Validated transcriptional targets of AP1 family members Fra1 and Fra2

No Pathway Network information available for Validated transcriptional targets of AP1 family members Fra1 and Fra2

Pathways in the Validated transcriptional targets of AP1 family members Fra1 and Fra2 SuperPath

#	Name	Source	Genes
1	Validated transcriptional targets of AP1 family members Fra1 and Fra2	PubChem	ATF4 BGLAP CCL2 CCNA2 CCND1 CDKN2A COL1A2 CXCL8 DCN DMTF1 EP300 FOSL1 FOSL2 GJA1 HMOX1 IL6 ITGB4 IVL JUN JUNB JUND LAMA3 LIF MGP MMP1 MMP2 MMP9 NFATC2 NOS3 PLAU PLAUR SP1 THBD TXLNG USF2 (see all 35) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	DMTF1	Cyclin D Binding Myb Like Transcription Factor 1	Protein Coding	1
2	MGP	Matrix Gla Protein	Protein Coding	1
3	TXLNG	Taxilin Gamma	Protein Coding	1
4	FOSL1	FOS Like 1, AP-1 Transcription Factor Subunit	Protein Coding	1
5	FOSL2	FOS Like 2, AP-1 Transcription Factor Subunit	Protein Coding	1
6	LIF	LIF Interleukin 6 Family Cytokine	Protein Coding	1
7	HMOX1	Heme Oxygenase 1	Protein Coding	1
8	NFATC2	Nuclear Factor Of Activated T Cells 2	Protein Coding	1
9	CCL2	C-C Motif Chemokine Ligand 2	Protein Coding	1
10	ATF4	Activating Transcription Factor 4	Protein Coding	1
11	CCNA2	Cyclin A2	Protein Coding	1
12	IL6	Interleukin 6	Protein Coding	1
13	USF2	Upstream Transcription Factor 2, C-Fos Interacting	Protein Coding	1
14	JUND	JunD Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
15	CCND1	Cyclin D1	Protein Coding	1
16	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	1
17	JUNB	JunB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
18	COL1A2	Collagen Type I Alpha 2 Chain	Protein Coding	1
19	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	1
20	NOS3	Nitric Oxide Synthase 3	Protein Coding	1
21	PLAUR	Plasminogen Activator, Urokinase Receptor	Protein Coding	1
22	PLAU	Plasminogen Activator, Urokinase	Protein Coding	1
23	THBD	Thrombomodulin	Protein Coding	1
24	DCN	Decorin	Protein Coding	1
25	MMP1	Matrix Metallopeptidase 1	Protein Coding	1
26	MMP2	Matrix Metallopeptidase 2	Protein Coding	1
27	LAMA3	Laminin Subunit Alpha 3	Protein Coding	1
28	ITGB4	Integrin Subunit Beta 4	Protein Coding	1
29	SP1	Sp1 Transcription Factor	Protein Coding	1
30	IVL	Involucrin	Protein Coding	1
31	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
32	EP300	EP300 Lysine Acetyltransferase	Protein Coding	1
33	GJA1	Gap Junction Protein Alpha 1	Protein Coding	1
34	MMP9	Matrix Metallopeptidase 9	Protein Coding	1
35	BGLAP	Bone Gamma-Carboxyglutamate Protein	Protein Coding	1

