Validated nuclear estrogen receptor alpha network

No Pathway Network information available for Validated nuclear estrogen receptor alpha network

Pathways in the Validated nuclear estrogen receptor alpha network SuperPath

#	Name	Source	Genes
1	Validated nuclear estrogen receptor alpha network	PubChem	ABCA3 ANP32A AP1B1 APBB1 ATP5PF AXIN2 BRCA1 C3 CALCOCO1 CCND1 CD82 CEBPB CHUK COL18A1 CTSD DDX17 DDX54 DSCAM EBAG9 EP300 ESR1 ESR2 GREB1 HDAC1 HDAC4 HSF2 JUN KLRC3 LCOR LMO4 MED1 MPG MTA1 MYC NCOA1 NCOA2 NCOA3 NCOA7 NCOR1 NCOR2 NDUFV3 NEDD8 NR0B1 NR0B2 NRIP1 PCNA PDIA2 PGR PHB2 POU4F1 POU4F2 PRDM15 PRL SAFB SET SFI1 SMAD4 SOD1 SRA1 STAT5A TFF1 TRIM59 UBA3 UBE2M XBP1 (see all 65) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	NCOA7	Nuclear Receptor Coactivator 7	Protein Coding	1
2	DDX54	DEAD-Box Helicase 54	Protein Coding	1
3	TRIM59	Tripartite Motif Containing 59	Protein Coding	1
4	CALCOCO1	Calcium Binding And Coiled-Coil Domain 1	Protein Coding	1
5	LCOR	Ligand Dependent Nuclear Receptor Corepressor	Protein Coding	1
6	LMO4	LIM Domain Only 4	Protein Coding	1
7	PRDM15	PR/SET Domain 15	Protein Coding	1
8	SRA1	Steroid Receptor RNA Activator 1	Protein Coding	1
9	KLRC3	Killer Cell Lectin Like Receptor C3	Protein Coding	1
10	CD82	CD82 Molecule	Protein Coding	1
11	NR0B2	Nuclear Receptor Subfamily 0 Group B Member 2	Protein Coding	1
12	HSF2	Heat Shock Transcription Factor 2	Protein Coding	1
13	XBP1	X-Box Binding Protein 1	Protein Coding	1
14	NR0B1	Nuclear Receptor Subfamily 0 Group B Member 1	Protein Coding	1
15	PRL	Prolactin	Protein Coding	1
16	PHB2	Prohibitin 2	Protein Coding	1
17	ANP32A	Acidic Nuclear Phosphoprotein 32 Family Member A	Protein Coding	1
18	POU4F1	POU Class 4 Homeobox 1	Protein Coding	1
19	POU4F2	POU Class 4 Homeobox 2	Protein Coding	1
20	UBA3	Ubiquitin Like Modifier Activating Enzyme 3	Protein Coding	1
21	HDAC4	Histone Deacetylase 4	Protein Coding	1
22	SAFB	Scaffold Attachment Factor B	Protein Coding	1
23	DDX17	DEAD-Box Helicase 17	Protein Coding	1
24	MTA1	Metastasis Associated 1	Protein Coding	1
25	SET	SET Nuclear Proto-Oncogene	Protein Coding	1
26	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	1
27	TFF1	Trefoil Factor 1	Protein Coding	1
28	NRIP1	Nuclear Receptor Interacting Protein 1	Protein Coding	1
29	GREB1	Growth Regulating Estrogen Receptor Binding 1	Protein Coding	1
30	EBAG9	Estrogen Receptor Binding Site Associated Antigen 9	Protein Coding	1
31	ESR2	Estrogen Receptor 2	Protein Coding	1
32	AXIN2	Axin 2	Protein Coding	1
33	CCND1	Cyclin D1	Protein Coding	1
34	C3	Complement C3	Protein Coding	1
35	UBE2M	Ubiquitin Conjugating Enzyme E2 M	Protein Coding	1
36	PGR	Progesterone Receptor	Protein Coding	1
37	CTSD	Cathepsin D	Protein Coding	1
38	APBB1	Amyloid Beta Precursor Protein Binding Family B Member 1	Protein Coding	1
39	PCNA	Proliferating Cell Nuclear Antigen	Protein Coding	1
40	MPG	N-Methylpurine DNA Glycosylase	Protein Coding	1
41	NDUFV3	NADH:Ubiquinone Oxidoreductase Subunit V3	Protein Coding	1
42	BRCA1	BRCA1 DNA Repair Associated	Protein Coding	1
43	COL18A1	Collagen Type XVIII Alpha 1 Chain	Protein Coding	1
44	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
45	MED1	Mediator Complex Subunit 1	Protein Coding	1
46	CEBPB	CCAAT Enhancer Binding Protein Beta	Protein Coding	1
47	NCOA3	Nuclear Receptor Coactivator 3	Protein Coding	1
48	NCOA1	Nuclear Receptor Coactivator 1	Protein Coding	1
49	NCOA2	Nuclear Receptor Coactivator 2	Protein Coding	1
50	NCOR2	Nuclear Receptor Corepressor 2	Protein Coding	1
51	SMAD4	SMAD Family Member 4	Protein Coding	1
52	EP300	EP300 Lysine Acetyltransferase	Protein Coding	1
53	DSCAM	DS Cell Adhesion Molecule	Protein Coding	1
54	SFI1	SFI1 Centrin Binding Protein	Protein Coding	1
55	ATP5PF	ATP Synthase Peripheral Stalk Subunit F6	Protein Coding	1
56	NCOR1	Nuclear Receptor Corepressor 1	Protein Coding	1
57	AP1B1	Adaptor Related Protein Complex 1 Subunit Beta 1	Protein Coding	1
58	NEDD8	NEDD8 Ubiquitin Like Modifier	Protein Coding	1
59	ABCA3	ATP Binding Cassette Subfamily A Member 3	Protein Coding	1
60	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
61	STAT5A	Signal Transducer And Activator Of Transcription 5A	Protein Coding	1
62	PDIA2	Protein Disulfide Isomerase Family A Member 2	Protein Coding	1
63	HDAC1	Histone Deacetylase 1	Protein Coding	1
64	SOD1	Superoxide Dismutase 1	Protein Coding	1
65	ESR1	Estrogen Receptor 1	Protein Coding	1

