Validated targets of C-MYC transcriptional repression

No Pathway Network information available for Validated targets of C-MYC transcriptional repression

Pathways in the Validated targets of C-MYC transcriptional repression SuperPath

#	Name	Source	Genes
1	Validated targets of C-MYC transcriptional repression	PubChem	ALDH9A1 BCL2 BRCA1 CCL5 CCND1 CDKN1A CDKN1B CDKN2B CEBPA CEBPD CFLAR CLU COL1A2 CREB1 CSDE1 DDIT3 DKK1 DNMT3A DNTT EP300 ERBB2 FOXO3 FTH1 GADD45A GFI1 GTF2H2 HDAC1 HDAC3 HMGCS2 ID2 IRF8 ITGA6 ITGB1 ITGB4 LGALS1 MAX MXD4 MYC NDRG1 NDRG2 NFYA NFYB NFYC PDGFRB PTPA RBL1 S100A7 SFRP1 SFXN3 SLC11A1 SMAD2 SMAD4 SP1 SPI1 TBP TJP2 TMEFF2 TMEM126A TSC2 WNT5A ZBTB17 ZFP36L1 (see all 62) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	NDRG2	NDRG Family Member 2	Protein Coding	1
2	ID2	Inhibitor Of DNA Binding 2	Protein Coding	1
3	TMEFF2	Transmembrane Protein With EGF Like And Two Follistatin Like Domains 2	Protein Coding	1
4	S100A7	S100 Calcium Binding Protein A7	Protein Coding	1
5	IRF8	Interferon Regulatory Factor 8	Protein Coding	1
6	SFXN3	Sideroflexin 3	Protein Coding	1
7	FTH1	Ferritin Heavy Chain 1	Protein Coding	1
8	LGALS1	Galectin 1	Protein Coding	1
9	CSDE1	Cold Shock Domain Containing E1	Protein Coding	1
10	PTPA	Protein Phosphatase 2 Phosphatase Activator	Protein Coding	1
11	DNTT	DNA Nucleotidylexotransferase	Protein Coding	1
12	DKK1	Dickkopf Wnt Signaling Pathway Inhibitor 1	Protein Coding	1
13	SFRP1	Secreted Frizzled Related Protein 1	Protein Coding	1
14	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
15	ALDH9A1	Aldehyde Dehydrogenase 9 Family Member A1	Protein Coding	1
16	GFI1	Growth Factor Independent 1 Transcriptional Repressor	Protein Coding	1
17	ZFP36L1	ZFP36 Ring Finger Protein Like 1	Protein Coding	1
18	CLU	Clusterin	Protein Coding	1
19	SPI1	Spi-1 Proto-Oncogene	Protein Coding	1
20	NDRG1	N-Myc Downstream Regulated 1	Protein Coding	1
21	ZBTB17	Zinc Finger And BTB Domain Containing 17	Protein Coding	1
22	DNMT3A	DNA Methyltransferase 3 Alpha	Protein Coding	1
23	MAX	MYC Associated Transcriptional Regulator X	Protein Coding	1
24	CFLAR	CASP8 And FADD Like Apoptosis Regulator	Protein Coding	1
