VEGF Signaling Pathway

Pathway network for the VEGF Signaling Pathway SuperPath

Sources:

PharmGKB
Sino Biological
WikiPathways

Pathways in the VEGF Signaling Pathway SuperPath

#	Name	Source	Genes
1	VEGF Signaling Pathway	PharmGKB	AKT1 AKT2 AKT3 CEP43 CRK CSK FGF2 FGFR1 FGFR1OP2 FGFR2 FGFR3 FGFR3P1 FGFR4 FGFRL1 FLT1 HRAS ITGAV ITGB3 ITGB5 KDR KRAS MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK4 MAPK6 MAPK7 MAPK8 MAPK9 NOS3 NRAS NRP1 PIGF PIK3C2A PIK3C2B PLCG1 PLCG2 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCI PRKCQ PRKCZ RAF1 TIMP3 VEGFA VEGFB VEGFC (see all 62) (see less)
2	VEGF Signaling Pathway	Sino Biological	AKT1 AKT2 AKT3 DAG1 GRB2 HRAS HSPB1 KRAS MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK15 MAPK3 MAPK6 MAPK7 MAPK8 MAPK9 MAPKAPK3 NRAS PIK3CB PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCI PRKCZ PTEN PTK2 PXN RAF1 SHC1 SHC4 VEGFA (see all 44) (see less)
3	TGF-beta Signaling Pathway	Sino Biological	AKT1 AKT2 AKT3 CDC42 GRB2 HRAS KRAS MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAPK1 MAPK14 MAPK3 MAPK6 MAPK7 NRAS PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCI PRKCZ RAC1 RAC2 RAC3 RAF1 RPS6KA6 SHC1 SHC4 SMAD1 SMAD2 SMAD3 SMAD5 SMURF1 (see all 38) (see less)
4	Nanoparticle-mediated activation of receptor signaling	WikiPathways	AKT3 AREG COL1A1 EGFR FN1 GRB2 HRAS ITGA1 ITGB1 KRAS MAP2K1 MAP2K2 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK8 MAPK9 NRAS PIK3CD PTK2 PXN RAF1 SOS1 SRC TLN1 (see all 28) (see less)