Disorders associated with Validated nuclear estrogen receptor alpha network SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Colorectal cancer	Enrichment	AXIN2, BRCA1, CCND1, EP300, SMAD4	4.23
2	Myeloma, multiple	Enrichment	CCND1, HDAC4, NCOR2	2.61
3	Palmoplantar keratoderma, punctate type ii	Enrichment	BRCA1	2.32
4	Keratitis-ichthyosis-deafness syndrome, autosomal recessive	Enrichment	AP1B1	2.32
5	Oligodontia-colorectal cancer syndrome	Enrichment	AXIN2	2.32
6	Hemolytic uremic syndrome, atypical 5	Enrichment	C3	2.32
7	Fetal encasement syndrome	Enrichment	CHUK	2.32
8	Ceroid lipofuscinosis, neuronal, 10	Enrichment	CTSD	2.32
9	46,xy sex reversal 2	Enrichment	NR0B1	2.32
10	Adrenal hypoplasia, congenital	Enrichment	NR0B1	2.32
11	Chromosome 2q37 deletion syndrome	Enrichment	HDAC4	2.32
12	Progesterone resistance	Enrichment	PGR	2.32
13	Infant-type hemispheric glioma	Enrichment	BRCA1	2.32
14	Major affective disorder 7	Enrichment	XBP1	2.32
15	Ovarian dysgenesis 8	Enrichment	ESR2	2.32
16	Ataxia-telangiectasia-like disorder 2	Enrichment	PCNA	2.32
17	Macular degeneration, age-related, 9	Enrichment	C3	2.32
18	Complement component 3 deficiency, autosomal recessive	Enrichment	C3	2.32
19	Congenital anomalies of kidney and urinary tract 3	Enrichment	NRIP1	2.32
20	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.32
21	Neurodevelopmental disorder with central hypotonia and dysmorphic facies	Enrichment	HDAC4	2.32
22	Primary interstitial lung disease specific to childhood due to pulmonary surfactant protein anomalies	Enrichment	ABCA3	2.32
23	Complement component 3 deficiency	Enrichment	C3	2.32
24	Heritable thoracic aortic disease	Enrichment	SMAD4	2.32
25	Membranoproliferative glomerulonephritis	Enrichment	C3	2.32
26	Primary membranoproliferative glomerulonephritis	Enrichment	C3	2.32
27	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.32
28	Primary peritoneal carcinoma	Enrichment	BRCA1	2.32
29	Precursor t-cell acute lymphoblastic leukemia	Enrichment	MYC, SET	2.27
30	Breast cancer	Enrichment	BRCA1, ESR1, JUN	2.26
31	Pancreatic cancer	Enrichment	BRCA1, SMAD4	2.20
32	Hirschsprung disease 1	Enrichment	AXIN2, DSCAM	2.07
33	Burkitt lymphoma	Enrichment	MYC	2.02
34	Myhre syndrome	Enrichment	SMAD4	2.02
35	Carbamoyl phosphate synthetase i deficiency, hyperammonemia due to	Enrichment	ABCA3	2.02
36	Surfactant metabolism dysfunction, pulmonary, 1	Enrichment	ABCA3	2.02
37	Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome	Enrichment	SMAD4	2.02
38	Ataxia, intention tremor, and hypotonia syndrome, childhood-onset	Enrichment	POU4F1	2.02
39	Fanconi anemia, complementation group s	Enrichment	BRCA1	2.02
40	Menke-hennekam syndrome 2	Enrichment	EP300	2.02
41	Pancreatic cancer 4	Enrichment	BRCA1	2.02