25	TBP	TATA-Box Binding Protein	Protein Coding	1
26	WNT5A	Wnt Family Member 5A	Protein Coding	1
27	CCND1	Cyclin D1	Protein Coding	1
28	CCL5	C-C Motif Chemokine Ligand 5	Protein Coding	1
29	CDKN2B	Cyclin Dependent Kinase Inhibitor 2B	Protein Coding	1
30	RBL1	RB Transcriptional Corepressor Like 1	Protein Coding	1
31	COL1A2	Collagen Type I Alpha 2 Chain	Protein Coding	1
32	MXD4	MAX Dimerization Protein 4	Protein Coding	1
33	GTF2H2	General Transcription Factor IIH Subunit 2	Protein Coding	1
34	TJP2	Tight Junction Protein 2	Protein Coding	1
35	BCL2	BCL2 Apoptosis Regulator	Protein Coding	1
36	TMEM126A	Transmembrane Protein 126A	Protein Coding	1
37	HMGCS2	3-Hydroxy-3-Methylglutaryl-CoA Synthase 2	Protein Coding	1
38	NFYC	Nuclear Transcription Factor Y Subunit Gamma	Protein Coding	1
39	NFYB	Nuclear Transcription Factor Y Subunit Beta	Protein Coding	1
40	NFYA	Nuclear Transcription Factor Y Subunit Alpha	Protein Coding	1
41	BRCA1	BRCA1 DNA Repair Associated	Protein Coding	1
42	ITGB4	Integrin Subunit Beta 4	Protein Coding	1
43	ITGA6	Integrin Subunit Alpha 6	Protein Coding	1
44	SP1	Sp1 Transcription Factor	Protein Coding	1
45	CEBPD	CCAAT Enhancer Binding Protein Delta	Protein Coding	1
46	CEBPA	CCAAT Enhancer Binding Protein Alpha	Protein Coding	1
47	SMAD4	SMAD Family Member 4	Protein Coding	1
48	SMAD2	SMAD Family Member 2	Protein Coding	1
49	FOXO3	Forkhead Box O3	Protein Coding	1
50	EP300	EP300 Lysine Acetyltransferase	Protein Coding	1
51	ITGB1	Integrin Subunit Beta 1	Protein Coding	1
52	HDAC3	Histone Deacetylase 3	Protein Coding	1
53	TSC2	TSC Complex Subunit 2	Protein Coding	1
54	SLC11A1	Solute Carrier Family 11 Member 1	Protein Coding	1
55	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
56	GADD45A	Growth Arrest And DNA Damage Inducible Alpha	Protein Coding	1
57	PDGFRB	Platelet Derived Growth Factor Receptor Beta	Protein Coding	1
58	HDAC1	Histone Deacetylase 1	Protein Coding	1
59	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	1
60	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	1
61	DDIT3	DNA Damage Inducible Transcript 3	Protein Coding	1
62	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	1

