Validated transcriptional targets of TAp63 isoforms

No Pathway Network information available for Validated transcriptional targets of TAp63 isoforms

Pathways in the Validated transcriptional targets of TAp63 isoforms SuperPath

#	Name	Source	Genes
1	Validated transcriptional targets of TAp63 isoforms	PubChem	ABL1 ADA AEN BAX BBC3 BTRC CABLES1 CDKN1A CDKN2A CHUK CLCA2 DHRS3 DICER1 DST EGR2 EP300 EVPL FAS FDXR FLOT2 GADD45A GDF15 GPX2 HBP1 IGFBP3 IKBKB ITCH ITGA3 ITGB4 JAG1 MDM2 MFGE8 NOC2L NQO1 OGG1 PERP PLK1 PMAIP1 PML PRKCD S100A2 SERPINB5 SHH SMARCD3 SP1 SPATA18 SSRP1 TFAP2C TP53I3 TP63 TRAF4 VDR WWP1 YWHAQ (see all 54) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SMARCD3	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit D3	Protein Coding	1
2	TRAF4	TNF Receptor Associated Factor 4	Protein Coding	1
3	DST	Dystonin	Protein Coding	1
4	MFGE8	Milk Fat Globule EGF And Factor V/VIII Domain Containing	Protein Coding	1
5	AEN	Apoptosis Enhancing Nuclease	Protein Coding	1
6	SPATA18	Spermatogenesis Associated 18	Protein Coding	1
7	CLCA2	Chloride Channel Accessory 2	Protein Coding	1
8	HBP1	HMG-Box Transcription Factor 1	Protein Coding	1
9	SERPINB5	Serpin Family B Member 5	Protein Coding	1
10	S100A2	S100 Calcium Binding Protein A2	Protein Coding	1
11	GDF15	Growth Differentiation Factor 15	Protein Coding	1
12	SHH	Sonic Hedgehog Signaling Molecule	Protein Coding	1
13	DICER1	Dicer 1, Ribonuclease III	Protein Coding	1
14	TP63	Tumor Protein P63	Protein Coding	1
15	WWP1	WW Domain Containing E3 Ubiquitin Protein Ligase 1	Protein Coding	1
16	NOC2L	NOC2 Like Nucleolar Associated Transcriptional Repressor	Protein Coding	1
17	TP53I3	Tumor Protein P53 Inducible Protein 3	Protein Coding	1
18	SSRP1	Structure Specific Recognition Protein 1	Protein Coding	1
19	IGFBP3	Insulin Like Growth Factor Binding Protein 3	Protein Coding	1
20	TFAP2C	Transcription Factor AP-2 Gamma	Protein Coding	1
21	GPX2	Glutathione Peroxidase 2	Protein Coding	1
22	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	1
23	FAS	Fas Cell Surface Death Receptor	Protein Coding	1
24	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	1
25	PML	PML Nuclear Body Scaffold	Protein Coding	1
26	BTRC	Beta-Transducin Repeat Containing E3 Ubiquitin Protein Ligase	Protein Coding	1
27	JAG1	Jagged Canonical Notch Ligand 1	Protein Coding	1
28	DHRS3	Dehydrogenase/Reductase 3	Protein Coding	1
29	OGG1	8-Oxoguanine DNA Glycosylase	Protein Coding	1
30	FLOT2	Flotillin 2	Protein Coding	1
31	ITCH	Itchy E3 Ubiquitin Protein Ligase	Protein Coding	1
32	PRKCD	Protein Kinase C Delta	Protein Coding	1
33	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	1
34	BBC3	BCL2 Binding Component 3	Protein Coding	1
35	PMAIP1	Phorbol-12-Myristate-13-Acetate-Induced Protein 1	Protein Coding	1
36	NQO1	NAD(P)H Quinone Dehydrogenase 1	Protein Coding	1
37	FDXR	Ferredoxin Reductase	Protein Coding	1
38	CABLES1	Cdk5 And Abl Enzyme Substrate 1	Protein Coding	1
39	ITGA3	Integrin Subunit Alpha 3	Protein Coding	1
40	ITGB4	Integrin Subunit Beta 4	Protein Coding	1
41	SP1	Sp1 Transcription Factor	Protein Coding	1
42	PERP	P53 Apoptosis Effector Related To PMP22	Protein Coding	1
43	EVPL	Envoplakin	Protein Coding	1
44	EGR2	Early Growth Response 2	Protein Coding	1
45	EP300	EP300 Lysine Acetyltransferase	Protein Coding	1
46	ABL1	ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase	Protein Coding	1
47	PLK1	Polo Like Kinase 1	Protein Coding	1
48	YWHAQ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Theta	Protein Coding	1
49	MDM2	MDM2 Proto-Oncogene	Protein Coding	1
50	VDR	Vitamin D Receptor	Protein Coding	1
51	GADD45A	Growth Arrest And DNA Damage Inducible Alpha	Protein Coding	1
52	ADA	Adenosine Deaminase	Protein Coding	1
53	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	1
54	BAX	BCL2 Associated X, Apoptosis Regulator	Protein Coding	1