42	Surfactant metabolism dysfunction, pulmonary, 3	Enrichment	ABCA3	2.02
43	Glaucoma, primary closed-angle	Enrichment	COL18A1	2.02
44	Spastic tetraplegia and axial hypotonia, progressive	Enrichment	SOD1	2.02
45	Inflammatory breast carcinoma	Enrichment	BRCA1	2.02
46	Intellectual developmental disorder, autosomal dominant 58	Enrichment	SET	2.02
47	Peritoneum cancer	Enrichment	BRCA1	2.02
48	Bilateral breast cancer	Enrichment	BRCA1	2.02
49	Thyroid carcinoma, familial medullary	Enrichment	ESR2	1.84
50	Juvenile polyposis syndrome	Enrichment	SMAD4	1.84
51	Niemann-pick disease, type a	Enrichment	APBB1	1.84
52	Niemann-pick disease, type b	Enrichment	APBB1	1.84
53	Mednik syndrome	Enrichment	AP1B1	1.84
54	Estrogen resistance	Enrichment	ESR1	1.84
55	Cerebellar dysfunction with variable cognitive and behavioral abnormalities	Enrichment	POU4F1	1.84
56	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	MYC	1.84
57	Migraine without aura	Enrichment	ESR1	1.84
58	Genetic atypical hemolytic-uremic syndrome	Enrichment	C3	1.84
59	Pediatric acute respiratory distress syndrome	Enrichment	ABCA3	1.84
60	Gastric cancer	Enrichment	BRCA1, SMAD4	1.74
61	Hereditary breast carcinoma	Enrichment	BRCA1, ESR1	1.73
62	Polyposis syndrome, hereditary mixed, 1	Enrichment	BRCA1	1.72
63	Cholangiocarcinoma	Enrichment	BRCA1	1.72
64	Mantle cell lymphoma	Enrichment	CCND1	1.72
65	Arthrogryposis multiplex congenita 3, myogenic type	Enrichment	ESR1	1.72
66	Knobloch syndrome	Enrichment	COL18A1	1.72
67	Niemann-pick disease, type c1	Enrichment	APBB1	1.62
68	Von hippel-lindau syndrome	Enrichment	CCND1	1.62
69	Knobloch syndrome 1	Enrichment	COL18A1	1.62
70	Amyotrophic lateral sclerosis 10 with or without frontotemporal dementia	Enrichment	SOD1	1.62
71	Breast-ovarian cancer, familial 2	Enrichment	BRCA1	1.62
72	Rubinstein-taybi syndrome 2	Enrichment	EP300	1.62
73	Pervasive developmental disorder	Enrichment	PRDM15	1.62
74	Niemann-pick disease	Enrichment	APBB1	1.62
75	Nonsyndromic 46,xx testicular disorders/differences of sex development	Enrichment	NR0B1	1.62
76	Hereditary pulmonary alveolar proteinosis	Enrichment	ABCA3	1.62
77	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	SMAD4	1.62
78	Rare pervasive developmental disorder	Enrichment	PRDM15	1.62
79	Inherited cancer-predisposing syndrome	Enrichment	AXIN2, BRCA1, SMAD4	1.60
80	Rubinstein-taybi syndrome 1	Enrichment	EP300	1.55
81	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	EP300	1.55
82	Renal hypoplasia	Enrichment	DDX54	1.55
83	Atypical hemolytic uremic syndrome with complement gene abnormality	Enrichment	C3	1.55
84	Motor neuron disease	Enrichment	SOD1	1.48
85	Gallbladder cancer	Enrichment	SMAD4	1.48
86	Hereditary hemorrhagic telangiectasia	Enrichment	SMAD4	1.48
