Wnt Pathway

Pathway network for the Wnt Pathway SuperPath

Sources:

Tocris
WikiPathways
PubChem
Reactome

Pathways in the Wnt Pathway SuperPath

#	Name	Source	Genes
1	Wnt Pathway	Tocris	CSNK1A1 CSNK1E CTNNB1 FZD1 GSK3B JUN PPP2CA PPP2CB WNT1 WNT10A WNT10B WNT11 WNT16 WNT2 WNT2B WNT3 WNT3A WNT4 WNT5A WNT5B WNT6 WNT7A WNT7B WNT8A WNT8B WNT9A WNT9B (see all 27) (see less)
2	Wnt signaling in kidney disease	WikiPathways	CTNNB1 DVL1 DVL2 DVL3 FZD1 FZD2 FZD3 FZD4 FZD5 FZD6 FZD7 FZD8 FZD9 INVS LRP5 LRP6 MAPK10 MAPK8 MAPK9 NPHP3-ACAD11 RHOA WNT1 WNT10A WNT10B WNT11 WNT16 WNT2 WNT2B WNT3 WNT3A WNT4 WNT5A WNT5B WNT6 WNT7A WNT7B WNT9B (see all 37) (see less)
3	Wnt signaling network	PubChem	ATP6AP2 CTHRC1 DKK1 FZD1 FZD10 FZD2 FZD4 FZD5 FZD7 FZD8 FZD9 IGFBP4 LRP5 LRP6 ROR2 RSPO1 RYK SOST WIF1 WNT1 WNT2 WNT3 WNT3A WNT5A WNT7A WNT7B (see all 26) (see less)
4	WNT ligand biogenesis and trafficking	Reactome	PORCN SNX3 TMED5 VPS26A VPS29 VPS35 WLS WNT1 WNT10A WNT10B WNT11 WNT16 WNT2 WNT2B WNT3 WNT3A WNT4 WNT5A WNT5B WNT6 WNT7A WNT7B WNT8A WNT8B WNT9A WNT9B (see all 26) (see less)
5	LGK974 inhibits PORCN	Reactome	PORCN