Disorders associated with Validated transcriptional targets of TAp63 isoforms SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	T-cell acute lymphoblastic leukemia	Enrichment	ABL1, BAX	4.33
2	Li-fraumeni syndrome	Enrichment	CDKN2A, MDM2	3.64
3	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	ABL1, CDKN2A	3.49
4	Isolated split hand-split foot malformation	Enrichment	BTRC, TP63	3.37
5	Lip and oral cavity carcinoma	Enrichment	ABL1, CDKN2A	3.00
6	Multiple sclerosis	Enrichment	DST, ITGB4	2.86
7	Precursor t-cell acute lymphoblastic leukemia	Enrichment	ABL1, CDKN2A	2.43
8	Holoprosencephaly 3	Enrichment	SHH	2.40
9	Rapp-hodgkin syndrome	Enrichment	TP63	2.40
10	Ankyloblepharon-ectodermal defects-cleft lip/palate	Enrichment	TP63	2.40
11	Rhabdomyosarcoma, embryonal, 2	Enrichment	DICER1	2.40
12	Split-hand/foot malformation 4	Enrichment	TP63	2.40
13	Ankyloblepharon filiforme adnatum and cleft palate	Enrichment	TP63	2.40
14	Charcot-marie-tooth disease, demyelinating, type 1d	Enrichment	EGR2	2.40
15	Microphthalmia/coloboma 5	Enrichment	SHH	2.40
16	Adult syndrome	Enrichment	TP63	2.40
17	Fetal encasement syndrome	Enrichment	CHUK	2.40
18	Accelerated tumor formation	Enrichment	MDM2	2.40
19	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.40
20	Charcot-marie-tooth disease, axonal, type 2hh	Enrichment	JAG1	2.40
21	Immunodeficiency 15b	Enrichment	IKBKB	2.40
22	Immunodeficiency 15a	Enrichment	IKBKB	2.40
23	Lessel-kubisch syndrome	Enrichment	MDM2	2.40
24	Hyperemesis gravidarum	Enrichment	GDF15	2.40
25	Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3	Enrichment	TP63	2.40
26	Dicer1 syndrome	Enrichment	DICER1	2.40
27	Limb-mammary syndrome	Enrichment	TP63	2.40
28	Pleuropulmonary blastoma	Enrichment	DICER1	2.40
29	Global developmental delay, lung cysts, overgrowth, and wilms tumor	Enrichment	DICER1	2.40
30	Autoimmune disease, multisystem, with facial dysmorphism	Enrichment	ITCH	2.40
31	Premature ovarian failure 21	Enrichment	TP63	2.40
32	Olmsted syndrome 2	Enrichment	PERP	2.40
33	Orofacial cleft 8	Enrichment	TP63	2.40
34	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.40
35	Deafness, congenital heart defects, and posterior embryotoxon	Enrichment	JAG1	2.40
36	Malignant sertoli-leydig cell tumor of ovary	Enrichment	DICER1	2.40
37	Erythrokeratodermia variabilis et progressiva 7	Enrichment	PERP	2.40
38	Cdkn2a cancer predisposition	Enrichment	CDKN2A	2.40
39	Syndromic multisystem autoimmune disease due to itch deficiency	Enrichment	ITCH	2.40
40	Rickets	Enrichment	VDR	2.40
41	Charcot-marie-tooth disease type 1d	Enrichment	EGR2	2.40
42	Tp63-related disorders	Enrichment	TP63	2.40
43	Supratentorial primitive neuroectodermal tumor	Enrichment	DICER1	2.40
44	Gynandroblastoma	Enrichment	DICER1	2.40
45	Dicer1 tumor predisposition	Enrichment	DICER1	2.40
46	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.40
47	Optic atrophy-ataxia-peripheral neuropathy-global developmental delay syndrome	Enrichment	FDXR	2.40
48	Autosomal dominant preaxial polydactyly-upperback hypertrichosis syndrome	Enrichment	SHH	2.40
49	Bladder cancer	Enrichment	CDKN1A, CDKN2A	2.23
50	Severe combined immunodeficiency	Enrichment	ADA, IKBKB	2.12
51	Melanoma-astrocytoma syndrome	Enrichment	CDKN2A	2.10
52	Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1	Enrichment	TP63	2.10
53	Neuropathy, congenital hypomyelinating, 1, autosomal recessive	Enrichment	EGR2	2.10
