VEGFR3 signaling in lymphatic endothelium

No Pathway Network information available for VEGFR3 signaling in lymphatic endothelium

Pathways in the VEGFR3 signaling in lymphatic endothelium SuperPath

#	Name	Source	Genes
1	VEGFR3 signaling in lymphatic endothelium	PubChem	AKT1 COL1A1 COL1A2 CREB1 CRK FLT4 FN1 GRB2 ITGA1 ITGA2 ITGA4 ITGA5 ITGB1 MAP2K4 MAPK14 MAPK3 PIK3CA PIK3R1 PRRT2 RPS6KA1 SHC1 SOS1 VEGFC VEGFD (see all 24) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PRRT2	Proline Rich Transmembrane Protein 2	Protein Coding	1
2	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
3	RPS6KA1	Ribosomal Protein S6 Kinase A1	Protein Coding	1
4	COL1A1	Collagen Type I Alpha 1 Chain	Protein Coding	1
5	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	1
6	COL1A2	Collagen Type I Alpha 2 Chain	Protein Coding	1
7	VEGFC	Vascular Endothelial Growth Factor C	Protein Coding	1
8	VEGFD	Vascular Endothelial Growth Factor D	Protein Coding	1
9	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
10	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
11	ITGA4	Integrin Subunit Alpha 4	Protein Coding	1
12	FN1	Fibronectin 1	Protein Coding	1
13	ITGA2	Integrin Subunit Alpha 2	Protein Coding	1
14	ITGA5	Integrin Subunit Alpha 5	Protein Coding	1
15	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
16	ITGB1	Integrin Subunit Beta 1	Protein Coding	1
17	ITGA1	Integrin Subunit Alpha 1	Protein Coding	1
18	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1
19	CRK	CRK Proto-Oncogene, Adaptor Protein	Protein Coding	1
20	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
21	FLT4	Fms Related Receptor Tyrosine Kinase 4	Protein Coding	1
22	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
23	SHC1	SHC Adaptor Protein 1	Protein Coding	1
24	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1