Disorders associated with Validated transcriptional targets of AP1 family members Fra1 and Fra2 SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Alzheimer disease 2	Enrichment	NOS3, PLAU	4.19
2	Epidermolysis bullosa, junctional 1a, intermediate	Enrichment	ITGB4, LAMA3	4.02
3	Junctional epidermolysis bullosa non-herlitz type	Enrichment	ITGB4, LAMA3	4.02
4	Junctional epidermolysis bullosa	Enrichment	ITGB4, LAMA3	3.64
5	Alzheimer disease, familial, 1	Enrichment	NOS3, PLAU	3.07
6	Palmoplantar keratoderma and congenital alopecia 1	Enrichment	GJA1	2.59
7	Ehlers-danlos syndrome, cardiac valvular type	Enrichment	COL1A2	2.59
8	Hypoplastic left heart syndrome 1	Enrichment	GJA1	2.59
9	Hemolytic uremic syndrome, atypical 6	Enrichment	THBD	2.59
10	Oculodentodigital dysplasia	Enrichment	GJA1	2.59
11	Keutel syndrome	Enrichment	MGP	2.59
12	Craniometaphyseal dysplasia, autosomal recessive	Enrichment	GJA1	2.59
13	Combined osteogenesis imperfecta and ehlers-danlos syndrome 2	Enrichment	COL1A2	2.59
14	Oculodentodigital dysplasia, autosomal recessive	Enrichment	GJA1	2.59
15	Thrombophilia due to thrombomodulin defect	Enrichment	THBD	2.59
16	Heme oxygenase 1 deficiency	Enrichment	HMOX1	2.59
17	Erythrokeratodermia variabilis et progressiva 3	Enrichment	GJA1	2.59
18	Cdkn2a cancer predisposition	Enrichment	CDKN2A	2.59
19	Aplasia cutis-enamel dysplasia syndrome	Enrichment	FOSL2	2.59
20	Melanoma-astrocytoma syndrome	Enrichment	CDKN2A	2.29
21	Epidermolysis bullosa, junctional 2c, laryngoonychocutaneous	Enrichment	LAMA3	2.29
22	Bruck syndrome 1	Enrichment	COL1A2	2.29
23	Quebec platelet disorder	Enrichment	PLAU	2.29
24	Corneal dystrophy, congenital stromal	Enrichment	DCN	2.29
25	Melanoma, cutaneous malignant 2	Enrichment	CDKN2A	2.29
26	Hallermann-streiff syndrome	Enrichment	GJA1	2.29
27	Syndactyly, type iii	Enrichment	GJA1	2.29
28	Syndactyly, type v	Enrichment	GJA1	2.29
29	Epidermolysis bullosa, junctional 2a, intermediate	Enrichment	LAMA3	2.29
30	Epidermolysis bullosa, junctional 5a, intermediate	Enrichment	ITGB4	2.29
31	Ehlers-danlos syndrome, arthrochalasia type, 2	Enrichment	COL1A2	2.29
32	Menke-hennekam syndrome 2	Enrichment	EP300	2.29
33	Craniometaphyseal dysplasia	Enrichment	GJA1	2.29
34	Recessive dystrophic epidermolysis bullosa	Enrichment	MMP1	2.29
35	Melanoma-pancreatic cancer syndrome	Enrichment	CDKN2A	2.29
36	Metaphyseal anadysplasia 2	Enrichment	MMP9	2.29
37	Epidermolysis bullosa, junctional 2b, severe	Enrichment	LAMA3	2.29
38	Metaphyseal anadysplasia	Enrichment	MMP9	2.29
39	Ehlers-danlos/osteogenesis imperfecta syndrome	Enrichment	COL1A2	2.29
40	Joint contractures, osteochondromas, and b-cell lymphoma	Enrichment	NFATC2	2.29
41	Localized junctional epidermolysis bullosa, non-herlitz type	Enrichment	ITGB4	2.29
42	Dentinogenesis imperfecta	Enrichment	COL1A2	2.29
43	Multicentric osteolysis, nodulosis, and arthropathy	Enrichment	MMP2	2.11
44	High bone mass osteogenesis imperfecta	Enrichment	COL1A2	2.11
45	Kaposi sarcoma	Enrichment	IL6	1.99
46	Ehlers-danlos syndrome, arthrochalasia type, 1	Enrichment	COL1A2	1.99
47	Epidermolysis bullosa simplex 5c, with pyloric atresia	Enrichment	ITGB4	1.99
48	Mantle cell lymphoma	Enrichment	CCND1	1.99
49	Osteogenesis imperfecta with normal sclerae, dominant form	Enrichment	COL1A2	1.99
50	Systemic-onset juvenile idiopathic arthritis	Enrichment	IL6	1.99
51	Epidermolysis bullosa simplex 1c, localized	Enrichment	ITGB4	1.89
52	Von hippel-lindau syndrome	Enrichment	CCND1	1.89
53	Rheumatoid arthritis, systemic juvenile	Enrichment	IL6	1.89
54	Rubinstein-taybi syndrome 2	Enrichment	EP300	1.89
55	Pre-eclampsia	Enrichment	NOS3	1.89
56	Aplasia cutis congenita	Enrichment	ITGB4	1.89
57	Cleft upper lip	Enrichment	GJA1	1.89
58	Ehlers-danlos syndrome, classic type, 1	Enrichment	COL1A2	1.81
59	Li-fraumeni syndrome	Enrichment	CDKN2A	1.81
