VEGF Pathway (Tocris)

No Pathway Network information available for VEGF Pathway (Tocris)

Pathways in the VEGF Pathway (Tocris) SuperPath

#	Name	Source	Genes
1	VEGF Pathway	Tocris	AKT1 AKT2 AKT3 ARAF BAD BAX BRAF CASP10 CASP12 CASP3 CASP6 CASP7 CASP8 CASP9 FLT1 FLT4 HRAS JUN KDR KRAS MAP2K1 MAP2K2 MAPK10 MAPK3 MAPK8 MAPK9 NOS3 NRAS PIK3C2A PIK3C2B PIK3C2G PIK3C3 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCI PRKCQ PRKCZ PTK2 RAF1 (see all 52) (see less)
2	Sorafenib Pharmacodynamics	PharmGKB	AKT1 BRAF FGFR1 FLT1 FLT3 FLT4 HRAS KDR KIT KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 NRAS PDGFRB PIK3C2A PIK3C2B PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 RAF1 RET (see all 27) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	2
2	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	2
3	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	2
4	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	2
5	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	2
6	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	2
7	PIK3C2A	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha	Protein Coding	2
8	PIK3C2B	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Beta	Protein Coding	2
9	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	2
10	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	2
11	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	2
12	PIK3CG	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma	Protein Coding	2
13	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	2
14	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	2
15	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	2
16	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	2
17	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	2
18	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	2
19	FLT1	Fms Related Receptor Tyrosine Kinase 1	Protein Coding	2
20	FLT4	Fms Related Receptor Tyrosine Kinase 4	Protein Coding	2
21	KDR	Kinase Insert Domain Receptor	Protein Coding	2
22	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	1
23	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	1
24	ARAF	A-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
25	BAX	BCL2 Associated X, Apoptosis Regulator	Protein Coding	1
26	CASP10	Caspase 10	Protein Coding	1
27	CASP12	Caspase 12 (Gene/Pseudogene)	Protein Coding	1
28	CASP3	Caspase 3	Protein Coding	1
29	CASP6	Caspase 6	Protein Coding	1
30	CASP7	Caspase 7	Protein Coding	1
31	CASP8	Caspase 8	Protein Coding	1
32	CASP9	Caspase 9	Protein Coding	1
33	PRKCA	Protein Kinase C Alpha	Protein Coding	1
34	PRKCB	Protein Kinase C Beta	Protein Coding	1
35	PRKCG	Protein Kinase C Gamma	Protein Coding	1
36	NOS3	Nitric Oxide Synthase 3	Protein Coding	1
37	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	1
38	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
39	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
40	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	1
41	PTK2	Protein Tyrosine Kinase 2	Protein Coding	1
42	PIK3C2G	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Gamma	Protein Coding	1
43	PIK3C3	Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3	Protein Coding	1
44	PIK3R4	Phosphoinositide-3-Kinase Regulatory Subunit 4	Protein Coding	1
45	PIK3R5	Phosphoinositide-3-Kinase Regulatory Subunit 5	Protein Coding	1
46	PRKCD	Protein Kinase C Delta	Protein Coding	1
47	PRKCE	Protein Kinase C Epsilon	Protein Coding	1
48	PRKCH	Protein Kinase C Eta	Protein Coding	1
49	PRKCI	Protein Kinase C Iota	Protein Coding	1
50	PRKCQ	Protein Kinase C Theta	Protein Coding	1
51	PRKCZ	Protein Kinase C Zeta	Protein Coding	1
52	BAD	BCL2 Associated Agonist Of Cell Death	Protein Coding	1
53	RET	Ret Proto-Oncogene	Protein Coding	1
54	FGFR1	Fibroblast Growth Factor Receptor 1	Protein Coding	1
55	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	1
56	PDGFRB	Platelet Derived Growth Factor Receptor Beta	Protein Coding	1
57	FLT3	Fms Related Receptor Tyrosine Kinase 3	Protein Coding	1
58	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1