Gene overlap in member pathways for Wnt Pathway SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	WNT1	Wnt Family Member 1	Protein Coding	4
2	WNT2	Wnt Family Member 2	Protein Coding	4
3	WNT3	Wnt Family Member 3	Protein Coding	4
4	WNT3A	Wnt Family Member 3A	Protein Coding	4
5	WNT5A	Wnt Family Member 5A	Protein Coding	4
6	WNT7A	Wnt Family Member 7A	Protein Coding	4
7	WNT7B	Wnt Family Member 7B	Protein Coding	4
8	WNT2B	Wnt Family Member 2B	Protein Coding	3
9	WNT4	Wnt Family Member 4	Protein Coding	3
10	WNT5B	Wnt Family Member 5B	Protein Coding	3
11	WNT6	Wnt Family Member 6	Protein Coding	3
12	WNT9B	Wnt Family Member 9B	Protein Coding	3
13	WNT10A	Wnt Family Member 10A	Protein Coding	3
14	WNT10B	Wnt Family Member 10B	Protein Coding	3
15	WNT11	Wnt Family Member 11	Protein Coding	3
16	WNT16	Wnt Family Member 16	Protein Coding	3
17	FZD1	Frizzled Class Receptor 1	Protein Coding	3
18	CTNNB1	Catenin Beta 1	Protein Coding	2
19	WNT8A	Wnt Family Member 8A	Protein Coding	2
20	WNT8B	Wnt Family Member 8B	Protein Coding	2
21	WNT9A	Wnt Family Member 9A	Protein Coding	2
22	FZD8	Frizzled Class Receptor 8	Protein Coding	2
23	FZD4	Frizzled Class Receptor 4	Protein Coding	2
24	LRP5	LDL Receptor Related Protein 5	Protein Coding	2
25	LRP6	LDL Receptor Related Protein 6	Protein Coding	2
26	FZD2	Frizzled Class Receptor 2	Protein Coding	2
27	FZD9	Frizzled Class Receptor 9	Protein Coding	2
28	FZD7	Frizzled Class Receptor 7	Protein Coding	2
29	FZD5	Frizzled Class Receptor 5	Protein Coding	2
30	PORCN	Porcupine O-Acyltransferase	Protein Coding	2
31	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
32	CSNK1A1	Casein Kinase 1 Alpha 1	Protein Coding	1
33	CSNK1E	Casein Kinase 1 Epsilon	Protein Coding	1
34	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
35	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	1
36	PPP2CB	Protein Phosphatase 2 Catalytic Subunit Beta	Protein Coding	1
37	FZD6	Frizzled Class Receptor 6	Protein Coding	1
38	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	1
39	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	1
40	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
41	RHOA	Ras Homolog Family Member A	Protein Coding	1
42	INVS	Inversin	Protein Coding	1
43	DVL3	Dishevelled Segment Polarity Protein 3	Protein Coding	1
44	DVL1	Dishevelled Segment Polarity Protein 1	Protein Coding	1
45	DVL2	Dishevelled Segment Polarity Protein 2	Protein Coding	1
46	FZD3	Frizzled Class Receptor 3	Protein Coding	1
47	NPHP3-ACAD11	NPHP3-ACAD11 Readthrough (NMD Candidate)	RNA Gene	1
48	RSPO1	R-Spondin 1	Protein Coding	1
49	FZD10	Frizzled Class Receptor 10	Protein Coding	1
50	CTHRC1	Collagen Triple Helix Repeat Containing 1	Protein Coding	1
51	DKK1	Dickkopf Wnt Signaling Pathway Inhibitor 1	Protein Coding	1
52	IGFBP4	Insulin Like Growth Factor Binding Protein 4	Protein Coding	1
53	ATP6AP2	ATPase H+ Transporting Accessory Protein 2	Protein Coding	1
54	ROR2	Receptor Tyrosine Kinase Like Orphan Receptor 2	Protein Coding	1
55	WIF1	Wnt Inhibitory Factor 1	Protein Coding	1
56	RYK	Receptor Like Tyrosine Kinase	Protein Coding	1
57	SOST	Sclerostin	Protein Coding	1
58	TMED5	Transmembrane P24 Trafficking Protein 5	Protein Coding	1
59	VPS29	VPS29 Retromer Complex Component	Protein Coding	1
60	VPS35	VPS35 Retromer Complex Component	Protein Coding	1
61	WLS	Wnt Ligand Secretion Mediator	Protein Coding	1
62	SNX3	Sorting Nexin 3	Protein Coding	1
63	VPS26A	VPS26 Retromer Complex Component A	Protein Coding	1

