Vitamin A and carotenoid metabolism

No Pathway Network information available for Vitamin A and carotenoid metabolism

Pathways in the Vitamin A and carotenoid metabolism SuperPath

#	Name	Source	Genes
1	Vitamin A and carotenoid metabolism	WikiPathways	ABCG5 ABCG8 ADH1A ADH4 ALDH1A1 ALDH1A2 ALDH1A3 AWAT2 BCO1 BCO2 CD36 CRABP1 CRABP2 CYP26A1 CYP26B1 CYP2E1 DHRS3 LPL LRAT MAPK1 NPC1L1 RARA RARB RARG RBP1 RBP2 RBP4 RBP7 RDH10 RDH12 RDH5 RDH8 RETSAT RLBP1 RPE65 RXRA RXRB RXRG SCARB1 SDR16C5 SULT1A1 SULT2B1 (see all 42) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SCARB1	Scavenger Receptor Class B Member 1	Protein Coding	1
2	CD36	CD36 Molecule (CD36 Blood Group)	Protein Coding	1
3	DHRS3	Dehydrogenase/Reductase 3	Protein Coding	1
4	LRAT	Lecithin Retinol Acyltransferase	Protein Coding	1
5	ALDH1A2	Aldehyde Dehydrogenase 1 Family Member A2	Protein Coding	1
6	BCO2	Beta-Carotene Oxygenase 2	Protein Coding	1
7	SULT2B1	Sulfotransferase Family 2B Member 1	Protein Coding	1
8	SULT1A1	Sulfotransferase Family 1A Member 1	Protein Coding	1
9	ABCG8	ATP Binding Cassette Subfamily G Member 8	Protein Coding	1
10	ABCG5	ATP Binding Cassette Subfamily G Member 5	Protein Coding	1
11	RXRG	Retinoid X Receptor Gamma	Protein Coding	1
12	RXRB	Retinoid X Receptor Beta	Protein Coding	1
13	RXRA	Retinoid X Receptor Alpha	Protein Coding	1
14	RPE65	Retinoid Isomerohydrolase RPE65	Protein Coding	1
15	RLBP1	Retinaldehyde Binding Protein 1	Protein Coding	1
16	RDH5	Retinol Dehydrogenase 5	Protein Coding	1
17	RBP4	Retinol Binding Protein 4	Protein Coding	1
18	RBP1	Retinol Binding Protein 1	Protein Coding	1
19	RARG	Retinoic Acid Receptor Gamma	Protein Coding	1
20	RARB	Retinoic Acid Receptor Beta	Protein Coding	1
21	RARA	Retinoic Acid Receptor Alpha	Protein Coding	1
22	CYP26B1	Cytochrome P450 Family 26 Subfamily B Member 1	Protein Coding	1
23	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
24	RETSAT	Retinol Saturase	Protein Coding	1
25	BCO1	Beta-Carotene Oxygenase 1	Protein Coding	1
26	LPL	Lipoprotein Lipase	Protein Coding	1
27	ALDH1A3	Aldehyde Dehydrogenase 1 Family Member A3	Protein Coding	1
28	ALDH1A1	Aldehyde Dehydrogenase 1 Family Member A1	Protein Coding	1
29	CYP26A1	Cytochrome P450 Family 26 Subfamily A Member 1	Protein Coding	1
30	RDH10	Retinol Dehydrogenase 10	Protein Coding	1
31	CYP2E1	Cytochrome P450 Family 2 Subfamily E Member 1	Protein Coding	1
32	RDH12	Retinol Dehydrogenase 12	Protein Coding	1
33	CRABP2	Cellular Retinoic Acid Binding Protein 2	Protein Coding	1
34	CRABP1	Cellular Retinoic Acid Binding Protein 1	Protein Coding	1
35	ADH4	Alcohol Dehydrogenase 4 (Class II), Pi Polypeptide	Protein Coding	1
36	ADH1A	Alcohol Dehydrogenase 1A (Class I), Alpha Polypeptide	Protein Coding	1
37	SDR16C5	Short Chain Dehydrogenase/Reductase Family 16C Member 5	Protein Coding	1
38	AWAT2	Acyl-CoA Wax Alcohol Acyltransferase 2	Protein Coding	1
39	RBP7	Retinol Binding Protein 7	Protein Coding	1
40	RBP2	Retinol Binding Protein 2	Protein Coding	1
41	RDH8	Retinol Dehydrogenase 8	Protein Coding	1
42	NPC1L1	NPC1 Like Intracellular Cholesterol Transporter 1	Protein Coding	1