Disorders associated with VEGF Pathway (Tocris) SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Rasopathy	Enrichment	BRAF, HRAS, KRAS, MAP2K1, MAP2K2, NRAS, RAF1	16.00
2	Lung non-small cell carcinoma	Enrichment	BRAF, HRAS, KRAS, MAP2K1, NRAS, PIK3CA	10.80
3	Noonan syndrome and noonan-related syndrome	Enrichment	BRAF, HRAS, KRAS, MAP2K1, MAP2K2, NRAS, RAF1	10.68
4	Noonan syndrome 1	Enrichment	BRAF, HRAS, KRAS, MAP2K1, MAP2K2, NRAS, RAF1	10.64
5	Cardiofaciocutaneous syndrome 1	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2	10.33
6	Cardiofaciocutaneous syndrome	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2	10.33
7	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS, PIK3CA	9.34
8	Pilomyxoid astrocytoma	Enrichment	BRAF, FGFR1, KRAS, RAF1	9.34
9	Melanocytic nevus syndrome, congenital	Enrichment	BRAF, HRAS, NRAS, RAF1	9.05
10	Differentiated thyroid carcinoma	Enrichment	BRAF, HRAS, KRAS, NRAS, RET	8.62
11	Lip and oral cavity carcinoma	Enrichment	BRAF, HRAS, KIT, PIK3CA	8.21
12	Langerhans cell histiocytosis	Enrichment	BRAF, MAP2K1, NRAS	8.15
13	Colorectal cancer	Enrichment	AKT1, BRAF, NRAS, PIK3CA, PIK3R1, RET	7.81
14	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	7.55
15	Breast adenocarcinoma	Enrichment	AKT1, KRAS, PIK3CA	6.85
16	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3CA, PIK3R2	6.67
17	Thyroid cancer, nonmedullary, 2	Enrichment	BRAF, HRAS, NRAS	6.61
18	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, MAP2K1, PIK3CA	6.61
19	Noonan syndrome 3	Enrichment	HRAS, KRAS, RAF1	6.61
20	Gallbladder cancer	Enrichment	BRAF, KRAS, PIK3CA	6.61
21	Follicular thyroid carcinoma	Enrichment	BRAF, HRAS, NRAS	6.61
22	Arteriovenous malformation	Enrichment	HRAS, MAP2K1, PIK3CA	6.23
23	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1, PIK3CA	6.08
24	Leukemia, acute myeloid	Enrichment	FLT3, KIT, KRAS, NRAS	5.97
25	Ovarian cancer	Enrichment	AKT1, KIT, KRAS, PIK3CA, RET	5.83
26	Hereditary breast carcinoma	Enrichment	AKT1, KRAS, PIK3CA, RET	5.80
27	Encephalocraniocutaneous lipomatosis	Enrichment	FGFR1, KRAS	5.42
28	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	5.42
29	Rosette-forming glioneuronal tumor	Enrichment	FGFR1, PIK3CA	5.42
30	Myeloma, multiple	Enrichment	BRAF, FLT3, KRAS, PIK3R2	5.37
31	Lung cancer	Enrichment	BRAF, CASP8, KRAS, PIK3CA	5.20
32	Breast cancer	Enrichment	AKT1, CASP8, JUN, KRAS, PIK3CA	5.02
33	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.94
34	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD, PIK3R1	4.94
35	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	4.94
36	Immunodeficiency 14	Enrichment	PIK3CD, PIK3R1	4.94
37	Tetralogy of fallot	Enrichment	FLT4, KDR, RET	4.75
38	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	4.64
39	Noonan syndrome with multiple lentigines	Enrichment	BRAF, RAF1	4.64
40	Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)	Enrichment	FLT3, KIT	4.64
41	Bladder cancer	Enrichment	HRAS, KRAS, PIK3CA	4.61
42	Non-immune hydrops fetalis	Enrichment	FLT4, HRAS, KRAS	4.52
43	Acute myeloid leukemia with maturation	Enrichment	FLT3, KIT	4.42
44	Acute myeloid leukemia with t(8;21)(q22;q22) translocation	Enrichment	FLT3, KIT	4.42
45	Primary hypereosinophilic syndrome	Enrichment	FGFR1, PDGFRB	4.42
46	Hemangioma, capillary infantile	Enrichment	FLT4, KDR	4.24
47	Lung squamous cell carcinoma	Enrichment	KRAS, PIK3CA	4.24
