VEGF Pathway (Qiagen)

Pathway network for the VEGF Pathway (Qiagen) SuperPath

Sources:

QIAGEN
GeneGo (Thomson Reuters)
PubChem
Reactome

Pathways in the VEGF Pathway (Qiagen) SuperPath

#	Name	Source	Genes
1	CCKBR-Gastrin Stimulated Signaling	QIAGEN	ACTA1 ACTA2 ACTB ACTG1 ACTG2 ATF2 BCAR1 CCK CCKBR DIRAS3 EGF EGFR ELK1 FOS GAST GNA12 GNA13 GRB2 HRAS JUN KRAS MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MEF2A MEF2C MEF2D MYL9 NRAS PLCB1 PLCB2 PLCB3 PLCB4 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCI PRKCQ PRKCZ PRKD1 PRKD3 PTK2 PTK2B PXN RAF1 RHOA RHOB RHOC RHOD RHOG RHOH RND2 RND3 ROCK1 ROCK2 SOS1 SOS2 SRC SRF (see all 75) (see less)
2	VEGF Pathway	QIAGEN	ACTA1 ACTA2 ACTB ACTG1 ACTG2 AKT1 BAD CASP9 GRB2 HRAS HSP90AA1 HSPB1 KDR KRAS MAP2K1 MAP2K2 MAP2K3 MAP2K6 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPKAPK2 MAPKAPK3 MRAS NOS3 NRAS PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PLA2G4A PLA2G4C PLCG1 PLCG2 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCI PRKCQ PRKCZ PRKD1 PRKD3 PTK2 PTK2B PXN RAF1 RRAS RRAS2 SHC2 SOS1 SOS2 SRC VEGFA VEGFC VEGFD (see all 62) (see less)
3	VEGF Family Ligands and Receptor Interactions	QIAGEN	ACTA1 ACTA2 ACTB ACTG1 ACTG2 AKT1 FLT1 FLT4 FOS GRB2 HRAS KDR KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 MRAS NOS3 NRAS NRP1 PGF PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PLA2G4A PLA2G4C PLCG1 PLCG2 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCI PRKCQ PRKCZ PRKD1 PRKD3 RAF1 RRAS RRAS2 SOS1 SOS2 VEGFA VEGFB VEGFC VEGFD (see all 51) (see less)
4	Development VEGF-family signaling	GeneGo (Thomson Reuters)	AKT1 AKT2 AKT3 FLT1 FLT4 FN1 FOS GRB2 HRAS ITGA5 ITGAV ITGB1 ITGB3 ITPR1 ITPR2 ITPR3 JUN KDR L1CAM MAP2K1 MAP2K2 MAPK1 MAPK3 NRP1 NRP2 PGF PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PLCG1 PLCG2 PRKCA RAF1 SHC1 SOS1 SOS2 VEGFA VEGFB VEGFC VEGFD VTN (see all 44) (see less)
5	VEGF and VEGFR signaling network	PubChem	FLT1 FLT4 KDR NRP1 NRP2 PGF VEGFA VEGFB VEGFC VEGFD (see all 10) (see less)
6	Neurophilin interactions with VEGF and VEGFR	Reactome	FLT1 KDR NRP1 NRP2