Disorders associated with VEGFR3 signaling in lymphatic endothelium SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Ehlers-danlos syndrome, arthrochalasia type, 2	Enrichment	COL1A1, COL1A2	5.52
2	Ehlers-danlos/osteogenesis imperfecta syndrome	Enrichment	COL1A1, COL1A2	5.52
3	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	5.05
4	High bone mass osteogenesis imperfecta	Enrichment	COL1A1, COL1A2	5.05
5	Ehlers-danlos syndrome, arthrochalasia type, 1	Enrichment	COL1A1, COL1A2	4.75
6	Osteogenesis imperfecta with normal sclerae, dominant form	Enrichment	COL1A1, COL1A2	4.75
7	Ehlers-danlos syndrome, classic type, 1	Enrichment	COL1A1, COL1A2	4.35
8	Osteogenesis imperfecta, type i	Enrichment	COL1A1, COL1A2	4.35
9	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA	4.35
10	Classic ehlers-danlos syndrome	Enrichment	COL1A1, COL1A2	4.35
11	Osteogenesis imperfecta, type ii	Enrichment	COL1A1, COL1A2	4.20
12	Cowden syndrome	Enrichment	AKT1, PIK3CA	3.97
13	Primary bone dysplasia	Enrichment	COL1A1, COL1A2	3.87
14	Osteochondrodysplasia	Enrichment	COL1A1, COL1A2	3.79
15	Meningioma	Enrichment	AKT1, PIK3CA	3.71
16	Osteogenesis imperfecta, type iv	Enrichment	COL1A1, COL1A2	3.64
17	Osteoporosis	Enrichment	COL1A1, COL1A2	3.57
18	Breast cancer	Enrichment	AKT1, PIK3CA, SHC1	3.52
19	Osteogenesis imperfecta, type iii	Enrichment	COL1A1, COL1A2	3.51
20	Colorectal cancer	Enrichment	AKT1, PIK3CA, PIK3R1	3.33
21	Ehlers-danlos syndrome	Enrichment	COL1A1, COL1A2	3.30
22	Brittle bone disorder	Enrichment	COL1A1, COL1A2	3.13
23	Macrodactyly	Enrichment	PIK3CA	2.75
24	Proteus syndrome	Enrichment	AKT1	2.75
25	Ehlers-danlos syndrome, cardiac valvular type	Enrichment	COL1A2	2.75
26	Noonan syndrome 4	Enrichment	SOS1	2.75
27	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.75
28	Cowden syndrome 5	Enrichment	PIK3CA	2.75
29	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.75
30	Short syndrome	Enrichment	PIK3R1	2.75
31	Combined osteogenesis imperfecta and ehlers-danlos syndrome 2	Enrichment	COL1A2	2.75
32	Hereditary lymphedema id	Enrichment	VEGFC	2.75
33	Lymphatic malformation 4	Enrichment	VEGFC	2.75
34	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.75
35	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.75
36	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.75
37	Cowden syndrome 6	Enrichment	AKT1	2.75
38	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.75
39	Congenital heart defects, multiple types, 7	Enrichment	FLT4	2.75
40	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.75
41	Asphyxia neonatorum	Enrichment	COL1A1	2.75
42	Hypospadias	Enrichment	PIK3CA	2.75
43	Rare venous malformation	Enrichment	PIK3CA	2.75
44	Fetomaternal alloimmune thrombocytopenia 3	Enrichment	ITGA2	2.75
45	Diaphragmatic eventration	Enrichment	PIK3CA	2.75
46	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.75
47	Congenital primary lymphedema of gordon	Enrichment	VEGFC	2.75
48	Rare combined vascular malformation	Enrichment	PIK3CA	2.75
49	Cavernous lymphangioma	Enrichment	PIK3CA	2.75
50	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.75
51	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.75
52	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.75
53	Macrodactyly of toe	Enrichment	PIK3CA	2.75
54	Hereditary breast carcinoma	Enrichment	AKT1, PIK3CA	2.57
55	Epiphyseal dysplasia, multiple, 1	Enrichment	COL1A1	2.45
56	Lymphatic malformation 1	Enrichment	FLT4	2.45
57	Fibromatosis, gingival, 1	Enrichment	SOS1	2.45
58	Spondyloepimetaphyseal dysplasia, strudwick type	Enrichment	FN1	2.45
59	Spondylometaphyseal dysplasia, corner fracture type	Enrichment	FN1	2.45
60	Bruck syndrome 1	Enrichment	COL1A2	2.45
61	Intracranial hypertension, idiopathic	Enrichment	FLT4	2.45
62	Dermatofibrosarcoma protuberans	Enrichment	COL1A1	2.45
63	Pulmonic stenosis	Enrichment	SOS1	2.45
64	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.45
65	Seizures, benign familial infantile, 2	Enrichment	PRRT2	2.45
66	Keratosis, seborrheic	Enrichment	PIK3CA	2.45
67	Noonan syndrome 8	Enrichment	PIK3CA	2.45
68	Combined osteogenesis imperfecta and ehlers-danlos syndrome 1	Enrichment	COL1A1	2.45
69	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.45
70	Stickler syndrome, type ii	Enrichment	COL1A1	2.45
71	Hereditary lymphedema i	Enrichment	FLT4	2.45
