Visual phototransduction

Pathway network for the Visual phototransduction SuperPath

Sources:

Reactome
PubChem

Pathways in the Visual phototransduction SuperPath

#	Name	Source	Genes
1	Visual phototransduction	Reactome	ABCA4 AGRN AKR1B10 AKR1C1 AKR1C3 AKR1C4 APOA1 APOA2 APOA4 APOB APOC2 APOC3 APOE APOM AWAT2 BCO1 BCO2 CALM1 CALM2 CALM3 CAMKMT CHURC1-FNTB CLPS CNGA1 CNGB1 CYP4V2 DHRS3 DHRS9 FNTA FNTB GNAT1 GNB1 GNB5 GNGT1 GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GPIHBP1 GRK1 GRK4 GRK7 GUCA1A GUCA1ANB-GUCA1A GUCA1B GUCA1C GUCY2D GUCY2F HSD17B1 HSD17B6 HSPG2 LDLR LPL LRAT LRP1 LRP10 LRP12 LRP2 LRP8 METAP1 METAP2 MYO7A NMT2 OPN1LW OPN1MW OPN1MW3 OPN1SW PDE6A PDE6B PDE6G PLB1 PNLIP PPEF1 PRKCA RBP1 RBP2 RBP3 RBP4 RCVRN RDH10 RDH11 RDH12 RDH16 RDH5 RDH8 RETSAT RGS9 RGS9BP RHO RLBP1 RPE65 SAG SDC1 SDC2 SDC3 SDC4 SDR9C7 SLC24A1 STRA6 TTR (see all 102) (see less)
2	Metabolism of fat-soluble vitamins	Reactome	AGRN AKR1B10 AKR1C1 AKR1C3 AKR1C4 APOA1 APOA2 APOA4 APOB APOC2 APOC3 APOE APOM BCO1 BCO2 CLPS GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GPIHBP1 HSPG2 LDLR LPL LRAT LRP1 LRP10 LRP12 LRP2 LRP8 PLB1 PNLIP RBP1 RBP2 RBP4 RDH11 RETSAT SDC1 SDC2 SDC3 SDC4 TTPA TTR UBIAD1 VKORC1 VKORC1L1 (see all 48) (see less)
3	Retinoid metabolism and transport	Reactome	AGRN AKR1B10 AKR1C1 AKR1C3 AKR1C4 APOA1 APOA2 APOA4 APOB APOC2 APOC3 APOE APOM BCO1 BCO2 CLPS GPC1 GPC2 GPC3 GPC4 GPC5 GPC6 GPIHBP1 HSPG2 LDLR LPL LRAT LRP1 LRP10 LRP12 LRP2 LRP8 PLB1 PNLIP RBP1 RBP2 RBP4 RDH11 RETSAT SDC1 SDC2 SDC3 SDC4 TTR (see all 44) (see less)
4	The phototransduction cascade	Reactome	CALM1 CALM2 CALM3 CAMKMT CHURC1-FNTB CNGA1 CNGB1 FNTA FNTB GNAT1 GNB1 GNB5 GNGT1 GRK1 GRK4 GRK7 GUCA1A GUCA1ANB-GUCA1A GUCA1B GUCA1C GUCY2D GUCY2F METAP1 METAP2 NMT2 PDE6A PDE6B PDE6G PPEF1 PRKCA RCVRN RGS9 RGS9BP RHO SAG SLC24A1 (see all 36) (see less)
5	Inactivation, recovery and regulation of the phototransduction cascade	Reactome	CALM1 CALM2 CALM3 CAMKMT CHURC1-FNTB CNGA1 CNGB1 FNTA FNTB GNAT1 GNB1 GNB5 GNGT1 GRK1 GRK4 GRK7 GUCA1A GUCA1ANB-GUCA1A GUCA1B GUCA1C GUCY2D GUCY2F METAP1 METAP2 NMT2 PDE6A PDE6B PDE6G PPEF1 PRKCA RCVRN RGS9 RGS9BP RHO SAG (see all 35) (see less)
6	Visual signal transduction: Rods	PubChem	CNGA1 GNAT1 GNB1 GNB5 GNGT1 GRK1 GUCY2D GUCY2F LRAT PDE6A PDE6B PDE6G RDH12 RDH5 RGS9 RGS9BP RHO RPE65 SAG SLC24A1 (see all 20) (see less)
7	the visual cycle I (vertebrates)	PubChem	DHRS3 DHRS9 LRAT RBP1 RBP2 RBP3 RBP4 RDH10 RDH11 RDH12 RDH5 RDH8 RLBP1 RPE65 (see all 14) (see less)
8	retinol biosynthesis	PubChem	BCO1 CES1 DHRS3 DHRS9 LRAT PNLIP RBP1 RBP2 RBP4 RDH10 RDH11 RDH12 RDH8 (see all 13) (see less)
9	Activation of the phototransduction cascade	Reactome	CNGA1 CNGB1 GNAT1 GNB1 GNGT1 PDE6A PDE6B PDE6G RHO SAG SLC24A1 (see all 11) (see less)
10	The retinoid cycle in cones (daylight vision)	Reactome	AWAT2 DHRS3 OPN1LW OPN1MW OPN1MW3 OPN1SW RBP3 RLBP1 (see all 8) (see less)
11	Defective visual phototransduction due to OPN1MW loss of function	Reactome	OPN1MW OPN1MW3
12	Defective visual phototransduction due to RDH5 loss of function	Reactome	RDH5 RLBP1
13	Defective visual phototransduction due to LRAT loss of function	Reactome	LRAT RBP1
14	Defective visual phototransduction due to RDH12 loss of function	Reactome	RDH12
15	Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D)	Reactome	SLC24A1
16	Defective visual phototransduction due to OPN1SW loss of function	Reactome	OPN1SW
17	Defective visual phototransduction due to OPN1LW loss of function	Reactome	OPN1LW
18	Vitamin E transport	Reactome	TTPA