Disorders associated with Wnt Pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Robinow syndrome, autosomal dominant 1	Enrichment	DVL1, DVL3, FZD2, WNT5A	10.12
2	Autosomal dominant robinow syndrome	Enrichment	DVL1, DVL3, FZD2, WNT5A	10.12
3	Robinow syndrome, autosomal recessive 1	Enrichment	DVL1, DVL3, FZD2, WNT5A	9.60
4	Autosomal recessive robinow syndrome	Enrichment	DVL1, DVL3, FZD2, WNT5A	9.14
5	Osteoporosis, juvenile	Enrichment	DKK1, WNT1, WNT3A	8.20
6	Exudative vitreoretinopathy 1	Enrichment	CTNNB1, FZD4, LRP5	6.73
7	Robinow syndrome, autosomal dominant 2	Enrichment	DVL1, DVL3, FZD2	6.73
8	Exudative vitreoretinopathy	Enrichment	CTNNB1, FZD4, LRP5	5.98
9	Van buchem disease	Enrichment	LRP5, SOST	5.45
10	Robinow syndrome, autosomal dominant 3	Enrichment	DVL3, FZD2	5.14
11	Polycystic liver disease	Enrichment	CTNNB1, LRP5, LRP6	4.91
12	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1, LRP5, LRP6	4.91
13	Retinopathy of prematurity	Enrichment	FZD4, LRP5	4.67
14	Tooth agenesis	Enrichment	LRP6, WNT10A, WNT10B	4.56
15	Focal dermal hypoplasia	Enrichment	PORCN	4.13
16	Osteoporosis	Enrichment	LRP5, WNT1	3.50
17	Macs syndrome	Enrichment	PORCN, WNT7B	3.18
18	Brittle bone disorder	Enrichment	LRP5, WNT1	3.06
19	Brachydactyly, type b1	Enrichment	ROR2	2.72
20	Chiari malformation type i	Enrichment	DKK1	2.72
21	Endosteal hyperostosis, autosomal dominant	Enrichment	LRP5	2.72
22	Craniodiaphyseal dysplasia, autosomal dominant	Enrichment	SOST	2.72
23	Bone mineral density quantitative trait locus 1	Enrichment	LRP5	2.72
24	Exudative vitreoretinopathy 4	Enrichment	LRP5	2.72
25	Sclerosteosis 1	Enrichment	SOST	2.72
26	Congenital disorder of glycosylation, type iir	Enrichment	ATP6AP2	2.72
27	Omodysplasia 2	Enrichment	FZD2	2.72
28	Tooth agenesis, selective, 7	Enrichment	LRP6	2.72
29	Exudative vitreoretinopathy 8	Enrichment	LRP6	2.72
30	Parkinsonism with spasticity, x-linked	Enrichment	ATP6AP2	2.72
31	Intellectual developmental disorder, x-linked, syndromic, hedera type	Enrichment	ATP6AP2	2.72
32	Palmoplantar hyperkeratosis with squamous cell carcinoma of skin and 46,xx sex reversal	Enrichment	RSPO1	2.72
33	Osteoporosis-pseudoglioma syndrome	Enrichment	LRP5	2.72
34	Coronary artery disease, autosomal dominant 2	Enrichment	LRP6	2.72
35	Bone mineral density quantitative trait locus 16	Enrichment	WNT1	2.72
36	Polycystic liver disease 4 with or without kidney cysts	Enrichment	LRP5	2.72
37	Santos syndrome	Enrichment	WNT7A	2.72
38	Microphthalmia/coloboma 11	Enrichment	FZD5	2.72
39	Lrp5-related primary osteoporosis	Enrichment	LRP5	2.72
40	Palmoplantar keratoderma-xx sex reversal-predisposition to squamous cell carcinoma syndrome	Enrichment	RSPO1	2.72
41	Syndromic x-linked intellectual disability hedera type	Enrichment	ATP6AP2	2.72
42	Osteosclerosis-developmental delay-craniosynostosis syndrome	Enrichment	LRP5	2.72
43	Mullerian aplasia and hyperandrogenism	Enrichment	WNT4	2.72
44	Microphthalmia, syndromic 8	Enrichment	SNX3	2.72
45	46,xx sex reversal with dysgenesis of kidneys, adrenals, and lungs	Enrichment	WNT4	2.72
46	Split-hand/foot malformation 6	Enrichment	WNT10B	2.72
47	Tooth agenesis, selective, 8	Enrichment	WNT10B	2.72
48	Parkinson disease 17	Enrichment	VPS35	2.72
