Validated targets of C-MYC transcriptional activation

No Pathway Network information available for Validated targets of C-MYC transcriptional activation

Pathways in the Validated targets of C-MYC transcriptional activation SuperPath

#	Name	Source	Genes
1	Validated targets of C-MYC transcriptional activation	PubChem	ACTL6A BAX BCAT1 BIRC5 BMI1 CAD CCNB1 CCND2 CDC25A CDCA7 CDK4 COMMD3-BMI1 DDX18 DKC1 E2F3 EIF2S1 EIF4A1 EIF4E EIF4G1 ENO1 FOSL1 GAPDH GPAM HMGA1 HSP90AA1 HSPA4 HSPD1 HUWE1 ID2 IREB2 KAT2A KAT5 KIR3DL1 LDHA LIN28B MAX MMP9 MTA1 MTDH MYC MYCT1 NBN NCL NDUFAF2 NME1 NME2 NPM1 ODC1 PDCD10 PEG10 PFKM PIM1 PMAIP1 POLR3D PRDX3 PTMA RCC1 RIOX2 RPL11 RUVBL1 RUVBL2 SERPINI1 SHMT1 SLC2A1 SMAD3 SMAD4 SNAI1 SUPT3H SUPT7L TAF10 TAF12 TAF4B TAF9 TERT TFRC TK1 TP53 TRRAP UBTF (see all 79) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CDCA7	Cell Division Cycle Associated 7	Protein Coding	1
2	PDCD10	Programmed Cell Death 10	Protein Coding	1
3	MYCT1	MYC Target 1	Protein Coding	1
4	PTMA	Prothymosin Alpha	Protein Coding	1
5	MTDH	Metadherin	Protein Coding	1
6	DDX18	DEAD-Box Helicase 18	Protein Coding	1
7	SERPINI1	Serpin Family I Member 1	Protein Coding	1
8	LIN28B	Lin-28 RNA Binding Posttranscriptional Regulator B	Protein Coding	1
9	PRDX3	Peroxiredoxin 3	Protein Coding	1
10	HUWE1	HECT, UBA And WWE Domain Containing E3 Ubiquitin Protein Ligase 1	Protein Coding	1
11	E2F3	E2F Transcription Factor 3	Protein Coding	1
12	ID2	Inhibitor Of DNA Binding 2	Protein Coding	1
13	FOSL1	FOS Like 1, AP-1 Transcription Factor Subunit	Protein Coding	1
14	PEG10	Paternally Expressed 10	Protein Coding	1
15	PIM1	Pim-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
16	NCL	Nucleolin	Protein Coding	1
17	KIR3DL1	Killer Cell Immunoglobulin Like Receptor, Three Ig Domains And Long Cytoplasmic Tail 1	Protein Coding	1
18	POLR3D	RNA Polymerase III Subunit D	Protein Coding	1
19	HSPD1	Heat Shock Protein Family D (Hsp60) Member 1	Protein Coding	1
20	UBTF	Upstream Binding Transcription Factor	Protein Coding	1
21	SUPT7L	SPT7 Like, STAGA Complex Subunit Gamma	Protein Coding	1
22	SUPT3H	SPT3 Homolog, SAGA And STAGA Complex Component	Protein Coding	1
23	KAT2A	Lysine Acetyltransferase 2A	Protein Coding	1
24	RCC1	Regulator Of Chromosome Condensation 1	Protein Coding	1
25	TAF9	TATA-Box Binding Protein Associated Factor 9	Protein Coding	1
26	TAF4B	TATA-Box Binding Protein Associated Factor 4b	Protein Coding	1
27	TAF12	TATA-Box Binding Protein Associated Factor 12	Protein Coding	1
28	TAF10	TATA-Box Binding Protein Associated Factor 10	Protein Coding	1
29	MTA1	Metastasis Associated 1	Protein Coding	1
30	RIOX2	Ribosomal Oxygenase 2	Protein Coding	1
31	EIF4A1	Eukaryotic Translation Initiation Factor 4A1	Protein Coding	1
32	DKC1	Dyskerin Pseudouridine Synthase 1	Protein Coding	1