Gene overlap in member pathways for Visual phototransduction SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	LRAT	Lecithin Retinol Acyltransferase	Protein Coding	7
2	RBP1	Retinol Binding Protein 1	Protein Coding	6
3	CNGA1	Cyclic Nucleotide Gated Channel Subunit Alpha 1	Protein Coding	5
4	RDH12	Retinol Dehydrogenase 12	Protein Coding	5
5	GNAT1	G Protein Subunit Alpha Transducin 1	Protein Coding	5
6	GNB1	G Protein Subunit Beta 1	Protein Coding	5
7	GNGT1	G Protein Subunit Gamma Transducin 1	Protein Coding	5
8	RDH11	Retinol Dehydrogenase 11	Protein Coding	5
9	PDE6A	Phosphodiesterase 6A	Protein Coding	5
10	PDE6G	Phosphodiesterase 6G	Protein Coding	5
11	PDE6B	Phosphodiesterase 6B	Protein Coding	5
12	RBP2	Retinol Binding Protein 2	Protein Coding	5
13	RBP4	Retinol Binding Protein 4	Protein Coding	5
14	RHO	Rhodopsin	Protein Coding	5
15	SAG	S-Antigen Visual Arrestin	Protein Coding	5
16	SLC24A1	Solute Carrier Family 24 Member 1	Protein Coding	5
17	GNB5	G Protein Subunit Beta 5	Protein Coding	4
18	CNGB1	Cyclic Nucleotide Gated Channel Subunit Beta 1	Protein Coding	4
19	GUCY2F	Guanylate Cyclase 2F, Retinal	Protein Coding	4
20	GUCY2D	Guanylate Cyclase 2D, Retinal	Protein Coding	4
21	RGS9BP	Regulator Of G Protein Signaling 9 Binding Protein	Protein Coding	4
22	BCO1	Beta-Carotene Oxygenase 1	Protein Coding	4
23	PNLIP	Pancreatic Lipase	Protein Coding	4
24	RDH5	Retinol Dehydrogenase 5	Protein Coding	4
25	GRK1	G Protein-Coupled Receptor Kinase 1	Protein Coding	4
26	RLBP1	Retinaldehyde Binding Protein 1	Protein Coding	4
27	RGS9	Regulator Of G Protein Signaling 9	Protein Coding	4
28	DHRS3	Dehydrogenase/Reductase 3	Protein Coding	4
29	CHURC1-FNTB	CHURC1-FNTB Readthrough	Protein Coding	3
30	GPC6	Glypican 6	Protein Coding	3
31	OPN1MW3	Opsin 1, Medium Wave Sensitive 3	Protein Coding	3
32	DHRS9	Dehydrogenase/Reductase 9	Protein Coding	3
33	METAP2	Methionyl Aminopeptidase 2	Protein Coding	3
34	AKR1C4	Aldo-Keto Reductase Family 1 Member C4	Protein Coding	3
35	GUCA1ANB-GUCA1A	GUCA1ANB-GUCA1A Readthrough	Protein Coding	3
36	CLPS	Colipase	Protein Coding	3
37	GRK7	G Protein-Coupled Receptor Kinase 7	Protein Coding	3
38	PLB1	Phospholipase B1	Protein Coding	3
39	RDH10	Retinol Dehydrogenase 10	Protein Coding	3
40	AKR1C1	Aldo-Keto Reductase Family 1 Member C1	Protein Coding	3
41	GPC2	Glypican 2	Protein Coding	3
42	GPC4	Glypican 4	Protein Coding	3
43	GPC5	Glypican 5	Protein Coding	3
44	METAP1	Methionyl Aminopeptidase 1	Protein Coding	3
45	FNTA	Farnesyltransferase, CAAX Box, Subunit Alpha	Protein Coding	3
46	FNTB	Farnesyltransferase, CAAX Box, Subunit Beta	Protein Coding	3
47	LRP10	LDL Receptor Related Protein 10	Protein Coding	3
48	OPN1MW	Opsin 1, Medium Wave Sensitive	Protein Coding	3
49	GPC3	Glypican 3	Protein Coding	3
50	GPC1	Glypican 1	Protein Coding	3
51	GRK4	G Protein-Coupled Receptor Kinase 4	Protein Coding	3
52	GUCA1A	Guanylate Cyclase Activator 1A	Protein Coding	3
53	GUCA1B	Guanylate Cyclase Activator 1B	Protein Coding	3