48	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	4.10
49	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3, PIK3R2	4.07
50	Cowden syndrome	Enrichment	AKT1, PIK3CA	3.87
51	Pre-eclampsia	Enrichment	FLT1, NOS3	3.84
52	Hemimegalencephaly	Enrichment	AKT3, PIK3CA	3.84
53	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3CD, PIK3R1	3.77
54	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS	3.60
55	Meningioma	Enrichment	AKT1, PIK3CA	3.60
56	Lung cancer susceptibility 3	Enrichment	BRAF, KRAS	3.47
57	Lynch syndrome	Enrichment	KRAS, PIK3CA	3.40
58	Lymphoma, non-hodgkin, familial	Enrichment	BRAF, CASP10	3.40
59	Dandy-walker syndrome	Enrichment	BRAF, PDGFRB	3.29
60	Adult hepatocellular carcinoma	Enrichment	CASP8, PIK3CA	3.29
61	Gastric cancer	Enrichment	CASP10, KRAS, PIK3CA	3.23
62	Stroke, ischemic	Enrichment	NOS3, PRKCH	3.20
63	Arteriovenous malformations of the brain	Enrichment	BRAF, KRAS	3.19
64	Hepatocellular carcinoma	Enrichment	PIK3CA, RET	3.07
65	Hydrops fetalis, nonimmune	Enrichment	FLT4, HRAS	2.92
66	Multiple endocrine neoplasia, type iib	Enrichment	RET	2.70
67	Macrodactyly	Enrichment	PIK3CA	2.70
68	Proteus syndrome	Enrichment	AKT1	2.70
69	Osteoglophonic dysplasia	Enrichment	FGFR1	2.70
70	Trigonocephaly 1	Enrichment	FGFR1	2.70
71	Oculoectodermal syndrome	Enrichment	KRAS	2.70
72	Premature aging syndrome, penttinen type	Enrichment	PDGFRB	2.70
73	Noonan syndrome 5	Enrichment	RAF1	2.70
74	Mastocytosis, cutaneous	Enrichment	KIT	2.70
75	Melorheostosis, isolated	Enrichment	MAP2K1	2.70
76	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.70
77	Noonan syndrome 7	Enrichment	BRAF	2.70
78	Leopard syndrome 3	Enrichment	BRAF	2.70
79	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.70
80	Cowden syndrome 5	Enrichment	PIK3CA	2.70
81	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.70
82	Myofibromatosis, infantile, 1	Enrichment	PDGFRB	2.70
83	Melanosis, neurocutaneous	Enrichment	NRAS	2.70
84	Noonan syndrome 6	Enrichment	NRAS	2.70
85	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.70
86	Noonan syndrome 13	Enrichment	MAPK1	2.70
87	Short syndrome	Enrichment	PIK3R1	2.70
88	Oculoskeletodental syndrome	Enrichment	PIK3C2A	2.70
89	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.70
90	Lymphangioma	Enrichment	BRAF	2.70
91	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.70
92	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.70
93	Phace association	Enrichment	BRAF	2.70
94	Melorheostosis	Enrichment	MAP2K1	2.70
95	Leopard syndrome 2	Enrichment	RAF1	2.70
96	Basal ganglia calcification, idiopathic, 4	Enrichment	PDGFRB	2.70
97	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.70
98	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.70
99	Cowden syndrome 6	Enrichment	AKT1	2.70
100	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	2.70
101	Myeloid and lymphoid neoplasms associated with pdgfrb rearrangement	Enrichment	PDGFRB	2.70
102	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.70
103	Acute myeloid leukemia with minimal differentiation	Enrichment	FLT3	2.70
104	Immunodeficiency 97 with autoinflammation	Enrichment	PIK3CG	2.70
105	Kosaki overgrowth syndrome	Enrichment	PDGFRB	2.70
106	Hartsfield syndrome	Enrichment	FGFR1	2.70
107	Congenital heart defects, multiple types, 7	Enrichment	FLT4	2.70
108	Ocular pterygium-digital keloid dysplasia syndrome	Enrichment	PDGFRB	2.70