Disorders associated with Validated targets of C-MYC transcriptional repression SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A, CDKN1B, CDKN2B	5.50
2	Inherited cancer-predisposing syndrome	Enrichment	BRCA1, CDKN1B, CEBPA, MAX, SMAD4, TSC2	4.53
3	Colorectal cancer	Enrichment	BRCA1, CCND1, EP300, ERBB2, SMAD4	4.33
4	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL2, MYC	4.21
5	Epidermolysis bullosa, junctional 5b, with pyloric atresia	Enrichment	ITGA6, ITGB4	3.52
6	Bladder cancer	Enrichment	BRCA1, CDKN1A, ERBB2	3.52
7	Junctional epidermolysis bullosa	Enrichment	ITGA6, ITGB4	3.14
8	Gastric cancer	Enrichment	BRCA1, ERBB2, SMAD4	3.01
9	Ovarian cancer	Enrichment	BRCA1, CDKN1B, ERBB2, TSC2	2.94
10	Rare genetic intellectual disability	Enrichment	DNMT3A, EP300	2.68
11	Palmoplantar keratoderma, punctate type ii	Enrichment	BRCA1	2.34
12	Chiari malformation type i	Enrichment	DKK1	2.34
13	Paget disease, extramammary	Enrichment	ERBB2	2.34
14	Ehlers-danlos syndrome, cardiac valvular type	Enrichment	COL1A2	2.34
15	Premature aging syndrome, penttinen type	Enrichment	PDGFRB	2.34
16	Buruli ulcer	Enrichment	SLC11A1	2.34
17	Deafness, autosomal dominant 51	Enrichment	TJP2	2.34
18	Myofibromatosis, infantile, 1	Enrichment	PDGFRB	2.34
19	Immunodeficiency 32a	Enrichment	IRF8	2.34
20	Visceral neuropathy, familial, 2, autosomal recessive	Enrichment	ERBB2	2.34
21	Agammaglobulinemia 10, autosomal dominant	Enrichment	SPI1	2.34
22	Parkinson disease 25, autosomal recessive early-onset, with impaired intellectual development	Enrichment	PTPA	2.34
23	Combined osteogenesis imperfecta and ehlers-danlos syndrome 2	Enrichment	COL1A2	2.34
24	Heyn-sproul-jackson syndrome	Enrichment	DNMT3A	2.34
25	Infant-type hemispheric glioma	Enrichment	BRCA1	2.34
26	Neuroendocrine tumor	Enrichment	CDKN1B	2.34
27	Optic atrophy 7 with or without auditory neuropathy	Enrichment	TMEM126A	2.34
28	Basal ganglia calcification, idiopathic, 4	Enrichment	PDGFRB	2.34
29	Polydactyly-macrocephaly syndrome	Enrichment	MAX	2.34
30	Myeloid and lymphoid neoplasms associated with pdgfrb rearrangement	Enrichment	PDGFRB	2.34
31	Loeys-dietz syndrome 6	Enrichment	SMAD2	2.34
32	Kosaki overgrowth syndrome	Enrichment	PDGFRB	2.34
33	Ocular pterygium-digital keloid dysplasia syndrome	Enrichment	PDGFRB	2.34
34	Autosomal recessive optic atrophy, opa7 type	Enrichment	TMEM126A	2.34
35	Congenital heart defects, multiple types, 8, with or without heterotaxy	Enrichment	SMAD2	2.34
36	Heritable thoracic aortic disease	Enrichment	SMAD4	2.34
37	Agammaglobulinemia	Enrichment	SPI1	2.34
38	Acute myeloid leukemia with mutated cebpa	Enrichment	CEBPA	2.34
39	Serous carcinoma of the corpus uteri	Enrichment	ERBB2	2.34
40	Primary peritoneal carcinoma	Enrichment	BRCA1	2.34
41	Pancreatic cancer	Enrichment	BRCA1, SMAD4	2.24
42	Burkitt lymphoma	Enrichment	MYC	2.04
43	Myeloproliferative disorder, chronic, with eosinophilia	Enrichment	PDGFRB	2.04
44	Myhre syndrome	Enrichment	SMAD4	2.04
45	Immunodeficiency 32b	Enrichment	IRF8	2.04
46	Vitreoretinochoroidopathy	Enrichment	FTH1	2.04
47	Bruck syndrome 1	Enrichment	COL1A2	2.04
48	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.04
49	Neutropenia, nonimmune chronic idiopathic, of adults	Enrichment	GFI1	2.04