33	RUVBL2	RuvB Like AAA ATPase 2	Protein Coding	1
34	NPM1	Nucleophosmin 1	Protein Coding	1
35	CCND2	Cyclin D2	Protein Coding	1
36	MAX	MYC Associated Transcriptional Regulator X	Protein Coding	1
37	CDC25A	Cell Division Cycle 25A	Protein Coding	1
38	HMGA1	High Mobility Group AT-Hook 1	Protein Coding	1
39	HSPA4	Heat Shock Protein Family A (Hsp70) Member 4	Protein Coding	1
40	EIF4E	Eukaryotic Translation Initiation Factor 4E	Protein Coding	1
41	BIRC5	Baculoviral IAP Repeat Containing 5	Protein Coding	1
42	BMI1	BMI1 Proto-Oncogene, Polycomb Ring Finger	Protein Coding	1
43	COMMD3-BMI1	COMMD3-BMI1 Readthrough	Protein Coding	1
44	TRRAP	Transformation/Transcription Domain Associated Protein	Protein Coding	1
45	TERT	Telomerase Reverse Transcriptase	Protein Coding	1
46	ACTL6A	Actin Like 6A	Protein Coding	1
47	RUVBL1	RuvB Like AAA ATPase 1	Protein Coding	1
48	KAT5	Lysine Acetyltransferase 5	Protein Coding	1
49	PMAIP1	Phorbol-12-Myristate-13-Acetate-Induced Protein 1	Protein Coding	1
50	ODC1	Ornithine Decarboxylase 1	Protein Coding	1
51	BCAT1	Branched Chain Amino Acid Transaminase 1	Protein Coding	1
52	NME1	NME/NM23 Nucleoside Diphosphate Kinase 1	Protein Coding	1
53	NME2	NME/NM23 Nucleoside Diphosphate Kinase 2	Protein Coding	1
54	CAD	Carbamoyl-Phosphate Synthetase 2, Aspartate Transcarbamylase, And Dihydroorotase	Protein Coding	1
55	NDUFAF2	NADH:Ubiquinone Oxidoreductase Complex Assembly Factor 2	Protein Coding	1
56	LDHA	Lactate Dehydrogenase A	Protein Coding	1
57	NBN	Nibrin	Protein Coding	1
58	SNAI1	Snail Family Transcriptional Repressor 1	Protein Coding	1
59	CDK4	Cyclin Dependent Kinase 4	Protein Coding	1
60	SMAD4	SMAD Family Member 4	Protein Coding	1
61	SMAD3	SMAD Family Member 3	Protein Coding	1
62	EIF4G1	Eukaryotic Translation Initiation Factor 4 Gamma 1	Protein Coding	1
63	RPL11	Ribosomal Protein L11	Protein Coding	1
64	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	1
65	TFRC	Transferrin Receptor	Protein Coding	1
66	IREB2	Iron Responsive Element Binding Protein 2	Protein Coding	1
67	SLC2A1	Solute Carrier Family 2 Member 1	Protein Coding	1
68	EIF2S1	Eukaryotic Translation Initiation Factor 2 Subunit Alpha	Protein Coding	1
69	PFKM	Phosphofructokinase, Muscle	Protein Coding	1
70	ENO1	Enolase 1	Protein Coding	1
71	GAPDH	Glyceraldehyde-3-Phosphate Dehydrogenase	Protein Coding	1
72	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
73	GPAM	Glycerol-3-Phosphate Acyltransferase, Mitochondrial	Protein Coding	1
74	CCNB1	Cyclin B1	Protein Coding	1
75	TP53	Tumor Protein P53	Protein Coding	1
76	SHMT1	Serine Hydroxymethyltransferase 1	Protein Coding	1
77	TK1	Thymidine Kinase 1	Protein Coding	1
78	MMP9	Matrix Metallopeptidase 9	Protein Coding	1
79	BAX	BCL2 Associated X, Apoptosis Regulator	Protein Coding	1

