Venlafaxine Pathway, Pharmacokinetics

Sources:

#	Name	Source	Genes
1	Venlafaxine Pathway, Pharmacokinetics	PharmGKB	ABCB1 CYP2C19 CYP2D6 CYP3A4 SLC6A2 SLC6A4 (see all 6) (see less)
2	Citalopram and Escitalopram Pathway, Pharmacokinetics	PharmGKB	ABCB1 CYP2C19 CYP2D6 CYP3A4
3	Omeprazole and Esomeprazole Pathway, Pharmacokinetics	PharmGKB	ABCB1 CYP2C19 CYP3A4
4	Lansoprazole Pathway, Pharmacokinetics	PharmGKB	ABCB1 CYP2C19 CYP3A4
5	Defective SLC6A2 causes orthostatic intolerance (OI)	Reactome	SLC6A2

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ABCB1	ATP Binding Cassette Subfamily B Member 1	Protein Coding	4
2	CYP2C19	Cytochrome P450 Family 2 Subfamily C Member 19	Protein Coding	4
3	CYP3A4	Cytochrome P450 Family 3 Subfamily A Member 4	Protein Coding	4
4	SLC6A2	Solute Carrier Family 6 Member 2	Protein Coding	2
5	CYP2D6	Cytochrome P450 Family 2 Subfamily D Member 6 (Gene/Pseudogene)	Protein Coding	2
6	SLC6A4	Solute Carrier Family 6 Member 4	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Postural orthostatic tachycardia syndrome	Enrichment	SLC6A2	4.13
2	Drug metabolism, poor, cyp2c19-related	Enrichment	CYP2C19	3.66
3	Colchicine resistance	Enrichment	ABCB1	3.66
4	Encephalopathy, acute transient	Enrichment	ABCB1	3.66
5	Inflammatory bowel disease 13	Enrichment	ABCB1	3.66
6	Vitamin d-dependent rickets, type 3	Enrichment	CYP3A4	3.66
7	Drug metabolism, poor, cyp2d6-related	Enrichment	CYP2D6	3.53
8	Orthostatic intolerance	Enrichment	SLC6A2	3.23
9	Obsessive-compulsive disorder	Enrichment	SLC6A4	3.05
10	Epilepsy, idiopathic generalized	Enrichment	ABCB1	2.61
11	Anxiety	Enrichment	SLC6A4	2.58

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Venlafaxine Pathway, Pharmacokinetics