54	LRP12	LDL Receptor Related Protein 12	Protein Coding	3
55	HSPG2	Heparan Sulfate Proteoglycan 2	Protein Coding	3
56	APOA1	Apolipoprotein A1	Protein Coding	3
57	APOA2	Apolipoprotein A2	Protein Coding	3
58	APOA4	Apolipoprotein A4	Protein Coding	3
59	APOB	Apolipoprotein B	Protein Coding	3
60	GPIHBP1	Glycosylphosphatidylinositol Anchored High Density Lipoprotein Binding Protein 1	Protein Coding	3
61	APOC2	Apolipoprotein C2	Protein Coding	3
62	APOC3	Apolipoprotein C3	Protein Coding	3
63	APOE	Apolipoprotein E	Protein Coding	3
64	AGRN	Agrin	Protein Coding	3
65	LDLR	Low Density Lipoprotein Receptor	Protein Coding	3
66	LPL	Lipoprotein Lipase	Protein Coding	3
67	LRP1	LDL Receptor Related Protein 1	Protein Coding	3
68	LRP2	LDL Receptor Related Protein 2	Protein Coding	3
69	RDH8	Retinol Dehydrogenase 8	Protein Coding	3
70	PPEF1	Protein Phosphatase With EF-Hand Domain 1	Protein Coding	3
71	RETSAT	Retinol Saturase	Protein Coding	3
72	PRKCA	Protein Kinase C Alpha	Protein Coding	3
73	APOM	Apolipoprotein M	Protein Coding	3
74	AKR1B10	Aldo-Keto Reductase Family 1 Member B10	Protein Coding	3
75	RBP3	Retinol Binding Protein 3	Protein Coding	3
76	OPN1LW	Opsin 1, Long Wave Sensitive	Protein Coding	3
77	RCVRN	Recoverin	Protein Coding	3
78	OPN1SW	Opsin 1, Short Wave Sensitive	Protein Coding	3
79	RPE65	Retinoid Isomerohydrolase RPE65	Protein Coding	3
80	SDC1	Syndecan 1	Protein Coding	3
81	SDC2	Syndecan 2	Protein Coding	3
82	SDC4	Syndecan 4	Protein Coding	3
83	TTR	Transthyretin	Protein Coding	3
84	LRP8	LDL Receptor Related Protein 8	Protein Coding	3
85	CAMKMT	Calmodulin-Lysine N-Methyltransferase	Protein Coding	3
86	CALM1	Calmodulin 1	Protein Coding	3
87	CALM2	Calmodulin 2	Protein Coding	3
88	CALM3	Calmodulin 3	Protein Coding	3
89	BCO2	Beta-Carotene Oxygenase 2	Protein Coding	3
90	AKR1C3	Aldo-Keto Reductase Family 1 Member C3	Protein Coding	3
91	NMT2	N-Myristoyltransferase 2	Protein Coding	3
92	GUCA1C	Guanylate Cyclase Activator 1C	Protein Coding	3
93	SDC3	Syndecan 3	Protein Coding	3
94	AWAT2	Acyl-CoA Wax Alcohol Acyltransferase 2	Protein Coding	2
95	TTPA	Alpha Tocopherol Transfer Protein	Protein Coding	2
96	SDR9C7	Short Chain Dehydrogenase/Reductase Family 9C Member 7	Protein Coding	1
97	ABCA4	ATP Binding Cassette Subfamily A Member 4	Protein Coding	1
98	CYP4V2	Cytochrome P450 Family 4 Subfamily V Member 2	Protein Coding	1
99	HSD17B1	Hydroxysteroid 17-Beta Dehydrogenase 1	Protein Coding	1
100	MYO7A	Myosin VIIA	Protein Coding	1
101	STRA6	Signaling Receptor And Transporter Of Retinol STRA6	Protein Coding	1
102	RDH16	Retinol Dehydrogenase 16	Protein Coding	1
103	HSD17B6	Hydroxysteroid 17-Beta Dehydrogenase 6	Protein Coding	1
104	VKORC1L1	Vitamin K Epoxide Reductase Complex Subunit 1L1	Protein Coding	1
105	UBIAD1	UbiA Prenyltransferase Domain Containing 1	Protein Coding	1
106	VKORC1	Vitamin K Epoxide Reductase Complex Subunit 1	Protein Coding	1
107	CES1	Carboxylesterase 1	Protein Coding	1

