Vitamin D-sensitive calcium signaling in depression

No Pathway Network information available for Vitamin D-sensitive calcium signaling in depression

Pathways in the Vitamin D-sensitive calcium signaling in depression SuperPath

#	Name	Source	Genes
1	Vitamin D-sensitive calcium signaling in depression	WikiPathways	ATP2B1 ATP2B2 ATP2B3 ATP2B4 BCL2 CACNA1C-IT2 CALB1 CHRM1 CYP27A1 CYP27B1 G6PD GCLC GGT1 GRIN1 GRIN2B GRIN2D GRM5 GSR ITPR1 ITPR2 ITPR3 KCNQ2 KCNQ3 KDM1A KDM1B KDM3A KDM6B NFE2L2 PVALB RXRA SLC8A1 TPH1 TPH2 VDR (see all 34) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CALB1	Calbindin 1	Protein Coding	1
2	VDR	Vitamin D Receptor	Protein Coding	1
3	TPH1	Tryptophan Hydroxylase 1	Protein Coding	1
4	SLC8A1	Solute Carrier Family 8 Member A1	Protein Coding	1
5	RXRA	Retinoid X Receptor Alpha	Protein Coding	1
6	BCL2	BCL2 Apoptosis Regulator	Protein Coding	1
7	PVALB	Parvalbumin	Protein Coding	1
8	ATP2B3	ATPase Plasma Membrane Ca2+ Transporting 3	Protein Coding	1
9	ATP2B1	ATPase Plasma Membrane Ca2+ Transporting 1	Protein Coding	1
10	NFE2L2	NFE2 Like BZIP Transcription Factor 2	Protein Coding	1
11	KCNQ3	Potassium Voltage-Gated Channel Subfamily Q Member 3	Protein Coding	1
12	KCNQ2	Potassium Voltage-Gated Channel Subfamily Q Member 2	Protein Coding	1
13	ITPR3	Inositol 1,4,5-Trisphosphate Receptor Type 3	Protein Coding	1
14	ITPR2	Inositol 1,4,5-Trisphosphate Receptor Type 2	Protein Coding	1
15	ITPR1	Inositol 1,4,5-Trisphosphate Receptor Type 1	Protein Coding	1
16	GSR	Glutathione-Disulfide Reductase	Protein Coding	1
17	GRM5	Glutamate Metabotropic Receptor 5	Protein Coding	1
18	GRIN2D	Glutamate Ionotropic Receptor NMDA Type Subunit 2D	Protein Coding	1
19	GRIN2B	Glutamate Ionotropic Receptor NMDA Type Subunit 2B	Protein Coding	1
20	GRIN1	Glutamate Ionotropic Receptor NMDA Type Subunit 1	Protein Coding	1
21	GCLC	Glutamate-Cysteine Ligase Catalytic Subunit	Protein Coding	1
22	GGT1	Gamma-Glutamyltransferase 1	Protein Coding	1
23	G6PD	Glucose-6-Phosphate Dehydrogenase	Protein Coding	1
24	KDM6B	Lysine Demethylase 6B	Protein Coding	1
25	KDM1A	Lysine Demethylase 1A	Protein Coding	1
26	KDM1B	Lysine Demethylase 1B	Protein Coding	1
27	CYP27B1	Cytochrome P450 Family 27 Subfamily B Member 1	Protein Coding	1
28	CYP27A1	Cytochrome P450 Family 27 Subfamily A Member 1	Protein Coding	1
29	TPH2	Tryptophan Hydroxylase 2	Protein Coding	1
30	CHRM1	Cholinergic Receptor Muscarinic 1	Protein Coding	1
31	CACNA1C-IT2	CACNA1C Intronic Transcript 2	RNA Gene	1
32	KDM3A	Lysine Demethylase 3A	Protein Coding	1
33	ATP2B4	ATPase Plasma Membrane Ca2+ Transporting 4	Protein Coding	1
34	ATP2B2	ATPase Plasma Membrane Ca2+ Transporting 2	Protein Coding	1