Gene overlap in member pathways for VEGF Signaling Pathway SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	4
2	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	4
3	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	4
4	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	4
5	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	4
6	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	4
7	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	4
8	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	4
9	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	4
10	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	3
11	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	3
12	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	3
13	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	3
14	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	3
15	MAPK6	Mitogen-Activated Protein Kinase 6	Protein Coding	3
16	MAPK7	Mitogen-Activated Protein Kinase 7	Protein Coding	3
17	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	3
18	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	3
19	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	3
20	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	3
21	MAPK13	Mitogen-Activated Protein Kinase 13	Protein Coding	3
22	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	3
23	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	3
24	PRKCD	Protein Kinase C Delta	Protein Coding	3
25	PRKCA	Protein Kinase C Alpha	Protein Coding	3
26	PRKCB	Protein Kinase C Beta	Protein Coding	3
27	PRKCE	Protein Kinase C Epsilon	Protein Coding	3
28	PRKCG	Protein Kinase C Gamma	Protein Coding	3
29	PRKCH	Protein Kinase C Eta	Protein Coding	3
30	PRKCI	Protein Kinase C Iota	Protein Coding	3
31	PRKCZ	Protein Kinase C Zeta	Protein Coding	3
32	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	3
33	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	2
34	MAP2K5	Mitogen-Activated Protein Kinase Kinase 5	Protein Coding	2
35	PTK2	Protein Tyrosine Kinase 2	Protein Coding	2
36	PXN	Paxillin	Protein Coding	2
37	SHC1	SHC Adaptor Protein 1	Protein Coding	2
38	SHC4	SHC Adaptor Protein 4	Protein Coding	2
39	VEGFB	Vascular Endothelial Growth Factor B	Protein Coding	1
40	VEGFC	Vascular Endothelial Growth Factor C	Protein Coding	1
41	TIMP3	TIMP Metallopeptidase Inhibitor 3	Protein Coding	1
42	FGF2	Fibroblast Growth Factor 2	Protein Coding	1
43	FGFR1	Fibroblast Growth Factor Receptor 1	Protein Coding	1
44	FGFR3	Fibroblast Growth Factor Receptor 3	Protein Coding	1
45	FGFR2	Fibroblast Growth Factor Receptor 2	Protein Coding	1
46	FGFR4	Fibroblast Growth Factor Receptor 4	Protein Coding	1
47	ITGB3	Integrin Subunit Beta 3	Protein Coding	1
48	ITGB5	Integrin Subunit Beta 5	Protein Coding	1
49	KDR	Kinase Insert Domain Receptor	Protein Coding	1
50	NRP1	Neuropilin 1	Protein Coding	1
51	NOS3	Nitric Oxide Synthase 3	Protein Coding	1
52	FLT1	Fms Related Receptor Tyrosine Kinase 1	Protein Coding	1
53	CRK	CRK Proto-Oncogene, Adaptor Protein	Protein Coding	1
54	MAPK4	Mitogen-Activated Protein Kinase 4	Protein Coding	1
55	MAP2K7	Mitogen-Activated Protein Kinase Kinase 7	Protein Coding	1
56	PIGF	Phosphatidylinositol Glycan Anchor Biosynthesis Class F	Protein Coding	1
57	PIK3C2A	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha	Protein Coding	1
58	PIK3C2B	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Beta	Protein Coding	1
59	PLCG1	Phospholipase C Gamma 1	Protein Coding	1
60	PLCG2	Phospholipase C Gamma 2	Protein Coding	1
61	FGFRL1	Fibroblast Growth Factor Receptor Like 1	Protein Coding	1
62	CSK	C-Terminal Src Kinase	Protein Coding	1
63	PRKCQ	Protein Kinase C Theta	Protein Coding	1
64	CEP43	Centrosomal Protein 43	Protein Coding	1
65	FGFR1OP2	FGFR1 Oncogene Partner 2	Protein Coding	1
66	FGFR3P1	Fibroblast Growth Factor Receptor 3 Pseudogene 1	Pseudogene	1
67	ITGAV	Integrin Subunit Alpha V	Protein Coding	1
68	DAG1	Dystroglycan 1	Protein Coding	1
69	HSPB1	Heat Shock Protein Family B (Small) Member 1	Protein Coding	1
70	MAPK15	Mitogen-Activated Protein Kinase 15	Protein Coding	1
71	MAPKAPK3	MAPK Activated Protein Kinase 3	Protein Coding	1
72	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	1
73	PTEN	Phosphatase And Tensin Homolog	Protein Coding	1
74	CDC42	Cell Division Cycle 42	Protein Coding	1
75	RAC1	Rac Family Small GTPase 1	Protein Coding	1
76	RAC2	Rac Family Small GTPase 2	Protein Coding	1
77	RAC3	Rac Family Small GTPase 3	Protein Coding	1
78	RPS6KA6	Ribosomal Protein S6 Kinase A6	Protein Coding	1
79	SMAD1	SMAD Family Member 1	Protein Coding	1
80	SMAD2	SMAD Family Member 2	Protein Coding	1
81	SMAD3	SMAD Family Member 3	Protein Coding	1
82	SMAD5	SMAD Family Member 5	Protein Coding	1
83	SMURF1	SMAD Specific E3 Ubiquitin Protein Ligase 1	Protein Coding	1
84	AREG	Amphiregulin	Protein Coding	1
85	COL1A1	Collagen Type I Alpha 1 Chain	Protein Coding	1
86	FN1	Fibronectin 1	Protein Coding	1
87	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	1
88	ITGB1	Integrin Subunit Beta 1	Protein Coding	1
89	ITGA1	Integrin Subunit Alpha 1	Protein Coding	1
90	TLN1	Talin 1	Protein Coding	1
91	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
92	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
93	EGFR	Epidermal Growth Factor Receptor	Protein Coding	1