Gene overlap in member pathways for VEGF Pathway (Qiagen) SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	KDR	Kinase Insert Domain Receptor	Protein Coding	5
2	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	4
3	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	4
4	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	4
5	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	4
6	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	4
7	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	4
8	PRKCA	Protein Kinase C Alpha	Protein Coding	4
9	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	4
10	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	4
11	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	4
12	VEGFD	Vascular Endothelial Growth Factor D	Protein Coding	4
13	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	4
14	VEGFC	Vascular Endothelial Growth Factor C	Protein Coding	4
15	FLT1	Fms Related Receptor Tyrosine Kinase 1	Protein Coding	4
16	NRP1	Neuropilin 1	Protein Coding	4
17	ACTA1	Actin Alpha 1, Skeletal Muscle	Protein Coding	3
18	ACTA2	Actin Alpha 2, Smooth Muscle	Protein Coding	3
19	ACTB	Actin Beta	Protein Coding	3
20	ACTG1	Actin Gamma 1	Protein Coding	3
21	ACTG2	Actin Gamma 2, Smooth Muscle	Protein Coding	3
22	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	3
23	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	3
24	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	3
25	PRKCB	Protein Kinase C Beta	Protein Coding	3
26	PRKCD	Protein Kinase C Delta	Protein Coding	3
27	PRKCE	Protein Kinase C Epsilon	Protein Coding	3
28	PRKCG	Protein Kinase C Gamma	Protein Coding	3
29	PRKCH	Protein Kinase C Eta	Protein Coding	3
30	PRKCI	Protein Kinase C Iota	Protein Coding	3
31	PRKD1	Protein Kinase D1	Protein Coding	3
32	PRKD3	Protein Kinase D3	Protein Coding	3
33	PRKCQ	Protein Kinase C Theta	Protein Coding	3
34	PRKCZ	Protein Kinase C Zeta	Protein Coding	3
35	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	3
36	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	3
37	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	3
38	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	3
39	PLCG1	Phospholipase C Gamma 1	Protein Coding	3
40	PLCG2	Phospholipase C Gamma 2	Protein Coding	3
41	FLT4	Fms Related Receptor Tyrosine Kinase 4	Protein Coding	3
42	PGF	Placental Growth Factor	Protein Coding	3
43	VEGFB	Vascular Endothelial Growth Factor B	Protein Coding	3
44	NRP2	Neuropilin 2	Protein Coding	3
45	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	2
46	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	2
47	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	2
48	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	2
49	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	2
50	MAPK13	Mitogen-Activated Protein Kinase 13	Protein Coding	2
51	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	2
52	PTK2	Protein Tyrosine Kinase 2	Protein Coding	2
53	PTK2B	Protein Tyrosine Kinase 2 Beta	Protein Coding	2
54	PXN	Paxillin	Protein Coding	2
55	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	2
56	MRAS	Muscle RAS Oncogene Homolog	Protein Coding	2
57	NOS3	Nitric Oxide Synthase 3	Protein Coding	2
58	PIK3R5	Phosphoinositide-3-Kinase Regulatory Subunit 5	Protein Coding	2
59	PIK3R4	Phosphoinositide-3-Kinase Regulatory Subunit 4	Protein Coding	2
60	PLA2G4A	Phospholipase A2 Group IVA	Protein Coding	2