72	Dentinogenesis imperfecta	Enrichment	COL1A2	2.45
73	Prrt2-related disorder	Enrichment	PRRT2	2.45
74	Hypertelorism	Enrichment	COL1A1, PIK3CA	2.42
75	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.28
76	Glomerulopathy with fibronectin deposits 2	Enrichment	FN1	2.28
77	Nuchal bleb, familial	Enrichment	SOS1	2.28
78	Glut1 deficiency syndrome 2	Enrichment	PRRT2	2.28
79	Caffey disease	Enrichment	COL1A1	2.28
80	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.28
81	Immunodeficiency 14	Enrichment	PIK3R1	2.28
82	Melanoma of soft tissue	Enrichment	CREB1	2.28
83	Keratoacanthoma	Enrichment	PIK3CA	2.28
84	Paroxysmal nonkinesigenic dyskinesia 1	Enrichment	PRRT2	2.15
85	Episodic kinesigenic dyskinesia 1	Enrichment	PRRT2	2.15
86	Phenylketonuria	Enrichment	COL1A1	2.15
87	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	2.15
88	Retinitis pigmentosa 26	Enrichment	ITGA4	2.15
89	Cerebrovascular disease	Enrichment	PIK3CA	2.15
90	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.15
91	Familial paroxysmal nonkinesigenic dyskinesia	Enrichment	PRRT2	2.15
92	Familial or sporadic hemiplegic migraine	Enrichment	PRRT2	2.15
93	Gingival fibromatosis	Enrichment	SOS1	2.15
94	Capillary malformations, congenital	Enrichment	PIK3CA	2.05
95	Convulsions, familial infantile, with paroxysmal choreoathetosis	Enrichment	PRRT2	2.05
96	Hemimegalencephaly	Enrichment	PIK3CA	2.05
97	Self-limited infantile epilepsy	Enrichment	PRRT2	2.05
98	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.98
99	Cowden syndrome 1	Enrichment	PIK3CA	1.98
100	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.98
101	Hemangioma, capillary infantile	Enrichment	FLT4	1.98
102	Keratoconus	Enrichment	COL1A1	1.98
103	Fetomaternal alloimmune thrombocytopenia 1	Enrichment	ITGA2	1.98
104	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.98
105	Nevus, epidermal	Enrichment	PIK3CA	1.91
106	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.91
107	Noonan syndrome 3	Enrichment	SOS1	1.91
108	Gallbladder cancer	Enrichment	PIK3CA	1.91
109	Overgrowth syndrome	Enrichment	PIK3R1	1.91
110	Ovarian cancer	Enrichment	AKT1, PIK3CA	1.87
111	Arteriovenous malformation	Enrichment	PIK3CA	1.80
112	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.80
113	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.76
114	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.76
115	Lung non-small cell carcinoma	Enrichment	PIK3CA	1.71
116	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.68
117	Aortic valve disease 1	Enrichment	SOS1	1.64
118	Neural tube defects	Enrichment	ITGB1	1.64
119	Generalized epilepsy with febrile seizures plus	Enrichment	PRRT2	1.61
120	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.61
121	Isolated macular dystrophy	Enrichment	ITGA4	1.61
122	Lynch syndrome	Enrichment	PIK3CA	1.58
123	Noonan syndrome and noonan-related syndrome	Enrichment	SOS1	1.58
124	Endometrial cancer	Enrichment	PIK3CA	1.44
125	Hepatocellular carcinoma	Enrichment	PIK3CA	1.42
126	Noonan syndrome 1	Enrichment	SOS1	1.40
127	Tetralogy of fallot	Enrichment	FLT4	1.35
128	Hydrops fetalis, nonimmune	Enrichment	FLT4	1.35
129	Rasopathy	Enrichment	SOS1	1.35
130	Bladder cancer	Enrichment	PIK3CA	1.30
131	Prostate cancer	Enrichment	PIK3CA	1.30
132	Non-immune hydrops fetalis	Enrichment	FLT4	1.27
133	Lung cancer	Enrichment	PIK3CA	1.26
134	Gastric cancer	Enrichment	PIK3CA	1.13
135	Nephrotic syndrome	Enrichment	FN1	1.13
136	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	COL1A1	1.12
137	Cone-rod dystrophy 2	Enrichment	ITGA4	0.94
138	Hereditary retinal dystrophy	Enrichment	ITGA4	0.39
139	Fundus dystrophy	Enrichment	ITGA4	0.39

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

VEGFR3 signaling in lymphatic endothelium

Pathway Network for VEGFR3 signaling in lymphatic endothelium

Member Pathways for VEGFR3 signaling in lymphatic endothelium

Pathways in the VEGFR3 signaling in lymphatic endothelium SuperPath

Associated Genes for VEGFR3 signaling in lymphatic endothelium

Associated Disorders for VEGFR3 signaling in lymphatic endothelium

Disorders associated with VEGFR3 signaling in lymphatic endothelium SuperPath

STRING Interaction Network for VEGFR3 signaling in lymphatic endothelium

Sources for VEGFR3 signaling in lymphatic endothelium