Warburg effect modulated by deubiquitinating enzymes and their substrates

No Pathway Network information available for Warburg effect modulated by deubiquitinating enzymes and their substrates

Pathways in the Warburg effect modulated by deubiquitinating enzymes and their substrates SuperPath

#	Name	Source	Genes
1	Warburg effect modulated by deubiquitinating enzymes and their substrates	WikiPathways	AKT1 FOXO1 G6PC1 HIF1A HK2 KDR LDHA MTOR MYC OTUB2 OTUD6B OTUD7B PGAM1 PGK1 PIK3CA SIRT7 SLC2A1 U2AF2 USP19 USP28 USP37 USP44 USP7 VEGFA VHL (see all 25) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	OTUB2	OTU Deubiquitinase, Ubiquitin Aldehyde Binding 2	Protein Coding	1
2	USP7	Ubiquitin Specific Peptidase 7	Protein Coding	1
3	VHL	Von Hippel-Lindau Tumor Suppressor	Protein Coding	1
4	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	1
5	SLC2A1	Solute Carrier Family 2 Member 1	Protein Coding	1
6	USP28	Ubiquitin Specific Peptidase 28	Protein Coding	1
7	OTUD7B	OTU Deubiquitinase 7B	Protein Coding	1
8	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
9	PGK1	Phosphoglycerate Kinase 1	Protein Coding	1
10	PGAM1	Phosphoglycerate Mutase 1	Protein Coding	1
11	OTUD6B	OTU Deubiquitinase 6B	Protein Coding	1
12	SIRT7	Sirtuin 7	Protein Coding	1
13	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
14	LDHA	Lactate Dehydrogenase A	Protein Coding	1
15	KDR	Kinase Insert Domain Receptor	Protein Coding	1
16	HK2	Hexokinase 2	Protein Coding	1
17	HIF1A	Hypoxia Inducible Factor 1 Subunit Alpha	Protein Coding	1
18	G6PC1	Glucose-6-Phosphatase Catalytic Subunit 1	Protein Coding	1
19	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	1
20	FOXO1	Forkhead Box O1	Protein Coding	1
21	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
22	USP44	Ubiquitin Specific Peptidase 44	Protein Coding	1
23	U2AF2	U2 Small Nuclear RNA Auxiliary Factor 2	Protein Coding	1
24	USP19	Ubiquitin Specific Peptidase 19	Protein Coding	1
25	USP37	Ubiquitin Specific Peptidase 37	Protein Coding	1