61	PLA2G4C	Phospholipase A2 Group IVC	Protein Coding	2
62	RRAS	RAS Related	Protein Coding	2
63	RRAS2	RAS Related 2	Protein Coding	2
64	RHOA	Ras Homolog Family Member A	Protein Coding	1
65	RHOB	Ras Homolog Family Member B	Protein Coding	1
66	RHOC	Ras Homolog Family Member C	Protein Coding	1
67	RHOD	Ras Homolog Family Member D	Protein Coding	1
68	RND3	Rho Family GTPase 3	Protein Coding	1
69	RHOG	Ras Homolog Family Member G	Protein Coding	1
70	RHOH	Ras Homolog Family Member H	Protein Coding	1
71	DIRAS3	DIRAS Family GTPase 3	Protein Coding	1
72	RND2	Rho Family GTPase 2	Protein Coding	1
73	ATF2	Activating Transcription Factor 2	Protein Coding	1
74	BCAR1	BCAR1 Scaffold Protein, Cas Family Member	Protein Coding	1
75	CCK	Cholecystokinin	Protein Coding	1
76	CCKBR	Cholecystokinin B Receptor	Protein Coding	1
77	EGF	Epidermal Growth Factor	Protein Coding	1
78	EGFR	Epidermal Growth Factor Receptor	Protein Coding	1
79	ELK1	ETS Transcription Factor ELK1	Protein Coding	1
80	GAST	Gastrin	Protein Coding	1
81	GNA12	G Protein Subunit Alpha 12	Protein Coding	1
82	GNA13	G Protein Subunit Alpha 13	Protein Coding	1
83	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	1
84	MAP2K5	Mitogen-Activated Protein Kinase Kinase 5	Protein Coding	1
85	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	1
86	MAPK7	Mitogen-Activated Protein Kinase 7	Protein Coding	1
87	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
88	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	1
89	MEF2A	Myocyte Enhancer Factor 2A	Protein Coding	1
90	MEF2C	Myocyte Enhancer Factor 2C	Protein Coding	1
91	MEF2D	Myocyte Enhancer Factor 2D	Protein Coding	1
92	MYL9	Myosin Light Chain 9	Protein Coding	1
93	PLCB1	Phospholipase C Beta 1	Protein Coding	1
94	PLCB2	Phospholipase C Beta 2	Protein Coding	1
95	PLCB3	Phospholipase C Beta 3	Protein Coding	1
96	PLCB4	Phospholipase C Beta 4	Protein Coding	1
97	ROCK1	Rho Associated Coiled-Coil Containing Protein Kinase 1	Protein Coding	1
98	ROCK2	Rho Associated Coiled-Coil Containing Protein Kinase 2	Protein Coding	1
99	SRF	Serum Response Factor	Protein Coding	1
100	BAD	BCL2 Associated Agonist Of Cell Death	Protein Coding	1
101	CASP9	Caspase 9	Protein Coding	1
102	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	1
103	HSPB1	Heat Shock Protein Family B (Small) Member 1	Protein Coding	1
104	MAPKAPK2	MAPK Activated Protein Kinase 2	Protein Coding	1
105	MAPKAPK3	MAPK Activated Protein Kinase 3	Protein Coding	1
106	SHC2	SHC Adaptor Protein 2	Protein Coding	1
107	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	1
108	FN1	Fibronectin 1	Protein Coding	1
109	ITGA5	Integrin Subunit Alpha 5	Protein Coding	1
110	ITGAV	Integrin Subunit Alpha V	Protein Coding	1
111	ITGB1	Integrin Subunit Beta 1	Protein Coding	1
112	ITGB3	Integrin Subunit Beta 3	Protein Coding	1
113	ITPR1	Inositol 1,4,5-Trisphosphate Receptor Type 1	Protein Coding	1
114	ITPR2	Inositol 1,4,5-Trisphosphate Receptor Type 2	Protein Coding	1
115	ITPR3	Inositol 1,4,5-Trisphosphate Receptor Type 3	Protein Coding	1
116	L1CAM	L1 Cell Adhesion Molecule	Protein Coding	1
117	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
118	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	1
119	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	1
120	SHC1	SHC Adaptor Protein 1	Protein Coding	1
121	VTN	Vitronectin	Protein Coding	1
122	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	1

