Vinka Alkaloid Pathway, Pharmacokinetics
Pathway network for the Vinka Alkaloid Pathway, Pharmacokinetics SuperPath
Sources:
- PharmGKB
- WikiPathways
Pathways in the Vinka Alkaloid Pathway, Pharmacokinetics SuperPath
| # | Name | Source | Genes |
|---|---|---|---|
| 1 | Vinka Alkaloid Pathway, Pharmacokinetics | PharmGKB | |
| 2 | Venetoclax Pathway, Pharmacokinetics/Pharmacodynamics | PharmGKB | |
| 3 | Influenza A virus infection | WikiPathways |
Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways
| # | Symbol | Description | Category | # Related Pathways |
|---|---|---|---|---|
| 1 | BCL2 | BCL2 Apoptosis Regulator | Protein Coding | 3 |
| 2 | CYP3A4 | Cytochrome P450 Family 3 Subfamily A Member 4 | Protein Coding | 2 |
| 3 | BAX | BCL2 Associated X, Apoptosis Regulator | Protein Coding | 1 |
| 4 | RALBP1 | RalA Binding Protein 1 | Protein Coding | 1 |
| 5 | ABCC3 | ATP Binding Cassette Subfamily C Member 3 | Protein Coding | 1 |
| 6 | ABCC1 | ATP Binding Cassette Subfamily C Member 1 (ABCC1 Blood Group) | Protein Coding | 1 |
| 7 | ABCB1 | ATP Binding Cassette Subfamily B Member 1 | Protein Coding | 1 |
| 8 | CYP3A5 | Cytochrome P450 Family 3 Subfamily A Member 5 | Protein Coding | 1 |
| 9 | ABCC2 | ATP Binding Cassette Subfamily C Member 2 | Protein Coding | 1 |
| 10 | ABCC10 | ATP Binding Cassette Subfamily C Member 10 | Protein Coding | 1 |
Disorders associated with Vinka Alkaloid Pathway, Pharmacokinetics SuperPath
according to GeneCards Suite gene sharing
| # | Disorder | Type | Genes | Score |
|---|---|---|---|---|
| 1 | Vitamin d-dependent rickets, type 3 | Enrichment | CYP3A4 | 3.83 |
| 2 | Intravascular large b-cell lymphoma | Enrichment | BCL2 | 3.83 |
| 3 | High-grade b-cell lymphoma double-hit/triple-hit | Enrichment | BCL2 | 3.66 |
| 4 | Follicular lymphoma | Enrichment | BCL2 | 3.43 |
| 5 | Colchicine resistance | Enrichment | ABCB1 | 3.13 |
| 6 | Encephalopathy, acute transient | Enrichment | ABCB1 | 3.13 |
| 7 | Deafness, autosomal dominant 77 | Enrichment | ABCC1 | 3.13 |
| 8 | Inflammatory bowel disease 13 | Enrichment | ABCB1 | 3.13 |
| 9 | Dubin-johnson syndrome | Enrichment | ABCC2 | 2.66 |
| 10 | T-cell acute lymphoblastic leukemia | Enrichment | BAX | 2.66 |
| 11 | Pseudoxanthoma elasticum | Enrichment | ABCC2 | 2.35 |
| 12 | Epilepsy, idiopathic generalized | Enrichment | ABCB1 | 2.09 |
| 13 | Hypertension, essential | Enrichment | CYP3A5 | 1.90 |
| 14 | Rare autosomal dominant non-syndromic sensorineural deafness type dfna | Enrichment | ABCC1 | 1.42 |
| 15 | Colorectal cancer | Enrichment | BAX | 1.21 |