Disorders associated with VEGF Signaling Pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Rasopathy	Enrichment	HRAS, KRAS, MAP2K1, MAP2K2, NRAS, RAF1, SOS1	16.00
2	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, KRAS, MAP2K1, MAP2K2, NRAS, RAF1	11.11
3	Lung non-small cell carcinoma	Enrichment	EGFR, HRAS, KRAS, MAP2K1, NRAS	10.56
4	Noonan syndrome 1	Enrichment	HRAS, KRAS, MAP2K1, MAP2K2, NRAS, RAF1, SOS1	10.51
5	Noonan syndrome 3	Enrichment	HRAS, KRAS, RAF1, SOS1	9.28
6	Nevus, epidermal	Enrichment	FGFR3, HRAS, KRAS, NRAS	7.86
7	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	7.50
8	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS, MAP2K1, MAP2K2	7.50
9	Cardiofaciocutaneous syndrome	Enrichment	KRAS, MAP2K1, MAP2K2	7.50
10	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, NRAS, RAF1	6.36
11	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, NRAS, PTEN	5.96
12	Follicular thyroid carcinoma	Enrichment	HRAS, NRAS, PTEN	5.96
13	Pilomyxoid astrocytoma	Enrichment	FGFR1, KRAS, RAF1	5.50
14	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	5.39
15	Langerhans cell histiocytosis	Enrichment	MAP2K1, NRAS	4.91
16	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	4.91
17	Pfeiffer syndrome	Enrichment	FGFR1, FGFR2	4.69
18	Jackson-weiss syndrome	Enrichment	FGFR1, FGFR2	4.69
19	Encephalocraniocutaneous lipomatosis	Enrichment	FGFR1, KRAS	4.69
20	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	4.61
21	Bladder cancer	Enrichment	EGFR, HRAS, KRAS	4.56
22	Differentiated thyroid carcinoma	Enrichment	HRAS, KRAS, NRAS	4.56
23	Lung squamous cell carcinoma	Enrichment	EGFR, KRAS	4.21
24	Crouzon syndrome	Enrichment	FGFR2, FGFR3	4.21
25	Lacrimoauriculodentodigital syndrome 1	Enrichment	FGFR2, FGFR3	4.21
26	Spermatocytoma	Enrichment	FGFR3, HRAS	4.21
27	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, MAP2K1	4.07
28	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	4.07
29	Breast cancer	Enrichment	AKT1, KRAS, PTEN, SHC1	4.00
30	Hemimegalencephaly	Enrichment	AKT3, PTEN	3.99
31	Breast adenocarcinoma	Enrichment	AKT1, KRAS	3.94
32	Saethre-chotzen syndrome	Enrichment	FGFR2, FGFR3	3.91
33	Arteriovenous malformation	Enrichment	HRAS, MAP2K1	3.83
34	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1	3.74
35	Hemifacial hyperplasia	Enrichment	FGFR2, FGFR3	3.69
36	Pre-eclampsia	Enrichment	FLT1, NOS3	3.69
37	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS	3.57
38	Lip and oral cavity carcinoma	Enrichment	EGFR, HRAS	3.57
39	Loeys-dietz syndrome	Enrichment	SMAD2, SMAD3	3.57
40	Cowden syndrome	Enrichment	AKT1, PTEN	3.44
41	Osteoporosis	Enrichment	COL1A1, SRC	3.43
42	Lung cancer susceptibility 3	Enrichment	EGFR, KRAS	3.43
43	Hereditary breast carcinoma	Enrichment	AKT1, KRAS, PTEN	3.42
44	Colorectal cancer	Enrichment	AKT1, FGFR2, FGFR3, NRAS	3.18
45	Meningioma	Enrichment	AKT1, PTEN	3.18
46	Arteriovenous malformations of the brain	Enrichment	EGFR, KRAS	3.16
47	Stroke, ischemic	Enrichment	NOS3, PRKCH	3.04
48	Rhabdomyosarcoma	Enrichment	HRAS, PTEN	2.92
49	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS	2.73
50	Lung cancer	Enrichment	EGFR, KRAS	2.71