Disorders associated with VEGF Pathway (Qiagen) SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Rasopathy	Enrichment	HRAS, KRAS, MAP2K1, MAP2K2, NRAS, RAF1, SOS1, SOS2	16.00
2	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, KRAS, MAP2K1, MAP2K2, NRAS, RAF1, SOS1	16.00
3	Noonan syndrome 1	Enrichment	HRAS, KRAS, MAP2K1, MAP2K2, MRAS, NRAS, RAF1, RRAS, RRAS2, SOS1, SOS2	11.83
4	Lung non-small cell carcinoma	Enrichment	EGFR, HRAS, KRAS, MAP2K1, NRAS	8.70
5	Noonan syndrome 3	Enrichment	HRAS, KRAS, RAF1, SOS1	8.21
6	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3CA, PIK3R2	6.90
7	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	6.70
8	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS, MAP2K1, MAP2K2	6.70
9	Cardiofaciocutaneous syndrome	Enrichment	KRAS, MAP2K1, MAP2K2	6.70
10	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS	5.76
11	Arteriovenous malformation	Enrichment	HRAS, MAP2K1, PIK3CA	5.58
12	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, NRAS, RAF1	5.56
13	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1, PIK3CA	5.42
14	Non-immune hydrops fetalis	Enrichment	ACTA1, FLT4, HRAS, KRAS	5.29
15	Hemangioma, capillary infantile	Enrichment	FLT4, KDR	5.14
16	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS, RRAS	4.97
17	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	4.86
18	Baraitser-winter cerebrofrontofacial syndrome	Enrichment	ACTB, ACTG1	4.86
19	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.51
20	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD, PIK3R1	4.51
21	Immunodeficiency 14	Enrichment	PIK3CD, PIK3R1	4.51
22	Langerhans cell histiocytosis	Enrichment	MAP2K1, NRAS	4.38
23	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	4.38
24	Lung cancer susceptibility 3	Enrichment	ACTA2, EGFR, KRAS	4.25
25	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3, PIK3R2	4.21
26	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	4.08
27	Breast cancer	Enrichment	AKT1, JUN, PIK3CA, SHC1	4.00
28	Hemimegalencephaly	Enrichment	AKT3, PIK3CA	3.99
29	Hydrops fetalis, nonimmune	Enrichment	ACTA1, FLT4, HRAS	3.91
30	Pre-eclampsia	Enrichment	FLT1, NOS3	3.86
31	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA	3.82
32	Tetralogy of fallot	Enrichment	FLT4, KDR	3.80
33	Differentiated thyroid carcinoma	Enrichment	HRAS, KRAS, NRAS	3.77
34	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1, PIK3CA	3.67
35	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, NRAS	3.54
36	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	3.54
37	Pilomyxoid astrocytoma	Enrichment	KRAS, RAF1	3.54
38	Follicular thyroid carcinoma	Enrichment	HRAS, NRAS	3.54
39	Tufted angioma of skin	Enrichment	KDR	3.53
40	Cowden syndrome	Enrichment	AKT1, PIK3CA	3.44
41	Lung squamous cell carcinoma	Enrichment	EGFR, KRAS	3.35
42	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3CD, PIK3R1	3.34
43	Bladder cancer	Enrichment	EGFR, HRAS, KRAS	3.27
44	Angioma, tufted	Enrichment	KDR	3.23
45	Stroke, ischemic	Enrichment	NOS3, PRKCH	3.21
46	Colorectal cancer	Enrichment	AKT1, NRAS, PIK3R1, SRC	3.18
47	Meningioma	Enrichment	AKT1, PIK3CA	3.18
48	Lip and oral cavity carcinoma	Enrichment	HRAS, PIK3CA	3.18
49	Lung cancer	Enrichment	ACTA2, EGFR, KRAS	3.14
50	Hereditary lymphedema id	Enrichment	VEGFC	3.13
51	Lymphatic malformation 4	Enrichment	VEGFC	3.13
52	Microvascular complications of diabetes 1	Enrichment	VEGFA	3.13
53	Congenital heart defects, multiple types, 7	Enrichment	FLT4	3.13
54	Congenital primary lymphedema of gordon	Enrichment	VEGFC	3.13
55	Lymphatic malformation 1	Enrichment	FLT4	2.83
56	Intracranial hypertension, idiopathic	Enrichment	FLT4	2.83
57	Hereditary lymphedema i	Enrichment	FLT4	2.83
58	Anhidrosis, isolated, with normal sweat glands	Enrichment	ITPR2	2.49
59	Macrodactyly	Enrichment	PIK3CA	2.49
60	Proteus syndrome	Enrichment	AKT1	2.49
61	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.49
