomaEnrichmentATM2.25
89Immunodeficiency 31bEnrichmentSTAT12.25
90Familial cold autoinflammatory syndrome 3EnrichmentPLCG22.25
91Acid sphingomyelinase deficiencyEnrichmentSMPD12.25
92Auriculocondylar syndrome 2bEnrichmentPLCB42.25
93Congenital pulmonary airway malformationEnrichmentKRAS2.25
94B-cell non-hodgkin lymphomaEnrichmentATM2.25
95Phakomatosis pigmentokeratoticaEnrichmentHRAS2.25
96Neurocutaneous melanocytosisEnrichmentNRAS2.25
97Hepatocellular carcinomaEnrichmentCASP8, TP532.18
98Adrenocortical carcinoma, hereditaryEnrichmentTP532.12
99Cervical cancerEnrichmentTP532.12
100Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2EnrichmentPIK3R52.12
101Lymphoma, hodgkin, classicEnrichmentTP532.12
102Cebalid syndromeEnrichmentMTOR2.12
103Congenital fibrosarcomaEnrichmentTP532.12
104Li-fraumeni syndrome 1EnrichmentTP532.12
105SarcomaEnrichmentTP532.12
106Cervix carcinomaEnrichmentTP532.12
107Hodgkin's lymphomaEnrichmentTP532.12
108Smith-kingsmore syndromeEnrichmentMTOR2.12
109Pleomorphic rhabdomyosarcomaEnrichmentTP532.12
110Costello syndromeEnrichmentHRAS1.95
111Encephalocraniocutaneous lipomatosisEnrichmentKRAS1.95
112Spermatogenic failure 17EnrichmentPLCZ11.95
113Immunodeficiency 31cEnrichmentSTAT11.95
114Cardiac valvular dysplasia, x-linkedEnrichmentATM1.95
115Noonan syndrome 12EnrichmentRRAS21.95
116High grade gliomaEnrichmentATM1.95
117Ocular melanomaEnrichmentPLCB41.95
118T-cell prolymphocytic leukemiaEnrichmentATM1.95
119Wooly hair nevusEnrichmentHRAS1.95
120Prostate cancerEnrichmentATM, TP531.94
121Langerhans cell histiocytosisEnrichmentMAP2K11.94
122Osteogenic sarcomaEnrichmentTP531.94
123Nasopharyngeal carcinomaEnrichmentTP531.94
124Congenital lipomatous overgrowth, vascular malformations, and epidermal neviEnrichmentPIK3R11.94
125Neonatal nephrocutaneous inflammatory syndromeEnrichmentEGFR1.94
126Immunodeficiency 14a with lymphoproliferation, autosomal dominantEnrichmentPIK3R11.94
127Atypical teratoid rhabdoid tumorEnrichmentTP531.94
128Anaplastic astrocytomaEnrichmentTP531.94
129Immunodeficiency 14EnrichmentPIK3R11.94
130Squamous cell carcinomaEnrichmentTP531.94
131Bone osteosarcomaEnrichmentTP531.94
132Neonatal inflammatory skin and bowel diseaseEnrichmentEGFR1.94
133Non-immune hydrops fetalisEnrichmentHRAS, KRAS1.89
134Cardiofaciocutaneous syndrome 1EnrichmentMAP2K11.82
135Small cell cancer of the lungEnrichmentTP531.82
136Thyroid cancer, nonmedullary, 1EnrichmentTP531.82
137Megalencephaly-capillary malformation-polymicrogyria syndromeEnrichmentPIK3R21.82
138Chromosome 22q11.2 deletion syndrome, distalEnrichmentMAPK11.82
139Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1EnrichmentPIK3R21.82
140Focal cortical dysplasia, type iiEnrichmentMTOR1.82
141Congenital generalized lipodystrophyEnrichmentFOS1.82
142Cardiofaciocutaneous syndromeEnrichmentMAP2K11.82
143Hereditary ataxiaEnrichmentPRKCG1.82
144Embryonal rhabdomyosarcomaEnrichmentTP531.82
145Isolated focal cortical dysplasia type iiEnrichmentMTOR1.82
146Ataxia-telangiectasiaEnrichmentATM1.78
147Polycythemia veraEnrichmentATM1.78
148Niemann-pick disease, type aEnrichmentSMPD11.78
149Niemann-pick disease, type bEnrichmentSMPD11.78
150Nephrotic syndrome, type 3EnrichmentPLCE11.78
151Ceroid lipofuscinosis, neuronal, 6aEnrichmentSMPD11.78
152Koolen-de vries syndromeEnrichmentATM1.78
153SpermatocytomaEnrichmentHRAS1.78
154Rhabdomyosarcoma 2EnrichmentTP531.72
155LymphomaEnrichmentTP531.72
156Histiocytoid hemangiomaEnrichmentFOS1.72
157Acute megakaryocytic leukemiaEnrichmentTP531.72
158HemimegalencephalyEnrichmentMTOR1.72