Disorders associated with Vitamin A and carotenoid metabolism SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Eye disease	Enrichment	LRAT, RBP4, RDH12, RLBP1, RPE65	7.17
2	Gallbladder disease 4	Enrichment	ABCG5, ABCG8	5.03
3	Sitosterolemia 1	Enrichment	ABCG5, ABCG8	4.55
4	Sitosterolemia	Enrichment	ABCG5, ABCG8	4.55
5	Microphthalmia	Enrichment	ALDH1A3, RARB, RBP4	4.39
6	Stargardt disease 1	Enrichment	LRAT, RDH12, RPE65	3.98
7	Lipid metabolism disorder	Enrichment	ABCG5, ABCG8	3.86
8	Fundus albipunctatus	Enrichment	RDH5, RLBP1	3.71
9	Hereditary retinal dystrophy	Enrichment	LRAT, RBP4, RDH12, RDH5, RLBP1, RPE65	3.60
10	Fundus dystrophy	Enrichment	LRAT, RBP4, RDH12, RDH5, RLBP1, RPE65	3.60
11	Homozygous familial hypercholesterolemia	Enrichment	ABCG5, ABCG8	3.59
12	Coronary heart disease 5	Enrichment	ABCG5, ABCG8	3.48
13	Retinitis pigmentosa	Enrichment	LRAT, RDH12, RDH5, RLBP1, RPE65	3.33
14	Microphthalmia/coloboma 12	Enrichment	RARB, RBP4	3.15
15	Coloboma of macula	Enrichment	RARB, RBP4	3.02
16	Macs syndrome	Enrichment	ALDH1A3, RBP4	2.77
17	Hypercarotenemia and vitamin a deficiency, autosomal dominant	Enrichment	BCO1	2.51
18	Coronary heart disease 7	Enrichment	CD36	2.51
19	High density lipoprotein cholesterol level quantitative trait locus 6	Enrichment	SCARB1	2.51
20	Bothnia retinal dystrophy	Enrichment	RLBP1	2.51
21	Newfoundland rod-cone dystrophy	Enrichment	RLBP1	2.51
22	Microphthalmia/coloboma 10	Enrichment	RBP4	2.51
23	Leber congenital amaurosis 2	Enrichment	RPE65	2.51
24	Noonan syndrome 13	Enrichment	MAPK1	2.51
25	Retinitis pigmentosa 87 with choroidal involvement	Enrichment	RPE65	2.51
26	Ichthyosis, congenital, autosomal recessive 14	Enrichment	SULT2B1	2.51
27	Diaphragmatic hernia 4, with cardiovascular defects	Enrichment	ALDH1A2	2.51
28	Platelet glycoprotein iv deficiency	Enrichment	CD36	2.51
29	Radiohumeral fusions with other skeletal and craniofacial anomalies	Enrichment	CYP26B1	2.51
30	Microphthalmia, syndromic 12	Enrichment	RARB	2.51
31	Retinitis pigmentosa 20	Enrichment	RPE65	2.51
32	Low density lipoprotein cholesterol level quantitative trait locus 7	Enrichment	NPC1L1	2.51
33	Lethal occipital encephalocele-skeletal dysplasia syndrome	Enrichment	CYP26B1	2.51
34	Hereditary hypercarotenemia and vitamin a deficiency	Enrichment	BCO1	2.51
35	Stargardt disease 5	Enrichment	RDH8	2.51
36	Leber plus disease	Enrichment	LRAT, RDH12, RPE65	2.50
37	Hyperlipoproteinemia, type i	Enrichment	LPL	2.21
38	Lipase deficiency, combined	Enrichment	LPL	2.21
39	Retinal dystrophy, iris coloboma, and comedogenic acne syndrome	Enrichment	RBP4	2.21
40	Acth deficiency, isolated	Enrichment	RPE65	2.21
41	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RARB	2.21