62	Hydrocephalus due to congenital stenosis of aqueduct of sylvius	Enrichment	L1CAM	2.49
63	Noonan syndrome 5	Enrichment	RAF1	2.49
64	Noonan syndrome 4	Enrichment	SOS1	2.49
65	Melorheostosis, isolated	Enrichment	MAP2K1	2.49
66	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.49
67	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.49
68	Cowden syndrome 5	Enrichment	PIK3CA	2.49
69	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.49
70	Noonan syndrome 9	Enrichment	SOS2	2.49
71	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.49
72	Noonan syndrome 13	Enrichment	MAPK1	2.49
73	Corpus callosum, partial agenesis of, x-linked	Enrichment	L1CAM	2.49
74	Hydrocephalus, congenital, x-linked	Enrichment	L1CAM	2.49
75	Charcot-marie-tooth disease, demyelinating, type 1j	Enrichment	ITPR3	2.49
76	Short syndrome	Enrichment	PIK3R1	2.49
77	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.49
78	Masa syndrome	Enrichment	L1CAM	2.49
79	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.49
80	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.49
81	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.49
82	Melorheostosis	Enrichment	MAP2K1	2.49
83	Leopard syndrome 2	Enrichment	RAF1	2.49
84	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.49
85	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.49
86	Autoinflammation, antibody deficiency, and immune dysregulation	Enrichment	PLCG2	2.49
87	Cowden syndrome 6	Enrichment	AKT1	2.49
88	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	2.49
89	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.49
90	Familial cold autoinflammatory syndrome 3	Enrichment	PLCG2	2.49
91	Trigonitis	Enrichment	RAF1	2.49
92	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.49
93	Hypospadias	Enrichment	PIK3CA	2.49
94	Capillary hemangioma	Enrichment	AKT3	2.49
95	Immunodeficiency 133 with ectodermal dysplasia with or without peripheral neuropathy	Enrichment	ITPR3	2.49
96	Rare venous malformation	Enrichment	PIK3CA	2.49
97	Immune dysregulation, neurodevelopmental defects, and colitis	Enrichment	ITGAV	2.49
98	Diaphragmatic eventration	Enrichment	PIK3CA	2.49
99	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.49
100	X-linked complicated spastic paraplegia type 1	Enrichment	L1CAM	2.49
101	Rare combined vascular malformation	Enrichment	PIK3CA	2.49
102	Cavernous lymphangioma	Enrichment	PIK3CA	2.49
103	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.49
104	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.49
105	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.49
106	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.49
107	Macrodactyly of toe	Enrichment	PIK3CA	2.49
108	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.49
109	Baraitser-winter syndrome 1	Enrichment	ACTB	2.42
110	Oculoectodermal syndrome	Enrichment	KRAS	2.42
111	Congenital myopathy 2a, typical, autosomal dominant	Enrichment	ACTA1	2.42
112	Melanosis, neurocutaneous	Enrichment	NRAS	2.42
113	Myopathy, scapulohumeroperoneal	Enrichment	ACTA1	2.42
114	Noonan syndrome 6	Enrichment	NRAS	2.42
115	Ataxia-oculomotor apraxia 3	Enrichment	PIK3R5	2.42
116	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.42
117	Noonan syndrome 11	Enrichment	MRAS	2.42
118	Megacystis-microcolon-intestinal hypoperistalsis syndrome 5	Enrichment	ACTG2	2.42
119	Congenital smooth muscle hamartoma, with or without hemihypertrophy	Enrichment	ACTB	2.42
120	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.42
121	Spinocerebellar ataxia 14	Enrichment	PRKCG	2.42
122	Becker nevus syndrome	Enrichment	ACTB	2.42
123	Dystonia-deafness syndrome 1	Enrichment	ACTB	2.42
124	Visceral neuropathy, familial, 3, autosomal dominant	Enrichment	ACTG2	2.42
125	Congenital myopathy 2b, severe infantile, autosomal recessive	Enrichment	ACTA1	2.42
126	Cytosolic phospholipase-a2 alpha deficiency associated bleeding disorder	Enrichment	PLA2G4A	2.42
127	Autosomal dominant familial visceral neuropathy	Enrichment	ACTG2	2.42
