Vitamin K metabolism and activation of dependent proteins

Pathway network for the Vitamin K metabolism and activation of dependent proteins SuperPath

Sources:

WikiPathways
PharmGKB
PubChem
Reactome

Pathways in the Vitamin K metabolism and activation of dependent proteins SuperPath

#	Name	Source	Genes
1	Vitamin K metabolism and activation of dependent proteins	WikiPathways	AIFM2 F10 F2 F7 F9 GGCX NQO1 PROC PROS1 PROZ UBIAD1 VKORC1 VKORC1L1 (see all 13) (see less)
2	Warfarin Pathway, Pharmacodynamics	PharmGKB	AIFM2 BGLAP CALU CYP4F2 EPHX1 F10 F2 F7 F9 GAS6 GGCX MGP NQO1 PROC PROS1 PROZ VKORC1 (see all 17) (see less)
3	vitamin K-epoxide cycle	PubChem	GGCX NQO1 VKORC1 VKORC1L1
4	Metabolism of vitamin K	Reactome	UBIAD1 VKORC1 VKORC1L1
5	menaquinol-4 biosynthesis II	PubChem	UBIAD1

Gene overlap in member pathways for Vitamin K metabolism and activation of dependent proteins SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	VKORC1	Vitamin K Epoxide Reductase Complex Subunit 1	Protein Coding	4
2	VKORC1L1	Vitamin K Epoxide Reductase Complex Subunit 1L1	Protein Coding	3
3	GGCX	Gamma-Glutamyl Carboxylase	Protein Coding	3
4	NQO1	NAD(P)H Quinone Dehydrogenase 1	Protein Coding	3
5	UBIAD1	UbiA Prenyltransferase Domain Containing 1	Protein Coding	3
6	AIFM2	AIF Family Member 2	Protein Coding	2
7	PROZ	Protein Z, Vitamin K Dependent Plasma Glycoprotein	Protein Coding	2
8	PROC	Protein C, Inactivator Of Coagulation Factors Va And VIIIa	Protein Coding	2
9	PROS1	Protein S	Protein Coding	2
10	F7	Coagulation Factor VII	Protein Coding	2
11	F9	Coagulation Factor IX	Protein Coding	2
12	F2	Coagulation Factor II, Thrombin	Protein Coding	2
13	F10	Coagulation Factor X	Protein Coding	2
14	BGLAP	Bone Gamma-Carboxyglutamate Protein	Protein Coding	1
15	CALU	Calumenin	Protein Coding	1
16	MGP	Matrix Gla Protein	Protein Coding	1
17	CYP4F2	Cytochrome P450 Family 4 Subfamily F Member 2	Protein Coding	1
18	EPHX1	Epoxide Hydrolase 1	Protein Coding	1
19	GAS6	Growth Arrest Specific 6	Protein Coding	1

Disorders associated with Vitamin K metabolism and activation of dependent proteins SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Hereditary combined deficiency of vitamin k-dependent clotting factors	Enrichment	GGCX, VKORC1	7.19
2	Cerebral sinovenous thrombosis	Enrichment	F2, PROZ	5.59
3	Thrombophilia due to thrombin defect	Enrichment	F2, VKORC1	4.75
4	Schnyder corneal dystrophy	Enrichment	UBIAD1	4.13
5	Vitamin k-dependent clotting factors, combined deficiency of, 2	Enrichment	VKORC1	3.66
6	Congenital vitamin k-dependent coagulation factors deficiency	Enrichment	VKORC1	3.66
7	Pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency	Enrichment	GGCX	3.53
8	Vitamin k-dependent clotting factors, combined deficiency of, 1	Enrichment	GGCX	3.53
9	Body skin hyperlaxity due to vitamin k-dependent coagulation factor deficiency	Enrichment	GGCX	3.53
10	Pseudoxanthoma elasticum-like skin manifestations with retinitis pigmentosa	Enrichment	GGCX	3.53
11	Cerebral palsy	Enrichment	F2, PROC	3.21
12	Coumarin resistance	Enrichment	VKORC1	3.18
13	Thrombocytopenia	Enrichment	F10, PROS1	3.03
14	Thrombophilia due to protein c deficiency, autosomal dominant	Enrichment	PROC	3.02
15	Factor vii deficiency	Enrichment	F7	3.02
16	Warfarin sensitivity, x-linked	Enrichment	F9	3.02
17	Prothrombin deficiency, congenital	Enrichment	F2	3.02
18	Thrombophilia due to protein s deficiency, autosomal dominant	Enrichment	PROS1	3.02
19	Thrombophilia due to protein s deficiency, autosomal recessive	Enrichment	PROS1	3.02
20	Protein z deficiency	Enrichment	PROZ	3.02
21	Thrombophilia, x-linked, due to factor ix defect	Enrichment	F9	3.02
22	Thrombophilia due to protein c deficiency, autosomal recessive	Enrichment	PROC	3.02
23	Pregnancy loss, recurrent 2	Enrichment	F2	3.02
24	Protein s deficiency	Enrichment	PROS1	3.02
25	Prothrombin deficiency	Enrichment	F2	3.02
26	Severe hereditary thrombophilia due to congenital protein c deficiency	Enrichment	PROC	3.02
27	Protein c deficiency	Enrichment	PROC	3.02
28	Hemophilia b leyden	Enrichment	F9	3.02
29	Hereditary thrombophilia due to congenital protein s deficiency	Enrichment	PROS1	3.02
30	Congenital factor vii deficiency	Enrichment	F7	3.02
31	Keutel syndrome	Enrichment	MGP	2.90
32	Genetic lipodystrophy	Enrichment	EPHX1	2.90
33	Hemophilia b	Enrichment	F9	2.72
34	Factor x deficiency	Enrichment	F10	2.54
35	Congenital factor x deficiency	Enrichment	F10	2.54
36	Hemophilia a	Enrichment	F9	2.42
37	Factor viii deficiency	Enrichment	F9	2.42
38	Familial hypercholanemia	Enrichment	EPHX1	2.13
39	Stroke, ischemic	Enrichment	F2	2.02
40	Myocardial infarction	Enrichment	F7	1.68
41	Cystic fibrosis	Enrichment	EPHX1	1.40

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Vitamin K metabolism and activation of dependent proteins

Pathway Network for Vitamin K metabolism and activation of dependent proteins

Pathway network for the Vitamin K metabolism and activation of dependent proteins SuperPath

Member Pathways for Vitamin K metabolism and activation of dependent proteins

Pathways in the Vitamin K metabolism and activation of dependent proteins SuperPath

Gene overlap in member pathways for Vitamin K metabolism and activation of dependent proteins SuperPath

Associated Genes for Vitamin K metabolism and activation of dependent proteins

Associated Disorders for Vitamin K metabolism and activation of dependent proteins

Disorders associated with Vitamin K metabolism and activation of dependent proteins SuperPath

STRING Interaction Network for Vitamin K metabolism and activation of dependent proteins

Sources for Vitamin K metabolism and activation of dependent proteins