109	Chronic mast cell leukemia	Enrichment	KIT	2.70
110	Trigonitis	Enrichment	RAF1	2.70
111	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.70
112	Tufted angioma of skin	Enrichment	KDR	2.70
113	Hypospadias	Enrichment	PIK3CA	2.70
114	Isolated bone marrow mastocytosis	Enrichment	KIT	2.70
115	Congenital pulmonary airway malformation	Enrichment	KRAS	2.70
116	Thyroid cancer	Enrichment	RET	2.70
117	Smoldering systemic mastocytosis	Enrichment	KIT	2.70
118	Rare venous malformation	Enrichment	PIK3CA	2.70
119	Diaphragmatic eventration	Enrichment	PIK3CA	2.70
120	Mastocytosis	Enrichment	KIT	2.70
121	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.70
122	Syringocystadenoma papilliferum	Enrichment	BRAF	2.70
123	Rare combined vascular malformation	Enrichment	PIK3CA	2.70
124	Ganglioglioma	Enrichment	BRAF	2.70
125	Cavernous lymphangioma	Enrichment	PIK3CA	2.70
126	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.70
127	Cutaneous mastocytoma	Enrichment	KIT	2.70
128	Nongerminomatous germ cell tumor	Enrichment	BRAF	2.70
129	Phace syndrome	Enrichment	BRAF	2.70
130	Oculocerebrodental syndrome	Enrichment	PIK3C2A	2.70
131	Typical urticaria pigmentosa	Enrichment	KIT	2.70
132	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.70
133	Classic hairy cell leukemia	Enrichment	BRAF	2.70
134	Nodular urticaria pigmentosa	Enrichment	KIT	2.70
135	Hartsfield-bixler-demyer syndrome	Enrichment	FGFR1	2.70
136	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.70
137	Pseudoxanthomatous diffuse cutaneous mastocytosis	Enrichment	KIT	2.70
138	Telangiectasia macularis eruptiva perstans	Enrichment	KIT	2.70
139	Acute mast cell leukemia	Enrichment	KIT	2.70
140	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.70
141	Plaque-form urticaria pigmentosa	Enrichment	KIT	2.70
142	Macrodactyly of toe	Enrichment	PIK3CA	2.70
143	Neurocutaneous melanocytosis	Enrichment	NRAS	2.70
144	Bullous diffuse cutaneous mastocytosis	Enrichment	KIT	2.70
145	Gastrointestinal system disease	Enrichment	RET	2.70
146	Multiple endocrine neoplasia	Enrichment	RET	2.70
147	Testis seminoma	Enrichment	KIT	2.70
148	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.42
149	Pallister-killian syndrome	Enrichment	ARAF	2.42
150	Caspase 8 deficiency	Enrichment	CASP8	2.42
151	Ataxia-oculomotor apraxia 3	Enrichment	PIK3R5	2.42
152	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.42
153	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.42
154	Autoimmune lymphoproliferative syndrome, type iia	Enrichment	CASP10	2.42
155	Spinocerebellar ataxia 14	Enrichment	PRKCG	2.42
156	Capillary hemangioma	Enrichment	AKT3	2.42
157	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.42
158	Lymphatic malformation 1	Enrichment	FLT4	2.40
159	Myeloproliferative disorder, chronic, with eosinophilia	Enrichment	PDGFRB	2.40
160	Costello syndrome	Enrichment	HRAS	2.40
161	Intracranial hypertension, idiopathic	Enrichment	FLT4	2.40
162	Pulmonic stenosis	Enrichment	BRAF	2.40
163	Piebald trait	Enrichment	KIT	2.40
164	Keratosis, seborrheic	Enrichment	PIK3CA	2.40
165	Pfeiffer syndrome	Enrichment	FGFR1	2.40
166	Jackson-weiss syndrome	Enrichment	FGFR1	2.40
167	Roifman-chitayat syndrome	Enrichment	PIK3CD	2.40
168	Angioma, tufted	Enrichment	KDR	2.40
169	Noonan syndrome 8	Enrichment	PIK3CA	2.40
170	Infantile myofibromatosis	Enrichment	PDGFRB	2.40
171	Medullary thyroid carcinoma	Enrichment	RET	2.40