159Diffuse gastric and lobular breast cancer syndromeEnrichmentKRAS1.65
160Auriculocondylar syndrome 1EnrichmentPLCB41.65
161Developmental and epileptic encephalopathy 12EnrichmentPLCB11.65
162Mantle cell lymphomaEnrichmentATM1.65
163Pilocytic astrocytomaEnrichmentKRAS1.65
164Epidermolytic nevusEnrichmentHRAS1.65
165Oculomotor apraxiaEnrichmentATM1.65
166Li-fraumeni syndromeEnrichmentTP531.64
167Cowden syndrome 1EnrichmentEGFR1.64
168Adrenocortical carcinomaEnrichmentTP531.64
169Esophageal cancerEnrichmentTP531.58
170Capillary malformation-arteriovenous malformation 1EnrichmentMAP2K11.58
171Renal cell carcinoma, papillary, 1EnrichmentMTOR1.58
172Essential thrombocythemiaEnrichmentTP531.58
173B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)EnrichmentTP531.58
174Niemann-pick disease, type c1EnrichmentSMPD11.56
175GlioblastomaEnrichmentATM1.56
176Niemann-pick diseaseEnrichmentSMPD11.56
177Autosomal thrombocytopenia with normal plateletsEnrichmentCYCS1.56
178Gastroesophageal refluxEnrichmentRPS6KA31.52
179Lymphoma, non-hodgkin, familialEnrichmentTP531.52
180Orthostatic intoleranceEnrichmentRPS6KA31.52
181Lennox-gastaut syndromeEnrichmentMAPK101.52
182Melanoma, uvealEnrichmentPLCB41.48
183Clear cell renal cell carcinomaEnrichmentATM1.48
184Chronic mucocutaneous candidiasisEnrichmentSTAT11.48
185Inflammatory bowel disease 1EnrichmentPRKCQ1.47
186Arteriovenous malformationEnrichmentMAP2K11.47
187Primary hyperaldosteronismEnrichmentTP531.47
188Ventricular septal defectEnrichmentRPS6KA31.47
189Cowden syndromeEnrichmentAKT11.47
190Stroke, ischemicEnrichmentPRKCH1.42
191Myopathy, x-linked, with excessive autophagyEnrichmentMAP2K11.42
192Familial colorectal cancerEnrichmentTP531.42
193Autosomal non-syndromic agammaglobulinemiaEnrichmentPIK3R11.42
194Inherited cancer-predisposing syndromeEnrichmentATM, EGFR, TP531.42
195Pilomyxoid astrocytomaEnrichmentKRAS1.41
196Myelodysplastic syndromeEnrichmentTP531.38
197MeningiomaEnrichmentAKT11.35
198Chromosome 1p36 deletion syndromeEnrichmentPRKCZ1.31
199Nephrotic syndrome, type 1EnrichmentPLCE11.31
200Developmental and epileptic encephalopathy 14EnrichmentPLCB11.31
201Colonic benign neoplasmEnrichmentATM1.31
202Lynch syndrome 1EnrichmentATM1.26
203Renal cell carcinoma, nonpapillaryEnrichmentMTOR1.25
204Rare genetic intellectual disabilityEnrichmentMTOR1.25
205Immune deficiency diseaseEnrichmentATM1.22
206Uterine corpus cancerEnrichmentATM1.22
207Familial colorectal cancer type xEnrichmentATM1.22
208Heart, malformation ofEnrichmentMAPK11.17
209Diffuse large b-cell lymphomaEnrichmentTP531.15
210Breast-ovarian cancer, familial 1EnrichmentATM1.15
211Protein-deficiency anemiaEnrichmentNRAS1.15
212HepatoblastomaEnrichmentTP531.11
213Lynch syndromeEnrichmentKRAS1.09
214Diamond-blackfan anemia 1EnrichmentTP531.07
215Focal segmental glomerulosclerosisEnrichmentPLCE10.97
216Endometrial cancerEnrichmentATM0.95
217Non-syndromic x-linked intellectual disabilityEnrichmentRPS6KA30.89
218Diamond-blackfan anemiaEnrichmentTP530.89
219Hydrops fetalis, nonimmuneEnrichmentHRAS0.87
220Genetic steroid-resistant nephrotic syndromeEnrichmentPLCE10.76
221HypertelorismEnrichmentRPS6KA30.74
222Benign epilepsy with centrotemporal spikesEnrichmentPLCB10.69
223Centralopathic epilepsyEnrichmentPLCB10.67
224Nephrotic syndromeEnrichmentPLCE10.67
225West syndromeEnrichmentPLCB10.66
226ThrombocytopeniaEnrichmentCYCS0.63
227Autism spectrum disorderEnrichmentMAP2K10.46
228MicrocephalyEnrichmentMAPK10.42

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