51	Oculoectodermal syndrome	Enrichment	KRAS	2.69
52	Noonan syndrome 5	Enrichment	RAF1	2.69
53	Noonan syndrome 4	Enrichment	SOS1	2.69
54	Melorheostosis, isolated	Enrichment	MAP2K1	2.69
55	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.69
56	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.69
57	Melanosis, neurocutaneous	Enrichment	NRAS	2.69
58	Noonan syndrome 6	Enrichment	NRAS	2.69
59	Noonan syndrome 13	Enrichment	MAPK1	2.69
60	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.69
61	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.69
62	Melorheostosis	Enrichment	MAP2K1	2.69
63	Leopard syndrome 2	Enrichment	RAF1	2.69
64	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.69
65	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	2.69
66	Thrombocytopenia 6	Enrichment	SRC	2.69
67	Trigonitis	Enrichment	RAF1	2.69
68	Asphyxia neonatorum	Enrichment	COL1A1	2.69
69	Capillary hemangioma	Enrichment	AKT3	2.69
70	Congenital pulmonary airway malformation	Enrichment	KRAS	2.69
71	Capillary leak syndrome	Enrichment	TLN1	2.69
72	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.69
73	Neurocutaneous melanocytosis	Enrichment	NRAS	2.69
74	Gliosarcoma	Enrichment	FGFR1, FGFR3	2.63
75	Giant cell glioblastoma	Enrichment	FGFR1, FGFR3	2.57
76	Proteus syndrome	Enrichment	AKT1	2.55
77	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.55
78	Immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis	Enrichment	RAC2	2.55
79	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.55
80	Neurodevelopmental disorder with structural brain anomalies and dysmorphic facies	Enrichment	RAC3	2.55
81	Immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia	Enrichment	RAC2	2.55
82	Spinocerebellar ataxia 14	Enrichment	PRKCG	2.55
83	Cowden syndrome 6	Enrichment	AKT1	2.55
84	Loeys-dietz syndrome 6	Enrichment	SMAD2	2.55
85	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.55
86	Immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia	Enrichment	RAC2	2.55
87	Congenital heart defects, multiple types, 8, with or without heterotaxy	Enrichment	SMAD2	2.55
88	Infantile lad-like disease due to rac2 deficiency	Enrichment	RAC2	2.55
89	Reticular dysgenesis-like severe combined immunodeficiency	Enrichment	RAC2	2.55
90	Nocarh syndrome	Enrichment	CDC42	2.55
91	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.55
92	Rac2-related combined immunodeficiency-bronchiectasis-cancer-predisposing syndrome	Enrichment	RAC2	2.55
93	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.55
94	Leukemia, acute myeloid	Enrichment	KRAS, NRAS	2.52
95	Vacterl association with hydrocephalus	Enrichment	PTEN	2.49
96	Muscular dystrophy-dystroglycanopathy , type a, 9	Enrichment	DAG1	2.49
97	Papillary tumor of the pineal region	Enrichment	PTEN	2.49
98	Microvascular complications of diabetes 1	Enrichment	VEGFA	2.49
99	Charcot-marie-tooth disease, axonal, type 2f	Enrichment	HSPB1	2.49
100	Muscular dystrophy-dystroglycanopathy , type c, 9	Enrichment	DAG1	2.49
101	Glioma susceptibility 2	Enrichment	PTEN	2.49
102	Macular dystrophy, patterned, 3	Enrichment	MAPKAPK3	2.49