Disorders associated with Vitamin D-sensitive calcium signaling in depression SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Seizures, benign familial neonatal, 2	Enrichment	KCNQ2, KCNQ3	5.21
2	Self-limited neonatal epilepsy	Enrichment	KCNQ2, KCNQ3	5.21
3	Self-limited infantile epilepsy	Enrichment	KCNQ2, KCNQ3	4.22
4	West syndrome	Enrichment	GRIN1, GRIN2B, KCNQ2	3.75
5	Autosomal dominant non-syndromic intellectual disability	Enrichment	GRIN1, GRIN2B, KCNQ2	3.58
6	Multiple sclerosis	Enrichment	CYP27B1, ITPR1	3.26
7	Developmental and epileptic encephalopathy 1	Enrichment	GRIN1, KCNQ2	2.75
8	Anhidrosis, isolated, with normal sweat glands	Enrichment	ITPR2	2.60
9	Glutathionuria	Enrichment	GGT1	2.60
10	Developmental and epileptic encephalopathy 7	Enrichment	KCNQ2	2.60
11	Anemia, congenital, nonspherocytic hemolytic, 7	Enrichment	GCLC	2.60
12	Developmental and epileptic encephalopathy 27	Enrichment	GRIN2B	2.60
13	Cerebrotendinous xanthomatosis	Enrichment	CYP27A1	2.60
14	Anemia, congenital, nonspherocytic hemolytic, 10	Enrichment	GSR	2.60
15	Intellectual developmental disorder, autosomal dominant 66	Enrichment	ATP2B1	2.60
16	Deafness, autosomal dominant 82	Enrichment	ATP2B2	2.60
17	Charcot-marie-tooth disease, demyelinating, type 1j	Enrichment	ITPR3	2.60
18	Immunodeficiency, developmental delay, and hypohomocysteinemia	Enrichment	NFE2L2	2.60
19	Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal recessive	Enrichment	GRIN1	2.60
20	Intellectual developmental disorder, autosomal dominant 6, with or without seizures	Enrichment	GRIN2B	2.60
21	Cleft palate, psychomotor retardation, and distinctive facial features	Enrichment	KDM1A	2.60
22	Developmental and epileptic encephalopathy 101	Enrichment	GRIN1	2.60
23	Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominant	Enrichment	GRIN1	2.60
24	Palatal anomalies-widely spaced teeth-facial dysmorphism-developmental delay syndrome	Enrichment	KDM1A	2.60
25	Kcnq3-related disorders	Enrichment	KCNQ3	2.60
26	Rickets	Enrichment	VDR	2.60
27	Immunodeficiency 133 with ectodermal dysplasia with or without peripheral neuropathy	Enrichment	ITPR3	2.60
28	Grin2b-related neurodevelopmental disorder	Enrichment	GRIN2B	2.60
29	Acth-independent macronodular adrenal hyperplasia 3	Enrichment	KDM1A	2.60
30	Congenital nonspherocytic hemolytic anemia	Enrichment	G6PD	2.60
31	Intellectual disability, autosomal dominant 8	Enrichment	GRIN1	2.60
32	Kcnq2-related disorders	Enrichment	KCNQ2	2.60
33	Benign epilepsy with centrotemporal spikes	Enrichment	GRIN1, KCNQ3	2.33
34	Spinocerebellar ataxia 29	Enrichment	ITPR1	2.30
35	Seizures, benign familial neonatal, 1	Enrichment	KCNQ2	2.30
36	Major affective disorder 1	Enrichment	TPH2	2.30
37	Spinocerebellar ataxia, x-linked 1	Enrichment	ATP2B3	2.30
38	Spinocerebellar ataxia, x-linked 5	Enrichment	ATP2B3	2.30
39	Seizures, benign familial infantile, 3	Enrichment	KCNQ2	2.30
40	Intravascular large b-cell lymphoma	Enrichment	BCL2	2.30
41	Bilateral generalized polymicrogyria	Enrichment	GRIN1	2.30
42	Developmental and epileptic encephalopathy 46	Enrichment	GRIN2D	2.30
43	Benign familial neonatal epilepsy	Enrichment	KCNQ3	2.30
44	Congenital hemolytic anemia	Enrichment	G6PD	2.30
45	Ichthyosis, congenital, autosomal recessive 10	Enrichment	KCNQ2	2.30
46	Glucosephosphate dehydrogenase deficiency	Enrichment	G6PD	2.30
47	Seizures, benign familial infantile, 5	Enrichment	KCNQ3	2.30
48	Stolerman neurodevelopmental syndrome	Enrichment	KDM6B	2.30
49	Dental caries	Enrichment	ATP2B3	2.30
50	Benign neonatal seizures	Enrichment	KCNQ3	2.30
51	Centralopathic epilepsy	Enrichment	GRIN1, KCNQ3	2.29
