Validated transcriptional targets of deltaNp63 isoforms

No Pathway Network information available for Validated transcriptional targets of deltaNp63 isoforms

Pathways in the Validated transcriptional targets of deltaNp63 isoforms SuperPath

#	Name	Source	Genes
1	Validated transcriptional targets of deltaNp63 isoforms	PubChem	ADA ADRM1 ATM AXL BDKRB2 BRCA2 CCNB2 CDKN2A CEBPD COL5A1 DLX5 DLX6 FASN FBXW7 FOSL2 GPX2 GSK3B HBP1 HELLS HES1 IGFBP3 IL1A ITCH ITGA3 KRT14 KRT5 MDM2 MRE11 NOTCH1 NRG1 PERP POU2F2 PPP2R5A RAB38 RACK1 RRAD RUNX1 SEC14L2 SFN STXBP4 TBXT TCF7L1 TOP2A TP63 VDR WWP1 YAP1 (see all 47) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	RAB38	RAB38, Member RAS Oncogene Family	Protein Coding	1
2	STXBP4	Syntaxin Binding Protein 4	Protein Coding	1
3	KRT5	Keratin 5	Protein Coding	1
4	KRT14	Keratin 14	Protein Coding	1
5	SEC14L2	SEC14 Like Lipid Binding 2	Protein Coding	1
6	HBP1	HMG-Box Transcription Factor 1	Protein Coding	1
7	DLX6	Distal-Less Homeobox 6	Protein Coding	1
8	NRG1	Neuregulin 1	Protein Coding	1
9	FBXW7	F-Box And WD Repeat Domain Containing 7	Protein Coding	1
10	POU2F2	POU Class 2 Homeobox 2	Protein Coding	1
11	COL5A1	Collagen Type V Alpha 1 Chain	Protein Coding	1
12	FOSL2	FOS Like 2, AP-1 Transcription Factor Subunit	Protein Coding	1
13	HELLS	Helicase, Lymphoid Specific	Protein Coding	1
14	TCF7L1	Transcription Factor 7 Like 1	Protein Coding	1
15	DLX5	Distal-Less Homeobox 5	Protein Coding	1
16	PPP2R5A	Protein Phosphatase 2 Regulatory Subunit B''Alpha	Protein Coding	1
17	TBXT	T-Box Transcription Factor T	Protein Coding	1
18	RRAD	RRAD, Ras Related Glycolysis Inhibitor And Calcium Channel Regulator	Protein Coding	1
19	TP63	Tumor Protein P63	Protein Coding	1
20	WWP1	WW Domain Containing E3 Ubiquitin Protein Ligase 1	Protein Coding	1
21	IGFBP3	Insulin Like Growth Factor Binding Protein 3	Protein Coding	1
22	ADRM1	ADRM1 26S Proteasome Ubiquitin Receptor	Protein Coding	1
23	CCNB2	Cyclin B2	Protein Coding	1
24	IL1A	Interleukin 1 Alpha	Protein Coding	1
25	GPX2	Glutathione Peroxidase 2	Protein Coding	1
26	NOTCH1	Notch Receptor 1	Protein Coding	1
27	YAP1	Yes1 Associated Transcriptional Regulator	Protein Coding	1
28	AXL	AXL Receptor Tyrosine Kinase	Protein Coding	1
29	ITCH	Itchy E3 Ubiquitin Protein Ligase	Protein Coding	1
30	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	1
31	FASN	Fatty Acid Synthase	Protein Coding	1
32	BRCA2	BRCA2 DNA Repair Associated	Protein Coding	1
33	MRE11	MRE11 Double Strand Break Repair Nuclease	Protein Coding	1
34	ITGA3	Integrin Subunit Alpha 3	Protein Coding	1
35	RACK1	Receptor For Activated C Kinase 1	Protein Coding	1
36	PERP	P53 Apoptosis Effector Related To PMP22	Protein Coding	1
37	CEBPD	CCAAT Enhancer Binding Protein Delta	Protein Coding	1
38	HES1	Hes Family BHLH Transcription Factor 1	Protein Coding	1
39	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
40	SFN	Stratifin	Protein Coding	1
41	RUNX1	RUNX Family Transcription Factor 1	Protein Coding	1
42	MDM2	MDM2 Proto-Oncogene	Protein Coding	1
43	VDR	Vitamin D Receptor	Protein Coding	1
44	ATM	ATM Serine/Threonine Kinase	Protein Coding	1
45	TOP2A	DNA Topoisomerase II Alpha	Protein Coding	1
46	ADA	Adenosine Deaminase	Protein Coding	1
47	BDKRB2	Bradykinin Receptor B2	Protein Coding	1

