Vitamin D metabolism

No Pathway Network information available for Vitamin D metabolism

#	Name	Source	Genes
1	Vitamin D metabolism	WikiPathways	CYP24A1 CYP27A1 CYP27B1 CYP2R1 DHCR7 GC PTH RXRA RXRB VDR (see all 10) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	VDR	Vitamin D Receptor	Protein Coding	1
2	RXRB	Retinoid X Receptor Beta	Protein Coding	1
3	RXRA	Retinoid X Receptor Alpha	Protein Coding	1
4	PTH	Parathyroid Hormone	Protein Coding	1
5	GC	GC Vitamin D Binding Protein	Protein Coding	1
6	DHCR7	7-Dehydrocholesterol Reductase	Protein Coding	1
7	CYP27B1	Cytochrome P450 Family 27 Subfamily B Member 1	Protein Coding	1
8	CYP27A1	Cytochrome P450 Family 27 Subfamily A Member 1	Protein Coding	1
9	CYP24A1	Cytochrome P450 Family 24 Subfamily A Member 1	Protein Coding	1
10	CYP2R1	Cytochrome P450 Family 2 Subfamily R Member 1	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Pulmonary disease, chronic obstructive	Enrichment	CYP2R1, GC, VDR	7.09
2	Vitamin d hydroxylation-deficient rickets, type 1a	Enrichment	CYP27B1, CYP2R1	5.83
3	Cerebrotendinous xanthomatosis	Enrichment	CYP27A1	3.13
4	Rickets	Enrichment	VDR	3.13
5	Hypoparathyroidism, familial isolated, 1	Enrichment	PTH	2.83
6	Vitamin d hydroxylation-deficient rickets, type 1b	Enrichment	CYP2R1	2.83
7	Hypercalcemia, infantile, 1	Enrichment	CYP24A1	2.83
8	Autosomal recessive infantile hypercalcemia	Enrichment	CYP24A1	2.83
9	Familial isolated hypoparathyroidism	Enrichment	PTH	2.66
10	Smith-lemli-opitz syndrome	Enrichment	DHCR7	2.53
11	Primary hyperparathyroidism	Enrichment	PTH	2.53
12	Vitamin d-dependent rickets, type 2a	Enrichment	VDR	2.43
13	Multiple sclerosis	Enrichment	CYP27B1	1.99
14	Isolated congenital microcephaly	Enrichment	DHCR7	1.93
15	Hepatoblastoma	Enrichment	DHCR7	1.81
16	Hepatocellular carcinoma	Enrichment	VDR	1.79
17	Myeloma, multiple	Enrichment	RXRA	1.39

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Vitamin D metabolism