54	Solitary median maxillary central incisor	Enrichment	SHH	2.10
55	Melanoma, cutaneous malignant 2	Enrichment	CDKN2A	2.10
56	Goiter, multinodular 1, with or without sertoli-leydig cell tumors	Enrichment	DICER1	2.10
57	Congenital heart defects and skeletal malformations syndrome	Enrichment	ABL1	2.10
58	Epidermolysis bullosa, junctional 5a, intermediate	Enrichment	ITGB4	2.10
59	Menke-hennekam syndrome 2	Enrichment	EP300	2.10
60	Vertebral anomalies and variable endocrine and t-cell dysfunction	Enrichment	DICER1	2.10
61	Epidermolysis bullosa, junctional 7, with interstitial lung disease and nephrotic syndrome	Enrichment	ITGA3	2.10
62	Bladder exstrophy	Enrichment	TP63	2.10
63	Melanoma-pancreatic cancer syndrome	Enrichment	CDKN2A	2.10
64	Pineoblastoma	Enrichment	DICER1	2.10
65	Fissured tongue	Enrichment	TP63	2.10
66	Localized junctional epidermolysis bullosa, non-herlitz type	Enrichment	ITGB4	2.10
67	Malignant granulosa cell tumor of the ovary	Enrichment	DICER1	2.10
68	Isolated radial hemimelia	Enrichment	SHH	2.10
69	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-negative, nk cell-negative, due to adenosine deaminase deficiency	Enrichment	ADA	1.92
70	Alagille syndrome 1	Enrichment	JAG1	1.92
71	Syndactyly, type iv	Enrichment	SHH	1.92
72	Epidermolysis bullosa simplex 3, localized or generalized intermediate, with bp230 deficiency	Enrichment	DST	1.92
73	Auditory neuropathy and optic atrophy	Enrichment	FDXR	1.92
74	Multiple mitochondrial dysfunctions syndrome 9b	Enrichment	FDXR	1.92
75	Dedifferentiated liposarcoma	Enrichment	MDM2	1.92
76	Mutilating palmoplantar keratoderma with periorificial keratotic plaques	Enrichment	PERP	1.92
77	Hypoplastic or aplastic tibia with polydactyly	Enrichment	SHH	1.92
78	Charcot-marie-tooth disease type 1	Enrichment	EGR2	1.92
79	Well-differentiated liposarcoma	Enrichment	MDM2	1.92
80	Vogt-koyanagi-harada disease	Enrichment	FAS	1.92
81	Polydactyly, preaxial ii	Enrichment	SHH	1.80
82	Schizencephaly	Enrichment	SHH	1.80
83	Autoimmune lymphoproliferative syndrome	Enrichment	FAS	1.80
84	Epidermolysis bullosa simplex 5c, with pyloric atresia	Enrichment	ITGB4	1.80
85	Neuropathy, hereditary sensory and autonomic, type vi	Enrichment	DST	1.80
86	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	ABL1	1.80
87	Embryonal rhabdomyosarcoma	Enrichment	DICER1	1.80
88	Adenosine deaminase deficiency	Enrichment	ADA	1.80
89	Middle aortic syndrome	Enrichment	JAG1	1.80
90	Cleft lip and alveolus	Enrichment	TP63	1.80
91	Hypertrophic neuropathy of dejerine-sottas	Enrichment	EGR2	1.70
92	Epidermolysis bullosa simplex 1c, localized	Enrichment	ITGB4	1.70
93	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative	Enrichment	ADA	1.70
94	Vitamin d-dependent rickets, type 2a	Enrichment	VDR	1.70
95	Rubinstein-taybi syndrome 2	Enrichment	EP300	1.70
96	Aplasia cutis congenita	Enrichment	ITGB4	1.70
97	Cleft upper lip	Enrichment	TP63	1.70
98	Rubinstein-taybi syndrome 1	Enrichment	EP300	1.63
99	Epidermolysis bullosa, junctional 1a, intermediate	Enrichment	ITGB4	1.63
100	Epidermolysis bullosa, junctional 5b, with pyloric atresia	Enrichment	ITGB4	1.63
101	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	EP300	1.63
102	Junctional epidermolysis bullosa non-herlitz type	Enrichment	ITGB4	1.63
103	Adrenocortical carcinoma	Enrichment	CDKN2A	1.63