87	Tooth agenesis, selective, 1	Enrichment	AXIN2	1.37
88	Charge syndrome	Enrichment	EP300	1.37
89	Loeys-dietz syndrome	Enrichment	ABCA3	1.37
90	Amyotrophic lateral sclerosis 1	Enrichment	SOD1	1.33
91	Leukemia, chronic lymphocytic	Enrichment	CCND1	1.33
92	Migraine with or without aura 1	Enrichment	ESR1	1.29
93	46,xy complete gonadal dysgenesis	Enrichment	NR0B1	1.29
94	Uterine corpus cancer	Enrichment	BRCA1	1.29
95	Breast-ovarian cancer, familial 1	Enrichment	BRCA1	1.22
96	Periventricular nodular heterotopia	Enrichment	BRCA1	1.19
97	Cataract	Enrichment	COL18A1	1.19
98	46,xy partial gonadal dysgenesis	Enrichment	NR0B1	1.19
99	Polydactyly, postaxial, type a1	Enrichment	EP300	1.16
100	Atypical hemolytic-uremic syndrome	Enrichment	C3	1.16
101	Neuronal ceroid lipofuscinosis	Enrichment	CTSD	1.16
102	Rare genetic intellectual disability	Enrichment	EP300	1.16
103	Rhabdomyosarcoma	Enrichment	BRCA1	1.13
104	Interstitial lung disease 2	Enrichment	ABCA3	1.11
105	Ovarian cancer	Enrichment	AXIN2, BRCA1	1.07
106	Endometrial cancer	Enrichment	BRCA1	1.02
107	Myocardial infarction	Enrichment	ESR1	1.00
108	Tooth agenesis	Enrichment	AXIN2	1.00
109	Bladder cancer	Enrichment	BRCA1	0.89
110	Prostate cancer	Enrichment	BRCA1	0.89
111	Stargardt disease 1	Enrichment	COL18A1	0.87
112	Lung cancer	Enrichment	BRCA1	0.85
113	Cakut	Enrichment	NRIP1	0.82
114	Fanconi anemia, complementation group a	Enrichment	BRCA1	0.81
115	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	SMAD4	0.72
116	Thrombocytopenia	Enrichment	SMAD4	0.69
117	Body mass index quantitative trait locus 11	Enrichment	NR0B2	0.67
118	Autosomal dominant non-syndromic intellectual disability	Enrichment	SET	0.67
119	Hereditary breast ovarian cancer syndrome	Enrichment	BRCA1	0.63
120	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	SOD1	0.61
121	Microcephaly	Enrichment	EP300	0.35
122	Retinitis pigmentosa	Enrichment	COL18A1	0.19
123	Hereditary retinal dystrophy	Enrichment	COL18A1	0.12
124	Fundus dystrophy	Enrichment	COL18A1	0.12

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Validated nuclear estrogen receptor alpha network

Pathway Network for Validated nuclear estrogen receptor alpha network

Member Pathways for Validated nuclear estrogen receptor alpha network

Pathways in the Validated nuclear estrogen receptor alpha network SuperPath

Associated Genes for Validated nuclear estrogen receptor alpha network

Associated Disorders for Validated nuclear estrogen receptor alpha network

Disorders associated with Validated nuclear estrogen receptor alpha network SuperPath

STRING Interaction Network for Validated nuclear estrogen receptor alpha network

Sources for Validated nuclear estrogen receptor alpha network