103	Muscle-eye-brain disease with bilateral multicystic leucodystrophy	Enrichment	DAG1	2.49
104	Segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome	Enrichment	PTEN	2.49
105	Craniosynostosis	Enrichment	FGFR2, FGFR3	2.43
106	Epiphyseal dysplasia, multiple, 1	Enrichment	COL1A1	2.38
107	Fibromatosis, gingival, 1	Enrichment	SOS1	2.38
108	Spondyloepimetaphyseal dysplasia, strudwick type	Enrichment	FN1	2.38
109	Costello syndrome	Enrichment	HRAS	2.38
110	Spondylometaphyseal dysplasia, corner fracture type	Enrichment	FN1	2.38
111	Dermatofibrosarcoma protuberans	Enrichment	COL1A1	2.38
112	Pulmonic stenosis	Enrichment	SOS1	2.38
113	Roifman-chitayat syndrome	Enrichment	PIK3CD	2.38
114	Combined osteogenesis imperfecta and ehlers-danlos syndrome 1	Enrichment	COL1A1	2.38
115	Ehlers-danlos syndrome, arthrochalasia type, 2	Enrichment	COL1A1	2.38
116	Senior-loken syndrome 7	Enrichment	AKT3	2.38
117	Stickler syndrome, type ii	Enrichment	COL1A1	2.38
118	Immune system disease	Enrichment	PIK3CD	2.38
119	Bardet-biedl syndrome 16	Enrichment	AKT3	2.38
120	Ehlers-danlos/osteogenesis imperfecta syndrome	Enrichment	COL1A1	2.38
121	Tafro syndrome	Enrichment	MAP2K2	2.38
122	Wooly hair nevus	Enrichment	HRAS	2.38
123	Ovarian cancer	Enrichment	AKT1, KRAS, PTEN	2.37
124	Hypochondroplasia	Enrichment	FGFR3	2.34
125	Beare-stevenson cutis gyrata syndrome	Enrichment	FGFR2	2.34
126	Osteoglophonic dysplasia	Enrichment	FGFR1	2.34
127	Thanatophoric dysplasia, type i	Enrichment	FGFR3	2.34
128	Trigonocephaly 1	Enrichment	FGFR1	2.34
129	Muenke syndrome	Enrichment	FGFR3	2.34
130	Scaphocephaly, maxillary retrusion, and impaired intellectual development	Enrichment	FGFR2	2.34
131	Apert syndrome	Enrichment	FGFR2	2.34
132	Thanatophoric dysplasia, type ii	Enrichment	FGFR3	2.34
133	Camptodactyly, tall stature, and hearing loss syndrome	Enrichment	FGFR3	2.34
134	Bent bone dysplasia syndrome 1	Enrichment	FGFR2	2.34
135	Hereditary lymphedema id	Enrichment	VEGFC	2.34
136	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.34
137	Oculoskeletodental syndrome	Enrichment	PIK3C2A	2.34
138	Lymphatic malformation 4	Enrichment	VEGFC	2.34
139	Crouzon syndrome with acanthosis nigricans	Enrichment	FGFR3	2.34
140	Autoinflammation, antibody deficiency, and immune dysregulation	Enrichment	PLCG2	2.34
141	Achondroplasia, severe, with developmental delay and acanthosis nigricans	Enrichment	FGFR3	2.34
142	Familial cold autoinflammatory syndrome 3	Enrichment	PLCG2	2.34
143	Hartsfield syndrome	Enrichment	FGFR1	2.34
144	Onychodystrophy, osteodystrophy, impaired intellectual development, and seizures syndrome	Enrichment	PIGF	2.34
145	Tufted angioma of skin	Enrichment	KDR	2.34
146	Lacrimoauriculodentodigital syndrome 2	Enrichment	FGFR3	2.34
147	Immune dysregulation, neurodevelopmental defects, and colitis	Enrichment	ITGAV	2.34
148	Fgfr3-related chondrodysplasia	Enrichment	FGFR3	2.34
149	Congenital primary lymphedema of gordon	Enrichment	VEGFC	2.34
150	Camptodactyly-tall stature-scoliosis-hearing loss syndrome	Enrichment	FGFR3	2.34
151	Oculocerebrodental syndrome	Enrichment	PIK3C2A	2.34
152	Hartsfield-bixler-demyer syndrome	Enrichment	FGFR1	2.34