104	Clear cell renal cell carcinoma	Enrichment	OGG1	1.63
105	Lung squamous cell carcinoma	Enrichment	CDKN2A	1.63
106	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A	1.56
107	Leukemia, chronic myeloid	Enrichment	ABL1	1.56
108	Epidermolysis bullosa simplex	Enrichment	ITGB4	1.56
109	Hereditary clear cell renal cell carcinoma	Enrichment	OGG1	1.56
110	Moyamoya angiopathy	Enrichment	ABL1	1.56
111	Charge syndrome	Enrichment	EP300	1.45
112	Junctional epidermolysis bullosa	Enrichment	ITGB4	1.45
113	Omenn syndrome	Enrichment	ADA	1.41
114	Melanoma	Enrichment	CDKN2A	1.41
115	Leukemia, acute lymphoblastic	Enrichment	CDKN2A	1.37
116	Septooptic dysplasia	Enrichment	SHH	1.33
117	Colorectal cancer	Enrichment	BAX, EP300	1.33
118	Pulmonary disease, chronic obstructive	Enrichment	VDR	1.30
119	Acute promyelocytic leukemia	Enrichment	PML	1.30
120	Premature menopause	Enrichment	TP63	1.30
121	Heart disease	Enrichment	ABL1	1.26
122	Cleft lip/palate	Enrichment	TP63	1.26
123	Renal cell carcinoma, nonpapillary	Enrichment	OGG1	1.24
124	Polydactyly, postaxial, type a1	Enrichment	EP300	1.24
125	Rare genetic intellectual disability	Enrichment	EP300	1.24
126	Septopreoptic holoprosencephaly	Enrichment	SHH	1.24
127	Male infertility with spermatogenesis disorder	Enrichment	TP63	1.24
128	Midline interhemispheric variant of holoprosencephaly	Enrichment	SHH	1.24
129	Ovarian cancer	Enrichment	CDKN2A, DICER1	1.21
130	Rhabdomyosarcoma	Enrichment	DICER1	1.21
131	Microform holoprosencephaly	Enrichment	SHH	1.21
132	Lobar holoprosencephaly	Enrichment	SHH	1.21
133	Melanoma, cutaneous malignant 1	Enrichment	CDKN2A	1.18
134	Alobar holoprosencephaly	Enrichment	SHH	1.18
135	Heart, malformation of	Enrichment	JAG1	1.16
136	Charcot-marie-tooth disease type 4	Enrichment	EGR2	1.16
137	Semilobar holoprosencephaly	Enrichment	SHH	1.16
138	Behcet syndrome	Enrichment	FAS	1.14
139	Macs syndrome	Enrichment	SHH	1.12
140	Hepatoblastoma	Enrichment	JAG1	1.09
141	Hepatocellular carcinoma	Enrichment	VDR	1.08
142	Skin disease	Enrichment	ITGB4	1.08
143	Microcephaly	Enrichment	ABL1, EP300	1.07
144	Pancreatic cancer	Enrichment	CDKN2A	1.02
145	Inherited cancer-predisposing syndrome	Enrichment	CDKN2A, DICER1	1.01
146	Tetralogy of fallot	Enrichment	JAG1	1.01
147	Auditory neuropathy	Enrichment	FDXR	1.01
148	Lung cancer	Enrichment	FAS	0.92
149	Charcot-marie-tooth disease	Enrichment	DST	0.82
150	Gastric cancer	Enrichment	CDKN2A	0.80
151	Nephrotic syndrome	Enrichment	ITGA3	0.80
152	Primary ovarian insufficiency	Enrichment	TP63	0.68
153	Autism	Enrichment	SHH	0.60
154	Hereditary retinal dystrophy	Enrichment	JAG1	0.16
155	Fundus dystrophy	Enrichment	JAG1	0.16

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Validated transcriptional targets of TAp63 isoforms

Pathway Network for Validated transcriptional targets of TAp63 isoforms

Member Pathways for Validated transcriptional targets of TAp63 isoforms

Pathways in the Validated transcriptional targets of TAp63 isoforms SuperPath

Associated Genes for Validated transcriptional targets of TAp63 isoforms

Associated Disorders for Validated transcriptional targets of TAp63 isoforms

Disorders associated with Validated transcriptional targets of TAp63 isoforms SuperPath

STRING Interaction Network for Validated transcriptional targets of TAp63 isoforms

Sources for Validated transcriptional targets of TAp63 isoforms