Disorders associated with Visual phototransduction SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Retinal disease	Direct
2	Fundus albipunctatus	Direct
3	Leber plus disease	Direct
4	Congenital stationary night blindness	Direct
5	Tritanopia	Direct
6	Color blindness	Direct
7	Hereditary retinal dystrophy	Enrichment	CNGA1, CNGB1, GNAT1, PDE6A, PDE6B, PDE6G, RHO, SAG, SLC24A1	11.35
8	Fundus dystrophy	Enrichment	CNGA1, CNGB1, GNAT1, PDE6A, PDE6B, PDE6G, RHO, SAG, SLC24A1	11.35
9	Retinitis pigmentosa	Enrichment	CNGA1, GNAT1, GUCY2D, LRAT, PDE6A, PDE6B, PDE6G, RDH12, RDH5, RHO, RPE65, SAG, SLC24A1	10.96
10	Cone-rod dystrophy 2	Enrichment	ABCA4, CNGA1, GUCA1A, GUCA1ANB-GUCA1A, GUCA1B, GUCY2D, OPN1LW, OPN1MW, PDE6B, RBP3, RDH12, RHO	10.38
11	Eye disease	Enrichment	LRAT, RBP4, RDH12, RLBP1, RPE65	9.76
12	Cone dystrophy 3	Enrichment	GUCA1A, GUCA1ANB-GUCA1A, GUCA1B	7.80
13	Familial hypercholesterolemia	Enrichment	APOA2, APOB, APOE, LDLR	6.89
14	Blue cone monochromacy	Enrichment	OPN1LW, OPN1MW	6.52
15	X-linked cone dysfunction syndrome with myopia	Enrichment	OPN1LW, OPN1MW	6.52
16	Hyperlipidemia, familial combined, 3	Enrichment	APOB, LDLR, LPL	6.50
17	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1, CALM2, CALM3	6.06
18	Night blindness, congenital stationary, autosomal dominant 2	Enrichment	PDE6B, SLC24A1	5.75
19	Oguchi disease 2	Enrichment	GRK1, SAG	5.69
20	Bradyopsia	Enrichment	RGS9, RGS9BP	5.69
21	Oguchi disease	Enrichment	GRK1, SAG	5.69
22	Cone-rod dystrophy 6	Enrichment	ABCA4, GUCA1A, GUCY2D, PDE6B	5.55
23	Stargardt disease 1	Enrichment	LRAT, RDH12, RPE65	5.46
24	Cone-rod dystrophy 14	Enrichment	GUCA1A, GUCA1ANB-GUCA1A	5.19
25	Hypercholesterolemia, familial, 1	Enrichment	APOA2, APOB, LDLR	5.05
26	Hyperlipoproteinemia, type i	Enrichment	GPIHBP1, LPL	4.99
27	Hyperlipoproteinemia, type iii	Enrichment	APOE, LDLR	4.99
28	Familial lipoprotein lipase deficiency	Enrichment	GPIHBP1, LPL	4.99
29	Hypercholesterolemia, familial, 2	Enrichment	APOB, LDLR	4.51
30	Simpson-golabi-behmel syndrome, type 1	Enrichment	GPC3, GPC4	4.51
31	Leber congenital amaurosis 14	Enrichment	ABCA4, LRAT	4.25
32	Leber congenital amaurosis 1	Enrichment	GUCY2D, LRAT	4.24
33	Long qt syndrome 1	Enrichment	CALM1, CALM2, CALM3	4.22
34	Coronary artery anomaly	Enrichment	APOC3, LPL	4.21
35	Choroidal dystrophy, central areolar, 1	Enrichment	GUCA1A, GUCY2D	4.19
36	Ataxia with vitamin e deficiency	Enrichment	TTPA	4.13
37	Isolated macular dystrophy	Enrichment	ABCA4, GUCA1A, GUCA1ANB-GUCA1A	3.85
38	Lipid metabolism disorder	Enrichment	APOE, LDLR	3.82
39	Bietti crystalline corneoretinal dystrophy	Enrichment	ABCA4, CYP4V2	3.78
40	Homozygous familial hypercholesterolemia	Enrichment	APOB, LDLR	3.55
41	Optic atrophy plus syndrome	Enrichment	ABCA4, CYP4V2, GUCY2D, RDH5	3.49
42	Coronary heart disease 5	Enrichment	APOB, LDLR	3.44
43	Cone dystrophy	Enrichment	GUCY2D, SAG	3.25
44	Colorblindness, partial, deutan series	Enrichment	OPN1MW	3.23