49	Diarrhea 9	Enrichment	WNT2B	2.72
50	Adenoid ameloblastoma	Enrichment	CTNNB1	2.70
51	Microcystic stromal tumor	Enrichment	CTNNB1	2.70
52	Nail disorder, nonsyndromic congenital, 1	Enrichment	FZD6	2.56
53	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.56
54	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.56
55	Nephronophthisis	Enrichment	INVS, NPHP3-ACAD11	2.44
56	Craniodiaphyseal dysplasia	Enrichment	SOST	2.42
57	Ulna and fibula, absence of, with severe limb deficiency	Enrichment	WNT7A	2.42
58	Bladder exstrophy and epispadias complex	Enrichment	WNT3	2.42
59	Tetraamelia syndrome 1	Enrichment	WNT3	2.42
60	Osteogenesis imperfecta, type xv	Enrichment	WNT1	2.42
61	Fibular aplasia or hypoplasia, femoral bowing, and poly-, syn-, and oligodactyly	Enrichment	WNT7A	2.42
62	Sclerosteosis	Enrichment	SOST	2.42
63	Osteosclerosis	Enrichment	LRP5	2.42
64	Bladder exstrophy-epispadias-cloacal exstrophy complex	Enrichment	WNT3	2.42
65	Tooth agenesis, selective, 4	Enrichment	WNT10A	2.42
66	Schopf-schulz-passarge syndrome	Enrichment	WNT10A	2.42
67	Odontoonychodermal dysplasia	Enrichment	WNT10A	2.42
68	Zaki syndrome	Enrichment	WLS	2.42
69	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	2.40
70	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	2.40
71	Houge-janssens syndrome 3	Enrichment	PPP2CA	2.40
72	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	2.40
73	Teratoma	Enrichment	CTNNB1	2.40
74	Spinocerebellar ataxia, autosomal recessive 24	Enrichment	NPHP3-ACAD11	2.26
75	Microphthalmia, syndromic 9	Enrichment	WNT7B	2.24
76	Osteopetrosis, autosomal dominant 1	Enrichment	LRP5	2.24
77	Tetraamelia syndrome	Enrichment	WNT3	2.24
78	Mullerian duct aplasia, unilateral renal agenesis, and cervicothoracic somite anomalies	Enrichment	WNT4	2.24
79	Tooth agenesis, selective, 2	Enrichment	WNT10A	2.24
80	Desmoid disease, hereditary	Enrichment	CTNNB1	2.22
81	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	2.22
82	Anus, imperforate	Enrichment	CTNNB1	2.22
83	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	2.22
84	Desmoid tumor	Enrichment	CTNNB1	2.22
85	Barrett esophagus	Enrichment	CTHRC1	2.12
86	Orofacial cleft	Enrichment	LRP6	2.12
87	Eyelid coloboma	Enrichment	FZD5	2.12
88	Vitreoretinopathy	Enrichment	LRP5	2.12
89	Orofacial clefting syndrome	Enrichment	LRP6	2.12
90	Lens coloboma	Enrichment	FZD5	2.12
91	Ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive	Enrichment	WNT10A	2.12
92	Ectodermal dysplasia	Enrichment	WNT10A	2.12
93	Glioma	Enrichment	VPS35	2.12
94	Pilomatrixoma	Enrichment	CTNNB1	2.10
95	Alazami syndrome	Enrichment	CTNNB1	2.10
96	Craniopharyngioma	Enrichment	CTNNB1	2.10
97	Meckel syndrome, type 7	Enrichment	NPHP3-ACAD11	2.09
98	Nephronophthisis 2	Enrichment	INVS	2.09
99	Nephronophthisis 3	Enrichment	NPHP3-ACAD11	2.09
100	Developmental and epileptic encephalopathy 44	Enrichment	NPHP3-ACAD11	2.09
101	Nail disease	Enrichment	FZD6	2.09
102	Renal-hepatic-pancreatic dysplasia	Enrichment	NPHP3-ACAD11	2.09
103	Norrie disease	Enrichment	FZD4	2.02
104	Persistent hyperplastic primary vitreous	Enrichment	FZD4	2.02
105	Coloboma of choroid and retina	Enrichment	FZD5	2.02
106	Autosomal recessive hypohidrotic ectodermal dysplasia syndrome	Enrichment	WNT10A	2.02