128	Congenital heart defects and ectodermal dysplasia	Enrichment	PRKD1	2.42
129	Gastrointestinal ulceration, recurrent, with dysfunctional platelets	Enrichment	PLA2G4A	2.42
130	Congenital myopathy 2c, severe infantile, autosomal dominant	Enrichment	ACTA1	2.42
131	Thrombocytopenia 8, with dysmorphic features and developmental delay	Enrichment	ACTB	2.42
132	Baraitser-winter syndrome	Enrichment	ACTB	2.42
133	Congenital pulmonary airway malformation	Enrichment	KRAS	2.42
134	Zebra body myopathy	Enrichment	ACTA1	2.42
135	Congenital smooth muscle hamartoma	Enrichment	ACTB	2.42
136	Developmental malformations-deafness-dystonia syndrome	Enrichment	ACTB	2.42
137	Cryptogenic multifocal ulcerous stenosing enteritis	Enrichment	PLA2G4A	2.42
138	Actin-accumulation myopathy	Enrichment	ACTA1	2.42
139	Malignant epithelial tumor of salivary glands	Enrichment	PRKD1	2.42
140	Myopathic intestinal pseudoobstruction	Enrichment	ACTG2	2.42
141	Neurocutaneous melanocytosis	Enrichment	NRAS	2.42
142	Actg2 visceral myopathy	Enrichment	ACTG2	2.42
143	Charcot-marie-tooth disease, axonal, type 2f	Enrichment	HSPB1	2.34
144	Macular dystrophy, patterned, 3	Enrichment	MAPKAPK3	2.34
145	Thrombocytopenia 6	Enrichment	SRC	2.34
146	Arteriovenous malformations of the brain	Enrichment	EGFR, KRAS	2.31
147	Hypomagnesemia 4, renal	Enrichment	EGF	2.26
148	Spondylometaphyseal dysplasia with corneal dystrophy	Enrichment	PLCB3	2.26
149	Auriculocondylar syndrome 2a	Enrichment	PLCB4	2.26
150	Neurodevelopmental disorder with hypotonia, stereotypic hand movements, and impaired language	Enrichment	MEF2C	2.26
151	Coronary artery disease, autosomal dominant, 1	Enrichment	MEF2A	2.26
152	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.26
153	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.26
154	Immunodeficiency 129	Enrichment	RHOH	2.26
155	Auriculocondylar syndrome 2b	Enrichment	PLCB4	2.26
156	T-cell immunodeficiency with epidermodysplasia verruciformis	Enrichment	RHOH	2.26
157	5q14.3 microdeletion syndrome	Enrichment	MEF2C	2.26
158	Complete atrioventricular septal defect without ventricular hypoplasia	Enrichment	MEF2C	2.26
159	Mef2c-related disorder	Enrichment	MEF2C	2.26
160	Egf-related primary hypomagnesemia with intellectual disability	Enrichment	EGF	2.26
161	Ovarian cancer	Enrichment	AKT1, KRAS, RRAS2	2.19
162	Spinocerebellar ataxia 29	Enrichment	ITPR1	2.19
163	Fibromatosis, gingival, 1	Enrichment	SOS1	2.19
164	Spondyloepimetaphyseal dysplasia, strudwick type	Enrichment	FN1	2.19
165	Costello syndrome	Enrichment	HRAS	2.19
166	Spondylometaphyseal dysplasia, corner fracture type	Enrichment	FN1	2.19
167	Pulmonic stenosis	Enrichment	SOS1	2.19
168	Keratosis, seborrheic	Enrichment	PIK3CA	2.19
169	Roifman-chitayat syndrome	Enrichment	PIK3CD	2.19
170	Noonan syndrome 8	Enrichment	PIK3CA	2.19
171	Senior-loken syndrome 7	Enrichment	AKT3	2.19
172	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.19
173	Immune system disease	Enrichment	PIK3CD	2.19
174	Bardet-biedl syndrome 16	Enrichment	AKT3	2.19
175	Tafro syndrome	Enrichment	MAP2K2	2.19
176	Wooly hair nevus	Enrichment	HRAS	2.19
177	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2	Enrichment	PIK3R5	2.12
178	Aortic aneurysm, familial thoracic 2	Enrichment	ACTA2	2.12
179	Deafness, autosomal dominant 20	Enrichment	ACTG1	2.12
180	Smooth muscle dysfunction syndrome	Enrichment	ACTA2	2.12
181	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	2.12
182	Aortic aneurysm, familial thoracic 6	Enrichment	ACTA2	2.12
183	Baraitser-winter syndrome 2	Enrichment	ACTG1	2.12
184	Moyamoya disease 5	Enrichment	ACTA2	2.12
185	Noonan syndrome 12	Enrichment	RRAS2	2.12
186	Intestinal obstruction	Enrichment	ACTG2	2.12
187	Hereditary breast carcinoma	Enrichment	AKT1, PIK3CA	2.05
188	Neuronopathy, distal hereditary motor, autosomal dominant 3	Enrichment	HSPB1	2.04
189	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	ITGB3	2.01