Disorders associated with Validated transcriptional targets of deltaNp63 isoforms SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Isolated split hand-split foot malformation	Enrichment	DLX5, DLX6, TP63	5.67
2	Epidermolysis bullosa simplex 1d, generalized, intermediate or severe, autosomal recessive	Enrichment	KRT14, KRT5	4.93
3	Epidermolysis bullosa simplex 1b, generalized intermediate	Enrichment	KRT14, KRT5	4.15
4	Chordoma	Enrichment	BRCA2, TBXT	4.15
5	Epidermolysis bullosa simplex generalized type	Enrichment	KRT14, KRT5	4.15
6	Pancreatic cancer	Enrichment	ATM, BRCA2, CDKN2A	4.07
7	Inherited cancer-predisposing syndrome	Enrichment	ATM, BRCA2, CDKN2A, MRE11, RUNX1	4.05
8	Epidermolysis bullosa simplex 2f, with mottled pigmentation	Enrichment	KRT14, KRT5	3.93
9	Epidermolysis bullosa simplex 1a, generalized severe	Enrichment	KRT14, KRT5	3.93
10	Epidermolysis bullosa simplex 1c, localized	Enrichment	KRT14, KRT5	3.93
11	Bladder cancer	Enrichment	ATM, BRCA2, CDKN2A	3.87
12	Li-fraumeni syndrome	Enrichment	CDKN2A, MDM2	3.76
13	Epidermolysis bullosa simplex	Enrichment	KRT14, KRT5	3.61
14	Ovarian cancer	Enrichment	ATM, BRCA2, CDKN2A, MRE11	3.39
15	Colonic benign neoplasm	Enrichment	ATM, MRE11	3.38
16	Gastric cancer	Enrichment	ATM, BRCA2, CDKN2A	3.36
17	Uterine corpus cancer	Enrichment	ATM, BRCA2	3.20
18	Familial colorectal cancer type x	Enrichment	ATM, BRCA2	3.20
19	Breast-ovarian cancer, familial 1	Enrichment	ATM, BRCA2	3.05
20	Hereditary breast ovarian cancer syndrome	Enrichment	ATM, BRCA2, MRE11	3.05
21	Myeloma, multiple	Enrichment	ATM, BRCA2, YAP1	3.02
22	Breast cancer	Enrichment	ATM, BRCA2, MRE11	2.66
23	Endometrial cancer	Enrichment	ATM, BRCA2	2.63
24	Colorectal cancer	Enrichment	ATM, BRCA2, FBXW7	2.47
25	Rapp-hodgkin syndrome	Enrichment	TP63	2.46
26	Dermatopathia pigmentosa reticularis	Enrichment	KRT14	2.46
27	Ankyloblepharon-ectodermal defects-cleft lip/palate	Enrichment	TP63	2.46
28	Split-hand/foot malformation 1 with sensorineural hearing loss, autosomal recessive	Enrichment	DLX5	2.46
29	Split-hand/foot malformation 4	Enrichment	TP63	2.46
30	Ankyloblepharon filiforme adnatum and cleft palate	Enrichment	TP63	2.46
31	Coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or impaired intellectual development	Enrichment	YAP1	2.46
32	Glioma susceptibility 3	Enrichment	BRCA2	2.46
33	Naegeli-franceschetti-jadassohn syndrome	Enrichment	KRT14	2.46
34	Adult syndrome	Enrichment	TP63	2.46
35	Sacral agenesis with vertebral anomalies	Enrichment	TBXT	2.46
36	Immunodeficiency-centromeric instability-facial anomalies syndrome 4	Enrichment	HELLS	2.46
37	Accelerated tumor formation	Enrichment	MDM2	2.46
38	Lessel-kubisch syndrome	Enrichment	MDM2	2.46
39	Pancreatic cancer 2	Enrichment	BRCA2	2.46
40	Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3	Enrichment	TP63	2.46
41	Uveal coloboma-cleft lip and palate-intellectual disability	Enrichment	YAP1	2.46
42	Limb-mammary syndrome	Enrichment	TP63	2.46
43	Ataxia-telangiectasia-like disorder 1	Enrichment	MRE11	2.46
44	Autoimmune disease, multisystem, with facial dysmorphism	Enrichment	ITCH	2.46