172	Immune system disease	Enrichment	PIK3CD	2.40
173	Hereditary lymphedema i	Enrichment	FLT4	2.40
174	Acute myeloid leukemia without maturation	Enrichment	FLT3	2.40
175	Interfrontal craniofaciosynostosis	Enrichment	FGFR1	2.40
176	Mixed phenotype acute leukemia with t(9;22)(q34.1;q11.2)	Enrichment	FLT3	2.40
177	B-lymphoblastic leukemia/lymphoma with t	Enrichment	KIT	2.40
178	Tafro syndrome	Enrichment	MAP2K2	2.40
179	Wooly hair nevus	Enrichment	HRAS	2.40
180	Hypertelorism	Enrichment	PIK3CA, RET	2.32
181	Hypogonadotropic hypogonadism 2 with or without anosmia	Enrichment	FGFR1	2.22
182	Thyroid carcinoma, familial medullary	Enrichment	RET	2.22
183	Ataxia-telangiectasia	Enrichment	BRAF	2.22
184	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.22
185	Chromosome 8p11 myeloproliferative syndrome	Enrichment	FGFR1	2.22
186	Tethered spinal cord syndrome	Enrichment	BRAF	2.22
187	Testicular germ cell cancer	Enrichment	KIT	2.22
188	Gingival overgrowth	Enrichment	RET	2.22
189	Spermatocytoma	Enrichment	HRAS	2.22
190	Mixed phenotype acute leukemia with t	Enrichment	FLT3	2.22
191	Keratoacanthoma	Enrichment	PIK3CA	2.22
192	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2	Enrichment	PIK3R5	2.12
193	Spermatogenic failure 17	Enrichment	PIK3C2G	2.12
194	Senior-loken syndrome 7	Enrichment	AKT3	2.12
195	Bardet-biedl syndrome 16	Enrichment	AKT3	2.12
196	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	2.10
197	Thyroid cancer, nonmedullary, 1	Enrichment	BRAF	2.10
198	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	2.10
199	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.10
200	Central hypoventilation syndrome, congenital, 1	Enrichment	RET	2.10
201	Lung sarcomatoid carcinoma	Enrichment	KRAS	2.10
202	Chronic myelomonocytic leukemia	Enrichment	FLT3	2.10
203	Cerebrovascular disease	Enrichment	PIK3CA	2.10
204	Craniopharyngioma	Enrichment	BRAF	2.10
205	Pilocytic astrocytoma	Enrichment	KRAS	2.10
206	Newborn respiratory distress syndrome	Enrichment	BRAF	2.10
207	Epidermolytic nevus	Enrichment	HRAS	2.10
208	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.10
209	Systemic mastocytosis with associated hematologic neoplasm	Enrichment	KIT	2.10
210	Haddad syndrome	Enrichment	RET	2.10
211	Capillary malformations, congenital	Enrichment	PIK3CA	2.00
212	Multiple endocrine neoplasia, type iia	Enrichment	RET	2.00
213	Holoprosencephaly	Enrichment	FGFR1	2.00
214	Dilated cardiomyopathy	Enrichment	BRAF, RAF1	1.96
215	T-cell acute lymphoblastic leukemia	Enrichment	BAX	1.94
216	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.92
217	Cowden syndrome 1	Enrichment	PIK3CA	1.92
218	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.92
219	Holoprosencephaly 1	Enrichment	FGFR1	1.92
220	Testicular germ cell tumor	Enrichment	KIT	1.92
221	Wilms tumor 5	Enrichment	BRAF	1.92
222	Sporadic pheochromocytoma/secreting paraganglioma	Enrichment	RET	1.92
223	Gastrointestinal stromal tumor	Enrichment	KIT	1.86
224	Overgrowth syndrome	Enrichment	PIK3R1	1.86
225	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	FLT3	1.86
226	Autoimmune lymphoproliferative syndrome	Enrichment	CASP10	1.82
227	Hereditary ataxia	Enrichment	PRKCG	1.82
228	Basal ganglia calcification, idiopathic, 1	Enrichment	PDGFRB	1.80
229	Renal hypodysplasia/aplasia 1	Enrichment	RET	1.80
230	Hypothyroidism	Enrichment	RET	1.80
231	Cardiomyopathy, familial hypertrophic, 4	Enrichment	BRAF	1.75