190	Bleeding disorder, platelet-type, 16	Enrichment	ITGB3	2.01
191	Gillespie syndrome	Enrichment	ITPR1	2.01
192	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.01
193	Glomerulopathy with fibronectin deposits 2	Enrichment	FN1	2.01
194	Nuchal bleb, familial	Enrichment	SOS1	2.01
195	Spermatocytoma	Enrichment	HRAS	2.01
196	Bleeding disorder, platelet-type, 24	Enrichment	ITGB3	2.01
197	Keratoacanthoma	Enrichment	PIK3CA	2.01
198	Leukemia, acute myeloid	Enrichment	KRAS, NRAS	2.01
199	Scoliosis, isolated 1	Enrichment	MAPK7	1.96
200	Ocular melanoma	Enrichment	PLCB4	1.96
201	Megacystis-microcolon-intestinal hypoperistalsis syndrome 4	Enrichment	MYL9	1.96
202	Microcephaly	Enrichment	ACTB, ACTG1, MAPK1	1.96
203	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	1.89
204	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.89
205	Spinocerebellar ataxia 15	Enrichment	ITPR1	1.89
206	Congenital generalized lipodystrophy	Enrichment	FOS	1.89
207	Cerebrovascular disease	Enrichment	PIK3CA	1.89
208	Noonan syndrome with multiple lentigines	Enrichment	RAF1	1.89
209	Epidermolytic nevus	Enrichment	HRAS	1.89
210	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.89
211	Gingival fibromatosis	Enrichment	SOS1	1.89
212	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	1.89
213	Bacteremia 2	Enrichment	MAPKAPK3	1.86
214	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	1.83
215	Nemaline myopathy 2	Enrichment	ACTA1	1.83
216	Megacystis-microcolon-intestinal hypoperistalsis syndrome 1	Enrichment	ACTG2	1.83
217	Autoimmune lymphoproliferative syndrome	Enrichment	ACTA2	1.83
218	Aminoacylase 1 deficiency	Enrichment	ACTB	1.83
219	Lung sarcomatoid carcinoma	Enrichment	KRAS	1.83
220	Hereditary ataxia	Enrichment	PRKCG	1.83
221	Pilocytic astrocytoma	Enrichment	KRAS	1.83
222	Intermediate nemaline myopathy	Enrichment	ACTA1	1.83
223	Pseudomyogenic hemangioendothelioma	Enrichment	ACTB	1.83
224	Capillary malformations, congenital	Enrichment	PIK3CA	1.79
225	Glanzmann thrombasthenia 2	Enrichment	ITGB3	1.79
226	Muscular dystrophy, limb-girdle, autosomal recessive 23	Enrichment	L1CAM	1.79
227	Histiocytoid hemangioma	Enrichment	FOS	1.79
228	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	1.78
229	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	1.78
230	Primary ovarian insufficiency	Enrichment	KDR	1.76
231	Tuberculosis	Enrichment	MAPKAPK3	1.74
232	Alzheimer disease 2	Enrichment	NOS3	1.73
233	Visceral myopathy 1	Enrichment	ACTG2	1.73
234	Congenital myopathy 3 with rigid spine	Enrichment	ACTA1	1.73
235	Coloboma of choroid and retina	Enrichment	ACTG1	1.73
236	Severe congenital nemaline myopathy	Enrichment	ACTA1	1.73
237	Myeloma, multiple	Enrichment	KRAS, PIK3R2	1.73
238	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.71
239	Cowden syndrome 1	Enrichment	PIK3CA	1.71
240	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.71
241	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	ITPR1	1.71
242	Fetomaternal alloimmune thrombocytopenia 1	Enrichment	ITGB3	1.71
243	Auriculocondylar syndrome 1	Enrichment	PLCB4	1.66
244	Developmental and epileptic encephalopathy 12	Enrichment	PLCB1	1.66
245	Moyamoya disease 1	Enrichment	ACTA2	1.65
246	Intestinal pseudo-obstruction	Enrichment	ACTG2	1.65
247	Typical nemaline myopathy	Enrichment	ACTA1	1.65
248	Glanzmann thrombasthenia 1	Enrichment	ITGB3	1.65
249	Gallbladder cancer	Enrichment	PIK3CA	1.65
250	Megacolon	Enrichment	AKT3	1.65
251	Overgrowth syndrome	Enrichment	PIK3R1	1.65
252	Neuronopathy, distal hereditary motor, autosomal dominant 2	Enrichment	HSPB1	1.64
253	Childhood-onset nemaline myopathy	Enrichment	ACTA1	1.58
254	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.54
255	Hydrops fetalis	Enrichment	L1CAM	1.54
256	Myelofibrosis	Enrichment	SRC	1.50
257	Polymicrogyria	Enrichment	AKT3	1.50
258	Autosomal dominant macrothrombocytopenia	Enrichment	ITGB3	1.50
259	Melanoma, uveal	Enrichment	PLCB4	1.49
260	Inflammatory bowel disease 1	Enrichment	PRKCQ	1.48