45	Premature ovarian failure 21	Enrichment	TP63	2.46
46	Olmsted syndrome 2	Enrichment	PERP	2.46
47	Endometrial serous adenocarcinoma	Enrichment	ATM	2.46
48	Orofacial cleft 8	Enrichment	TP63	2.46
49	Erythrokeratodermia variabilis et progressiva 7	Enrichment	PERP	2.46
50	Developmental delay, hypotonia, and impaired language	Enrichment	FBXW7	2.46
51	Cdkn2a cancer predisposition	Enrichment	CDKN2A	2.46
52	Syndromic multisystem autoimmune disease due to itch deficiency	Enrichment	ITCH	2.46
53	Rickets	Enrichment	VDR	2.46
54	Sacral agenesis-abnormal ossification of the vertebral bodies-persistent notochordal canal syndrome	Enrichment	TBXT	2.46
55	Tp63-related disorders	Enrichment	TP63	2.46
56	B-cell non-hodgkin lymphoma	Enrichment	ATM	2.46
57	Split hand-foot malformation 1 with sensorineural hearing loss	Enrichment	DLX5	2.46
58	Pneumothorax	Enrichment	COL5A1	2.46
59	Aplasia cutis-enamel dysplasia syndrome	Enrichment	FOSL2	2.46
60	Prostate cancer	Enrichment	ATM, BRCA2	2.35
61	Connective tissue disease	Enrichment	COL5A1, NOTCH1	2.26
62	Melanoma-astrocytoma syndrome	Enrichment	CDKN2A	2.16
63	Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1	Enrichment	TP63	2.16
64	Storage pool platelet disease	Enrichment	RUNX1	2.16
65	Epidermolysis bullosa simplex 2e, with migratory circinate erythema	Enrichment	KRT5	2.16
66	Melanoma, cutaneous malignant 2	Enrichment	CDKN2A	2.16
67	Adams-oliver syndrome 5	Enrichment	NOTCH1	2.16
68	Fibromuscular dysplasia, multifocal	Enrichment	COL5A1	2.16
69	Epidermolysis bullosa simplex 2d, generalized, intermediate or severe, autosomal recessive	Enrichment	KRT5	2.16
70	Cardiac valvular dysplasia, x-linked	Enrichment	ATM	2.16
71	Sjogren-larsson syndrome	Enrichment	KRT14	2.16
72	Epidermolysis bullosa, junctional 7, with interstitial lung disease and nephrotic syndrome	Enrichment	ITGA3	2.16
73	Bladder exstrophy	Enrichment	TP63	2.16
74	Diffuse midline glioma, h3 k27m-mutant	Enrichment	BRCA2	2.16
75	Melanoma-pancreatic cancer syndrome	Enrichment	CDKN2A	2.16
76	High grade glioma	Enrichment	ATM	2.16
77	Fanconi anemia, complementation group d1	Enrichment	BRCA2	2.16
78	T-cell prolymphocytic leukemia	Enrichment	ATM	2.16
79	Inflammatory breast carcinoma	Enrichment	BRCA2	2.16
80	Fissured tongue	Enrichment	TP63	2.16
81	Epidermolysis bullosa simplex 2a, generalized severe	Enrichment	KRT5	2.16
82	Bilateral breast cancer	Enrichment	BRCA2	2.16
83	Tafro syndrome	Enrichment	RUNX1	2.16
84	Neuroendocrine tumor of pancreas	Enrichment	BRCA2	2.16
85	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	COL5A1, NOTCH1	1.99
86	Hereditary breast carcinoma	Enrichment	ATM, BRCA2	1.99
87	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-negative, nk cell-negative, due to adenosine deaminase deficiency	Enrichment	ADA	1.98
88	Ataxia-telangiectasia	Enrichment	ATM	1.98
89	Polycythemia vera	Enrichment	ATM	1.98
90	Platelet disorder, familial, with associated myeloid malignancy	Enrichment	RUNX1	1.98
91	Ehlers-danlos syndrome, classic type, 2	Enrichment	COL5A1	1.98
92	Tumor predisposition syndrome 1	Enrichment	BRCA2	1.98