153	Non-syndromic unicoronal craniosynostosis	Enrichment	FGFR2	2.34
154	Scoliosis, isolated 1	Enrichment	MAPK7	2.25
155	Loeys-dietz syndrome 3	Enrichment	SMAD3	2.25
156	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.25
157	Glomerulopathy with fibronectin deposits 2	Enrichment	FN1	2.21
158	Nuchal bleb, familial	Enrichment	SOS1	2.21
159	Caffey disease	Enrichment	COL1A1	2.21
160	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	2.21
161	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD	2.21
162	Immunodeficiency 14	Enrichment	PIK3CD	2.21
163	High bone mass osteogenesis imperfecta	Enrichment	COL1A1	2.21
164	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	2.21
165	Neuronopathy, distal hereditary motor, autosomal dominant 3	Enrichment	HSPB1	2.19
166	Vacterl with hydrocephalus	Enrichment	PTEN	2.19
167	Juvenile polyposis of infancy	Enrichment	PTEN	2.19
168	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	SMAD2, SMAD3	2.17
169	Ehlers-danlos syndrome, arthrochalasia type, 1	Enrichment	COL1A1	2.08
170	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	2.08
171	Phenylketonuria	Enrichment	COL1A1	2.08
172	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	2.08
173	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3	2.08
174	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.08
175	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3	2.08
176	Lung sarcomatoid carcinoma	Enrichment	KRAS	2.08
177	Noonan syndrome with multiple lentigines	Enrichment	RAF1	2.08
178	Pilocytic astrocytoma	Enrichment	KRAS	2.08
179	Epidermolytic nevus	Enrichment	HRAS	2.08
180	Osteogenesis imperfecta with normal sclerae, dominant form	Enrichment	COL1A1	2.08
181	Gingival fibromatosis	Enrichment	SOS1	2.08
182	Loeys-dietz syndrome 1	Enrichment	SMAD2	2.08
183	Gastric cancer	Enrichment	KRAS, PTEN	2.07
184	Sorsby fundus dystrophy	Enrichment	TIMP3	2.04
185	Cervical cancer	Enrichment	FGFR3	2.04
186	Aural atresia, congenital	Enrichment	FGFR2	2.04
187	Keratosis, seborrheic	Enrichment	FGFR3	2.04
188	Angioma, tufted	Enrichment	KDR	2.04
189	Antley-bixler syndrome without genital anomalies or disordered steroidogenesis	Enrichment	FGFR2	2.04
190	Split hand-foot malformation	Enrichment	FGFR2	2.04
191	Rosette-forming glioneuronal tumor	Enrichment	FGFR1	2.04
192	Cervix carcinoma	Enrichment	FGFR3	2.04
193	Interfrontal craniofaciosynostosis	Enrichment	FGFR1	2.04
194	Autosomal dominant nonsyndromic deafness	Enrichment	FGFR2	2.04
195	Bacteremia 2	Enrichment	MAPKAPK3	2.01
196	Laryngeal squamous cell carcinoma	Enrichment	PTEN	2.01
197	Hereditary ataxia	Enrichment	PRKCG	1.95
198	Aortic aneurysm	Enrichment	SMAD3	1.95
199	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	1.95
200	Ehlers-danlos syndrome, classic type, 1	Enrichment	COL1A1	1.91
201	Osteogenesis imperfecta, type i	Enrichment	COL1A1	1.91
202	Cowden syndrome 1	Enrichment	EGFR	1.91
203	Keratoconus	Enrichment	COL1A1	1.91
204	Classic ehlers-danlos syndrome	Enrichment	COL1A1	1.91
205	Tuberculosis	Enrichment	MAPKAPK3	1.89
206	Glioma	Enrichment	PTEN	1.89
207	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	ITGB3	1.86