Disorders associated with Warburg effect modulated by deubiquitinating enzymes and their substrates SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Hemimegalencephaly	Enrichment	MTOR, PIK3CA	4.49
2	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA	4.31
3	Renal cell carcinoma, papillary, 1	Enrichment	MTOR, VHL	4.17
4	Multiple enchondromatosis, maffucci type	Enrichment	HIF1A, VHL	4.17
5	Cowden syndrome	Enrichment	AKT1, PIK3CA	3.93
6	Meningioma	Enrichment	AKT1, PIK3CA	3.67
7	Renal cell carcinoma, nonpapillary	Enrichment	MTOR, VHL	3.47
8	Macrodactyly	Enrichment	PIK3CA	2.73
9	Proteus syndrome	Enrichment	AKT1	2.73
10	Phosphoglycerate kinase 1 deficiency	Enrichment	PGK1	2.73
11	Stomatin-deficient cryohydrocytosis with neurologic defects	Enrichment	SLC2A1	2.73
12	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.73
13	Cowden syndrome 5	Enrichment	PIK3CA	2.73
14	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.73
15	Developmental delay, dysmorphic facies, and brain anomalies	Enrichment	U2AF2	2.73
16	Microvascular complications of diabetes 1	Enrichment	VEGFA	2.73
17	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.73
18	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.73
19	Epilepsy, idiopathic generalized 12	Enrichment	SLC2A1	2.73
20	Cowden syndrome 6	Enrichment	AKT1	2.73
21	Intellectual developmental disorder with dysmorphic facies, seizures, and distal limb anomalies	Enrichment	OTUD6B	2.73
22	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.73
23	Tufted angioma of skin	Enrichment	KDR	2.73
24	Hypospadias	Enrichment	PIK3CA	2.73
25	Rare venous malformation	Enrichment	PIK3CA	2.73
26	Diaphragmatic eventration	Enrichment	PIK3CA	2.73
27	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.73
28	Epilepsy with myoclonic absences	Enrichment	SLC2A1	2.73
29	Rare combined vascular malformation	Enrichment	PIK3CA	2.73
30	Cavernous lymphangioma	Enrichment	PIK3CA	2.73
31	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.73
32	Male infertility due to obstructive azoospermia	Enrichment	PGK1	2.73
33	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.73
34	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.73
35	Macrodactyly of toe	Enrichment	PIK3CA	2.73
36	Hereditary cryohydrocytosis with reduced stomatin	Enrichment	SLC2A1	2.73
37	Retinal hemangioblastoma	Enrichment	VHL	2.73
38	Epilepsy	Enrichment	OTUD6B, SLC2A1	2.61
39	Hereditary breast carcinoma	Enrichment	AKT1, PIK3CA	2.53
40	Burkitt lymphoma	Enrichment	MYC	2.43
41	Fanconi-bickel syndrome	Enrichment	LDHA	2.43
42	Dystonia 9	Enrichment	SLC2A1	2.43
43	Glut1 deficiency syndrome 1	Enrichment	SLC2A1	2.43
44	Keratosis, seborrheic	Enrichment	PIK3CA	2.43
45	Angioma, tufted	Enrichment	KDR	2.43
46	Noonan syndrome 8	Enrichment	PIK3CA	2.43
47	Cebalid syndrome	Enrichment	MTOR	2.43
48	Glucose transporter type 1 deficiency syndrome	Enrichment	SLC2A1	2.43
49	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.43
50	Hao-fountain syndrome	Enrichment	USP7	2.43
51	Smith-kingsmore syndrome	Enrichment	MTOR	2.43
52	Acute leukemia of ambiguous lineage	Enrichment	VHL	2.43
53	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.26
54	Myasthenic syndrome, congenital, 6, presynaptic	Enrichment	VHL	2.26
55	Glut1 deficiency syndrome 2	Enrichment	SLC2A1	2.26
56	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA	2.26
57	Primary polycythemia	Enrichment	VHL	2.26
58	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	MYC	2.26
59	Chromosome 17q23.1-q23.2 deletion syndrome	Enrichment	SLC2A1	2.26
60	Enchondromatosis	Enrichment	HIF1A	2.26
61	Keratoacanthoma	Enrichment	PIK3CA	2.26
62	Glycogen storage disease ia	Enrichment	G6PC1	2.13
63	Erythrocytosis, familial, 2	Enrichment	VHL	2.13
64	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	2.13
65	Focal cortical dysplasia, type ii	Enrichment	MTOR	2.13
66	Au-kline syndrome	Enrichment	VHL	2.13
67	Cerebrovascular disease	Enrichment	PIK3CA	2.13
68	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.13
69	Isolated focal cortical dysplasia type ii	Enrichment	MTOR	2.13
70	Breast cancer	Enrichment	AKT1, PIK3CA	2.08
71	Capillary malformations, congenital	Enrichment	PIK3CA	2.04
72	Enchondromatosis, multiple, ollier type	Enrichment	HIF1A	2.04
73	Fanconi anemia, complementation group d2	Enrichment	VHL	2.04
74	Von hippel-lindau syndrome	Enrichment	VHL	2.04
75	Rhabdomyosarcoma 2	Enrichment	FOXO1	2.04
76	Hypoglycemia	Enrichment	G6PC1	2.04
77	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.96
78	Cowden syndrome 1	Enrichment	PIK3CA	1.96
79	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.96
80	Hemangioma, capillary infantile	Enrichment	KDR	1.96
81	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.96
82	Sporadic pheochromocytoma/secreting paraganglioma	Enrichment	VHL	1.96
83	Colorectal cancer	Enrichment	AKT1, PIK3CA	1.96
84	Nevus, epidermal	Enrichment	PIK3CA	1.89
85	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.89
86	Gallbladder cancer	Enrichment	PIK3CA	1.89
87	Paroxysmal dystonia	Enrichment	SLC2A1	1.89
88	Overgrowth syndrome	Enrichment	MTOR	1.89
89	Alternating hemiplegia of childhood	Enrichment	SLC2A1	1.83
90	Ovarian cancer	Enrichment	AKT1, PIK3CA	1.83
91	Myoclonic-atonic epilepsy	Enrichment	SLC2A1	1.78
92	Arteriovenous malformation	Enrichment	PIK3CA	1.78
93	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.78
94	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.74
95	Glycogen storage disease	Enrichment	G6PC1	1.70
96	Lung non-small cell carcinoma	Enrichment	PIK3CA	1.70
97	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.66
98	Pheochromocytoma	Enrichment	VHL	1.59
99	Lynch syndrome	Enrichment	PIK3CA	1.56
100	Rare genetic intellectual disability	Enrichment	MTOR	1.56
101	Diffuse large b-cell lymphoma	Enrichment	FOXO1	1.46
102	Leukodystrophy	Enrichment	U2AF2	1.44
103	Endometrial cancer	Enrichment	PIK3CA	1.42
104	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	VHL	1.42
105	Hepatocellular carcinoma	Enrichment	PIK3CA	1.40
106	Precursor t-cell acute lymphoblastic leukemia	Enrichment	MYC	1.38
107	Developmental and epileptic encephalopathy 1	Enrichment	SLC2A1	1.35
108	Tetralogy of fallot	Enrichment	KDR	1.33
109	Strabismus	Enrichment	SLC2A1	1.31
110	Bladder cancer	Enrichment	PIK3CA	1.28
111	Prostate cancer	Enrichment	PIK3CA	1.28
112	Lung cancer	Enrichment	PIK3CA	1.24
113	Fanconi anemia, complementation group a	Enrichment	VHL	1.20
114	Benign epilepsy with centrotemporal spikes	Enrichment	SLC2A1	1.14
115	Centralopathic epilepsy	Enrichment	SLC2A1	1.12
116	Gastric cancer	Enrichment	PIK3CA	1.12
117	West syndrome	Enrichment	SLC2A1	1.11
118	Hypertelorism	Enrichment	PIK3CA	1.04
119	Primary ovarian insufficiency	Enrichment	KDR	0.99
120	Microcephaly	Enrichment	SLC2A1	0.69
121	Inherited cancer-predisposing syndrome	Enrichment	VHL	0.66

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Warburg effect modulated by deubiquitinating enzymes and their substrates

Pathway Network for Warburg effect modulated by deubiquitinating enzymes and their substrates

Member Pathways for Warburg effect modulated by deubiquitinating enzymes and their substrates

Pathways in the Warburg effect modulated by deubiquitinating enzymes and their substrates SuperPath

Associated Genes for Warburg effect modulated by deubiquitinating enzymes and their substrates

Associated Disorders for Warburg effect modulated by deubiquitinating enzymes and their substrates

Disorders associated with Warburg effect modulated by deubiquitinating enzymes and their substrates SuperPath

STRING Interaction Network for Warburg effect modulated by deubiquitinating enzymes and their substrates

Sources for Warburg effect modulated by deubiquitinating enzymes and their substrates