93	Epidermolysis bullosa simplex 2b, generalized intermediate	Enrichment	KRT5	1.98
94	Koolen-de vries syndrome	Enrichment	ATM	1.98
95	Dedifferentiated liposarcoma	Enrichment	MDM2	1.98
96	Mutilating palmoplantar keratoderma with periorificial keratotic plaques	Enrichment	PERP	1.98
97	Adenocarcinoma	Enrichment	ATM	1.98
98	Epidermolysis bullosa simplex 2c, localized	Enrichment	KRT5	1.98
99	Bap1 tumor predisposition syndrome	Enrichment	BRCA2	1.98
100	Well-differentiated liposarcoma	Enrichment	MDM2	1.98
101	Hereditary thrombocytopenia and hematological cancer predisposition syndrome associated with runx1	Enrichment	RUNX1	1.98
102	Keratoacanthoma	Enrichment	NOTCH1	1.98
103	Dowling-degos disease 1	Enrichment	KRT5	1.86
104	Ataxia, early-onset, with oculomotor apraxia and hypoalbuminemia	Enrichment	MRE11	1.86
105	Polyposis syndrome, hereditary mixed, 1	Enrichment	BRCA2	1.86
106	Cholangiocarcinoma	Enrichment	BRCA2	1.86
107	Mantle cell lymphoma	Enrichment	ATM	1.86
108	Dowling-degos disease	Enrichment	KRT5	1.86
109	Malignant epithelioid hemangioendothelioma	Enrichment	YAP1	1.86
110	Nijmegen breakage syndrome-like disorder	Enrichment	MRE11	1.86
111	Blood platelet disease	Enrichment	RUNX1	1.86
112	Adenosine deaminase deficiency	Enrichment	ADA	1.86
113	Cleft lip and alveolus	Enrichment	TP63	1.86
114	Oculomotor apraxia	Enrichment	ATM	1.86
115	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative	Enrichment	ADA	1.76
116	Vitamin d-dependent rickets, type 2a	Enrichment	VDR	1.76
117	Breast-ovarian cancer, familial 2	Enrichment	BRCA2	1.76
118	Pervasive developmental disorder	Enrichment	FBXW7	1.76
119	Glioblastoma	Enrichment	ATM	1.76
120	Epidermolysis bullosa	Enrichment	KRT5	1.76
121	Cleft upper lip	Enrichment	TP63	1.76
122	Aggressive systemic mastocytosis	Enrichment	RUNX1	1.76
123	Acute myeloid leukemia with t(8;21)(q22;q22) translocation	Enrichment	RUNX1	1.76
124	Rare pervasive developmental disorder	Enrichment	FBXW7	1.76
125	Ehlers-danlos syndrome, classic type, 1	Enrichment	COL5A1	1.69
126	Kabuki syndrome 1	Enrichment	BRCA2	1.69
127	Split-hand/foot malformation 1	Enrichment	DLX5	1.69
128	Inguinal hernia	Enrichment	COL5A1	1.69
129	Immunodeficiency-centromeric instability-facial anomalies syndrome	Enrichment	HELLS	1.69
130	Pain disorder	Enrichment	COL5A1	1.69
131	Pancytopenia	Enrichment	RUNX1	1.69
132	Adrenocortical carcinoma	Enrichment	CDKN2A	1.69
133	Clear cell renal cell carcinoma	Enrichment	ATM	1.69
134	Lung squamous cell carcinoma	Enrichment	CDKN2A	1.69
135	Classic ehlers-danlos syndrome	Enrichment	COL5A1	1.69
136	Leukemia, chronic myeloid	Enrichment	RUNX1	1.62
137	Renal cell carcinoma, papillary, 1	Enrichment	ATM	1.62
138	Adams-oliver syndrome	Enrichment	NOTCH1	1.62
139	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	CDKN2A	1.62
140	Gastroesophageal reflux	Enrichment	COL5A1	1.56
141	Isolated growth hormone deficiency, type ia	Enrichment	BRCA2	1.56
142	Orthostatic intolerance	Enrichment	COL5A1	1.56
143	Hypoplastic left heart syndrome	Enrichment	NOTCH1	1.56
144	Tracheoesophageal fistula with or without esophageal atresia	Enrichment	BRCA2	1.51