Disorders associated with Validated targets of C-MYC transcriptional activation SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Gastric cancer	Enrichment	CDK4, NBN, SMAD4, TP53	3.96
2	Dyskeratosis congenita	Enrichment	DKC1, NPM1, TERT	3.76
3	Lung sarcomatoid carcinoma	Enrichment	TERT, TP53	3.70
4	Hepatocellular carcinoma	Enrichment	NBN, TERT, TP53	3.57
5	Pancreatic cancer	Enrichment	NBN, SMAD4, TP53	3.40
6	Adrenocortical carcinoma	Enrichment	TERT, TP53	3.31
7	Hoyeraal-hreidarsson syndrome	Enrichment	DKC1, TERT	3.31
8	Gallbladder cancer	Enrichment	SMAD4, TP53	3.16
9	Inherited cancer-predisposing syndrome	Enrichment	CDK4, MAX, NBN, SMAD4, TP53	2.99
10	Aplastic anemia	Enrichment	NBN, TERT	2.84
11	Leukemia, acute myeloid	Enrichment	NPM1, TERT, TP53	2.79
12	Melanoma, cutaneous malignant 1	Enrichment	CDK4, TERT	2.37
13	Polycystic liver disease	Enrichment	CDC25A, RUVBL1	2.37
14	Autosomal dominant polycystic liver disease	Enrichment	CDC25A, RUVBL1	2.37
15	Diffuse large b-cell lymphoma	Enrichment	NBN, TP53	2.27
16	Torticollis	Enrichment	ACTL6A	2.23
17	Cerebral cavernous malformations 3	Enrichment	PDCD10	2.23
18	Encephalopathy, familial, with neuroserpin inclusion bodies	Enrichment	SERPINI1	2.23
19	Melanoma, cutaneous malignant 3	Enrichment	CDK4	2.23
20	Stomatin-deficient cryohydrocytosis with neurologic defects	Enrichment	SLC2A1	2.23
21	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3	Enrichment	CCND2	2.23
22	Parkinson disease 18, autosomal dominant	Enrichment	EIF4G1	2.23
23	Diamond-blackfan anemia 7	Enrichment	RPL11	2.23
24	Spinocerebellar ataxia, autosomal recessive 32	Enrichment	PRDX3	2.23
25	Trigonocephaly with short stature and developmental delay	Enrichment	HUWE1	2.23
26	Bone marrow failure syndrome 5	Enrichment	TP53	2.23
27	Bachmann-bupp syndrome	Enrichment	ODC1	2.23
28	Papilloma of choroid plexus	Enrichment	TP53	2.23
29	Basal cell carcinoma 7	Enrichment	TP53	2.23
30	Autism 19	Enrichment	EIF4E	2.23
31	Cataracts, hearing impairment, nephrotic syndrome, and enterocolitis 1	Enrichment	DKC1	2.23
32	Anaplastic thyroid carcinoma	Enrichment	TP53	2.23
33	Intellectual developmental disorder, x-linked, syndromic, turner type	Enrichment	HUWE1	2.23
34	Spastic paraplegia 13, autosomal dominant	Enrichment	HSPD1	2.23
35	Epilepsy, idiopathic generalized 12	Enrichment	SLC2A1	2.23
36	Polydactyly-macrocephaly syndrome	Enrichment	MAX	2.23
37	Immunodeficiency 46	Enrichment	TFRC	2.23
38	Immunodeficiency-centromeric instability-facial anomalies syndrome 3	Enrichment	CDCA7	2.23
39	Spermatogenic failure 13	Enrichment	TAF4B	2.23
40	Syndromic x-linked intellectual disability turner type	Enrichment	HUWE1	2.23
41	Corneal dystrophy, punctiform and polychromatic pre-descemet	Enrichment	PRDX3	2.23
42	Ductal carcinoma in situ	Enrichment	TP53	2.23
43	Deafness, autosomal dominant 75	Enrichment	TRRAP	2.23
44	Neurodegeneration, early-onset, with choreoathetoid movements and microcytic anemia	Enrichment	IREB2	2.23
45	Developmental delay with or without dysmorphic facies and autism	Enrichment	TRRAP	2.23
46	Autosomal recessive dyskeratosis congenita 4	Enrichment	TERT	2.23
47	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.23
48	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.23
49	Heritable thoracic aortic disease	Enrichment	SMAD4	2.23
50	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.23
51	Fischer-zirnsak progeroid syndrome	Enrichment	SUPT7L	2.23