42	Sitosterolemia 2	Enrichment	ABCG5	2.21
43	Microphthalmia, isolated 8	Enrichment	ALDH1A3	2.21
44	Short-rib thoracic dysplasia 15 with polydactyly	Enrichment	ABCG5	2.21
45	Familial lipoprotein lipase deficiency	Enrichment	LPL	2.21
46	Leber congenital amaurosis 14	Enrichment	LRAT	2.21
47	Progressive retinal dystrophy due to retinol transport defect	Enrichment	RBP4	2.21
48	Congenital isolated adrenocorticotropic hormone deficiency	Enrichment	RPE65	2.21
49	Hyperalphalipoproteinemia 1	Enrichment	SCARB1	2.03
50	Ichthyosis, congenital, autosomal recessive 1	Enrichment	SULT2B1	2.03
51	Leber congenital amaurosis 13	Enrichment	RDH12	2.03
52	Isolated anophthalmia-microphthalmia syndrome	Enrichment	ALDH1A3	2.03
53	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.91
54	Macular dystrophy with or without cone dysfunction	Enrichment	RDH12	1.91
55	Blood platelet disease	Enrichment	CD36	1.91
56	Coronary artery anomaly	Enrichment	LPL	1.91
57	Cerebral malaria	Enrichment	CD36	1.91
58	Hyperlipidemia, familial combined, 3	Enrichment	LPL	1.81
59	Ichthyosis, congenital, autosomal recessive 2	Enrichment	SULT2B1	1.81
60	Autism	Enrichment	ALDH1A3, RPE65	1.68
61	Mitochondrial dna depletion syndrome 4a	Enrichment	RLBP1	1.67
62	Retinal degeneration	Enrichment	RPE65	1.67
63	Leber congenital amaurosis 1	Enrichment	LRAT	1.61
64	Congenital nonbullous ichthyosiform erythroderma	Enrichment	SULT2B1	1.52
65	Nanophthalmos	Enrichment	ALDH1A3	1.47
66	Specific learning disability	Enrichment	MAPK1	1.47
67	Acute promyelocytic leukemia	Enrichment	RARA	1.40
68	Anterior segment dysgenesis	Enrichment	RBP4	1.34
69	Autosomal recessive congenital ichthyosis	Enrichment	SULT2B1	1.34
70	Heart, malformation of	Enrichment	MAPK1	1.27
71	Cardiomyopathy, dilated, 1a	Enrichment	LPL	1.20
72	Malaria	Enrichment	CD36	1.16
73	Congenital stationary night blindness	Enrichment	RDH5	1.16
74	Short-rib thoracic dysplasia 1 with or without polydactyly	Enrichment	ABCG5	1.01
75	Optic atrophy plus syndrome	Enrichment	RDH5	0.89
76	Myeloma, multiple	Enrichment	RXRA	0.80
77	Cone-rod dystrophy 2	Enrichment	RDH12	0.72
78	Microcephaly	Enrichment	MAPK1	0.50

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Vitamin A and carotenoid metabolism

Pathway Network for Vitamin A and carotenoid metabolism

Member Pathways for Vitamin A and carotenoid metabolism

Pathways in the Vitamin A and carotenoid metabolism SuperPath

Associated Genes for Vitamin A and carotenoid metabolism

Associated Disorders for Vitamin A and carotenoid metabolism

Disorders associated with Vitamin A and carotenoid metabolism SuperPath

STRING Interaction Network for Vitamin A and carotenoid metabolism

Sources for Vitamin A and carotenoid metabolism