208	Achondroplasia	Enrichment	FGFR3	1.86
209	Hypogonadotropic hypogonadism 2 with or without anosmia	Enrichment	FGFR1	1.86
210	Larsen syndrome	Enrichment	FGFR3	1.86
211	Bleeding disorder, platelet-type, 16	Enrichment	ITGB3	1.86
212	Chromosome 8p11 myeloproliferative syndrome	Enrichment	FGFR1	1.86
213	Hamartoma	Enrichment	FGFR3	1.86
214	Testicular germ cell cancer	Enrichment	FGFR3	1.86
215	Bleeding disorder, platelet-type, 24	Enrichment	ITGB3	1.86
216	Testicular cancer	Enrichment	FGFR3	1.86
217	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS, PTEN	1.86
218	Osteogenesis imperfecta, type ii	Enrichment	COL1A1	1.84
219	Myelofibrosis	Enrichment	SRC	1.84
220	Squamous cell carcinoma, head and neck	Enrichment	EGFR	1.84
221	Gallbladder cancer	Enrichment	KRAS	1.84
222	Megacolon	Enrichment	AKT3	1.84
223	Neuronopathy, distal hereditary motor, autosomal dominant 2	Enrichment	HSPB1	1.79
224	Macrocephaly/autism syndrome	Enrichment	PTEN	1.79
225	Hemangioma	Enrichment	PTEN	1.79
226	Acute megakaryocytic leukemia	Enrichment	PTEN	1.79
227	Lennox-gastaut syndrome	Enrichment	MAPK10	1.79
228	Non-syndromic bicoronal craniosynostosis	Enrichment	FGFR3	1.74
229	Polymicrogyria	Enrichment	AKT3	1.69
230	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3CD	1.69
231	Primary bone dysplasia	Enrichment	COL1A1	1.69
232	Osteochondrodysplasia	Enrichment	COL1A1	1.65
233	Specific learning disability	Enrichment	MAPK1	1.65
234	Alzheimer disease 2	Enrichment	NOS3	1.64
235	Glanzmann thrombasthenia 2	Enrichment	ITGB3	1.64
236	Holoprosencephaly	Enrichment	FGFR1	1.64
237	Primary hypereosinophilic syndrome	Enrichment	FGFR1	1.64
238	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.60
239	Familial thoracic aortic aneurysm and dissection	Enrichment	SMAD3	1.60
240	Aortic valve disease 1	Enrichment	SOS1	1.58
241	Osteogenesis imperfecta, type iv	Enrichment	COL1A1	1.58
242	Neural tube defects	Enrichment	ITGB1	1.58
243	Protein-deficiency anemia	Enrichment	NRAS	1.58
244	Myeloma, multiple	Enrichment	FGFR3, KRAS	1.57
245	Split-hand/foot malformation 1	Enrichment	FGFR2	1.57
246	Holoprosencephaly 1	Enrichment	FGFR1	1.57
247	Testicular germ cell tumor	Enrichment	FGFR3	1.57
248	Hemangioma, capillary infantile	Enrichment	KDR	1.57
249	Fetomaternal alloimmune thrombocytopenia 1	Enrichment	ITGB3	1.57
250	46,xy disorder of sex development	Enrichment	FGFR3	1.57
251	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.54
252	Primary ovarian insufficiency	Enrichment	KDR, NOS3	1.53
253	Osteogenesis imperfecta, type iii	Enrichment	COL1A1	1.52
254	Lynch syndrome	Enrichment	KRAS	1.52
255	Glanzmann thrombasthenia 1	Enrichment	ITGB3	1.50
256	Melanoma	Enrichment	PTEN	1.50
257	Meningioma, familial	Enrichment	PTEN	1.45
258	Uterine corpus cancer	Enrichment	PTEN	1.45
259	Chromosome 1p36 deletion syndrome	Enrichment	PRKCZ	1.45
260	Heart, malformation of	Enrichment	MAPK1	1.44
261	Ehlers-danlos syndrome	Enrichment	COL1A1	1.41
262	Aortic aneurysm, familial thoracic 1	Enrichment	SMAD3	1.41
263	Inflammatory bowel disease 1	Enrichment	PRKCQ	1.39
264	Hypogonadotropic hypogonadism	Enrichment	FGFR1	1.39