52	Gillespie syndrome	Enrichment	ITPR1	2.12
53	Vitamin d hydroxylation-deficient rickets, type 1a	Enrichment	CYP27B1	2.12
54	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL2	2.12
55	Intellectual developmental disorder, autosomal dominant 30, with speech delay and behavioral abnormalities	Enrichment	ATP2B1	2.12
56	Muscular atrophy	Enrichment	ATP2B3	2.12
57	Cushing syndrome due to bilateral macronodular adrenocortical disease	Enrichment	KDM1A	2.12
58	Spastic ataxia	Enrichment	ATP2B3, ITPR1	2.11
59	Astigmatism	Enrichment	GRIN2B	2.00
60	Spinocerebellar ataxia 15	Enrichment	ITPR1	2.00
61	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	G6PD	1.90
62	Vitamin d-dependent rickets, type 2a	Enrichment	VDR	1.90
63	Major depressive disorder	Enrichment	TPH2	1.90
64	Follicular lymphoma	Enrichment	BCL2	1.90
65	Sleep disorder	Enrichment	GRIN2B	1.90
66	Pierre robin syndrome	Enrichment	ATP2B1	1.83
67	Deafness, autosomal recessive 12	Enrichment	ATP2B2	1.83
68	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	ITPR1	1.83
69	Megacolon	Enrichment	SLC8A1	1.76
70	Coronary heart disease 5	Enrichment	G6PD	1.65
71	Developmental and epileptic encephalopathy 14	Enrichment	KCNQ2	1.65
72	Epilepsy, myoclonic juvenile	Enrichment	KCNQ3	1.56
73	Epicanthus	Enrichment	KCNQ2	1.53
74	Congenital long qt syndrome	Enrichment	ITPR3	1.53
75	Clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly	Enrichment	ATP2B1	1.49
76	Pulmonary disease, chronic obstructive	Enrichment	VDR	1.49
77	Clubfoot	Enrichment	ATP2B1	1.49
78	Periventricular nodular heterotopia	Enrichment	ATP2B1	1.46
79	Anterior segment dysgenesis	Enrichment	ITPR1	1.43
80	Microcephaly	Enrichment	ATP2B3, GRIN2B	1.42
81	Complex neurodevelopmental disorder	Enrichment	ATP2B1, GRIN2B	1.42
82	Early infantile developmental and epileptic encephalopathy	Enrichment	GRIN1	1.35
83	Craniosynostosis	Enrichment	GRIN2B	1.31
84	Hepatocellular carcinoma	Enrichment	VDR	1.27
85	Myocardial infarction	Enrichment	GCLC	1.27
86	Malaria	Enrichment	G6PD	1.25
87	Scoliosis	Enrichment	GRIN2B	1.23
88	Long qt syndrome 1	Enrichment	ITPR3	1.14
89	Lung cancer	Enrichment	NFE2L2	1.11
90	Cystic fibrosis	Enrichment	GCLC	1.11
91	Developmental and epileptic encephalopathy	Enrichment	KCNQ2	1.06
92	Fetal akinesia deformation sequence 1	Enrichment	ATP2B3	1.05
93	Cerebral palsy	Enrichment	GRIN2B	1.03
94	Epilepsy	Enrichment	GRIN2B	1.02
95	Distal arthrogryposis	Enrichment	ATP2B3	1.00
96	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ATP2B2	0.91
97	Myeloma, multiple	Enrichment	RXRA	0.88
98	Undetermined early-onset epileptic encephalopathy	Enrichment	GRIN2D	0.88
99	Autosomal recessive non-syndromic intellectual disability	Enrichment	GRIN1	0.87
100	Autism	Enrichment	ATP2B1	0.78
101	Colorectal cancer	Enrichment	NFE2L2	0.71
102	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	ATP2B2	0.70
103	Autism spectrum disorder	Enrichment	GRIN2B	0.62

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Vitamin D-sensitive calcium signaling in depression

Pathway Network for Vitamin D-sensitive calcium signaling in depression

Member Pathways for Vitamin D-sensitive calcium signaling in depression

Pathways in the Vitamin D-sensitive calcium signaling in depression SuperPath

Associated Genes for Vitamin D-sensitive calcium signaling in depression

Associated Disorders for Vitamin D-sensitive calcium signaling in depression

Disorders associated with Vitamin D-sensitive calcium signaling in depression SuperPath

STRING Interaction Network for Vitamin D-sensitive calcium signaling in depression

Sources for Vitamin D-sensitive calcium signaling in depression