52	Acute myeloid leukemia with multilineage dysplasia	Enrichment	NPM1	2.23
53	Choroid plexus cancer	Enrichment	TP53	2.23
54	Acute myeloid leukemia with npm1 somatic mutations	Enrichment	NPM1	2.23
55	Epilepsy with myoclonic absences	Enrichment	SLC2A1	2.23
56	Infection-induced acute-onset axonal neuropathy	Enrichment	RCC1	2.23
57	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.23
58	Hereditary cryohydrocytosis with reduced stomatin	Enrichment	SLC2A1	2.23
59	Hepatoblastoma	Enrichment	TERT, TP53	2.18
60	Diamond-blackfan anemia 1	Enrichment	RPL11, TP53	2.11
61	Developmental and epileptic encephalopathy 1	Enrichment	CAD, SLC2A1	2.04
62	Burkitt lymphoma	Enrichment	MYC	1.94
63	Myhre syndrome	Enrichment	SMAD4	1.94
64	Adrenocortical carcinoma, hereditary	Enrichment	TP53	1.94
65	Fanconi-bickel syndrome	Enrichment	LDHA	1.94
66	Glycogen storage disease vii	Enrichment	PFKM	1.94
67	Autism x-linked 2	Enrichment	HUWE1	1.94
68	Dystonia 9	Enrichment	SLC2A1	1.94
69	Cervical cancer	Enrichment	TP53	1.94
70	Leukodystrophy, hypomyelinating, 4	Enrichment	HSPD1	1.94
71	Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome	Enrichment	SMAD4	1.94
72	Glut1 deficiency syndrome 1	Enrichment	SLC2A1	1.94
73	Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 1	Enrichment	TERT	1.94
74	Developmental and epileptic encephalopathy 50	Enrichment	CAD	1.94
75	Lymphoma, hodgkin, classic	Enrichment	TP53	1.94
76	Loeys-dietz syndrome 3	Enrichment	SMAD3	1.94
77	Neurodevelopmental disorder with dysmorphic facies, sleep disturbance, and brain abnormalities	Enrichment	KAT5	1.94
78	Immunodeficiency, common variable, 15	Enrichment	RUVBL1	1.94
79	Microcephaly 21, primary, autosomal recessive	Enrichment	GAPDH	1.94
80	Mitochondrial complex i deficiency, nuclear type 10	Enrichment	NDUFAF2	1.94
81	Glucose transporter type 1 deficiency syndrome	Enrichment	SLC2A1	1.94
82	Cerebral cavernous malformation 1	Enrichment	PDCD10	1.94
83	Congenital fibrosarcoma	Enrichment	TP53	1.94
84	Metaphyseal anadysplasia 2	Enrichment	MMP9	1.94
85	Li-fraumeni syndrome 1	Enrichment	TP53	1.94
86	Sarcoma	Enrichment	TP53	1.94
87	Melanoma, cutaneous malignant 9	Enrichment	TERT	1.94
88	Cervix carcinoma	Enrichment	TP53	1.94
89	Hodgkin's lymphoma	Enrichment	TP53	1.94
90	Idiopathic interstitial pneumonia	Enrichment	TERT	1.94
91	Acute myeloid leukemia without maturation	Enrichment	NPM1	1.94
92	Metaphyseal anadysplasia	Enrichment	MMP9	1.94
93	Lymphomatoid papulosis	Enrichment	NPM1	1.94
94	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	1.94
95	Primary cutaneous anaplastic large cell lymphoma	Enrichment	NPM1	1.94
96	Bladder cancer	Enrichment	TERT, TP53	1.91
97	Prostate cancer	Enrichment	NBN, TP53	1.91
98	Colorectal cancer	Enrichment	BAX, SMAD4, TP53	1.85
99	Cleidocranial dysplasia 1	Enrichment	SUPT3H	1.76
100	Cerebral cavernous malformations	Enrichment	PDCD10	1.76
101	Juvenile polyposis syndrome	Enrichment	SMAD4	1.76
102	Nijmegen breakage syndrome	Enrichment	NBN	1.76
103	Dyskeratosis congenita, x-linked	Enrichment	DKC1	1.76
104	Osteogenic sarcoma	Enrichment	TP53	1.76
105	Glut1 deficiency syndrome 2	Enrichment	SLC2A1	1.76
106	Nasopharyngeal carcinoma	Enrichment	TP53	1.76
107	Uv-sensitive syndrome 2	Enrichment	NDUFAF2	1.76
108	Neurodevelopmental disorder with progressive spasticity and brain abnormalities	Enrichment	RUVBL1	1.76
109	Umbilical hernia	Enrichment	ACTL6A	1.76
110	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	MYC	1.76
111	Dedifferentiated liposarcoma	Enrichment	CDK4	1.76