45	Bothnia retinal dystrophy	Enrichment	RLBP1	3.23
46	Newfoundland rod-cone dystrophy	Enrichment	RLBP1	3.23
47	Retinitis pigmentosa 66	Enrichment	RBP3	3.23
48	Colorblindness, partial, protan series	Enrichment	OPN1LW	3.23
49	Red-green color blindness	Enrichment	OPN1MW	3.23
50	Night blindness, congenital stationary, autosomal dominant 1	Enrichment	RHO	3.09
51	Retinitis pigmentosa 57	Enrichment	PDE6G	3.09
52	Retinitis pigmentosa 47	Enrichment	SAG	3.09
53	Oguchi disease 1	Enrichment	SAG	3.09
54	Night blindness, congenital stationary, autosomal dominant 3	Enrichment	GNAT1	3.09
55	Night blindness, congenital stationary, type 1g	Enrichment	GNAT1	3.09
56	Night blindness, congenital stationary, type 1d	Enrichment	SLC24A1	3.09
57	Retinitis pigmentosa 4	Enrichment	RHO	3.09
58	Retinitis pigmentosa 45	Enrichment	CNGB1	3.09
59	Retinitis pigmentosa 43	Enrichment	PDE6A	3.09
60	Intellectual developmental disorder, autosomal dominant 42	Enrichment	GNB1	3.09
61	Retinitis pigmentosa 96	Enrichment	SAG	3.09
62	Hypercarotenemia and vitamin a deficiency, autosomal dominant	Enrichment	BCO1	3.02
63	Microphthalmia/coloboma 10	Enrichment	RBP4	3.02
64	Drug metabolism, altered, ces1-related	Enrichment	CES1	3.02
65	Pancreatic lipase deficiency	Enrichment	PNLIP	3.02
66	Pancreatic triacylglycerol lipase deficiency	Enrichment	PNLIP	3.02
67	Hereditary hypercarotenemia and vitamin a deficiency	Enrichment	BCO1	3.02
68	Stargardt disease 5	Enrichment	RDH8	3.02
69	Leber congenital amaurosis 2	Enrichment	RPE65	2.99
70	Retinitis pigmentosa 87 with choroidal involvement	Enrichment	RPE65	2.99
71	Retinitis pigmentosa 20	Enrichment	RPE65	2.99
72	Night blindness, congenital stationary, type1i	Enrichment	GUCY2D	2.83
73	Prolonged electroretinal response suppression 1	Enrichment	RGS9	2.83
74	Lodder-merla syndrome, type 2, with developmental delay and with or without cardiac arrhythmia	Enrichment	GNB5	2.83
75	Neuropathy, congenital hypomyelinating, 2	Enrichment	RHO	2.79
76	Retinitis pigmentosa 49	Enrichment	CNGA1	2.79
77	Optic disk drusen	Enrichment	RHO	2.79
78	Cerebral visual impairment	Enrichment	GNB1	2.79
79	Usher syndrome	Enrichment	GUCA1A, GUCA1ANB-GUCA1A, MYO7A	2.72
80	Retinal dystrophy, juvenile cataracts, and short stature syndrome	Enrichment	RDH11	2.72
81	Retinal dystrophy, iris coloboma, and comedogenic acne syndrome	Enrichment	RBP4	2.72
82	Progressive retinal dystrophy due to retinol transport defect	Enrichment	RBP4	2.72
83	Acth deficiency, isolated	Enrichment	RPE65	2.69
84	Congenital isolated adrenocorticotropic hormone deficiency	Enrichment	RPE65	2.69
85	Retinitis pigmentosa 40	Enrichment	PDE6B	2.61
86	Microcephaly 17, primary, autosomal recessive	Enrichment	RHO	2.61
87	Long qt syndrome 16	Enrichment	CALM3	2.59
88	Retinitis pigmentosa 48	Enrichment	GUCA1B	2.59
89	Long qt syndrome 15	Enrichment	CALM2	2.59
90	Long qt syndrome	Enrichment	CALM1, CALM2	2.54
91	Leber congenital amaurosis 13	Enrichment	RDH12	2.54
