VEGFR1 specific signals

No Pathway Network information available for VEGFR1 specific signals

Pathways in the VEGFR1 specific signals SuperPath

#	Name	Source	Genes
1	VEGFR1 specific signals	PubChem	AKT1 CAV1 CBL CD2AP FLT1 HIF1A HSP90AA1 MAPK3 NCK1 NOS3 NRP1 NRP2 PDPK1 PGF PIK3CA PIK3R1 PLCG1 PRKACA PRKCA PRKCB PTPN11 RASA1 SHC2 VEGFA VEGFB (see all 25) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	HIF1A	Hypoxia Inducible Factor 1 Subunit Alpha	Protein Coding	1
2	PGF	Placental Growth Factor	Protein Coding	1
3	SHC2	SHC Adaptor Protein 2	Protein Coding	1
4	FLT1	Fms Related Receptor Tyrosine Kinase 1	Protein Coding	1
5	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
6	NOS3	Nitric Oxide Synthase 3	Protein Coding	1
7	CAV1	Caveolin 1	Protein Coding	1
8	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	1
9	CD2AP	CD2 Associated Protein	Protein Coding	1
10	RASA1	RAS P21 Protein Activator 1	Protein Coding	1
11	NRP2	Neuropilin 2	Protein Coding	1
12	PRKCA	Protein Kinase C Alpha	Protein Coding	1
13	NCK1	NCK Adaptor Protein 1	Protein Coding	1
14	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	1
15	PLCG1	Phospholipase C Gamma 1	Protein Coding	1
16	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
17	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	1
18	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	1
19	CBL	Cbl Proto-Oncogene	Protein Coding	1
20	PRKCB	Protein Kinase C Beta	Protein Coding	1
21	VEGFB	Vascular Endothelial Growth Factor B	Protein Coding	1
22	NRP1	Neuropilin 1	Protein Coding	1
23	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
24	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
25	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	1

