Valproic Acid Pathway, Pharmacokinetics

Sources:

#	Name	Source	Genes
1	Valproic Acid Pathway, Pharmacokinetics	PharmGKB	ACADSB CYP2A6 CYP2B6 CYP2C9 ECH1 HSD17B10 IVD (see all 7) (see less)
2	Valproic acid pathway	WikiPathways	ABAT ACADSB ACSM1 CYP2A6 CYP2B6 CYP2C9 EHHADH HADHA HADHB HDAC1 HSD17B10 IVD (see all 12) (see less)
3	Isovaleric acidemia	Reactome	IVD

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	IVD	Isovaleryl-CoA Dehydrogenase	Protein Coding	3
2	ACADSB	Acyl-CoA Dehydrogenase Short/Branched Chain	Protein Coding	2
3	CYP2A6	Cytochrome P450 Family 2 Subfamily A Member 6	Protein Coding	2
4	CYP2B6	Cytochrome P450 Family 2 Subfamily B Member 6	Protein Coding	2
5	CYP2C9	Cytochrome P450 Family 2 Subfamily C Member 9	Protein Coding	2
6	HSD17B10	Hydroxysteroid 17-Beta Dehydrogenase 10	Protein Coding	2
7	ECH1	Enoyl-CoA Hydratase 1	Protein Coding	1
8	HDAC1	Histone Deacetylase 1	Protein Coding	1
9	HADHB	Hydroxyacyl-CoA Dehydrogenase Trifunctional Multienzyme Complex Subunit Beta	Protein Coding	1
10	HADHA	Hydroxyacyl-CoA Dehydrogenase Trifunctional Multienzyme Complex Subunit Alpha	Protein Coding	1
11	EHHADH	Enoyl-CoA Hydratase And 3-Hydroxyacyl CoA Dehydrogenase	Protein Coding	1
12	ABAT	4-Aminobutyrate Aminotransferase	Protein Coding	1
13	ACSM1	Acyl-CoA Synthetase Medium Chain Family Member 1	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Isovaleric acidemia	Direct
2	Coumarin resistance	Enrichment	CYP2A6, CYP2C9	6.16
3	Mitochondrial trifunctional protein deficiency 1	Enrichment	HADHA, HADHB	5.67
4	Mitochondrial trifunctional protein deficiency	Enrichment	HADHA, HADHB	5.67
5	Hsd10 mitochondrial disease	Enrichment	HSD17B10	3.29
6	2-methylbutyryl-coa dehydrogenase deficiency	Enrichment	ACADSB	3.29
7	Syndromic x-linked intellectual disability type 10	Enrichment	HSD17B10	3.29
8	Efavirenz, poor metabolism of	Enrichment	CYP2B6	3.29
9	Letrozole toxicity	Enrichment	CYP2A6	3.29
10	Fanconi renotubular syndrome 3	Enrichment	EHHADH	3.05
11	Gaba aminotransferase deficiency	Enrichment	ABAT	3.05
12	Gaba-transaminase deficiency	Enrichment	ABAT	3.05
13	Mitochondrial trifunctional protein deficiency 2	Enrichment	HADHB	3.05
14	Acute fatty liver of pregnancy	Enrichment	HADHA	3.05
15	Tobacco addiction	Enrichment	CYP2A6	2.69
16	D-bifunctional protein deficiency	Enrichment	EHHADH	2.58
17	Long-chain 3-hydroxyacyl-coa dehydrogenase deficiency	Enrichment	HADHA	2.58
18	Primary fanconi renotubular syndrome	Enrichment	EHHADH	2.45
19	Lung cancer	Enrichment	CYP2A6	1.79

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Valproic Acid Pathway, Pharmacokinetics