92	Prolonged electroretinal response suppression 2	Enrichment	RGS9BP	2.53
93	Lodder-merla syndrome, type 1, with impaired intellectual development and cardiac arrhythmia	Enrichment	GNB5	2.53
94	Carpal tunnel syndrome 1	Enrichment	TTR	2.49
95	Hyperthyroxinemia, dystransthyretinemic	Enrichment	TTR	2.49
96	Atrophoderma vermiculata	Enrichment	LRP1	2.49
97	Sea-blue histiocyte disease	Enrichment	APOE	2.49
98	Lipoprotein glomerulopathy	Enrichment	APOE	2.49
99	Amyloidosis, hereditary systemic 1	Enrichment	TTR	2.49
100	Hyperlipoproteinemia, type id	Enrichment	GPIHBP1	2.49
101	Keratosis pilaris atrophicans	Enrichment	LRP1	2.49
102	Donnai-barrow syndrome	Enrichment	LRP2	2.49
103	Keipert syndrome	Enrichment	GPC4	2.49
104	Tubulointerstitial kidney disease, autosomal dominant 6	Enrichment	APOA4	2.49
105	Apolipoprotein c-iii deficiency	Enrichment	APOC3	2.49
106	Prolactin-producing pituitary gland adenoma	Enrichment	LRP2	2.49
107	Amyloidosis	Enrichment	TTR	2.49
108	Hereditary amyloidosis	Enrichment	TTR	2.49
109	Attrv30m amyloidosis	Enrichment	TTR	2.49
110	Aapoaii amyloidosis	Enrichment	APOA2	2.49
111	Attrv122i amyloidosis	Enrichment	TTR	2.49
112	Vitamin k-dependent clotting factors, combined deficiency of, 2	Enrichment	VKORC1	2.45
113	Schnyder corneal dystrophy	Enrichment	UBIAD1	2.45
114	Congenital vitamin k-dependent coagulation factors deficiency	Enrichment	VKORC1	2.45
115	Macular dystrophy with or without cone dysfunction	Enrichment	RDH12	2.42
116	Retinal detachment	Enrichment	RHO	2.39
117	Albinism, oculocutaneous, type ii	Enrichment	PDE6B	2.39
118	Night blindness, congenital stationary, type 1c	Enrichment	GNAT1	2.39
119	Night blindness	Enrichment	RHO	2.39
120	Mitochondrial dna depletion syndrome 4a	Enrichment	RLBP1	2.38
121	Polr3-related leukodystrophy	Enrichment	GUCY2D	2.35
122	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	2.29
123	Long qt syndrome 14	Enrichment	CALM1	2.29
124	2p21 microdeletion syndrome without cystinuria	Enrichment	CAMKMT	2.29
125	Coats disease	Enrichment	RHO	2.25
126	Achromatopsia	Enrichment	OPN1MW	2.23
127	Hypothyroidism	Enrichment	GNB1	2.19
128	Apolipoprotein c-ii deficiency	Enrichment	APOC2	2.19
129	Omodysplasia 1	Enrichment	GPC6	2.19
130	Alzheimer disease 3	Enrichment	APOE	2.19
131	Mononeuropathy of the median nerve, mild	Enrichment	TTR	2.19
132	Lipase deficiency, combined	Enrichment	LPL	2.19
133	Schwartz-jampel syndrome, type 1	Enrichment	HSPG2	2.19
134	Hypobetalipoproteinemia, familial, 1	Enrichment	APOB	2.19
135	Amyotrophic lateral sclerosis 28	Enrichment	LRP12	2.19
136	Developmental dysplasia of the hip 3	Enrichment	LRP1	2.19
137	Familial apolipoprotein c-ii deficiency	Enrichment	APOC2	2.19
138	Hypobetalipoproteinemia	Enrichment	APOB	2.19
139	Hypoalphalipoproteinemia, primary, 2, intermediate	Enrichment	APOA1	2.19
140	Amyloidosis, hereditary systemic 3	Enrichment	APOA1	2.19
141	Non-syndromic syndactyly	Enrichment	LRP2	2.19