112	Chromosome 17q23.1-q23.2 deletion syndrome	Enrichment	SLC2A1	1.76
113	Interstitial lung disease	Enrichment	TERT	1.76
114	Atypical teratoid rhabdoid tumor	Enrichment	TP53	1.76
115	Anaplastic astrocytoma	Enrichment	TP53	1.76
116	Cleidocranial dysplasia	Enrichment	SUPT3H	1.76
117	Squamous cell carcinoma	Enrichment	TP53	1.76
118	Macrocytic anemia	Enrichment	TERT	1.76
119	T-cell acute lymphoblastic leukemia	Enrichment	BAX	1.76
120	Adenocarcinoma	Enrichment	TP53	1.76
121	Bone osteosarcoma	Enrichment	TP53	1.76
122	Neurodegeneration, childhood-onset, with brain atrophy	Enrichment	UBTF	1.76
123	Well-differentiated liposarcoma	Enrichment	CDK4	1.76
124	Cavernous hemangioma	Enrichment	PDCD10	1.76
125	Diamond-blackfan anemia	Enrichment	RPL11, TP53	1.73
126	Small cell cancer of the lung	Enrichment	TP53	1.64
127	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	1.64
128	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	CCND2	1.64
129	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.64
130	Aortic aneurysm	Enrichment	SMAD3	1.64
131	Familial cerebral cavernous malformations	Enrichment	PDCD10	1.64
132	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	SMAD3, SMAD4	1.57
133	Hereditary breast carcinoma	Enrichment	NBN, TP53	1.57
134	Cockayne syndrome a	Enrichment	NDUFAF2	1.54
135	Rhabdomyosarcoma 2	Enrichment	TP53	1.54
136	Autosomal recessive cerebellar ataxia	Enrichment	PRDX3	1.54
137	Lymphoma	Enrichment	TP53	1.54
138	Acute myeloid leukemia with maturation	Enrichment	NPM1	1.54
139	Acute megakaryocytic leukemia	Enrichment	TP53	1.54
140	Rare syndromic intellectual disability	Enrichment	UBTF	1.54
141	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	SMAD4	1.54
142	Idiopathic aplastic anemia	Enrichment	TERT	1.54
143	Dyskeratosis congenita, autosomal dominant 1	Enrichment	TERT	1.46
144	Li-fraumeni syndrome	Enrichment	TP53	1.46
145	Inguinal hernia	Enrichment	ACTL6A	1.46
146	Immunodeficiency-centromeric instability-facial anomalies syndrome	Enrichment	CDCA7	1.46
147	Pulmonary fibrosis	Enrichment	TERT	1.46
148	Breast adenocarcinoma	Enrichment	TP53	1.46
149	Kidney clear cell sarcoma	Enrichment	TERT	1.46
150	Esophageal cancer	Enrichment	TP53	1.40
151	Squamous cell carcinoma, head and neck	Enrichment	TP53	1.40
152	Dyskeratosis congenita, autosomal dominant 2	Enrichment	TERT	1.40
153	Essential thrombocythemia	Enrichment	TP53	1.40
154	Cockayne syndrome	Enrichment	NDUFAF2	1.40
155	Hereditary hemorrhagic telangiectasia	Enrichment	SMAD4	1.40
156	Paroxysmal dystonia	Enrichment	SLC2A1	1.40
157	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	1.40
158	Hereditary breast ovarian cancer syndrome	Enrichment	NBN, TP53	1.39
159	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	HUWE1, TAF4B	1.38
160	Glioma susceptibility 1	Enrichment	TP53	1.34
161	Gastroesophageal reflux	Enrichment	ACTL6A	1.34
162	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.34
163	Alternating hemiplegia of childhood	Enrichment	SLC2A1	1.34
164	Neuroblastoma	Enrichment	LIN28B	1.34
165	Myoclonic-atonic epilepsy	Enrichment	SLC2A1	1.29
166	Loeys-dietz syndrome	Enrichment	SMAD3	1.29
167	Adult hepatocellular carcinoma	Enrichment	TP53	1.29
168	Primary hyperaldosteronism	Enrichment	TP53	1.29
169	Familial thoracic aortic aneurysm and dissection	Enrichment	SMAD3	1.29
170	Leukemia, chronic lymphocytic	Enrichment	TP53	1.25
171	Familial colorectal cancer	Enrichment	TP53	1.25
172	Leukemia, acute lymphoblastic	Enrichment	NBN	1.21
