Valproic Acid Pathway, Pharmacodynamics

Pathway network for the Valproic Acid Pathway, Pharmacodynamics SuperPath

Sources:

PharmGKB
PubChem

Pathways in the Valproic Acid Pathway, Pharmacodynamics SuperPath

#	Name	Source	Genes
1	Valproic Acid Pathway, Pharmacodynamics	PharmGKB	ABAT ALDH5A1 CACNA1C CACNA1D CACNA1F GOT1 GOT1L1 GOT2 GOT2P1 GOT2P2 GOT2P3 HDAC1 HDAC11 HDAC9 OGDH SUCLA2 SUCLA2P1 SUCLG1 SUCLG2 (see all 19) (see less)
2	aspartate biosynthesis	PubChem	GOT1 GOT1L1
3	L-aspartate biosynthesis	PubChem	GOT1

Gene overlap in member pathways for Valproic Acid Pathway, Pharmacodynamics SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	GOT1	Glutamic-Oxaloacetic Transaminase 1	Protein Coding	3
2	GOT1L1	Glutamic-Oxaloacetic Transaminase 1 Like 1	Protein Coding	2
3	CACNA1F	Calcium Voltage-Gated Channel Subunit Alpha1 F	Protein Coding	1
4	HDAC11	Histone Deacetylase 11	Protein Coding	1
5	ALDH5A1	Aldehyde Dehydrogenase 5 Family Member A1	Protein Coding	1
6	CACNA1C	Calcium Voltage-Gated Channel Subunit Alpha1 C	Protein Coding	1
7	CACNA1D	Calcium Voltage-Gated Channel Subunit Alpha1 D	Protein Coding	1
8	HDAC9	Histone Deacetylase 9	Protein Coding	1
9	SUCLG2	Succinate-CoA Ligase GDP-Forming Subunit Beta	Protein Coding	1
10	SUCLG1	Succinate-CoA Ligase GDP/ADP-Forming Subunit Alpha	Protein Coding	1
11	SUCLA2	Succinate-CoA Ligase ADP-Forming Subunit Beta	Protein Coding	1
12	GOT2	Glutamic-Oxaloacetic Transaminase 2	Protein Coding	1
13	HDAC1	Histone Deacetylase 1	Protein Coding	1
14	OGDH	Oxoglutarate Dehydrogenase	Protein Coding	1
15	ABAT	4-Aminobutyrate Aminotransferase	Protein Coding	1
16	SUCLA2P1	SUCLA2 Pseudogene 1	Pseudogene	1
17	GOT2P3	GOT2 Pseudogene 3	Pseudogene	1
18	GOT2P1	GOT2 Pseudogene 1	Pseudogene	1
19	GOT2P2	GOT2 Pseudogene 2	Pseudogene	1