265	Nk-cell enteropathy	Enrichment	PIK3CB	1.38
266	Walker-warburg syndrome	Enrichment	DAG1	1.35
267	Meier-gorlin syndrome 1	Enrichment	FGFR2	1.35
268	Autosomal dominant macrothrombocytopenia	Enrichment	ITGB3	1.35
269	Brittle bone disorder	Enrichment	COL1A1	1.33
270	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.31
271	Autism spectrum disorder	Enrichment	MAP2K1, PTEN	1.31
272	Pancreatic cancer	Enrichment	KRAS	1.30
273	Creatine phosphokinase, elevated serum	Enrichment	DAG1	1.30
274	Isolated elevated serum creatine phosphokinase levels	Enrichment	DAG1	1.30
275	Hydrops fetalis, nonimmune	Enrichment	HRAS	1.28
276	Septooptic dysplasia	Enrichment	FGFR1	1.27
277	Renal hypodysplasia/aplasia 3	Enrichment	FGFR3	1.27
278	Diffuse large b-cell lymphoma	Enrichment	PTEN	1.22
279	Hypogonadotropic hypogonadism 7 with or without anosmia	Enrichment	FGFR1	1.21
280	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	1.18
281	Endometrial cancer	Enrichment	PTEN	1.18
282	Hydrocephalus	Enrichment	FGFR2	1.18
283	Left ventricular noncompaction	Enrichment	RAF1	1.16
284	Microform holoprosencephaly	Enrichment	FGFR1	1.15
285	Lobar holoprosencephaly	Enrichment	FGFR1	1.15
286	Malaria	Enrichment	MAPKAPK3	1.14
287	Alzheimer disease, familial, 1	Enrichment	NOS3	1.13
288	Hypertension, essential	Enrichment	NOS3	1.13
289	Semilobar holoprosencephaly	Enrichment	FGFR1	1.10
290	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	FGFR1	1.10
291	Nephrotic syndrome	Enrichment	FN1	1.07
292	Connective tissue disease	Enrichment	SMAD3	1.07
293	Prostate cancer	Enrichment	PTEN	1.05
294	Hepatoblastoma	Enrichment	FGFR3	1.04
295	Thrombocytopenia	Enrichment	SRC	1.02
296	Myocardial infarction	Enrichment	ITGB3	1.02
297	Tooth agenesis	Enrichment	FGFR1	1.02
298	Kallmann syndrome	Enrichment	FGFR1	1.00
299	Hypertelorism	Enrichment	COL1A1	0.99
300	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.98
301	Type 2 diabetes mellitus	Enrichment	AKT2	0.95
302	Tetralogy of fallot	Enrichment	KDR	0.95
303	Severe covid-19	Enrichment	ITGAV	0.90
304	Charcot-marie-tooth disease	Enrichment	HSPB1	0.90
305	Dilated cardiomyopathy	Enrichment	RAF1	0.82
306	Microcephaly	Enrichment	MAPK1	0.65
307	Inherited cancer-predisposing syndrome	Enrichment	EGFR	0.62
308	Congenital nervous system abnormality	Enrichment	PTEN	0.53
309	Nervous system disease	Enrichment	PTEN	0.53
310	Complex neurodevelopmental disorder	Enrichment	RAC3	0.53
311	Hereditary retinal dystrophy	Enrichment	TIMP3	0.13
312	Fundus dystrophy	Enrichment	TIMP3	0.13

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

VEGF Signaling Pathway

Pathway Network for VEGF Signaling Pathway

Pathway network for the VEGF Signaling Pathway SuperPath

Member Pathways for VEGF Signaling Pathway

Pathways in the VEGF Signaling Pathway SuperPath

Gene overlap in member pathways for VEGF Signaling Pathway SuperPath

Associated Genes for VEGF Signaling Pathway

Associated Disorders for VEGF Signaling Pathway

Disorders associated with VEGF Signaling Pathway SuperPath

STRING Interaction Network for VEGF Signaling Pathway

Sources for VEGF Signaling Pathway