145	Polydactyly	Enrichment	BRCA2	1.51
146	Atypical chronic myeloid leukemia, bcr-abl1 negative	Enrichment	RUNX1	1.51
147	Lynch syndrome 1	Enrichment	ATM	1.47
148	Leukemia, chronic lymphocytic	Enrichment	ATM	1.47
149	Omenn syndrome	Enrichment	ADA	1.47
150	Melanoma	Enrichment	CDKN2A	1.47
151	Isolated tracheo-esophageal fistula	Enrichment	BRCA2	1.47
152	Immune deficiency disease	Enrichment	ATM	1.43
153	Leukemia, acute lymphoblastic	Enrichment	CDKN2A	1.43
154	Cutis laxa	Enrichment	COL5A1	1.39
155	Lip and oral cavity carcinoma	Enrichment	CDKN2A	1.39
156	Aortic valve disease 1	Enrichment	NOTCH1	1.36
157	Microphthalmia/coloboma 12	Enrichment	YAP1	1.36
158	Clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly	Enrichment	COL5A1	1.36
159	Neural tube defects	Enrichment	TBXT	1.36
160	Pulmonary disease, chronic obstructive	Enrichment	VDR	1.36
161	Premature menopause	Enrichment	TP63	1.36
162	Clubfoot	Enrichment	COL5A1	1.36
163	Nk-cell enteropathy	Enrichment	AXL	1.36
164	Medulloblastoma	Enrichment	BRCA2	1.32
165	Aortic aneurysm, familial thoracic 1	Enrichment	NOTCH1	1.32
166	Cataract	Enrichment	COL5A1	1.32
167	Cleft lip/palate	Enrichment	TP63	1.32
168	Coloboma of macula	Enrichment	YAP1	1.29
169	Renal cell carcinoma, nonpapillary	Enrichment	ATM	1.29
170	Wilms tumor 1	Enrichment	BRCA2	1.29
171	Male infertility with spermatogenesis disorder	Enrichment	TP63	1.29
172	Rhabdomyosarcoma	Enrichment	BRCA2	1.27
173	Gliosarcoma	Enrichment	ATM	1.27
174	Melanoma, cutaneous malignant 1	Enrichment	CDKN2A	1.24
175	Giant cell glioblastoma	Enrichment	ATM	1.24
176	Diffuse large b-cell lymphoma	Enrichment	BRCA2	1.19
177	Esophageal atresia/tracheoesophageal fistula	Enrichment	BRCA2	1.19
178	Ehlers-danlos syndrome	Enrichment	COL5A1	1.19
179	Hepatoblastoma	Enrichment	BRCA2	1.15
180	Hepatocellular carcinoma	Enrichment	VDR	1.13
181	Skin disease	Enrichment	KRT14	1.13
182	Precursor t-cell acute lymphoblastic leukemia	Enrichment	CDKN2A	1.11
183	Tetralogy of fallot	Enrichment	NOTCH1	1.06
184	Severe combined immunodeficiency	Enrichment	ADA	0.97
185	Fanconi anemia, complementation group a	Enrichment	BRCA2	0.94
186	Cerebral palsy	Enrichment	BRCA2	0.90
187	Leukemia, acute myeloid	Enrichment	RUNX1	0.89
188	Nephrotic syndrome	Enrichment	ITGA3	0.86
189	Thrombocytopenia	Enrichment	RUNX1	0.81
190	Primary ovarian insufficiency	Enrichment	TP63	0.73

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Validated transcriptional targets of deltaNp63 isoforms

Pathway Network for Validated transcriptional targets of deltaNp63 isoforms

Member Pathways for Validated transcriptional targets of deltaNp63 isoforms

Pathways in the Validated transcriptional targets of deltaNp63 isoforms SuperPath

Associated Genes for Validated transcriptional targets of deltaNp63 isoforms

Associated Disorders for Validated transcriptional targets of deltaNp63 isoforms

Disorders associated with Validated transcriptional targets of deltaNp63 isoforms SuperPath

STRING Interaction Network for Validated transcriptional targets of deltaNp63 isoforms

Sources for Validated transcriptional targets of deltaNp63 isoforms