142	Hereditary combined deficiency of vitamin k-dependent clotting factors	Enrichment	VKORC1	2.15
143	Retinal degeneration	Enrichment	RPE65	2.14
144	3-methylglutaconic aciduria, type iii	Enrichment	GUCY2D	2.13
145	Deafness, autosomal recessive 2	Enrichment	MYO7A	2.12
146	Mandibulofacial dysostosis with impaired intellectual development	Enrichment	ABCA4	2.12
147	Deafness, autosomal dominant 11	Enrichment	MYO7A	2.12
148	Ichthyosis, congenital, autosomal recessive 13	Enrichment	SDR9C7	2.12
149	Usher syndrome type 1b	Enrichment	MYO7A	2.12
150	Atypical hypotonia-cystinuria syndrome	Enrichment	CAMKMT	2.11
151	Leukemia, acute lymphoblastic	Enrichment	GNB1	2.05
152	Myelodysplastic syndrome	Enrichment	GNB1	2.05
153	Hyperalphalipoproteinemia 1	Enrichment	APOC3	2.01
154	Dyssegmental dysplasia, silverman-handmaker type	Enrichment	HSPG2	2.01
155	Intellectual developmental disorder with microcephaly and pontine and cerebellar hypoplasia	Enrichment	LDLR	2.01
156	Alzheimer disease 4	Enrichment	APOE	2.01
157	Hypercholesterolemia, familial, 4	Enrichment	LDLR	2.01
158	46,xy sex reversal 8	Enrichment	AKR1C4	2.01
159	Hypoalphalipoproteinemia, primary, 2	Enrichment	APOA1	2.01
160	Keratosis follicularis spinulosa decalvans	Enrichment	LRP1	2.01
161	Syndromic x-linked intellectual disability najm type	Enrichment	LDLR	2.01
162	Spastic paraplegia 50, autosomal recessive	Enrichment	APOA1	2.01
163	Macs syndrome	Enrichment	RBP4, STRA6	2.01
164	2p21 microdeletion syndrome	Enrichment	CAMKMT	1.99
165	Coumarin resistance	Enrichment	VKORC1	1.98
166	Cataract	Enrichment	RHO	1.95
167	Microphthalmia	Enrichment	RBP4, STRA6	1.93
168	Microphthalmia/coloboma 12	Enrichment	RBP4	1.91
169	Macular degeneration, age-related, 1	Enrichment	APOE	1.89
170	Hypoalphalipoproteinemia, primary, 1	Enrichment	APOA1	1.89
171	Prolactinoma	Enrichment	LRP2	1.89
172	Cleft palate, isolated	Enrichment	GNB1	1.86
173	Coloboma of macula	Enrichment	RBP4	1.85
174	Anterior segment dysgenesis	Enrichment	RBP4	1.85
175	Stargardt disease 3	Enrichment	ABCA4	1.82
176	Cone-rod dystrophy 3	Enrichment	ABCA4	1.82
177	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	1.81
178	Alzheimer disease 2	Enrichment	APOE	1.79
179	Amyloidosis, hereditary systemic 2	Enrichment	APOA1	1.79
180	Myasthenic syndrome, congenital, 8	Enrichment	AGRN	1.79
181	Developmental dysplasia of the hip 1	Enrichment	AKR1C1	1.71
182	Cowden syndrome 1	Enrichment	LDLR	1.71
183	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	1.69
184	Strabismus	Enrichment	GNB1	1.66
185	Macular degeneration, age-related, 2	Enrichment	ABCA4	1.65
186	Retinitis pigmentosa 1	Enrichment	ABCA4	1.65
187	Microphthalmia, syndromic 9	Enrichment	STRA6	1.65
188	Retinitis pigmentosa 19	Enrichment	ABCA4	1.65
189	Age related macular degeneration	Enrichment	ABCA4	1.65
190	Oculopharyngodistal myopathy 1	Enrichment	LRP12	1.65
191	Thrombophilia due to thrombin defect	Enrichment	VKORC1	1.61