173	Myelodysplastic syndrome	Enrichment	TP53	1.21
174	Combined immunodeficiency	Enrichment	TFRC	1.21
175	Atrial heart septal defect	Enrichment	ACTL6A	1.21
176	Glycogen storage disease	Enrichment	PFKM	1.21
177	Combined t cell and b cell immunodeficiency	Enrichment	TFRC	1.21
178	Interatrial communication	Enrichment	ACTL6A	1.21
179	Combined t and b cell immunodeficiency	Enrichment	TFRC	1.21
180	Meningioma	Enrichment	TERT	1.17
181	Lip and oral cavity carcinoma	Enrichment	TP53	1.17
182	Breast cancer	Enrichment	NBN, TP53	1.15
183	Breast-ovarian cancer, familial 1	Enrichment	NBN	1.14
184	Acute promyelocytic leukemia	Enrichment	NPM1	1.14
185	Premature menopause	Enrichment	NBN	1.14
186	Protein-deficiency anemia	Enrichment	RPL11	1.14
187	Pheochromocytoma	Enrichment	MAX	1.10
188	Aortic aneurysm, familial thoracic 1	Enrichment	SMAD3	1.10
189	Lung cancer susceptibility 3	Enrichment	TP53	1.10
190	Cerebellar hypoplasia/atrophy, epilepsy, and global developmental delay	Enrichment	DKC1	1.05
191	Rhabdomyosarcoma	Enrichment	TP53	1.05
192	Gliosarcoma	Enrichment	TP53	1.05
193	Interstitial lung disease 2	Enrichment	TERT	1.02
194	Giant cell glioblastoma	Enrichment	TP53	1.02
195	Arteriovenous malformations of the brain	Enrichment	PDCD10	0.98
196	Ehlers-danlos syndrome	Enrichment	SMAD3	0.98
197	Leukodystrophy	Enrichment	HSPD1	0.96
198	Lissencephaly	Enrichment	NBN	0.94
199	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	MAX	0.94
200	Ovarian cancer	Enrichment	NBN, TP53	0.93
201	Precursor t-cell acute lymphoblastic leukemia	Enrichment	MYC	0.90
202	Parkinson disease, late-onset	Enrichment	EIF4G1	0.88
203	Strabismus	Enrichment	SLC2A1	0.84
204	Differentiated thyroid carcinoma	Enrichment	TERT	0.81
205	Microcephaly	Enrichment	NBN, SLC2A1	0.79
206	Complex neurodevelopmental disorder	Enrichment	ACTL6A, HUWE1	0.79
207	Connective tissue disease	Enrichment	SMAD3	0.77
208	Non-syndromic x-linked intellectual disability	Enrichment	HUWE1	0.72
209	Mitochondrial complex i deficiency, nuclear type 1	Enrichment	NDUFAF2	0.70
210	Epilepsy	Enrichment	SLC2A1	0.68
211	Benign epilepsy with centrotemporal spikes	Enrichment	SLC2A1	0.67
212	Type 2 diabetes mellitus	Enrichment	HMGA1	0.66
213	Centralopathic epilepsy	Enrichment	SLC2A1	0.65
214	West syndrome	Enrichment	SLC2A1	0.64
215	Thrombocytopenia	Enrichment	SMAD4	0.61
216	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	TRRAP	0.58
217	Myeloma, multiple	Enrichment	TP53	0.55
218	Primary ovarian insufficiency	Enrichment	NBN	0.53
219	Leigh syndrome, nuclear	Enrichment	NDUFAF2	0.48
220	Leigh disease	Enrichment	NDUFAF2	0.44
221	Congenital nervous system abnormality	Enrichment	SERPINI1	0.33
222	Nervous system disease	Enrichment	SERPINI1	0.33

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Validated targets of C-MYC transcriptional activation

Pathway Network for Validated targets of C-MYC transcriptional activation

Member Pathways for Validated targets of C-MYC transcriptional activation

Pathways in the Validated targets of C-MYC transcriptional activation SuperPath

Associated Genes for Validated targets of C-MYC transcriptional activation

Associated Disorders for Validated targets of C-MYC transcriptional activation

Disorders associated with Validated targets of C-MYC transcriptional activation SuperPath

STRING Interaction Network for Validated targets of C-MYC transcriptional activation

Sources for Validated targets of C-MYC transcriptional activation