Disorders associated with VEGFR1 specific signals SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	5.01
2	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CBL, PTPN11	4.71
3	Capillary malformations, congenital	Enrichment	PIK3CA, RASA1	4.49
4	Pre-eclampsia	Enrichment	FLT1, NOS3	4.49
5	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA, RASA1	4.31
6	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA	4.31
7	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA, RASA1	4.17
8	Arteriovenous malformation	Enrichment	PIK3CA, RASA1	3.93
9	Cowden syndrome	Enrichment	AKT1, PIK3CA	3.93
10	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA, RASA1	3.84
11	Juvenile myelomonocytic leukemia	Enrichment	CBL, PTPN11	3.67
12	Meningioma	Enrichment	AKT1, PIK3CA	3.67
13	Noonan syndrome and noonan-related syndrome	Enrichment	CBL, PTPN11	3.47
14	Colorectal cancer	Enrichment	AKT1, PIK3CA, PIK3R1	3.28
15	Noonan syndrome 1	Enrichment	CBL, PTPN11	3.09
16	Rasopathy	Enrichment	CBL, PTPN11	2.99
17	Macrodactyly	Enrichment	PIK3CA	2.73
18	Proteus syndrome	Enrichment	AKT1	2.73
19	Metachondromatosis	Enrichment	PTPN11	2.73
20	Cystic angiomatosis of bone, diffuse	Enrichment	RASA1	2.73
21	Lipodystrophy, congenital generalized, type 3	Enrichment	CAV1	2.73
22	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.73
23	Leopard syndrome 1	Enrichment	PTPN11	2.73
24	Cowden syndrome 5	Enrichment	PIK3CA	2.73
25	Pulmonary hypertension, primary, 3	Enrichment	CAV1	2.73
26	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.73
27	Short syndrome	Enrichment	PIK3R1	2.73
28	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.73
29	Lipodystrophy, familial partial, type 7	Enrichment	CAV1	2.73
30	Microvascular complications of diabetes 1	Enrichment	VEGFA	2.73
31	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.73
32	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.73
33	Focal segmental glomerulosclerosis 3	Enrichment	CD2AP	2.73
34	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.73
35	Cowden syndrome 6	Enrichment	AKT1	2.73
36	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.73
37	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.73
38	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.73
39	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.73
40	Hypospadias	Enrichment	PIK3CA	2.73
41	Rare venous malformation	Enrichment	PIK3CA	2.73
42	Gorham's disease	Enrichment	RASA1	2.73
43	Diaphragmatic eventration	Enrichment	PIK3CA	2.73
44	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.73
45	Rare combined vascular malformation	Enrichment	PIK3CA	2.73
46	Cavernous lymphangioma	Enrichment	PIK3CA	2.73
47	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.73
48	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.73
49	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.73
50	Macrodactyly of toe	Enrichment	PIK3CA	2.73
51	Malignant astrocytoma	Enrichment	PTPN11	2.73
52	Hereditary breast carcinoma	Enrichment	AKT1, PIK3CA	2.53
53	Ovarian germ cell cancer	Enrichment	CBL	2.43
54	Keratosis, seborrheic	Enrichment	PIK3CA	2.43
55	Noonan syndrome 8	Enrichment	PIK3CA	2.43
56	Werner syndrome	Enrichment	PTPN11	2.43
57	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.43
58	Fibrolamellar carcinoma	Enrichment	PRKACA	2.43
59	Malignant germ cell tumor of ovary	Enrichment	CBL	2.43
60	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.26
61	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.26
62	Wieacker-wolff syndrome	Enrichment	RASA1	2.26
63	Immunodeficiency 14	Enrichment	PIK3R1	2.26
64	Tricuspid valve insufficiency	Enrichment	PTPN11	2.26
65	Enchondromatosis	Enrichment	HIF1A	2.26
66	Keratoacanthoma	Enrichment	PIK3CA	2.26
67	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	2.13
68	Cerebrovascular disease	Enrichment	PIK3CA	2.13
69	Noonan syndrome with multiple lentigines	Enrichment	PTPN11	2.13
70	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.13
71	Breast cancer	Enrichment	AKT1, PIK3CA	2.08
72	Enchondromatosis, multiple, ollier type	Enrichment	HIF1A	2.04
73	Alzheimer disease 2	Enrichment	NOS3	2.04
74	Lymphoma	Enrichment	PTPN11	2.04
75	Myeloproliferative neoplasm	Enrichment	CBL	2.04
76	Hemimegalencephaly	Enrichment	PIK3CA	2.04
77	Aggressive systemic mastocytosis	Enrichment	CBL	2.04
78	Diffuse cutaneous systemic sclerosis	Enrichment	CAV1	2.04
79	Cowden syndrome 1	Enrichment	PIK3CA	1.96
80	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	RASA1	1.96
81	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.96
82	Hemangioma, capillary infantile	Enrichment	RASA1	1.96
83	Basal cell carcinoma 1	Enrichment	RASA1	1.96
84	Patent ductus arteriosus	Enrichment	PTPN11	1.96
85	Limited scleroderma	Enrichment	CAV1	1.96
86	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.96
87	Nevus, epidermal	Enrichment	PIK3CA	1.89
88	Noonan syndrome 3	Enrichment	PTPN11	1.89
89	Multiple enchondromatosis, maffucci type	Enrichment	HIF1A	1.89
90	Gallbladder cancer	Enrichment	PIK3CA	1.89
91	Hereditary hemorrhagic telangiectasia	Enrichment	RASA1	1.89
92	Overgrowth syndrome	Enrichment	PIK3R1	1.89
93	Ovarian cancer	Enrichment	AKT1, PIK3CA	1.83
94	Ellis-van creveld syndrome	Enrichment	PRKACA	1.78
95	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.78
96	Stroke, ischemic	Enrichment	NOS3	1.74
97	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.74
98	Pectus excavatum	Enrichment	PTPN11	1.70
99	Lung non-small cell carcinoma	Enrichment	PIK3CA	1.70
100	Heritable pulmonary arterial hypertension	Enrichment	CAV1	1.70
101	Specific learning disability	Enrichment	PTPN11	1.70
102	Epicanthus	Enrichment	PTPN11	1.66
103	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.66
104	Congenital long qt syndrome	Enrichment	PTPN11	1.66
105	Lynch syndrome	Enrichment	PIK3CA	1.56
106	Rhabdomyosarcoma	Enrichment	CBL	1.54
107	Alzheimer disease, familial, 1	Enrichment	NOS3	1.51
108	Hypertension, essential	Enrichment	NOS3	1.51
109	Patent foramen ovale	Enrichment	PTPN11	1.49
110	Endometrial cancer	Enrichment	PIK3CA	1.42
111	Hepatocellular carcinoma	Enrichment	PIK3CA	1.40
112	Scoliosis	Enrichment	PTPN11	1.36
113	Hydrops fetalis, nonimmune	Enrichment	PTPN11	1.33
114	Strabismus	Enrichment	PTPN11	1.31
115	Bladder cancer	Enrichment	PIK3CA	1.28
116	Prostate cancer	Enrichment	PIK3CA	1.28
117	Long qt syndrome 1	Enrichment	PTPN11	1.27
118	Non-immune hydrops fetalis	Enrichment	PTPN11	1.25
119	Lung cancer	Enrichment	PIK3CA	1.24
120	Genetic steroid-resistant nephrotic syndrome	Enrichment	CD2AP	1.22
121	Gastric cancer	Enrichment	PIK3CA	1.12
122	Hypertrophic cardiomyopathy	Enrichment	PTPN11	1.12
123	Thrombocytopenia	Enrichment	PTPN11	1.07
124	Hypertelorism	Enrichment	PIK3CA	1.04
125	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	1.01
126	Primary ovarian insufficiency	Enrichment	NOS3	0.99
127	Autism spectrum disorder	Enrichment	PTPN11	0.74
128	Microcephaly	Enrichment	PTPN11	0.69
129	Inherited cancer-predisposing syndrome	Enrichment	PTPN11	0.66

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

VEGFR1 specific signals

Pathway Network for VEGFR1 specific signals

Member Pathways for VEGFR1 specific signals

Pathways in the VEGFR1 specific signals SuperPath

Associated Genes for VEGFR1 specific signals

Associated Disorders for VEGFR1 specific signals

Disorders associated with VEGFR1 specific signals SuperPath

STRING Interaction Network for VEGFR1 specific signals

Sources for VEGFR1 specific signals