50	Spinocerebellar ataxia 17	Enrichment	TBP	2.04
51	Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome	Enrichment	SMAD4	2.04
52	Lymphangioleiomyomatosis	Enrichment	TSC2	2.04
53	Retinitis pigmentosa 50	Enrichment	FTH1	2.04
54	Cholestasis, progressive familial intrahepatic, 4	Enrichment	TJP2	2.04
55	Neutropenia, severe congenital, 2, autosomal dominant	Enrichment	GFI1	2.04
56	Multiple endocrine neoplasia, type iv	Enrichment	CDKN1B	2.04
57	Charcot-marie-tooth disease, demyelinating, type 4d	Enrichment	NDRG1	2.04
58	Epidermolysis bullosa, junctional 5a, intermediate	Enrichment	ITGB4	2.04
59	Fanconi anemia, complementation group s	Enrichment	BRCA1	2.04
60	Ehlers-danlos syndrome, arthrochalasia type, 2	Enrichment	COL1A2	2.04
61	Menke-hennekam syndrome 2	Enrichment	EP300	2.04
62	Infantile myofibromatosis	Enrichment	PDGFRB	2.04
63	Intravascular large b-cell lymphoma	Enrichment	BCL2	2.04
64	3-hydroxy-3-methylglutaryl-coa synthase-2 deficiency	Enrichment	HMGCS2	2.04
65	Pancreatic cancer 4	Enrichment	BRCA1	2.04
66	Hemochromatosis, type 5	Enrichment	FTH1	2.04
67	Tatton-brown-rahman syndrome	Enrichment	DNMT3A	2.04
68	Inflammatory breast carcinoma	Enrichment	BRCA1	2.04
69	Peritoneum cancer	Enrichment	BRCA1	2.04
70	Charcot-marie-tooth disease type 4d	Enrichment	NDRG1	2.04
71	Ehlers-danlos/osteogenesis imperfecta syndrome	Enrichment	COL1A2	2.04
72	Bilateral breast cancer	Enrichment	BRCA1	2.04
73	Localized junctional epidermolysis bullosa, non-herlitz type	Enrichment	ITGB4	2.04
74	Neurodegeneration with brain iron accumulation 9	Enrichment	FTH1	2.04
75	Dentinogenesis imperfecta	Enrichment	COL1A2	2.04
76	Lung cancer	Enrichment	BRCA1, ERBB2	2.03
77	Juvenile polyposis syndrome	Enrichment	SMAD4	1.86
78	Tuberous sclerosis 1	Enrichment	TSC2	1.86
79	Polycystic kidney disease, infantile severe, with tuberous sclerosis	Enrichment	TSC2	1.86
80	Osteoporosis, juvenile	Enrichment	DKK1	1.86
81	Hypercholanemia, familial 1	Enrichment	TJP2	1.86
82	Tuberous sclerosis 2	Enrichment	TSC2	1.86
83	Epidermolysis bullosa, junctional 6, with pyloric atresia	Enrichment	ITGA6	1.86
84	Loeys-dietz syndrome 1	Enrichment	SMAD2	1.86
85	Hamartoma	Enrichment	TSC2	1.86
86	Xanthinuria, type ii	Enrichment	TSC2	1.86
87	Myxoid liposarcoma	Enrichment	DDIT3	1.86
88	High bone mass osteogenesis imperfecta	Enrichment	COL1A2	1.86
89	Melanoma of soft tissue	Enrichment	CREB1	1.86
90	Leukemia, acute myeloid	Enrichment	CEBPA, DNMT3A	1.84
91	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	SMAD2, SMAD4	1.76
92	Ehlers-danlos syndrome, arthrochalasia type, 1	Enrichment	COL1A2	1.74
93	Robinow syndrome, autosomal dominant 1	Enrichment	WNT5A	1.74
94	Polyposis syndrome, hereditary mixed, 1	Enrichment	BRCA1	1.74
95	Epidermolysis bullosa simplex 5c, with pyloric atresia	Enrichment	ITGB4	1.74
96	Focal cortical dysplasia, type ii	Enrichment	TSC2	1.74
97	Bestrophinopathy, autosomal recessive	Enrichment	FTH1	1.74
98	Cholangiocarcinoma	Enrichment	BRCA1	1.74
99	Barrett esophagus	Enrichment	ERBB2	1.74
100	Mantle cell lymphoma	Enrichment	CCND1	1.74
101	Tuberous sclerosis	Enrichment	TSC2	1.74
102	Tuberculosis	Enrichment	SLC11A1	1.74
103	Autosomal dominant robinow syndrome	Enrichment	WNT5A	1.74