232	Atypical chronic myeloid leukemia, bcr-abl1 negative	Enrichment	FLT3	1.75
233	Hypogonadotropic hypogonadism	Enrichment	FGFR1	1.75
234	Congenital central hypoventilation syndrome	Enrichment	RET	1.75
235	Primary hyperaldosteronism	Enrichment	BRAF	1.75
236	Ventricular septal defect	Enrichment	BRAF	1.75
237	Renal agenesis, bilateral	Enrichment	RET	1.75
238	Alzheimer disease 2	Enrichment	NOS3	1.72
239	Melanoma	Enrichment	BRAF	1.70
240	Primary ovarian insufficiency	Enrichment	KDR, NOS3	1.67
241	Leukemia, acute lymphoblastic	Enrichment	FLT3	1.66
242	Specific learning disability	Enrichment	MAPK1	1.66
243	Septooptic dysplasia	Enrichment	FGFR1	1.63
244	Renal hypodysplasia/aplasia 3	Enrichment	RET	1.63
245	Protein-deficiency anemia	Enrichment	NRAS	1.59
246	Nk-cell enteropathy	Enrichment	PIK3CB	1.59
247	Megacolon	Enrichment	AKT3	1.58
248	Hypogonadotropic hypogonadism 7 with or without anosmia	Enrichment	FGFR1	1.56
249	Pheochromocytoma	Enrichment	RET	1.56
250	Inherited cancer-predisposing syndrome	Enrichment	KIT, RET	1.55
251	Wilms tumor 1	Enrichment	BRAF	1.53
252	Hydrocephalus	Enrichment	PDGFRB	1.53
253	Lennox-gastaut syndrome	Enrichment	MAPK10	1.52
254	Rhabdomyosarcoma	Enrichment	HRAS	1.50
255	Gliosarcoma	Enrichment	FGFR1	1.50
256	Microform holoprosencephaly	Enrichment	FGFR1	1.50
257	Lobar holoprosencephaly	Enrichment	FGFR1	1.50
258	Melanoma, cutaneous malignant 1	Enrichment	BRAF	1.48
259	Giant cell glioblastoma	Enrichment	FGFR1	1.48
260	Inflammatory bowel disease 1	Enrichment	PRKCQ	1.47
261	Heart, malformation of	Enrichment	MAPK1	1.45
262	Semilobar holoprosencephaly	Enrichment	FGFR1	1.45
263	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	FGFR1	1.45
264	Diffuse large b-cell lymphoma	Enrichment	BRAF	1.43
265	Polymicrogyria	Enrichment	AKT3	1.42
266	Endometrial cancer	Enrichment	PIK3CA	1.39
267	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	RET	1.39
268	Tooth agenesis	Enrichment	FGFR1	1.37
269	Kallmann syndrome	Enrichment	FGFR1	1.35
270	Precursor t-cell acute lymphoblastic leukemia	Enrichment	FLT3	1.35
271	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.33
272	Pancreatic cancer	Enrichment	KRAS	1.31
273	Chromosome 1p36 deletion syndrome	Enrichment	PRKCZ	1.31
274	Hirschsprung disease 1	Enrichment	RET	1.25
275	Prostate cancer	Enrichment	PIK3CA	1.25
276	Alzheimer disease, familial, 1	Enrichment	NOS3	1.20
277	Hypertension, essential	Enrichment	NOS3	1.20
278	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	1.20
279	Left ventricular noncompaction	Enrichment	RAF1	1.17
280	Cerebral palsy	Enrichment	PDGFRB	1.13
281	Sensorineural hearing loss	Enrichment	RET	1.04
282	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	1.00
283	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS	0.98
284	Severe covid-19	Enrichment	CASP10	0.98
285	Type 2 diabetes mellitus	Enrichment	AKT2	0.83
286	Autism spectrum disorder	Enrichment	MAP2K1	0.71
287	Microcephaly	Enrichment	MAPK1	0.66

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

VEGF Pathway (Tocris)

Pathway Network for VEGF Pathway (Tocris)

Member Pathways for VEGF Pathway (Tocris)

Pathways in the VEGF Pathway (Tocris) SuperPath

Associated Genes for VEGF Pathway (Tocris)

Associated Disorders for VEGF Pathway (Tocris)

Disorders associated with VEGF Pathway (Tocris) SuperPath

STRING Interaction Network for VEGF Pathway (Tocris)

Sources for VEGF Pathway (Tocris)