Vitamin B12 metabolism

No Pathway Network information available for Vitamin B12 metabolism

#	Name	Source	Genes
1	Vitamin B12 metabolism	WikiPathways	CBLIF CCL2 CUBN LRP2 NFKB1 NFKB2 RELA TCN1 TCN2 (see all 9) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CUBN	Cubilin	Protein Coding	1
2	TCN2	Transcobalamin 2	Protein Coding	1
3	TCN1	Transcobalamin 1	Protein Coding	1
4	CCL2	C-C Motif Chemokine Ligand 2	Protein Coding	1
5	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
6	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	1
7	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
8	LRP2	LDL Receptor Related Protein 2	Protein Coding	1
9	CBLIF	Cobalamin Binding Intrinsic Factor	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Common variable immunodeficiency	Enrichment	NFKB1, NFKB2	5.09
2	Transcobalamin i deficiency	Enrichment	TCN1	3.18
3	Donnai-barrow syndrome	Enrichment	LRP2	3.18
4	Intrinsic factor deficiency	Enrichment	CBLIF	3.18
5	Congenital intrinsic factor deficiency	Enrichment	CBLIF	3.18
6	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	3.18
7	Prolactin-producing pituitary gland adenoma	Enrichment	LRP2	3.18
8	Transcobalamin ii deficiency	Enrichment	TCN2	2.88
9	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.88
10	Immunodeficiency, common variable, 10	Enrichment	NFKB2	2.88
11	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.88
12	Rela fusion-positive ependymoma	Enrichment	RELA	2.88
13	Common variable immunodeficiency 12	Enrichment	NFKB1	2.88
14	Non-syndromic syndactyly	Enrichment	LRP2	2.88
15	Proteinuria, chronic benign	Enrichment	CUBN	2.70
16	Immunodeficiency, common variable, 1	Enrichment	NFKB2	2.58
17	Prolactinoma	Enrichment	LRP2	2.58
18	Pancytopenia	Enrichment	TCN2	2.40
19	Megaloblastic anemia	Enrichment	CUBN	2.40
20	Imerslund-grasbeck syndrome 1	Enrichment	CUBN	2.33
21	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	2.18
22	Chronic kidney disease	Enrichment	CUBN	2.07
23	Human immunodeficiency virus type 1	Enrichment	CCL2	1.93
24	Autism spectrum disorder	Enrichment	CUBN	1.15
25	Hereditary retinal dystrophy	Enrichment	LRP2	0.75
26	Fundus dystrophy	Enrichment	LRP2	0.75

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Vitamin B12 metabolism