104	Osteogenesis imperfecta with normal sclerae, dominant form	Enrichment	COL1A2	1.74
105	Primary hyperparathyroidism	Enrichment	CDKN1B	1.74
106	Isolated focal cortical dysplasia type ii	Enrichment	TSC2	1.74
107	Macular dystrophy, vitelliform, 2	Enrichment	FTH1	1.64
108	Epidermolysis bullosa simplex 1c, localized	Enrichment	ITGB4	1.64
109	Von hippel-lindau syndrome	Enrichment	CCND1	1.64
110	Robinow syndrome, autosomal recessive 1	Enrichment	WNT5A	1.64
111	Breast-ovarian cancer, familial 2	Enrichment	BRCA1	1.64
112	Rubinstein-taybi syndrome 2	Enrichment	EP300	1.64
113	Follicular lymphoma	Enrichment	BCL2	1.64
114	Myeloproliferative neoplasm	Enrichment	DNMT3A	1.64
115	Glioblastoma	Enrichment	DNMT3A	1.64
116	Epidermolysis bullosa	Enrichment	ITGA6	1.64
117	Aplasia cutis congenita	Enrichment	ITGB4	1.64
118	Autosomal dominant severe congenital neutropenia	Enrichment	GFI1	1.64
119	Inherited acute myeloid leukemia	Enrichment	CEBPA	1.64
120	Acute myeloid leukemia with t(8;21)(q22;q22) translocation	Enrichment	CEBPA	1.64
121	Primary hypereosinophilic syndrome	Enrichment	PDGFRB	1.64
122	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	SMAD4	1.64
123	Myeloma, multiple	Enrichment	CCND1, DNMT3A	1.57
124	Ehlers-danlos syndrome, classic type, 1	Enrichment	COL1A2	1.57
125	Branchiootorenal syndrome 1	Enrichment	TJP2	1.57
126	Osteogenesis imperfecta, type i	Enrichment	COL1A2	1.57
127	Rubinstein-taybi syndrome 1	Enrichment	EP300	1.57
128	Epidermolysis bullosa, junctional 1a, intermediate	Enrichment	ITGB4	1.57
129	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	EP300	1.57
130	Junctional epidermolysis bullosa non-herlitz type	Enrichment	ITGB4	1.57
131	Autosomal recessive robinow syndrome	Enrichment	WNT5A	1.57
132	Classic ehlers-danlos syndrome	Enrichment	COL1A2	1.57
133	Familial hypercholanemia	Enrichment	TJP2	1.57
134	Sporadic pheochromocytoma/secreting paraganglioma	Enrichment	DNMT3A	1.57
135	Polycystic kidney disease 1 with or without polycystic liver disease	Enrichment	TSC2	1.50
136	Osteogenesis imperfecta, type ii	Enrichment	COL1A2	1.50
137	Polycystic kidney disease 1	Enrichment	TSC2	1.50
138	Branchiootorenal syndrome	Enrichment	TJP2	1.50
139	Gallbladder cancer	Enrichment	SMAD4	1.50
140	Hereditary hemorrhagic telangiectasia	Enrichment	SMAD4	1.50
141	Epidermolysis bullosa simplex	Enrichment	ITGB4	1.50
142	Glioma susceptibility 1	Enrichment	ERBB2	1.44
143	Basal ganglia calcification, idiopathic, 1	Enrichment	PDGFRB	1.44
144	Charge syndrome	Enrichment	EP300	1.39
145	Loeys-dietz syndrome	Enrichment	SMAD2	1.39
146	Adult hepatocellular carcinoma	Enrichment	TSC2	1.39
147	Primary biliary cholangitis	Enrichment	TJP2	1.39
148	Leukemia, chronic lymphocytic	Enrichment	CCND1	1.35
149	Melanoma	Enrichment	DNMT3A	1.35
150	Autosomal non-syndromic agammaglobulinemia	Enrichment	SPI1	1.35
151	Primary bone dysplasia	Enrichment	COL1A2	1.35
152	Breast cancer	Enrichment	BRCA1, CDKN2B	1.34
153	Osteochondrodysplasia	Enrichment	COL1A2	1.31
154	Lung non-small cell carcinoma	Enrichment	ERBB2	1.31
155	Uterine corpus cancer	Enrichment	BRCA1	1.31
156	Specific learning disability	Enrichment	DNMT3A	1.31
157	Osteogenesis imperfecta, type iv	Enrichment	COL1A2	1.24
158	Neural tube defects	Enrichment	ITGB1	1.24