107	Renal-hepatic-pancreatic dysplasia 1	Enrichment	NPHP3-ACAD11	1.96
108	Acyl-coa dehydrogenase, very long-chain, deficiency of	Enrichment	DVL2	1.96
109	Coloboma of optic nerve	Enrichment	FZD5	1.94
110	Renal dysplasia, cystic	Enrichment	WNT9B	1.94
111	Renal hypoplasia	Enrichment	WNT9B	1.94
112	Diarrhea	Enrichment	WNT2B	1.94
113	Weyers acrofacial dysostosis	Enrichment	CTNNB1	1.92
114	Adrenocortical carcinoma	Enrichment	CTNNB1	1.92
115	Coats disease	Enrichment	FZD4	1.87
116	Gallbladder cancer	Enrichment	CTNNB1	1.86
117	Renal hypodysplasia/aplasia 1	Enrichment	WNT9B	1.82
118	Isolated split hand-split foot malformation	Enrichment	WNT10B	1.82
119	Hemihyperplasia, isolated	Enrichment	RHOA	1.79
120	Multicystic kidney dysplasia	Enrichment	FZD3	1.79
121	Multicystic dysplastic kidney	Enrichment	FZD3	1.79
122	Renal agenesis, bilateral	Enrichment	WNT9B	1.77
123	Adult hepatocellular carcinoma	Enrichment	CTNNB1	1.75
124	Cat eye syndrome	Enrichment	FZD5	1.72
125	Lennox-gastaut syndrome	Enrichment	MAPK10	1.67
126	Infantile nephronophthisis	Enrichment	INVS	1.67
127	Colorectal cancer	Enrichment	CTNNB1, FZD3	1.63
128	Microphthalmia/coloboma 12	Enrichment	FZD5	1.61
129	Osteogenesis imperfecta, type iv	Enrichment	WNT1	1.61
130	Chronic kidney disease	Enrichment	WNT9B	1.61
131	Medulloblastoma	Enrichment	CTNNB1	1.56
132	Coloboma of macula	Enrichment	FZD5	1.55
133	Osteogenesis imperfecta, type iii	Enrichment	WNT1	1.55
134	Senior-loken syndrome 1	Enrichment	INVS	1.46
135	Hydrocephalus	Enrichment	FZD3	1.40
136	Hepatoblastoma	Enrichment	CTNNB1	1.39
137	Microphthalmia	Enrichment	WNT7B	1.38
138	Hepatocellular carcinoma	Enrichment	CTNNB1	1.37
139	Parkinson disease, late-onset	Enrichment	VPS35	1.35
140	Polycystic kidney disease	Enrichment	NPHP3-ACAD11	1.32
141	Developmental and epileptic encephalopathy 1	Enrichment	CSNK1E	1.31
142	Bladder cancer	Enrichment	CTNNB1	1.25
143	Hydrops fetalis, nonimmune	Enrichment	FZD6	1.16
144	Fetal akinesia deformation sequence 1	Enrichment	ROR2	1.16
145	Distal arthrogryposis	Enrichment	ROR2	1.11
146	Non-immune hydrops fetalis	Enrichment	FZD6	1.09
147	West syndrome	Enrichment	CSNK1E	1.08
148	Developmental and epileptic encephalopathy	Enrichment	NPHP3-ACAD11	1.03
149	Hereditary retinal dystrophy	Enrichment	FZD4, LRP5	0.98
150	Fundus dystrophy	Enrichment	FZD4, LRP5	0.98
151	Optic atrophy plus syndrome	Enrichment	NPHP3-ACAD11	0.95
152	Joubert syndrome 1	Enrichment	NPHP3-ACAD11	0.89
153	Breast cancer	Enrichment	JUN	0.86
154	Ovarian cancer	Enrichment	CTNNB1	0.74
155	Congenital nervous system abnormality	Enrichment	CTNNB1	0.72
156	Nervous system disease	Enrichment	CTNNB1	0.72
157	Microcephaly	Enrichment	CTNNB1	0.66
158	Complex neurodevelopmental disorder	Enrichment	PPP2CA	0.66

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Wnt Pathway

Pathway Network for Wnt Pathway

Pathway network for the Wnt Pathway SuperPath

Member Pathways for Wnt Pathway

Pathways in the Wnt Pathway SuperPath

Gene overlap in member pathways for Wnt Pathway SuperPath

Associated Genes for Wnt Pathway

Associated Disorders for Wnt Pathway

Disorders associated with Wnt Pathway SuperPath

STRING Interaction Network for Wnt Pathway

Sources for Wnt Pathway