60	Osteogenesis imperfecta, type i	Enrichment	COL1A2	1.81
61	Rubinstein-taybi syndrome 1	Enrichment	EP300	1.81
62	Epidermolysis bullosa, junctional 1b, severe	Enrichment	LAMA3	1.81
63	Type 1 diabetes mellitus	Enrichment	IL6	1.81
64	Epidermolysis bullosa, junctional 5b, with pyloric atresia	Enrichment	ITGB4	1.81
65	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	EP300	1.81
66	Adrenocortical carcinoma	Enrichment	CDKN2A	1.81
67	Lung squamous cell carcinoma	Enrichment	CDKN2A	1.81
68	Classic ehlers-danlos syndrome	Enrichment	COL1A2	1.81
69	Atypical hemolytic uremic syndrome with complement gene abnormality	Enrichment	THBD	1.81
70	Osteogenesis imperfecta, type ii	Enrichment	COL1A2	1.75
71	Epidermolysis bullosa simplex	Enrichment	ITGB4	1.75
72	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	CDKN2A	1.75
73	Erythrokeratodermia variabilis et progressiva 1	Enrichment	GJA1	1.69
74	Hypoplastic left heart syndrome	Enrichment	GJA1	1.69
75	Colorectal cancer	Enrichment	CCND1, EP300	1.68
76	Charge syndrome	Enrichment	EP300	1.64
77	Inflammatory bowel disease 1	Enrichment	IL6	1.64
78	Leukemia, chronic lymphocytic	Enrichment	CCND1	1.59
79	Stroke, ischemic	Enrichment	NOS3	1.59
80	Melanoma	Enrichment	CDKN2A	1.59
81	Primary bone dysplasia	Enrichment	COL1A2	1.59
82	Leukemia, acute lymphoblastic	Enrichment	CDKN2A	1.55
83	Osteochondrodysplasia	Enrichment	COL1A2	1.55
84	Lip and oral cavity carcinoma	Enrichment	CDKN2A	1.52
85	Osteogenesis imperfecta, type iv	Enrichment	COL1A2	1.48
86	Pulmonary disease, chronic obstructive	Enrichment	HMOX1	1.48
87	Multiple sclerosis	Enrichment	ITGB4	1.45
88	Osteoporosis	Enrichment	COL1A2	1.45
89	Polydactyly, postaxial, type a1	Enrichment	EP300	1.42
90	Osteogenesis imperfecta, type iii	Enrichment	COL1A2	1.42
91	Rare genetic intellectual disability	Enrichment	EP300	1.42
92	Hypertension, essential	Enrichment	NOS3	1.37
93	Melanoma, cutaneous malignant 1	Enrichment	CDKN2A	1.37
94	Human immunodeficiency virus type 1	Enrichment	CCL2	1.34
95	Arteriovenous malformations of the brain	Enrichment	IL6	1.32
96	Ehlers-danlos syndrome	Enrichment	COL1A2	1.32
97	Cardiomyopathy, dilated, 1a	Enrichment	NFATC2	1.28
98	Skin disease	Enrichment	ITGB4	1.26
99	Brittle bone disorder	Enrichment	COL1A2	1.24
100	Precursor t-cell acute lymphoblastic leukemia	Enrichment	CDKN2A	1.24
101	Pancreatic cancer	Enrichment	CDKN2A	1.20
102	Bladder cancer	Enrichment	CDKN2A	1.14
103	Cystic fibrosis	Enrichment	HMOX1	1.10
104	Type 2 diabetes mellitus	Enrichment	IL6	0.99
105	Gastric cancer	Enrichment	CDKN2A	0.98
106	Thrombocytopenia	Enrichment	THBD	0.93
107	Myeloma, multiple	Enrichment	CCND1	0.87
108	Primary ovarian insufficiency	Enrichment	NOS3	0.85
109	Breast cancer	Enrichment	JUN	0.75
110	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	GJA1	0.69
111	Ovarian cancer	Enrichment	CDKN2A	0.64
112	Microcephaly	Enrichment	EP300	0.56
113	Inherited cancer-predisposing syndrome	Enrichment	CDKN2A	0.54

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Validated transcriptional targets of AP1 family members Fra1 and Fra2

Pathway Network for Validated transcriptional targets of AP1 family members Fra1 and Fra2

Member Pathways for Validated transcriptional targets of AP1 family members Fra1 and Fra2

Pathways in the Validated transcriptional targets of AP1 family members Fra1 and Fra2 SuperPath

Associated Genes for Validated transcriptional targets of AP1 family members Fra1 and Fra2

Associated Disorders for Validated transcriptional targets of AP1 family members Fra1 and Fra2

Disorders associated with Validated transcriptional targets of AP1 family members Fra1 and Fra2 SuperPath

STRING Interaction Network for Validated transcriptional targets of AP1 family members Fra1 and Fra2

Sources for Validated transcriptional targets of AP1 family members Fra1 and Fra2