Disorders associated with Valproic Acid Pathway, Pharmacodynamics SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Aspartate aminotransferase, serum level of, quantitative trait locus 1	Enrichment	GOT1	4.13
2	Mitochondrial dna depletion syndrome 9	Enrichment	SUCLG1	2.85
3	Oxoglutarate dehydrogenase deficiency	Enrichment	OGDH	2.85
4	Auriculocondylar syndrome 4	Enrichment	HDAC9	2.85
5	Cone-rod dystrophy, x-linked, 3	Enrichment	CACNA1F	2.85
6	Mitochondrial dna depletion syndrome 5	Enrichment	SUCLA2	2.85
7	Gaba aminotransferase deficiency	Enrichment	ABAT	2.85
8	Primary aldosteronism, seizures, and neurologic abnormalities	Enrichment	CACNA1D	2.85
9	Brugada syndrome 3	Enrichment	CACNA1C	2.85
10	Gaba-transaminase deficiency	Enrichment	ABAT	2.85
11	Sinoatrial node dysfunction and deafness	Enrichment	CACNA1D	2.85
12	Atypical timothy syndrome	Enrichment	CACNA1C	2.85
13	Aldosterone-producing adenoma with seizures and neurological abnormalities	Enrichment	CACNA1D	2.85
14	Timothy syndrome type 2	Enrichment	CACNA1C	2.85
15	Suclg1-related mitochondrial dna depletion syndrome, encephalomyopathic form with methylmalonic aciduria	Enrichment	SUCLG1	2.85
16	Timothy syndrome type 1	Enrichment	CACNA1C	2.85
17	Cacna1c-related disorders	Enrichment	CACNA1C	2.85
18	Timothy syndrome	Enrichment	CACNA1C	2.55
19	Night blindness, congenital stationary, type 2a	Enrichment	CACNA1F	2.55
20	Long qt syndrome 8	Enrichment	CACNA1C	2.55
21	Developmental and epileptic encephalopathy 82	Enrichment	GOT2	2.55
22	Congenital disorder of glycosylation, type iw, autosomal dominant	Enrichment	CACNA1D	2.55
23	Succinic semialdehyde dehydrogenase deficiency	Enrichment	ALDH5A1	2.38
24	Neurodevelopmental disorder with hypotonia, language delay, and skeletal defects with or without seizures	Enrichment	CACNA1C	2.38
25	Aland island eye disease	Enrichment	CACNA1F	2.25
26	Ventricular fibrillation, paroxysmal familial, 1	Enrichment	CACNA1C	2.25
27	Heart conduction disease	Enrichment	CACNA1C	2.16
28	Amblyopia	Enrichment	CACNA1F	2.16
29	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	CACNA1C	1.90
30	Cardiac conduction defect	Enrichment	CACNA1C	1.78
31	Cone-rod dystrophy 6	Enrichment	CACNA1F	1.71
32	Myopia	Enrichment	CACNA1F	1.68
33	Congenital stationary night blindness	Enrichment	CACNA1F	1.50
34	Cardiomyopathy, familial hypertrophic, 1	Enrichment	CACNA1C	1.48
35	Brugada syndrome	Enrichment	CACNA1C	1.45
36	Long qt syndrome 1	Enrichment	CACNA1C	1.38
37	Long qt syndrome	Enrichment	CACNA1C	1.37
38	Eye disease	Enrichment	CACNA1F	1.32
39	Developmental and epileptic encephalopathy	Enrichment	GOT2	1.31
40	Fetal akinesia deformation sequence 1	Enrichment	ALDH5A1	1.30
41	Cerebral palsy	Enrichment	CACNA1C	1.27
42	Distal arthrogryposis	Enrichment	ALDH5A1	1.24
43	Optic atrophy plus syndrome	Enrichment	CACNA1F	1.22
44	Cone-rod dystrophy 2	Enrichment	CACNA1F	1.04
45	Complex neurodevelopmental disorder	Enrichment	CACNA1C	0.80
46	Retinitis pigmentosa	Enrichment	CACNA1F	0.59
47	Hereditary retinal dystrophy	Enrichment	CACNA1F	0.47
48	Fundus dystrophy	Enrichment	CACNA1F	0.47

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Valproic Acid Pathway, Pharmacodynamics

Pathway Network for Valproic Acid Pathway, Pharmacodynamics

Pathway network for the Valproic Acid Pathway, Pharmacodynamics SuperPath

Member Pathways for Valproic Acid Pathway, Pharmacodynamics

Pathways in the Valproic Acid Pathway, Pharmacodynamics SuperPath

Gene overlap in member pathways for Valproic Acid Pathway, Pharmacodynamics SuperPath

Associated Genes for Valproic Acid Pathway, Pharmacodynamics

Associated Disorders for Valproic Acid Pathway, Pharmacodynamics

Disorders associated with Valproic Acid Pathway, Pharmacodynamics SuperPath

STRING Interaction Network for Valproic Acid Pathway, Pharmacodynamics

Sources for Valproic Acid Pathway, Pharmacodynamics