192	Dystonia	Enrichment	GNB1	1.55
193	Retinitis pigmentosa 91	Enrichment	ABCA4	1.53
194	Choroideremia	Enrichment	CYP4V2	1.53
195	Vitreoretinopathy	Enrichment	ABCA4	1.53
196	Cerebral palsy	Enrichment	GNB1	1.51
197	Attention deficit-hyperactivity disorder	Enrichment	GNB5	1.50
198	Presynaptic congenital myasthenic syndromes	Enrichment	AGRN	1.45
199	Macular degeneration	Enrichment	ABCA4	1.43
200	Postsynaptic congenital myasthenic syndromes	Enrichment	AGRN	1.42
201	Autosomal dominant non-syndromic intellectual disability	Enrichment	GNB1	1.40
202	Alzheimer's disease	Enrichment	APOE	1.38
203	Chromosome 1p36 deletion syndrome	Enrichment	HSPG2	1.38
204	Sudden infant death syndrome	Enrichment	CALM2	1.37
205	Syndromic rod-cone dystrophy	Enrichment	ABCA4	1.35
206	Congenital myasthenic syndrome	Enrichment	AGRN	1.35
207	Wilms tumor 1	Enrichment	GPC3	1.32
208	Meniere disease	Enrichment	MYO7A	1.29
209	Alzheimer disease, familial, 1	Enrichment	APOE	1.27
210	Craniosynostosis	Enrichment	GPC4	1.20
211	Cardiomyopathy, dilated, 1a	Enrichment	LPL	1.18
212	Myocardial infarction	Enrichment	LRP8	1.16
213	Autism	Enrichment	RPE65	1.14
214	Congenital nonbullous ichthyosiform erythroderma	Enrichment	SDR9C7	1.14
215	Usher syndrome type 2	Enrichment	MYO7A	1.10
216	Autism spectrum disorder	Enrichment	GNB1	1.07
217	Microcephaly	Enrichment	GNB1	1.02
218	Usher syndrome, type i	Enrichment	MYO7A	0.97
219	Autosomal recessive congenital ichthyosis	Enrichment	SDR9C7	0.97
220	Charcot-marie-tooth disease	Enrichment	TTR	0.90
221	Congenital nervous system abnormality	Enrichment	GNB5	0.84
222	Nervous system disease	Enrichment	GNB5	0.84
223	Body mass index quantitative trait locus 11	Enrichment	SDC3	0.82
224	Ear malformation	Enrichment	MYO7A	0.78
225	Auditory neuropathy	Enrichment	MYO7A	0.75
226	Non-syndromic genetic deafness	Enrichment	MYO7A	0.62
227	Nonsyndromic hearing loss	Enrichment	MYO7A	0.57
228	Sensorineural hearing loss	Enrichment	MYO7A	0.52
229	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	MYO7A	0.49
230	Hereditary breast ovarian cancer syndrome	Enrichment	MYO7A	0.47
231	Deafness, autosomal recessive	Enrichment	MYO7A	0.42
232	Autosomal recessive nonsyndromic deafness	Enrichment	MYO7A	0.42
233	Rare genetic deafness	Enrichment	MYO7A	0.35
234	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	MYO7A	0.31

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Visual phototransduction

Pathway Network for Visual phototransduction

Pathway network for the Visual phototransduction SuperPath

Member Pathways for Visual phototransduction

Pathways in the Visual phototransduction SuperPath

Gene overlap in member pathways for Visual phototransduction SuperPath

Associated Genes for Visual phototransduction

Associated Disorders for Visual phototransduction

Disorders associated with Visual phototransduction SuperPath

STRING Interaction Network for Visual phototransduction

Sources for Visual phototransduction