261	Specific learning disability	Enrichment	MAPK1	1.45
262	Dilated cardiomyopathy	Enrichment	ACTA1, RAF1	1.44
263	Cat eye syndrome	Enrichment	ACTG1	1.43
264	Nemaline myopathy	Enrichment	ACTA1	1.43
265	Hereditary breast ovarian cancer syndrome	Enrichment	BCAR1, KRAS	1.43
266	Squamous cell carcinoma, head and neck	Enrichment	EGFR	1.42
267	Congenital long qt syndrome	Enrichment	ITPR3	1.42
268	Aortic valve disease 1	Enrichment	SOS1	1.38
269	Neural tube defects	Enrichment	ITGB1	1.38
270	Nk-cell enteropathy	Enrichment	PIK3CB	1.38
271	Lennox-gastaut syndrome	Enrichment	MAPK10	1.36
272	Multiple sclerosis	Enrichment	ITPR1	1.35
273	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.35
274	Anterior segment dysgenesis	Enrichment	ITPR1	1.32
275	Lynch syndrome	Enrichment	PIK3CA	1.32
276	Chromosome 1p36 deletion syndrome	Enrichment	PRKCZ	1.32
277	Protein-deficiency anemia	Enrichment	NRAS	1.32
278	Developmental and epileptic encephalopathy 14	Enrichment	PLCB1	1.31
279	Rhabdomyosarcoma	Enrichment	HRAS	1.30
280	Congenital myopathy 4a, autosomal dominant	Enrichment	ACTA1	1.26
281	Heart, malformation of	Enrichment	MAPK1	1.25
282	Alzheimer disease, familial, 1	Enrichment	NOS3	1.21
283	Hypertension, essential	Enrichment	NOS3	1.21
284	Osteoporosis	Enrichment	SRC	1.21
285	Neuromuscular disease	Enrichment	ACTA1	1.18
286	Endometrial cancer	Enrichment	PIK3CA	1.18
287	Hepatocellular carcinoma	Enrichment	PIK3CA	1.16
288	Myocardial infarction	Enrichment	ITGB3	1.16
289	Congenital myopathy	Enrichment	ACTA1	1.16
290	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.12
291	Lissencephaly	Enrichment	ACTG1	1.12
292	Centronuclear myopathy	Enrichment	ACTA1	1.12
293	Gliosarcoma	Enrichment	EGFR	1.07
294	Pancreatic cancer	Enrichment	KRAS	1.05
295	Giant cell glioblastoma	Enrichment	EGFR	1.05
296	Prostate cancer	Enrichment	PIK3CA	1.05
297	Severe covid-19	Enrichment	ITGAV	1.05
298	Long qt syndrome 1	Enrichment	ITPR3	1.03
299	Malaria	Enrichment	MAPKAPK3	1.00
300	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	0.99
301	Left ventricular noncompaction	Enrichment	RAF1	0.97
302	Connective tissue disease	Enrichment	ACTA2	0.94
303	Cakut	Enrichment	ACTG1	0.92
304	Autism spectrum disorder	Enrichment	MAP2K1, MEF2C	0.91
305	Non-syndromic genetic deafness	Enrichment	ACTG1	0.90
306	Type 2 diabetes mellitus	Enrichment	AKT2	0.89
307	Fetal akinesia deformation sequence 1	Enrichment	ACTA1	0.89
308	Gastric cancer	Enrichment	PIK3CA	0.88
309	Nephrotic syndrome	Enrichment	FN1	0.88
310	Myopathy	Enrichment	ACTA1	0.85
311	Thrombocytopenia	Enrichment	ITGB3	0.84
312	Distal arthrogryposis	Enrichment	ACTA1	0.83
313	Nonsyndromic hearing loss	Enrichment	ACTG1	0.83
314	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	ACTA2	0.82
315	Hypertelorism	Enrichment	PIK3CA	0.81
316	Spastic ataxia	Enrichment	ITPR1	0.80
317	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.80
318	Charcot-marie-tooth disease	Enrichment	HSPB1	0.77
319	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ACTG1	0.75
320	Benign epilepsy with centrotemporal spikes	Enrichment	PLCB1	0.69
321	Centralopathic epilepsy	Enrichment	PLCB1	0.67
322	West syndrome	Enrichment	PLCB1	0.66
323	Rare genetic deafness	Enrichment	ACTG1	0.59
324	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	MEF2C	0.56
325	Inherited cancer-predisposing syndrome	Enrichment	EGFR	0.28

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

VEGF Pathway (Qiagen)

Pathway Network for VEGF Pathway (Qiagen)

Pathway network for the VEGF Pathway (Qiagen) SuperPath

Member Pathways for VEGF Pathway (Qiagen)

Pathways in the VEGF Pathway (Qiagen) SuperPath

Gene overlap in member pathways for VEGF Pathway (Qiagen) SuperPath

Associated Genes for VEGF Pathway (Qiagen)

Associated Disorders for VEGF Pathway (Qiagen)

Disorders associated with VEGF Pathway (Qiagen) SuperPath

STRING Interaction Network for VEGF Pathway (Qiagen)

Sources for VEGF Pathway (Qiagen)