159	Breast-ovarian cancer, familial 1	Enrichment	BRCA1	1.24
160	Multiple sclerosis	Enrichment	ITGB4	1.21
161	Osteoporosis	Enrichment	COL1A2	1.21
162	Pheochromocytoma	Enrichment	MAX	1.21
163	Lung cancer susceptibility 3	Enrichment	ERBB2	1.21
164	Periventricular nodular heterotopia	Enrichment	BRCA1	1.21
165	Polydactyly, postaxial, type a1	Enrichment	EP300	1.18
166	Osteogenesis imperfecta, type iii	Enrichment	COL1A2	1.18
167	Hydrocephalus	Enrichment	PDGFRB	1.18
168	Autosomal dominant polycystic kidney disease	Enrichment	TSC2	1.18
169	Rhabdomyosarcoma	Enrichment	BRCA1	1.15
170	Gliosarcoma	Enrichment	DNMT3A	1.15
171	Melanoma, cutaneous malignant 1	Enrichment	CDKN2B	1.13
172	Dandy-walker syndrome	Enrichment	PDGFRB	1.13
173	Giant cell glioblastoma	Enrichment	DNMT3A	1.13
174	Human immunodeficiency virus type 1	Enrichment	CCL5	1.10
175	Charcot-marie-tooth disease type 4	Enrichment	NDRG1	1.10
176	Diffuse large b-cell lymphoma	Enrichment	DNMT3A	1.08
177	Esophageal atresia/tracheoesophageal fistula	Enrichment	IRF8	1.08
178	Ehlers-danlos syndrome	Enrichment	COL1A2	1.08
179	Parkinson's disease	Enrichment	TBP	1.08
180	Congenital nervous system abnormality	Enrichment	DNMT3A, TSC2	1.07
181	Nervous system disease	Enrichment	DNMT3A, TSC2	1.07
182	Autism spectrum disorder	Enrichment	DNMT3A, TSC2	1.05
183	Endometrial cancer	Enrichment	BRCA1	1.04
184	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	MAX	1.04
185	Skin disease	Enrichment	ITGB4	1.02
186	Brittle bone disorder	Enrichment	COL1A2	1.00
187	Precursor t-cell acute lymphoblastic leukemia	Enrichment	MYC	1.00
188	Parkinson disease, late-onset	Enrichment	TBP	0.98
189	Hirschsprung disease 1	Enrichment	ERBB2	0.90
190	Prostate cancer	Enrichment	BRCA1	0.90
191	Cystic fibrosis	Enrichment	SLC11A1	0.86
192	Fanconi anemia, complementation group a	Enrichment	BRCA1	0.83
193	Cerebral palsy	Enrichment	PDGFRB	0.79
194	Charcot-marie-tooth disease	Enrichment	NDRG1	0.77
195	Optic atrophy plus syndrome	Enrichment	TMEM126A	0.74
196	West syndrome	Enrichment	TSC2	0.74
197	Hereditary breast carcinoma	Enrichment	BRCA1	0.74
198	Thrombocytopenia	Enrichment	SMAD4	0.70
199	Body mass index quantitative trait locus 11	Enrichment	DNMT3A	0.69
200	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	TJP2	0.67
201	Hereditary breast ovarian cancer syndrome	Enrichment	BRCA1	0.65
202	Microcephaly	Enrichment	EP300	0.36
203	Hereditary retinal dystrophy	Enrichment	FTH1	0.13
204	Fundus dystrophy	Enrichment	FTH1	0.13

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Validated targets of C-MYC transcriptional repression

Pathway Network for Validated targets of C-MYC transcriptional repression

Member Pathways for Validated targets of C-MYC transcriptional repression

Pathways in the Validated targets of C-MYC transcriptional repression SuperPath

Associated Genes for Validated targets of C-MYC transcriptional repression

Associated Disorders for Validated targets of C-MYC transcriptional repression

Disorders associated with Validated targets of C-MYC transcriptional repression SuperPath

STRING Interaction Network for Validated targets of C-MYC transcriptional repression

Sources for Validated targets of C-MYC transcriptional repression